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Sex-and gender-specific disparities in colorectal cancer risk

World Journal of Gastroenterology 2015年第17期21卷 5167-5175页

作者： sung-eun kim Hee Young Paik Hyuk Yoon Jung eun Lee Nayoung kim Mi-Kyung sung Department of Food and Nutrition Sookmyung Women’s UniversitySeoul 140-742South Korea Department of Food and Nutrition Seoul National UniversitySeoul 151-742South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam 463-707South Korea

Colorectal cancer is one of the most common causes of cancer morbidity both in men and in ***,females over 65 years old show higher mortality and lower 5-year survival rate of colorectal cancer compared to their age-matched male *** objective of this review is to suggest gender-based innovations to improve colorectal cancer outcomes in *** have a higher risk of developing right-sided(proximal) colon cancer than men,which is associated with more aggressive form of neoplasia compared to left-sided(distal) colon *** differences in tumor location between women and men,most of scientific researchers do not consider sex specificity for study design and ***,colorectal cancer screening guidelines do not distinguish females from male,which may explain the higher frequency of more advanced neoplasia when tumors are first detected and false negative results in colonoscopy in ***,socio-cultural barriers within females are present to delay screening and *** studies,among studies that included both men and women,have reported sex-specific estimates of dietary risk factors which are crucial to establish cancer prevention guidelines despite sex-and genderassociated differences in nutrient metabolism and dietary ***,anti-cancer drug use for colorectal cancer treatment can cause toxicity to the reproductive system,and gender-specific recurrence and survival rates are ***,by understanding sex-and gender-related biological and socio-cultural differences in colorectal cancer risk,gender-specific strategies for screening,treatment and prevention protocols can be established to reduce the mortality and improve the quality of life.

关键词： Colorectal cancer Sex Gender Screening Treatment Prevention

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Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study

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World Journal of Gastroenterology 2019年第40期25卷 6129-6144页

作者： Jae Ryang Chu Saem-Yi Kang sung-eun kim Sol-Ji Lee Young-Chul Lee Mi-Kyung sung Department of Food and Nutrition Sookmyung Women’s UniversitySeoul 04310South Korea Unigen Inc.Cheonan 31257South Korea

BACKGROUND Constipation is a common functional gastrointestinal disorder and its etiology is *** evidence suggests that intestinal dysbiosis is associated with the development of *** are subjected to bacterial fermentation in the gut to produce short-chain fatty acids(SCFAs),which can help relieve constipation *** prebiotic UG1601 consists of inulin,lactitol,and aloe vera gel,which are known laxatives,but randomized,controlled clinical trials that examine the effects of this supplement on gut microbiota composition are *** To assess the efficacy of the prebiotic UG1601 in suppressing constipation-related adverse events in subjects with mild *** Adults with a stool frequency of less than thrice a week were randomized to receive either prebiotics or a placebo supplement for 4 *** participants provided their fecal and blood samples at baseline and at the end of *** symptoms and stool frequency were *** concentrations of serum endotoxemia markers and fecal SCFAs were *** relative abundance of SCFA-producing bacteria and the gut microbial community in the responders and non-responders in the prebiotics supplementation group were *** There were no significant differences in gastrointestinal symptoms between groups,although the prebiotic group showed greater symptom ***,after prebiotic usage,serum cluster of differentiation(CD)14 and lipopolysaccharide(LPS)concentrations were significantly decreased(CD14,P=0.012;LPS,P<0.001).The change in LPS concentration was significantly larger in the prebiotic group than in the placebo group(P<0.001).Fecal SCFAs concentrations did not differ between groups,while the relative abundance of Roseburia hominis,a major butyrate producer,was significantly increased in the prebiotic group(P=0.045).The abundances of the phylum Firmicutes and the family Lachnospiraceae(phylum Firmicutes,class Cl

关键词： Prebiotics Constipation Gut microbiota Endotoxemia Short-chain fatty acids

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Superior mesenteric vein thrombosis induced by influenza infection:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4193-4199页

作者： Gyu Man Oh Kyoungwon Jung Jae Hyun kim sung eun kim Won Moon Moo In Park Seun Ja Park Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Among the various types and causes of mesenteric ischemia,superior mesenteric vein(SMV)thrombosis is a rare and ambiguous *** a patient presents with SMV thrombosis,past medical history should be reviewed,and the patient should be screened for underlying *** thrombosis may also occur due to systemic *** this report,we describe a case of SMV thrombosis complicated by influenza B *** SUMMARY A 64-year-old male visited the hospital with general weakness,muscle aches,fever,and abdominal *** patient underwent computed tomography(CT)and was diagnosed with SMV *** the patient’s muscle pain and fever could not be explained by the SMV thrombosis,the clinician performed a test for influenza,which produced a positive result for influenza *** patient had a thrombus in the SMV only,with no invasion of the portal or splenic veins,and was clinically *** treatment was prescribed without surgery or other *** follow-up CT scan showed improvement,and the patient was subsequently discharged with continued oral anticoagulant *** This case provides evidence that influenza may be a possible risk factor for SMV *** unexplained abdominal pain is accompanied by an influenza infection,examination of an abdominal CT scan may be necessary to screen for possible SMV thrombosis.

关键词： Influenza B virus Mesenteric ischemia Venous thrombosis Mesenteric vascular occlusion Influenza Human Case reports

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Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer

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World Journal of Gastroenterology 2017年第3期23卷 505-515页

作者： Jae Hyun kim Jun Yeop Lee Hae Koo kim Jin Wook Lee sung Gyu Jung Kyoungwon Jung sung eun kim Won Moon Moo In Park Seun Ja Park Division of Gastroenterology Department of Internal MedicineKosin University College of MedicineBusan 602-702South Korea

AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression *** The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ *** In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC.

关键词： Colorectal cancer Neutrophil Lymphocyte Platelet Prognosis

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Blood Pressure Variability and Outcome in Patients with Acute Nonlobar Intracerebral Hemorrhage following Intensive Antihypertensive Treatment

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Chinese Medical Journal 2018年第6期131卷 657-664页

作者： Jin Pyeong Jeon Chulho kim sung-eun kim Department of Neurosurgery Hallym University College of Medicine Chuncheon 200-704 Korea Institute of New Frontier Research Hallym University College of Medicine Chuncheon 200-704 Korea Department of Neurology Hallym University College of Medicine Chuncheon 200-704 Korea Department of Emergency Medicine Seoul Emergency Operations Center Seoul Korea

Background： Blood pressure （BP） variability has been associated with stroke risk. We elucidated the association between systolic BP （SBP） variation and outcomes in patients with nonlobar intracerebral hemorrhage （ICH） following intensive antihypertensive treatment upfront. Methods： We screened consecutive patients with spontaneous ICH who underwent intensive antihypertensive treatments targeting BP 〈140 mmHg between 2008 and 2016. SBPs were monitored hourly during the acute period （〈7 days after symptom onset） in the intensive care unit. SBP variability was determined in terms of range, standard deviation （SD）, coefficient of variation （CoV）, and mean absolnte change （MAC）. The primary outcomes included hematoma growth and poor clinical outcome at 3 months （modified Rankin Scale [mRS] score 〉3. The secondary outcome was an ordinal shift in mRS at 3 months. Results： A total of 104 individuals （mean age, 63.0 ± 13.5 years： male, 57.7%） were included in this study. In multivariable model, MAC （adjusted odds ratio [OR], ***; 95% confidence interval [CI]： 1.02-1.21; P = 0.01 2） rather than the range of SD or CoV, was significantly associated with hematoma growth even after adjusting for mean SBP level. Sixty-eight out of 104 patients （65.4%） had a poor clinical outcome at 3 months. SD and CoV of SBP were significantly associated with a 3-month poor clinical outcome even after adjusting for mean SBR In addition, in multivariable ordinal logistic models, the MAC of SBP was significantly associated with higher shift of mRS at 3 months （adjusted OR, 1.08; 95% CI： 1.02-1.15： P = 0.008）. Conclusions： The MAC of SBP is associated with hematoma growth, and SD and COV are correlated with 3-month poor outcome in patients with supratentorial nonlobar ICH. Therelbre, sustained SBP control, with a reduction in SBP variability is essential to reinforce the beneficial effect of intensive antihypertensive treatment.

关键词： Blood Pressure: Hemorrhage Outcome

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Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes

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World Journal of Gastroenterology 2017年第6期23卷 1059-1066页

作者： sung eun kim Moo In Park Seun Ja Park Won Moon Jae Hyun kim Kyoungwon Jung Hae Koo kim Young Dal Lee Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication *** study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and *** overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9% (95%CI: 70.1%-77.4%) and 94.5% (95%CI: 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR = 3.99, 95%CI: 1.56-10.20, P = 0.004) was associated with H. pylori eradication therapy *** second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure.

关键词： Helicobacter pylori Disease eradication Treatment failure Bismuth Diabetes mellitus

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Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis

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Bioactive Materials 2022年第1期7卷 14-25页

作者： Bo-Bae Seo Youngjoong Kwon Jun kim Ki Hyun Hong sung-eun kim Hae-Ryong Song Young-Min kim Soo-Chang Song Center for Biomaterials Korea Institute of Science&TechnologySeoul02792South Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea Department of Orthopedic Surgery and Rare Diseases Institute Korea University Medical College Guro HospitalSeoul08308South Korea

Treatment of osteoarthritis(OA)by administration of corticosteroids is a commonly used method in clinics using anti-inflammatory *** administration or intra-articular injection of corticosteroids can reduce the pain and progress of cartilage degeneration,but they are usually insufficient to show local and long-term anti-inflammatory effects because of their fast clearance in the *** this study,we suggest an injectable anti-OA drug depot system for sustained drug release that provides long-term effective therapeutic *** poly(organophosphazene),which has temperature-dependent nanoparticle forming and sol-gel transition behaviors when dissolved in aqueous solution,was synthesized for triamcinolone acetonide(TCA)*** hydrophobic parts of the polymer can interact with hydrophobic parts of the TCA,the TCA was encapsulated into the self-assembled polymeric *** TCA-encapsulated polymeric nanoparticles(TePNs)were well dispersed in an aqueous solution below room temperature so that they can be easily injected as a sol state into an intra-articular ***,the TePNs solution transforms immediately to a viscose 3D hydrogel like a synovial fluid in the intra-articular region via the conducted body *** in vitro TCA release study showed sustained TCA release for six ***-time injection of the TePN hydrogel system in an early stage of OA-induced rat model showed a great inhibition effect against further OA *** OA-induced knees completely recovered as a healthy cartilage without any abnormal symptoms.

关键词： Thermosensitive hydrogel Triamcinolone acetonide Polymer nanoparticle Osteoarthritis Sustained release

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RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering

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Regenerative Biomaterials 2017年第3期4卷 159-166页

作者： Yong Cheol Shin Jeonghyo kim sung eun kim Su-Jin Song SuckWon Hong Jin-Woo Oh Jaebeom Lee Jong-Chul Park Suong-Hyu Hyon Dong-Wook Han Department of Cogno-Mechatronics Engineering Department of Optics and Mechatronics Engineering Department of Nanoenergy Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Korea Cellbiocontrol Laboratory Department of Medical EngineeringYonsei University College of MedicineSeoul 03722Korea and 5Center for Fiber and Textile Science Kyoto Institute of TechnologyMatsugasakiKyoto 606-8585Japan

In recent years,much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular *** our study,RGD peptide and graphene oxide(GO)co-functionalized poly(lactide-co-glycolide,PLGA)(RGD-GO-PLGA)nanofiber mats were fabricated via electrospinning,and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue *** electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of randomoriented electrospun nanofibers with average diameter of *** successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic ***,the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and *** was found that the mats were thermally stable under the cell culture ***,the initial attachment and proliferation of primarily cultured vascular smoothmuscle cells(VSMCs)on the RGD-GO-PLGA nanofibermats were *** was revealed that the RGD-GO-PLGA nanofibermats can effectively promote the growth of *** conclusion,our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.

关键词： RGD peptide graphene oxide poly(lactic-co-glycolic acid) biofunctional scaffold vascular smooth muscle cell

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Experience of primary intestinal lymphangiectasia in adults: Twelve case series from a tertiary referral hospital

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World Journal of Clinical Cases 2024年第4期12卷 746-757页

作者： Ji eun Na Ji eun kim Sujin Park eun Ran kim sung Noh Hong Young-Ho kim Dong Kyung Chang Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSeoul 06351South Korea Department of Pathology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND While primary intestinal lymphangiectasia(PIL)is considered a rare condition,there have been several reported cases in ***,the absence of clear guidance from diagnosis to treatment and prognosis poses challenges for both physicians and *** To enhance understanding by investigating clinical presentation,diagnosis,treatment,complications,and prognoses in adult PIL *** We enrolled adult patients diagnosed with PIL between March 2016 and September *** primary outcome involved examining the diagnosis and treatment process of these *** secondary outcomes included identifying complications(infections,thromboembolism)and assessing prognoses(frequency of hospitalization and mortality)during the follow-up *** Among the 12 included patients,peripheral edema(100%)and diarrhea(75%)were the main presenting *** tests showed that all the pati-ents exhibited symptoms of hypoalbuminemia and ***,the predominant findings were edema of the small intestine(67%)and ascites(58%).The typical endoscopic finding with a snowflake appearance was observed in 75%of *** the 12 patients,two responded positive-ly to octreotide and sirolimus,and eight who could undergo maintenance therapy discontinued *** due to PIL led to infection in half of the patients,thromboembolism in three patients,and one *** PIL can be diagnosed in adults across various age groups,with different severity and treatment responses among patients,leading to diverse complications and ***,tailored treatments will be *** anticipate that our findings will contribute to the management of PIL,an etiology of protein-losing enteropathy.

关键词： Primary intestinal lymphangiectasia in adults Protein-losing enteropathy Diagnosis Treatment Prognosis

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Assessment of colon polyp morphology: Is education effective?

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World Journal of Gastroenterology 2017年第34期23卷 6281-6286页

作者： Jae Hyun kim Kyoung Sik Nam Hye Jung Kwon Youn Jung Choi Kyoungwon Jung sung eun kim Won Moon Moo In Park Seun Ja Park Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine

AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among *** For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same *** The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy.

关键词： Colon polyp Morphology Education

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