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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina h.omada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tngCs). however, the use of tngCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth.of blood vessels from the surrounding tissue into the regenerating nerve within the tngC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tngCs and compared the various features of these improved silk^(+) tngCs with the tubes without holes(silk^(–) tngCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tngCs induced the growth.of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tngCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth.of blood vessels th.ough the tubular walls of silk^(+) tngCs, but without improved functional recovery at 12 weeks postoperatively. our data proves that macroporous tngCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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System Dynamic Modelling of Patient Flow and Transferral Problem in a Mixed Public-Private healthcare System:A Case Study of h.ng Kong SAR

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Journal of Systems Science and Systems Engineering 2020年第5期29卷 590-608页

作者： C.K.M.LEE W.C.TAI Kam K.h.ng Department of Industrial and Systems Engineering The Hon g Kong Polytechnic UniversityHung HornHong Kong SARChina Sch.ol of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The current healthcare system in h.ng Kong is experiencing pressure due to constrained resources,with dramatic increases in inpatient services queue lengths,dissatisfaction with the working environment,unacceptable workforce arrangements and high turnover rate of hospital *** maintain the robustness of the healthcare system and a sustainable inpatients flow,the Food and health Bureau launched a public-private partnership programme to utilise the resources of the public and private *** research investigates the potential for extension of the programme and further enhancing the sustainability of the long-term inpatient services under a mixed public-private healthcare policy via system dynamic *** findings show that an increase of human resources in public hospitals does not substantially improve inpatient flow rate ***,the results from the system dynamic approach provide insights into the expansion of the service areas of the programme and suggest increasing the number of referrals to private hospitals.

关键词： System dynamic models scenario analysis inpatient transferral mixed public-private healthcare system

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Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-hsien ChEN Kam K.h.ng Xin YUAN Cho Yin YIU human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China Sch.ol of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge tech.ologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** ch.nges in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot operations(DPo)to Single-Pilot operations(SPo)th.ough a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPo were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SPo measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPo-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour ch.nges Eye tracker Electroencephalogram

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Calculation of electric field–temperature (E, T) phase diagram of a ferroelectric liquid crystal near the SmA–SmC_α~* transition

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Chinese Physics B 2018年第3期27卷 444-450页

作者： F Trabelsi h Dh.ouadi o Riahi T othman Universite de Tunis El-Manar Faculte des Sciences de TunisLaboratoire de physique de la matiere molle et de modelisation electromagnetique(LP3ME)Campus Universitaire Farhat Hached 2092 Tunis Tunisie

In this work we perform a th.oretical calculation in order to reconstitute the （E-T） phase diagram of a chiral smectic liquid crystal in the vicinity of the SmA-SmCα＊ transition. This reconstruction is carried out on the basis of a thermo-dynamic calculation of the slope of the curve joining the SmC＊ domain and the unwound SmC＊. An empiric correction of the mean field term of Landau De-Gennes development is necessary to accomplish this reconstruction. Thereafter, an experimental validation is performed to verify our calculations.

关键词： field-temperature phase diagram liquid orystal

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optimal deployment schedule of an active twist rotor for performance enhancement and vibration reduction in high-speed flights

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Chinese Journal of Aeronautics 2017年第4期30卷 1427-1440页

作者： Young h.YoU sung N.JUng Ch.ng J.KIM Department of Aerospace Information Engineering Konkuk University Seoul 05019 Republic of Korea

The best active twist schedules exploiting various waveform types are sought taking advantage of the global search algorithm for the reduction of hub vibration and/or power required of a rotor in high-speed conditions. The active twist schedules include two non-harmonic inputs formed based on segmented step functions as well as the simple harmonic waveform input. An advanced Particle Swarm assisted Genetic Algorithm（PSGA） is employed for the optimizer. A rotorcraft Computational Structural Dynamics（CSD） code CAMRAD II is used to perform the rotor aeromechanics analysis. A Computation Fluid Dynamics（CFD） code is coupled with CSD for verification and some physical insights. The PSGA optimization results are verified against the parameter sweep study performed using the harmonic actuation. The optimum twist schedules according to the performance and/or vibration reduction strategy are obtained and their optimization gains are compared between the actuation cases. A two-phase non-harmonic actuation schedule demonstrates the best outcome in decreasing the power required while a four-phase non-harmonic schedule results in the best vibration reduction as well as the simultaneous reductions in the power required and vibration. The mechanism of reduction to the performance gains is identified illustrating the section airloads, angle-of-attack distribution, and elastic twist deformation predicted by the present approaches.

关键词： Active twist high-speed flight hub vibration Non-harmonic Power required

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用原位腔内清洗提高Al刻蚀的MTBC

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功能材料与器件学报 2013年第5期19卷 252-254页

作者： F.Chen Y.huang Q.Ge h.ng Applied Materials China Applied Materials USA

优化原位腔清洗工艺可延长清洗之间Al刻蚀腔加工时间(MTBC),不损伤清洗腔内部,同时也保持了合理的产额。Cl/o2能非常有效地去除碳基聚合物,而BCl3/Cl最有利于去除Al副产品。通过提高压力得到了顶盖/侧壁清洗均匀性方面最好的改进。实行... 详细信息

优化原位腔清洗工艺可延长清洗之间Al刻蚀腔加工时间(MTBC),不损伤清洗腔内部,同时也保持了合理的产额。Cl/o2能非常有效地去除碳基聚合物,而BCl3/Cl最有利于去除Al副产品。通过提高压力得到了顶盖/侧壁清洗均匀性方面最好的改进。实行最佳清洗工艺后,MTBC提高了4倍。

关键词： Al MTBC 清洗工艺均匀性聚合物薄膜产额碳基半导体器件淀积逻辑器件

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抑郁症状快速评定量表自评版(QIDS-SR)应用于hBV相关肝脏疾病患者的心理测量学特性（英文）

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上海精神医学 2017年第1期29卷 15-20页

作者：刘梅王园园赵景郑素军 Gabor S.UngVARI Chee h.ng 段钟平项玉涛 Artificial Liver Center Beijing YouAn HospitalCapital Medical University Unit of Psychiatry Faculty of Health SciencesUniversity of Macao The University of Notre Dame Australia/Marian Centre Sch.ol of Psychiatry & Clinical Neurosciences University of Western Australia Department of Psychiatry University of Melbourne

背景:乙型肝炎病毒(hBV)感染伴发抑郁症是一种常见的现象。建立精确并且有时效的工具,用以评估hBV患者抑郁症状,对研究和临床实践是非常重要的。目的:这项研究测试了抑郁症状快速评定量表自评版(QIDS-SR)在乙型肝炎患者中使用的心理测... 详细信息

背景:乙型肝炎病毒(hBV)感染伴发抑郁症是一种常见的现象。建立精确并且有时效的工具,用以评估hBV患者抑郁症状,对研究和临床实践是非常重要的。目的:这项研究测试了抑郁症状快速评定量表自评版(QIDS-SR)在乙型肝炎患者中使用的心理测量学特性。方法:这项研究招募了245名患有乙型肝炎病毒和相关肝病的抑郁症患者。采用蒙特玛莉抑郁评定量表(MADRS)和QIDS-SR评估抑郁症状的严重程度。结果:QIDS-SR的内部一致性((Cronbachα)为0.796.其总分与MADRS总分显著相关r=0.698,p<0.001)。探索性因素分析的QIDS-SR显示一维测量性能结论:QIDS-SR(中文版)在乙型肝炎患者中有良好的心理测量学特性,并且在评估临床抑郁症方面是有用的。

关键词：抑郁症状心理测量学特性 QIDS-SR 乙型肝炎病毒

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SCALIng PRoPERTIES oF NUCLEAR MULTIFRAGMENTATIoN

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Chinese Science Bulletin 1991年第14期36卷 1162-1166页

作者：郑玉明 h. ng■ C. ng■ S. LERAY Institute of Atomic Energy P.O.Box 275 18 Beijing 102413 PRC Division de Physique Th.orique Institut de Physique Nucléaire 91406 Orsay France Laboratoire National Saturne 91191 Gif sur Yvette Cedex France

Under given conditions, for instance, by heavy-ion collisions at intermediate and high energies, nuclei can break into several pieces. This new reaction mechanism is called nuclear multifragmentation. In analogy with a macroscopic system where a critical phenomenon takes place, nuclear multifragmentation also shows .the scaling properties. however, these properties can only be described partly by the restructured aggregation

关键词： nuclear multifragmentation the scaling property the critical exponent.

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Three-dimensional biogenic C-doped Bi_2Moo_6/In_2o_3-Zno Z-scheme heterojunctions derived from a layered precursor

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Journal of Environmental Sciences 2019年第5期31卷 54-66页

作者： h.ngyan Li Jia Li Ping Yang Dickon h.L.ng Xinling Cui Fei Ji Sch.ol of Material Science and Engineering University of Jinan Department of Physics The Chinese University of Hong Kong

Novel 3D biogenic C-doped Bi_2 Moo_6/In_2o_3-Zno Z-scheme heterojunctions were synthesized for the first time, using cotton fiber as template. The as-prepared samples showed excellent adsorption and photodegradation performance toward the hazardous antibiotic doxycycline under simulated sunlight irradiation. The morphology, phase composition and in situ carbon doping could be precisely controlled by adjusting processing parameters. The carbon doping in Bi_2 Moo_6/In_2o_3-Zno was derived from the cotton template, and the carbon content could be varied in the range 0.9–4.4 wt.% via controlling the heat treatment temperature. The sample with Bi_2 Moo_6/In_2o_3-Zno molar ratio of 1:2 and carbon content of1.1 wt.% exhibited the highest photocatalytic activity toward doxycycline degradation,which was 3.6 and 4.3 times higher than those of pure Bi_2 Moo_6 and Zn In Al-CLDh(calcined layered double hydroxides), respectively. It is believed that the Z-scheme heterojunction with C-doping, the 3D hierarchically micro–meso–macro porous structure, as well as the high adsorption capacity, contributed significantly to the enhanced photocatalytic activity.

关键词： Biotemplate Bi2Moo6 ZnInAl-layered double hydroxides (LDh) Adsorption Photocatalysis

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Asymptotic iteration approach to supersymmetric bistable potentials

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Chinese Physics B 2012年第1期21卷 68-73页

作者： h. Ciftci o. zer P. Roy Gazi niversitesi Fen-Edebiyat Fakültesi Fizik Blümü 06500 Teknikokullar-Ankara Turkey Department of Engineering Physics Faculty of Engineering University of Gaziantep 27310 Gaziantep Turkey Physics and Applied Mathematics Unit Indian Statistical Institute Calcutta 700035 India

We examine quasi exactly solvable bistable potentials and their supersymmetric partners within the framework of the asymptotic iteration method （AIM）. It is shown that the AIM produces excellent approximate spectra and that sometimes it is found to be more useful to use the partner potential for computation. We also discuss the direct application of the AIM to the Fokker-Planck equation.

关键词： bistable potentials asymptotic iteration

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