RGD peptide and graphene oxide co-functionalized PLGA nanofiber scaffolds for vascular tissue engineering
作者机构：Department of Cogno-Mechatronics Engineering Department of Optics and Mechatronics Engineering Department of Nanoenergy EngineeringCollege of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Korea Cellbiocontrol LaboratoryDepartment of Medical EngineeringYonsei University College of MedicineSeoul 03722Korea and 5Center for Fiber and Textile ScienceKyoto Institute of TechnologyMatsugasakiKyoto 606-8585Japan
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2017年第4卷第3期
页 面：159-166页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This study was supported by the Bio&Medical Technology Development Program of the National Research Foundation(NRF)funded by the Korean government(MEST)(No.2015M3A9E2028643) Basic Science Research Program through the NRF of Korea funded by the Ministry of Education(No.2016R1D1A1B03931076)
主 题：RGD peptide graphene oxide poly(lactic-co-glycolic acid) biofunctional scaffold vascular smooth muscle cell
摘 要：In recent years,much research has been suggested and examined for the development of tissue engineering scaffolds to promote cellular *** our study,RGD peptide and graphene oxide(GO)co-functionalized poly(lactide-co-glycolide,PLGA)(RGD-GO-PLGA)nanofiber mats were fabricated via electrospinning,and their physicochemical and thermal properties were characterized to explore their potential as biofunctional scaffolds for vascular tissue *** electron microscopy images revealed that the RGD-GO-PLGA nanofiber mats were readily fabricated and composed of randomoriented electrospun nanofibers with average diameter of *** successful co-functionalization of RGD peptide and GO into the PLGA nanofibers was confirmed by Fourier-transform infrared spectroscopic ***,the surface hydrophilicity of the nanofiber mats was markedly increased by co-functionalizing with RGD peptide and *** was found that the mats were thermally stable under the cell culture ***,the initial attachment and proliferation of primarily cultured vascular smoothmuscle cells(VSMCs)on the RGD-GO-PLGA nanofibermats were *** was revealed that the RGD-GO-PLGA nanofibermats can effectively promote the growth of *** conclusion,our findings suggest that the RGD-GO-PLGA nanofiber mats can be promising candidates for tissue engineering scaffolds effective for the regeneration of vascular smooth muscle.
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