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THE EPIDEMIOLOGY OF OSTEOPOROSIS IN KOREA

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THE EPIDEMIOLOGY OF OSTEOPOROSIS IN KOREA

Phase Ⅱ study of R-CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma:consortium for improving survival of lymphoma(CISL)study

The Third International Congress on Osteoporosis

作者： Young K.Choi In-kwon Han Nam H.Cho Kyung-Hee University School of Medicine sung-Kyun-Kwan University College of Medicine Seoul Korea Ajou University School of Medicine Suwon Korea

＜正＞INTRODUCTION It has been well documented that decreased bone mineral density（BMD） is closely related to osteoporosis and fracture of the *** is one of the most prevalent senile disease and results a significant economic,social,and psychological burden as well as major public health problem for the elderly（1）.Despite its deleterious effect on women’s health,knowledge of the epidemiology of osteoporosis in Korea is only beginning to accumulate in most recent ***,because of nation’s sudden economic growth and advancement of both medical system,technology,diagnosis and treatment of osteoporosis,the clinical aspects of the disease exceed epidemiological understanding of *** to this phenomena,osteoporosis is often misunderstood by the public and some clinicians in ***,prevention and interventionof osteoporosis has been hampered by the lack of epidemiological information.

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Cancer Communications 2019年第1期39卷 526-535页

作者： sung Yong Oh won Seog Kim Jin Seok Kim Seok Jin Kim Dok Hyun Yoon Deok-Hwan Yang won Sik Lee Hyo Jung Kim Ho-Young Yhim Seong Hyun Jeong Jong Ho won Suee Lee Jee Hyun Kong sung-Nam Lim Jun Ho Ji Kyung A.kwon Gyeong-won Lee Jae Hoon Lee Ho Sup Lee Ho-Jin Shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Republic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology-Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology-Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology-Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology-Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

Background:The response rate and survival improvement for rituximab,a CD20-targeting monoclonal antibody,have been demonstrated in marginal zone lymphoma(MZL)as monotherapy and in combination with chemotherapeutic regimens,yet relapses still occur despite treatment ***,extending the period of remission in MZL patients remains an essential *** multicenter,single-arm,open-label phase II study evaluated the survival efficacy of 2 years of rituximab-maintenance therapy in patients with stage III-IV CD20-positive MZL who had responded to first-line R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone).The objective of this study was to determine whether rituximab maintenance following R-CVP warrants further ***:Prior to rituximab-maintenance therapy,patients received 6-8 cycles of first-line R-CVP therapy for stage III-IV ***(375 mg/m^(2)),cyclophosphamide(750 mg/m^(2)),and vincristine(1.4 mg/m^(2);maximum 2 mg)were administered via an intravenous infusion on day 1 of each 3-week cycle,while oral prednisolone(100 mg)was given on days 1-5 of each 3-week *** patients who achieved complete response(CR),partial response(PR),or stable disease(SD)to R-CVP treatment,were prescribed rituximab-maintenance therapy which was administered intravenously at a dose of 375 mg/m^(2) every 8 weeks for up to 12 *** primary endpoint was progression-free survival(PFS).Secondary endpoints were overall survival(OS)and treatment ***:47 patients were enrolled,of whom,45(96%)received rituximab-maintenance ***(33%)patients had nodal *** R-CVP first-line therapy,20(44%),22(49%),and 3(7%)patients achieved CR,PR,and SD,*** a median follow-up of 38.2 months,their observed 3-year PFS rate was 81%.During the rituximab-maintenance,6 PR and 1 SD patients achieved CR following the administration of *** LDH and the presence of B symptoms were found to be significant prognostic fac

关键词： Marginal zone Lymphoma Advanced stage Rituximab Cyclophosphamide Vincristine Maintenance Multicenter Open label Survival

基于NF-κB信号通路的细柱五加中impressic acid的抗炎作用研究

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中草药 2020年第22期51卷 5781-5787页

作者：肖瑾李小军黄建军高圣权陆昌洙刘向前湖南中医药大学药学院湖南长沙410208 赣南医学院药学院江西赣州341000 中南大学湘雅医学院湖南长沙41001 世明大学韩方食品营养学部韩国堤川27136 庆熙大学药学院韩国首尔13070

目的研究细柱五加Acanthopanax gracilistylus ***中impressic acid(IA)对脂多糖(LPS)诱导的小鼠单核巨噬细胞RAW264.7的抗炎作用。方法以LPS诱导RAW264.7细胞建立炎症模型;使用EZ4U细胞增殖与细胞毒性分析试剂盒检测IA对RAW264.7细胞... 详细信息

目的研究细柱五加Acanthopanax gracilistylus ***中impressic acid(IA)对脂多糖(LPS)诱导的小鼠单核巨噬细胞RAW264.7的抗炎作用。方法以LPS诱导RAW264.7细胞建立炎症模型;使用EZ4U细胞增殖与细胞毒性分析试剂盒检测IA对RAW264.7细胞的毒性作用;Griess法测定一氧化氮(NO)水平;ELISA法测肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)水平;RT-PCR法检测TNF-α、IL-1βmRNA表达;Western blotting检测高迁移率族蛋白B1(HMGB1)蛋白表达;ELISA法细胞质和细胞核的核因子-κB(NF-κB)水平。结果Impressic acid可以显著抑制LPS诱导的RAW264.7细胞中TNF-α、IL-1β水平和HMGB1蛋白表达,并抑制NF-κB从细胞质向细胞核的转移(P<0.05、0.01)。结论细柱五加中IA对LPS诱导的RAW264.7细胞具有抗炎作用。

关键词：细柱五加 impressic acid 三萜抗炎高迁移率族蛋白B1 核因子-κB

Bulk-Si photonics technology for DRAM interface[Invited]

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Photonics Research 2014年第3期2卷 S0025-S0033页

作者： Hyunil Byun Jinkwon Bok Kwansik Cho Keunyeong Cho Hanmei Choi Jinyong Choi Sanghun Choi Sangdeuk Han Seokyong Hong Seokhun Hyun TJJeong Ho-Chul Ji In-sung Joe Beomseok Kim Donghyun Kim Junghye Kim Jeong-Kyoum Kim Kiho Kim Seong-Gu Kim Duanhua Kong Bongjin Kuh Hyuckjoon kwon Beomsuk Lee Hocheol Lee Kwanghyun Lee Shinyoung Lee Kyoungwon Na Jeongsik Nam Amir Nejadmalayeri Yongsang Park Sunil Parmar Junghyung Pyo Dongjae Shin Joonghan Shin Yong-hwack Shin sung-Dong Suh Honggoo Yoon Yoondong Park Junghwan Choi Kyoung-Ho Ha Gitae Jeong Samsung Electronics 1 SamsungjeonjaroHwasungshiGyoung-gido445-330South Korea

We present photonics technology based on a bulk-Si substrate for cost-sensitive dynamic random-access memory(DRAM)optical interface *** summarize the progress on passive and active photonic devices using a local-crystallized Si waveguide fabricated by solid phase epitaxy or laser-induced epitaxial growth on bulk-Si *** process of integration of a photonic integrated circuit(IC)with an electronic IC is demonstrated using a 65 nm DRAM periphery process on 300 mm wafers to prove the possibility of seamless integration with various complementary metal-oxide-semiconductor *** the bulk-Si photonic devices,we show the feasibility of high-speed multidrop interface:the Mach–Zehnder interferometer modulators and commercial photodetectors are used to demonstrate four-drop link operation at 10 Gb∕s,and the transceiver chips with photonic die and electronic die work for the DDR3 DRAM interface at 1.6 Gb∕s under a 1∶4 multidrop configuration.

关键词： interferometer waveguide interface

辣椒Pun1位点对辣椒素酯类物质合成的控制

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辣椒杂志 2013年第1期11卷 38-47页

作者： Koeun Han Hee-Jin Jeong Joohee sung Young Soo Keum Myeong-Cheoul Cho Jeong-Han Kim Jin-Kyung kwon Byung-Dong Kim Byoung-Cheorl Kang 孔秋生(译) 植物学系植物基因组学和育种研究所农业和生命科学研究院农业科学学院国立首尔大学应用生命化学系农业科学学院国立首尔大学蔬菜研究室国家园艺和中草药研究所农村发展局华中农业大学园艺林学学院

辣椒由于含有生物碱化合物辣椒素和辣椒素类物质(capsaicinoids)而具有独特的辣味。虽然辣椒素类物质已被证实对人体健康有药理和生理作用,但由于具有辛辣味,使得辣椒素类物质的应用受到限制。在无辣味的辣椒中发现的辣椒素酯类物质(cap... 详细信息

辣椒由于含有生物碱化合物辣椒素和辣椒素类物质(capsaicinoids)而具有独特的辣味。虽然辣椒素类物质已被证实对人体健康有药理和生理作用,但由于具有辛辣味,使得辣椒素类物质的应用受到限制。在无辣味的辣椒中发现的辣椒素酯类物质(capsinoids)与辣椒素类物质具有非常相近的结构和相似的生物效应。以前的研究表明,p-AMT基因突变与辣椒素酯类物质的产生相关,然而,辣椒素酯类物质的合成途径尚未被完全阐明。在本研究中,我们对F6重组自交系群体进行了遗传分析,以确定辣椒素酯类物质的合成机制。在这个群体中,辣椒素酯类物质的产生与否表现出了与具有Pun1位点的基因型植株的共分离。此外,我们筛选了辣椒素酯类物质的合成模式,以及在p-AMT突变系中Pun1位点与辣椒素酯类物质合成的相关性。在辣椒种质中,我们筛选到p-AMT基因中PLP结合结构域中的氨基酸取代突变体。隐性pun1基因存在时不合成辣椒素酯类物质,同时还发现p-AMT突变型和辣椒素酯类物质的含量之间并无关系。由此认为Pun1基因不仅负责辣椒素类物质合成,同时也控制着辣椒素酯类物质的合成。

关键词：辣椒素合成酶辣椒属辣味 Pun1 拟转氨酶

5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（FEPMTX）:A Wide-Spectrum Regimen of Salvage Chemotherapyfor High- Grade Advanced Gastric Cancer

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5-fluorouracil,Methotrexate,Leucovorin,CDDP and Epirubicin（...

Effects of Trekking Pole Use on Metabolic Cost in Novice Hikers on Steep Terrains

2000全国肿瘤学术大会

作者： Kazuo Kinoshita Yutaka Yonemura Toshiharu Sawa Tatsukazu Miyata Hiroshi Sakuma Nobuo Matsuki Sigehiro Tanaka Sachio Fushida Takashi Fujimura Young Jae Mok Byung Sik Kim Jong In Lee Dong Wook Choi Young Jin Song Doo Hyun Yang sung Joon kwon Itsuo Miyazaki Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Department of Surgery Ⅱ School of medicineKanazawa University13-1 Takara-machiKanazawaJapan M.D. Korea University Hospital M.D. Ulsan University Hospital M.D. Korean Cancer Center Hospital M.D. Korean Cancer Center Hospital M.D. Chungbuk National University Hospital M.D. Chonbuk National University Hospital M.D. Hanyang University Hospital Korea M.D. Department of Surgery Ⅱ School of medicine Kanazawa University13-1 Takara-machiKanazawaJapan M.D.

＜正＞Twenty-one patients with primary high-grade advanced gastric cancer in whom the presence of stage ? was con- firmed by preoperative diagnostic imaging,were treated with a wide-spectrum regimen,designated as FEPMTX therapy to establish an effective salvage *** therapy consisted of 5-fluorouracil（5-FU）and the triple biochemical modulators;methotrexate（MTX）,calcium leucovorin（LV）,cisplatin（CDDP）,and in addition of epiru- bicin（EPI）.The schedule comprised 3 days continuous administration of 5-FU（350 mg/m2/day）and MTX（35 mg/ m2）on day 1,LV（30 mg/m2）on the day 2,LV（30 mg/m2）and CDDP（30 mg/m2）and EPI（20 mg/m2）on day *** treatment was performed two or more courses with 2 weeks interval in *** partial responses（PR）, five no changes（NC）and five progressive diseases（PD）were obtained,and the response rate was 52%.Ten patients （PR 7,NC 2,PD 1）were received gastrectomy（resectability rate 48%）.The survival in all cases resulted in median survival of 184 days and one-year survival rate of 23%.While there is no significant difference insurvival between the cases with or without the resection of the primary lesion,the survival of responders was significantly longer than that of non-responders（median survival time;responder 356days,non-responder 152days）.Adverse effects such as myelo- suppression and anorexia and fatigue sometimes occurred,but were mild and all the patients well *** therapy is thought to be an effective regimen for neoadjuvant chemotherapy with longer survival and little toxic for patients with stage?gastric cancer.

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Journal of Sports Science 2017年第5期5卷 256-264页

作者： Yong Bin Han Ik Jin kwon Dae Taek Lee Eun Jin Hwang Jong Kwang Kim Eun Hyung Cho Graduate Program of Sports Engineering Convergence Kookmin University Seou102 707 Korea Department of Sports Health and Rehabilitation Kookmin University Seou102707 Korea Graduate School of Sports Natural Science Kookmin University Seou102707 Korea College of Sport Science Sung Kyun Kwan University Gyeonggi-do 16419 Korea

PURPOSE： This study examined whether the use of trekking poles alters metabolic cost in steep hiking by novice hikers and whether the response would be dependent on the grade of the terrain. METHODS： Twelve participants completed two trekking trials （with poles [WP] and without trekking poles [NP]） with round trips comprising three grades： 7.0 ± 0.7°, 12.9 ± 0.7°, and 18.8 ± 1.3°） over a steep mountain at self-paced speeds. During the trials, time spent for trekking （TT）, oxygen consumption （VO2）, heart rate （HR）, ratings of perceived exertion （RPE）, and step frequency （Sf） were measured, and step efficiency （Se） and oxygen pulse （OP） were calculated. RESULTS： TT tended to be longer in the WP than NP for both terrains （P 〈 0.05）. HR, VO2, and RPE were the same for the WP and NP. Sfwas lower in WP going uphill （P 〈 0.05） but was unchanged going downhill. Se in the WP was higher than in the NP for both terrains （P 〈 0.01）. When analyzed by slope, VO2 during uphill at 18.8° was lower in WP （37.2 ± 6.3） than in NP （38.6 ± 7.1 ml .kg-1 .min-1, P 〈 0.05）, but no difference in VO2 was found between WP and NP at the 12.9° and 7.0°. TT during uphill was slower in WP than NP at 12.9°（7.9± 1.1 vs. 7.4 ± 1.0） and 18.8° （5.3 ± 1.3 vs. 4.9± 1.0 min, respectively, P 〈 0.05）. No differences were noticed in HR and OP during uphill at every grade. CONCLUSIONS： Pole use decreased metabolic cost in the novice hikers only in the highest grade but not in the other two lower grades.

关键词： Oxygen uptake heart rate uphill downhill.

超表面驱动OLED显示屏每英寸超10000像素

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家电科技 2021年第3期3卷 18-18页

作者： won-Jae Joo Jisoo Kyoung Majid Esfandyarpour sung-Hoon Lee Hyun Koo Sunjin Song Young-Nam kwon Seok Ho Song Jun Cheol Bae Ara Jo MyongJong kwon sung Hyun Han sung-Han Kim sungwoo Hwang Mark L.Brongersma 不详

光学表面材料被广泛集成于设备中。可以增强和控制光波的发射、调制、动态整形和检测。在相关研究中,《科学》报道了有机发光二极管(OLED)显示器的体系结构可以通过引入纳米图案的超表面反射镜得以实现。在最终的meta-OLED显示器中,不同... 详细信息

光学表面材料被广泛集成于设备中。可以增强和控制光波的发射、调制、动态整形和检测。在相关研究中,《科学》报道了有机发光二极管(OLED)显示器的体系结构可以通过引入纳米图案的超表面反射镜得以实现。在最终的meta-OLED显示器中,不同的metasurface图案定义了红色、绿色和蓝色的像素,并确保从有机白色发光体中优化提取这些颜色。这种新的体系结构有助于创建使用可缩放纳米压印光刻技术的新兴显示应用程序(例如虚拟现实)所需的超高像素密度(每英寸>10000像素)设备。相对于标准的彩色滤光白色OLED,超表面驱动的OLED显示屏所制造的像素具有两倍的发光效率和出色的色纯度。

关键词：虚拟现实应用程序 OLED显示屏发光体光学表面色纯度发光效率像素

健康人群和病毒性肝炎病人基于人群和个性化的肝脾体积参考区间

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国际医学放射学杂志 2022年第1期 105-105页

作者： D.W.Kim J.Ha S.S.Lee J.H.kwon N.Y.Kim Y.S.sung 李鹏飞

摘要指导肝和脾体积评估的参考区间尚未建立。目的建立基于人群和个性化的肝脏体积、脾体积和肝脾体积比（LSVR）参考区间。材料与方法本回顾性研究连续纳入

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