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Newly-modeled graphene-based ternary nanocomposite for the magnetophotocatalytic reduction of CO_(2) with electrochemical performance

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Frontiers of Chemical Science and Engineering 2022年第10期16卷 1438-1459页

作者： Zambaga Otgonbayar Kwang Youn cho chong-hun Jung Won-Chun Oh Department of Advanced Materials Science&Engineering Hanseo UniversitySeosan-Si 31962Korea Korea Institutes of Ceramic Engineering and Technology Jinju-Si 660031Korea Decommissioning Technology Research Division Korea Atomic Energy Research InstituteDaejeon 305-600Korea Anhui International Joint Research Center for Nano Carbon-based Materials and Environmental Health College of Materials Science and EngineeringAnhui University of Science&TechnologyHuainan 232001China

The development of CO_(2)into hydrocarbon fuels has emerged as a green method that could help mitigate global *** novel structured photocatalyst is a promising material for use in a photocatalytic and magneto-electrochemical method that fosters the reduction of CO_(2)by suppressing the recombination of electron−hole pairs and effectively transferring the electrons to the surface for the chemical reaction of CO_(2)*** our study,we have developed a novel-structured AgCuZnS_(2)–graphene–TiO_(2)to analyze its catalytic activity toward the selective evolution of CO_(2).The selectivity of each nanocomposite substantially enhanced the activity of the AgCuZnS_(2)–graphene–TiO_(2)ternary nanocomposite due to the successful interaction,and the selectivity of the final product was improved to a value 3 times higher than that of the pure AgCuZnS_(2)and 2 times higher than those of AgCuZnS_(2)–graphene and AgCuZnS_(2)–TiO_(2)under ultraviolet(UV)-light(λ=254 nm)irradiation in the photocatalytic *** electrochemical CO_(2)reduction test was also conducted to analyze the efficacy of the AgCuZnS_(2)–graphene–TiO_(2)when used as a working electrode in laboratory electrochemical *** electrochemical process was conducted under different experimental conditions,such as various scan rates(mV·s^(–1)),under UV-light and with a 0.07 T *** evolution of CO_(2)substantially improved under UV-light(λ=254 nm)and with 0.07 T magnetic-core treatment;these improvements were attributed to the facts that the UV-light activated the electron-transfer pathway and the magnetic core controlled the pathway of electrontransmission/prevention to protect it from chaotic electron *** all tested nanocomposites,AgCuZnS_(2)–graphene–TiO_(2)absorbed the CO_(2)most strongly and showed the best ability to transfer the electron to reduce the CO_(2)to *** believe that our newly-modeled ternary nanocomposite opens up new opportunities for the evolution of C

关键词： ternary nanocomposite photocatalytic electrochemical CO_(2) reduction UV-light magnetic core

Water stable and matrix addressable OLED fiber textiles for wearable displays with large emission area

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npj Flexible Electronics 2022年第1期6卷 664-671页

作者： Hayoung Song Young Jin Song Jinwook Hong Ki Suk Kang Sera Yu Ha-Eun cho Jae-hun Kim sung-Min Lee School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea School of Electrical Engineering KAISTDaejeon 34141Republic of Korea

Organic light-emitting diode(OLED)fibers with favorable electroluminescence properties and interconnectable pixel configurations have represented the potential for wearable electronic textile ***,the current technology of OLED fiber-based textile displays still leaves to be desired due to several challenges,including limited emission area and lack of encapsulation *** we present a fibrous OLED textile display that can attain a large emission area and long-term stability by implementing addressable networks comprised of integrated phosphorescence OLED fibers and by designing multilayer *** integrated fiber configuration offers decoupled functional fiber surfaces for an interconnectable 1-dimensional OLED pixel array and a data-addressing *** triadic metal/ultrathin oxide/polymer multilayer enables not only the oxygen/water permeation inhibition but also the controllable conductive channels of dielectric *** with reliable bending stability,the long-term operation of OLED textiles in water manifests the feasibility of the present device concept toward water-resistant full-emitting-area fibrous textile displays.

关键词： fiber OLED wear

Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer's Disease

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Chinese Journal of Integrative Medicine 2018年第5期24卷 378-384页

作者： Minji choi Younghyurk Lee Seung-hun cho Department of Psychiatry Hospital of Korean Medicine Kyung Hee University Medical Center

Objective: To research Angelica tenuissima Nakai(ATN) for use in novel Alzheimer’s disease(AD) therapeutics. Methods: The effect of a 30% ethanol extract of ATN(KH032) on AD-like cognitive impairment and neuropathological and neuroinflammatory changes induced by bilateral intracerebroventricular injections of β-amyloid(Aβ) peptide(Aβ1-42) was investigated. Male C57 Bl/6 mice were randomly divided into 4 groups, 10 in each group. KH032-treated groups were administrated with a low or high dose of KH032(50 and 200 mg/kg, respectively), intragastrically for 16 days; distilled water was applied in the sham and negative groups. Open field test, Y maze and Morris water maze test were used for behavior test and cognitive ability. In addition, the neuroprotective effects of KH032 in Aβ1-42-infused mice on the histopathological markers [neuronspecific nuclear protein(Neu N), Aβ1-42] of neurodegeneration were examined. The levels of glial fibrillary acidic protein(GFAP), Neu N, phosphorylation extracellular signal-regulated kinase(ERK)/ERK, brain-derived neurotrophic factor(BDNF), phosphorylation c AMP response element-binding(CREB)/CREB protein expression were measured by Western blot. Results: KH032 treatment ameliorated cognitive impairments, reduced the overexpression of Aβ1-42, and inhibited neuronal loss and neuroinflammatory response in the Aβ1-42-infused mice. Moreover, KH032 treatment enhanced BDNF expression levels in the hippocampus. Finally, KH032 treatment increased phosphorylation of ERK1/2 and CREB, vital for ERK-CREB signaling. Conclusions: KH032 attenuated cognitive deficits in the Aβ1-42-infused mice by increasing BDNF expression and ERK1/2 and CREB phosphorylation and inhibiting neuronal loss and neuroinflammatory response, suggesting that KH032 has therapeutic potential in neurodegenerative disorders such as AD.

关键词： Alzheimer's disease Angelica tenuissima Nakai beta amyloid cognitive impairment neurogenesis

Intraoperative sudden arrhythmias in cervical spine surgery adjacent to the stellate ganglion:A case report

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世界临床病例杂志 2023年第24期11卷 5789-5796页

作者： Jong-hun Seo Su-Yeon cho Ji-Hwan Park Jin-Young Seo Hyun-Young Lee Dong-Joon Kim Department of Neurosurgery Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine College of MedicineChosun UniversityGwangju 61453South Korea

BACKGROUND Atrial arrhythmias such as paroxysmal supraventricular tachycardia(PSVT)and atrial flutter(AF)are common in the perioperative *** commonly resolve ***,occasionally,they may continually progress to fatal arrhythmias or cause ***,prompt and appropriate management is *** SUMMARY A 46-year-old female patient diagnosed with cervical C6-7 radiculopathy characterized by decreased sensation in the right third,fourth and fifth fingers underwent C6-7 anterior cervical disc fusion *** showed PSVT and ventricular tachycardia during C6-7 disc ***,the patient remained *** treatment with esmolol and lidocaine for ventricular tachycardia was *** massage and Valsalva maneuver were attempted but PSVT did not *** surgery was paused,and the patient’s fraction of inspired oxygen was set to 100%.Adenosine was administered for pharmacological management of *** arrhythmia temporarily ***,it then transformed into *** was administered,which briefly decreased blood pressure,which immediately *** resumed while the patient was in normal sinus *** was discharged safely on postoperative day 6 without complications or ***,she is living a healthy life without arrhythmia *** Ganglia associated with cardiac arrhythmias in the surgical site should be identified during cervical spine surgery.

关键词： Supraventricular tachycardia Atrial flutter Stellate ganglion Adenosine Diltiazem Case Report

Syndrome Pattern and Its Application in Parallel Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2013年第3期19卷 163-171页

作者： Byung-Cheul Shin Sina Kim Young-hun cho Division of Clinical Medicine School of Korean MedicinePusan National University Department of Korean Medicine School of Korean MedicinePusan National University Department of Korean Medical Science School of Korean MedicinePusan National University

Syndrome pattern （SP） is a core concept of Chinese medicine （CM） and is used to diagnose and treat patients based on an overall analysis of symptoms and signs. This study aimed to systematically review randomized controlled trials （RCTs） using the SP concept and to demonstrate how the SP concept could be applied to the study design of parallel RCTs, considering a gold standard of clinical research. After conducting a brief systematic review by way of a PubMed search, we analyzed how the SP concept was applied to the design of RCT in a CM herbal medicine trial. We then formulated possible research questions, applied the SP concept to answer the research questions, and suggested possible RCT designs to be used for conducting future trials. Fourteen RCTs were included in our systematic review, and three key points of the SP concept were formulated for the design of parallel RCTs： the time point of SP diagnosis between before and after randomization; the relationship between the international classification of diseases （ICD） and SP for the inclusion of target population; and the proper diagnostic method of SP. In this study, we formulated three possible research questions and then suggested perspectives for five possible RCT models arrived at using SP concepts. Future trials applying SP concept to RCTs should overcome the shortcomings of past SP trials, moving CM forward from experience-based to evidence-based medicine.

关键词： syndrome pattern randomized controlled trial traditional Chinese medicine evidence-basedmedicine integrative medicine

Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

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Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-Hyun Jeong Ji-hun Jang Hea-Young cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

Effect of focal laser photocoagulation in eyes with mild to moderate non-proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1439-1443页

作者： Seong hun Jeong Jung Il Han sung Won cho Dong Won Lee Chul Gu Kim Tae Gon Lee Jong Woo Kim Department of Ophthalmology Kim's Eye HospitalMyung-Gok Eye Research InstituteKonyang University College of Medicine

AIM：To report the effect of focal laser photocoagulation on both the severity of hard exudates（HEs） and the rate of disease progression in eyes with mild to moderate non-proliferative diabetic retinopathy（NPDR）.METHODS： We retrospectively reviewed the medical records of 33 patients（60 eyes） who had been diagnosed with mild to moderate NPDR between January 2006 and December *** patients were divided into 2 groups：Group A（38 eyes in 20 patients treated using focal laser photocoagulation） and Group B（treated without laser photocoagulation）.We also reviewed the best corrected visual acuity measurements,and the fundus photographs taken at both baseline and follow-up visits. RESULTS： In Group A,HE severity grade had decreased significantly from baseline to the final visit（P 〈0.05）,but this was not the case in Group B（P =0.662）.The cumulative probabilities of retinopathy progression at 5y were 26% in Group A and 30% in Group *** survival curves showed no significant difference between the groups with regard to retinopathy progression（P =0.805）.CONCLUSION： Focal laser photocoagulation reduced the levels of HEs in eyes with mild to moderate ***,the treatment was not able to decelerate the progression of DR.

关键词： focal laser diabetic retinopathy retina non-proliferative diabetic retinopathy

Development of a hybrid scaffold and a bioreactor for cartilage regeneration

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Chinese Science Bulletin 2009年第19期54卷 3608-3612页

作者： LEE Seung-Jae LEE In Hwan PARK Jeong hun GWAK So-Jung RHIE Jong-Won cho Dong-Woo KO Tae Jo KIM Dong sung BK21 Mechatronics Group at Chungnam National University School of Mechanical Engineering Chungbuk National University DDS Research Lab. CKD Research Institute CKD Pharmaceutical Corp. Department of Plastic Surgery College of Medicine The Catholic University of Korea Department of Mechanical Engineering Pohang University of Science and Technology School of Mechanical Engineering Yeungnam University School of Mechanical Engineering Chung-Ang University

We developed a hybrid scaffold and a bioreactor for cartilage regeneration. The hybrid scaffold was developed as combination of two components: a biodegradable framework and hydrogel-containing chondrocytes. We performed the MTT cell proliferation assay to compare the proliferation and viability of chondrocytes on three types of scaffolds: an alginate gel, the hybrid scaffold, and an alginate sponge. Cells were encapsulated in 2% agarose gel. The bioreactor consisted of a circulation system and a compression system. We performed dynamic cell culture on these agarose gels in the bioreactor for 3 days.

关键词： MTT 生物分解凝解胶研究

A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 435-444页

作者： Cuong Viet Pham Jong-Suep Baek Jong-hun Park Sang-hun Jung Jong-Seong Kang Cheong-Weon cho College of Pharmacy and Institute of Drug Research and Development Chungnam National UniversityDaejeon 34134Republic of Korea Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea

Until now, there are no publications about the preformulation studies on(S)-zaltoprofen((S)-ZPF). Hence, we first investigated the solubility of(S)-ZPF, screened solubilizers and performed the pharmacokinetic study of(S)-ZPF in the presence of the solubilizers. The measurement of the solubility of(S)-ZPF in 26 different solvents was carried out, including d-alpha tocopheryl polyethylene glycol 1000 succinate(TPGS), 2-hydroxypropyl-β-cyclodextrin(HPCD), and mixtures of individual solvent. The plasma concentration of(S)-ZPF and the amount of(S)-ZPF retained in stomach were determined after oral(35.0 mg/kg) and intravenous(5.0 mg/kg) administration. The solubility of(S)-ZPF showed an increase of 484-fold in TPGS compared to its aqueous solubility. There was a significant increase of AUC 0-24 h for pure(S)-ZPF in the TPGS group(813.59 ± 64.17 μg h/ml) in comparison with AUC 0-24 h in the HPCD group(595.57 ± 71.76 μg h/ml) and water group(465.57 ± 90.89 μg h/ml). In addition, the T max of(S)-ZPF in the TPGS group was 2 h, much faster than that in the HPCD or water groups(5.50 or 5.67 h, respectively). This suggested that TPGS played a significant role in the increase of solubility and bioavailability of(S)-ZPF.

关键词： (S)-zaltoprofen Solubility Bioavailability D-alpha tocopheryl polyethylene glycol 1000 succinate 2-hydroxypropyl-β-cyclodextrin