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Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Sohi Kang Joong-Sun kim sung-ho kim hongbing Wang Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea Department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,DPI)and chronic phase(28DPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(DG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and DG subregions in the early phase of EAE,but only reduced in the DG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

Epigenetic mechanisms involved in the neuroprotective effect of scorpion extract in a Parkinson's disease murine model based on multi-omics approach

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Journal of Traditional Chinese Medicine 2021年第3期41卷 390-396页

作者： Joong Sun kim Hye-Sun Lim Byeong Cheol Moon Mary Jasmin Ang sung-ho kim Changjong Moon Boseok Seong Yunji Jang Hyung-Yong kim Chul kim Herbal Medicine Resources Research Center Korea Institute of Oriental MedicineJeollanamdo 58245Republic of Korea College of Veterinary Medicine and BK21 Plus Project Team Chonnam National UniversityGwangju 61186Republic of Korea Future Medicine Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Research and Development Center Insilicogen Inc.Yonginsi 16954Republic of Korea

OBJECTIVE: To investigate whether scorpion extract elicits a neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice models, and the genes associated with the therapeutic effects using RNA sequencing(seq)***: This study investigated the changes in interaction between messenger ribonucleic acid(m RNA) expression and deoxyribonucleic acid(DNA) methylation related to the protective effects of scorpion extracts, in the substantia nigra(SN)region of a MPTP-induced Parkinson's disease(PD)***: In this model, scorpion extracts attenuated the motor impairment as demonstrated by the rotarod and open field tests. Scorpion extracts consistently attenuated the decrease of tyrosine hydroxylase(TH) positive neural cells in the SN and striatum of mice. We profiled genomewide DNA methylation using Methyl-Seq and measured the transcriptome using RNA-Seq in murine SN in the following groups: vehicle-treated MPTP-induced PD mice and scorpion extracttreated MPTP-induced PD mice. In total, 13 479 differentially expressed genes were identified in association with the anti-PD effect of the scorpion extract, mainly in the promoter and coding *** them, 47 were negatively correlated downregulated genes. Nineteen genes out of 47 downregulated genes were negatively correlated with the expression of the other 28 genes. Among these genes, SGSM1 was related to dopaminergic neurons including dopamine transporters, TH, dihydroxyphenylalanine decarboxylase, and dopamine D2 ***: This study provides insights into the anti-parkinsonian effects of scorpion extract and reveals the epigenetic targets in its therapeutic mechanism.

关键词： scorpions 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine Parkinson disease DNA methylation

Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression

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Neural Regeneration Research 2019年第9期14卷 1530-1535页

作者： Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon sung ho kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun kim Division of Basic Radiation Bioscience Korea Institute of Radiological&Medical Sciences(KIRMAS)SeoulRepublic of Korea National Primate Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)CheongjuRepublic of Korea College of Pharmacy Kyungpook National UniversityDaeguRepublic of Korea College of Veterinary Medicine Veterinary Medical Research InstituteChonnam National UniversityGwangjuRepublic of Korea School of Medicine Wonkwang UniversityJeonbukRepublic of Korea Research Center Dongnam Institute of Radiological&Medical Sciences(DIRAMS)BusanRepublic of Korea

Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain *** investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial *** impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after *** also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic ***-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** butyrate pretreatment reversed these *** findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor *** study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval ***16-0002)on December 30,2016.

关键词： sodium butyrate radioprotector ionizing radiation hippocampal damage cAMP response element binding brain-derived neurotrophic factor histone deacetylase inhibitor neurogenesis

Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment

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Neural Regeneration Research 2012年第21期7卷 1651-1658页

作者： Miyoung Yang Juhwan kim sung-ho kim Joong-Sun kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy College of Veterinary Medicine and Animal Medical Institute Chonnam National University Department of Experimental Radiation Research Center Dongnam Institute of Radiological & Medical Sciences (DIRAMS) Department of Veterinary Anatomy College of Veterinary Medicine Jeju National University

Methotrexate, which is used to treat many malignancies and autoimmune diseases, affects brain functions including hippocampal-dependent memory function. however, the precise mechanisms underlying methotrexate-induced hippocampal dysfunction are poorly understood. To evaluate temporal changes in synaptic plasticity-related signals, the expression and activity of N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, extracellular signal-regulated kinase 1/2, cAMP responsive element-binding protein, glutamate receptor 1, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor were examined in the hippocampi of adult C57BL/6 mice after methotrexate （40 mg/kg） intraperitoneal injection. Western blot analysis showed biphasic changes in synaptic plasticity-related signals in adult hippocampi following methotrexate treatment. N-methyI-D-aspartic acid receptor 1, calcium/calmodulin-dependent protein kinase II, and glutamate receptor 1 were acutely activated during the early phase （1 day post-injection）, while extracellular signal-regulated kinase 1/2 and cAMP responsive element-binding protein activation showed biphasic increases during the eady （1 day post-injection） and late phases （7-14 days post-injection）. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression increased significantly during the late phase （7-14 days post-injection）. Therefore, methotrexate treatment affects synaptic plasticity-related signals in the adult mouse hippocampus, suggesting that changes in synaptic plasticity-related signals may be associated with neuronal survival and plasticity-related cellular remodeling.

关键词： hippocampus methotrexate neurotrophic factor synaptic plasticity-related signal neuralregeneration

A Neighborhood Method for Statistical Analysis of fMRI Data

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Open Journal of Biophysics 2012年第1期2卷 15-22页

作者： Fayyaz Ahmad Ghanim Ullah sung-ho kim 不详

In an effort to cope with the fact that functional magnetic resonance imaging (fMRI) data are spatiotemporally correlated, we propose a novel statistical method with a view to improve the detection of brain regions with increased neu-ronal activity in fMRI. In this method, we make use of information from neighboring voxels of a voxel, for estimation at the voxel. We examined performance of the method against the statistical parametric mapping (SPM) method using both simulated and real data. The proposed method is shown to be considerably better than the SPM in the context of receiver operating characteristics (ROC) curves.

关键词： Statistical Parametric Mapping Autoregressive Model Initial Values ROC Curve GLM Regions of Interest

Statistical Analysis on Gender Difference in Neural Activity for Spatial Ability Tasks

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Open Journal of Biophysics 2023年第1期13卷 14-27页

作者： sung-ho kim Namgil Lee Chang-Hyun Park Department of Mathematical Sciences Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Information Statistics Kangwon National University Chuncheon South Korea Center for Neuroprosthetics and Brain Mind Institute Swiss Federal Institute of Technology(EPFL) Geneva Switzeland

Gender differences are investigated from the viewpoint of cognitive neuroscience in the domain of spatial ability. Five task types of geometric problems are used for the collection of task-evoked fMRI data. Although there was no gender-difference in task performance, we found gender differences in neural activity. Some of the important gender differences that we found are 1) that there are far more joint neuro-activations among the brain regions, co-activations or reverse-activations, in males than in females, 2) that the two types of joint activations were nearly half and half in females while it was mostly co-activations in males, 3) that males tend to have more co-activations in the left hemisphere than expected while females tend to have more between-hemisphere co-activations than expected, and 4) that the left-right pairs of BA's are more highly associated than average for males while they are far less associated than average for females.

关键词： Cross-Correlation Functional Magnetic Resonance Imaging Co-Activation and Reverse-Activation Between and Within Hemisphere

应用覆膜支架介入救治颈动脉破裂并假性动脉瘤

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介入放射学杂志 2006年第3期15卷 142-145页

作者：徐高峰 Dae Chul Suh ho sung kim 江苏盐城市第一人民医院放射科 224006 韩国Ulsan大学医学院Asan医疗中心放射科

目的探讨应用覆膜支架介入治疗颈动脉破裂并假性动脉瘤。方法4例肿瘤所致颈动脉破裂并假性动脉瘤形成的患者,均出现颈部或口腔危及生命的出血,采用Seldinger方法,选用自膨式聚四氟乙烯覆膜支架治疗。结果4例成功施行血管内介入治疗,其... 详细信息

目的探讨应用覆膜支架介入治疗颈动脉破裂并假性动脉瘤。方法4例肿瘤所致颈动脉破裂并假性动脉瘤形成的患者,均出现颈部或口腔危及生命的出血,采用Seldinger方法,选用自膨式聚四氟乙烯覆膜支架治疗。结果4例成功施行血管内介入治疗,其中颈总动脉中段1例,颈动脉球2例,颈总动脉远段1例。共置入覆膜支架6枚。术后假性动脉瘤腔被隔绝,颈动脉通畅,患者的临床症状明显改善,无神经功能障碍。1例患者11 d后支架下缘颈总动脉与原瘤腔相通,再次置入覆膜支架,2个月的随访无再出血。1例患者经钢圈栓塞、放置覆膜支架及裸支架瘤腔隔绝,但术后6周先前的支架下缘出现假性动脉瘤,经置入覆膜支架后出血停止。结论自膨式聚四氟乙烯覆膜支架治疗颈动脉破裂并假性动脉瘤是患者安全、有效的方法,特别是在救治伴有出血的颈部假性动脉瘤,支架的长期效果有待于进一步随访观察。

关键词：颈动脉破裂假性动脉瘤覆膜支架放射学介入性

A Study of Electrochemical Behavior for the Pure Li2 MnO3 Material via the Synthesis Methods and the Effect of the Composite Materials

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A Study of Electrochemical Behavior for the Pure Li2 MnO3 Ma...

2012 International Conference on Power and Energy Systems(ICPES 2012)

作者： JuHee Kang IkHyun Oh ChaeHwan Jeong SeongJae Boo TaeWon kim Moosung Lee ho-sung kim Korea Institute of Industrial Technology Gwangju 500-480 Korea Department of Advance Chemicals and Engineering Chonnam University Gwangju 500-757 Korea

The pure Li2 MnO3 material was prepared by the two kinds of process, co-precipitation and solid state method. Both sample powders showed a typical pattern of monoclinic structure including superlattice peaks. however, they showed much different electrochemical behaviors according to the synthesized process of Li2 MnO3 material. The pure Li2 MnO3 material, which was prepared by co-precipitation process, showed more clear kinetic properties, which are the two pairs of redox peaks at around 3V and 4V characteristic of spinel present. Furthernore, as the Li2 MnO3 material was mixed with a little additive materials, LiMO2 (M = Ni, Mn, Co), electrochemical properties with cycle were greatly improved even as charged at a high potential range of around 5V.

关键词： Lithium ion battery, Li 2 MnO 3 -based cathode materials, Electrochemical properties.

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红带与镜带商场

城市环境设计 2015年第5期92卷 124-131页

作者： sung-ho kim Chang-ho Shin Bok-ki Lee Jung-hoon Lee Eun-young kim Kyung Rho WISE建筑事务所

建筑位于首尔江南区驿三洞618-2号,共两层,水平的条形镜带与垂直向的红色透明条互相重叠并且反射,营造出强烈的视觉错觉。沿着层间狭窄的楼梯往上走,反复的折射光和摇晃的不锈钢条使行走其中的人产生一种晕炫感。楼梯连接着地面和屋顶平... 详细信息

建筑位于首尔江南区驿三洞618-2号,共两层,水平的条形镜带与垂直向的红色透明条互相重叠并且反射,营造出强烈的视觉错觉。沿着层间狭窄的楼梯往上走,反复的折射光和摇晃的不锈钢条使行走其中的人产生一种晕炫感。楼梯连接着地面和屋顶平台,提供了不同的行走体验,改变了过去首尔常见的商业体块模式。我们将这条红色反光镜组成的楼梯走道称为"非凡的建筑漫步通道"。最

关键词：商业建筑商场百货商店楼梯江南区镜面板走道屋顶平台