Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration

作     者：Jinwook Kim Sueun Lee Sohi Kang Sung-Ho Kim Jong-Choon Kim Miyoung Yang Changjong Moon 

作者机构：Departments of Veterinary Anatomy and Veterinary ToxicologyCollege of Veterinary Medicine and BK21 PLUS Project TeamChonnam National University Department of AnatomySchool of Medicine and Institute for Environmental ScienceWonkwang University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第10期

页      面：1733-1741页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a grant from Wonkwang University in 2017 

主　　题：brain derived neurotropic factor neurotoxicity gamma aminobutyric acid ergic transmission neurodegenerative diseases neural regeneration 

摘      要：Neurotoxicity induced by stress,radiation,chemicals,or metabolic diseases,is commonly associated with excitotoxicity,oxidative stress,and *** pathological process of neurotoxicity induces neuronal death,interrupts synaptic plasticity in the brain,and is similar to that of diverse neurodegenerative *** models of neurotoxicity have revealed that clinical symptoms and brain lesions can recover over time via neuroregenerative ***,brain-derived neurotropic factor（BDNF） and gamma-aminobutyric acid（GABA）-ergic transmission are related to both neurodegeneration and *** review summarizes the accumulating evidences that suggest a pathogenic role of BDNF and GABAergic transmission,their underlying mechanisms,and the relationship between BDNF and GABA in neurodegeneration and *** review will provide a comprehensive overview of the underlying mechanisms of neuroregeneration that may help in developing potential strategies for pharmacotherapeutic approaches to treat neurotoxicity and neurodegenerative disease.