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Hepatoprotective and antioxidant properties of marine halophyte Luminetzera racemosa bark extract in CCL_4 induced hepatotoxicity

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 462-465页

作者： Murugesan Gnanadesigan sundaram ravikumar Samuel Jacob Inbaneson School of Marine Sciences Department of Oceanography and Coastal Area StudiesAlagappa UniversityThondi CampusThondi-623409TamilnaduIndia

Objective:To identify the hepatoprotective and antioxidant activity of Luminetzera racemosa （L racemosa）bark ***:Wistar albino rats were divided into 6 groups:Group 1 served as control;Group 2 served as hepatotoxin（CCL4 treated） group;Group 3 served as positive control（Silymarin） treated groups;Group 4,5 and 6 served as（100,200 and 300 mg/kg bw p.o.） L racemosa bark extract treated ***,in vitro antioxidant indexes,including DPPH, hydroxyl radical scavenging activity（HRSA）,NO,ferric reducing antioxidant power（FRAP）,lipid hydroperoxide（LPO） and super oxide dismutase（SOD） were also analyzed in the bark extract. Results:The results suggested that,the level of serum glutamate oxyloacetic transaminase（SCOT）, serum glutamic pyruvic transaminase（SGPT）,alkaline phosphatise（ALP）,bilurubin,cholesterol, sugar and lactate dehydrogenase（LDH） were significantly（P50 values were observed as（44.17±6.87）μ/mL,（42.45±2.81）μg/mL,（62.37±3.98）μg/mL,（54.24±3.09）μg/mL, （87.25±5.90）μg/mL and（71.54±5.42）μg/mL for ***,NO,FRAP,LPO and SOD radical scavenging activities,***:The hepatoprotective and antioxidant activities of the bark extract might be to the presence of unique chemical classes such as flavonoids, alkaloids and polyphenols.

关键词： Antioxidant Hepatoprotective Histopathology Mangroves

In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 103-106页

作者： Samuel Jacob Inbaneson sundaram ravikumar Palavesam Suganthi Department of Oceanography and Coastal Area Studies School of Marine SciencesAlagappa UniversityThondi CampusThondi-623 409Ramanathapuram DistrictTamil NaduIndia

Objective:To identify the possible antiplasmodial compounds from leaf,stem,root and flower extracts of Ocimum canum(***),Ocimum sanctum(***) and Ocimum basilicum (***).Methods:The ***,*** and *** were collected from Ramanalhapuram District,Tamil Nadu and the extraction was carried out in *** filter sterilized extracts(100,30,23,12.5,6.23 and 3.125μg/mL) of leaf,stem,root and flower extracts of ***,*** and *** were tested for antiplasmodial activity against Plasmodium falciparum(***).The potential extracts were also tested for their phytochemical ***:The leaf extract of *** showed excellent antiplasmodial activity(IC_(50) 3538μg/mL) followed by leaf extract of ***(IC_(50) 4341μg/mL). The leaf extract of ***,root extracts of *** and ***,the stem and flower extracts of all the three tested Ocimum species showed IC_(50) values between 50 and 100μg/mL Statistical analysis reveals that,significant antiplasmodial activity(P<0.01) was observed between the concentrations and time of *** chemical injury to erythrocytes was also carried out and it shows that,there were no morphological changes in erythrocytes by the ethanolic extract of ***,*** and *** in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,flavonoids,phenols,saponins,triterpenoids,proteins,resins, steroids and tannins in the ethanolic extracts of tested ***:The ethanolic leaf extracts of *** possess lead compounds for the development of antiplasmodial drugs.

关键词： Antiplasmodial activity IC_(50) Phytochemicals Plasmodium falciparum Ocimum species

Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 348-352页

作者： sundaram ravikumar Murugesan Gnanadesigan chool of Marine Sciences Department of Oceanography and Coastal Area Studies.Alagappa University

Objective:To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa(***) leaf ***:Animals in Group 1 served as vehicle control. Group 2 served as hepatotoxin(CCL_4 treated) *** 3 served as positive control(Silyntarin) group,and Group 4.S and ft served as(73,150 and 300 nig/kg bw p.o.)*** leaf extract treated ***,in vitro antioxidant DPPH,hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO) and super oxide dismutase(SOD) were also analyzed for the leaf ***:The levels of the serum parameters such as serum glutamic oxaloacetic transaminase(SGOT).serum glutamic pyruvic transaminase(SGPT).alkaline phosphatase(ALP),bilirubin,cholesterol(CHL).sugar and lactate dehydrogenase(LDH) were significantly increased in COL_4 treated rats when compared with the control group(P<0.05).But the *** leaf extract treated rats showed maximum reduction of SGOT[(210.16±19.63)IU/L].SGPT[(82.37±13.87) IU/L].ALP[(197.63±23.4.3)IU/L],bilurubilt[(2.13 ±0.84) mg/dL].cholesterol[(163.83± 13.63) mg/dL].sugar[(93.00±7.63) mg/dL]and LDH[(1134.00) ±285.00)IU/L]were observed with the high dose(300 mg/kg bw) of leaf extract treated rats. Histopathological scores showed that,no visible changes were observed with high dose(300 mg/ kgbw) of leaf extract treated rats except few mild *** IC_(50) values were observed as(56.37 ±4.87)μg/mL,(57.68±1.98) μg/mL,(64.15±2.90)μg/mL,(61.94±3.98)μg/mL,(94.53± 1.68) μg/mL and(69.7±2.65)μg/mL for DPPH,HRSA,NO,FRAP,LPO and SOL) radical scavenging activities, ***:In conclusion,the hepatoprotective effect of the *** leaf extract might be due to the presence of phenolic groups,terpenoids and alkaloids and in vitro antioxidant properties.

关键词： Antioxidant CCL_4 Histopathology Mangroves Hepatoprotective activity Lumnitzera racemosa Histopathological Phenolic Alkaloid Antioxidant property Hepatoprotective Radical scavenging activity Phenolic Alkaloid

In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 364-367页

作者： Samuel Jacob Inbaneson sundaram ravikumar Palavesam Suganthi Department of Oceanography and Coastal Area Studies School of Marine SciencesAlagappa University

Objective:To identify the possible anliplasmodial compounds from Achyranlhes aspera(A. aspera).Acalypha indica(***),Jatropha glandulifera(***)and Phyllanlhus amarus(***).Methods:The ***,***,*** and *** were collected along Palk Strait and the extraction was carried out in *** filter sterilized extracts(100,50,25,12.5,6.25 and 3.125μg/mL) of leaf,stem,root and flower extracts of A aspera,A. indica,*** and *** were tested for anliplasmodial activity against Plasnuxlium *** potential extracts were also tested for their phytochemical ***: Of the selected plants species parts,the stem extract of *** showed excellent antiplasmodial activity(IC_(50)=43.81μg/mL) followed by stem extract of ***(IC_(50)= 49.14μg/mL).The stem extract of ***,leaf and root extracts of ***,leaf,root and seed extracts of J. glanduUfera and leaf and stem extracts of *** showed IC_(50),values between 50 and 100 μg/ *** analysis revealed that,significant antiplasmodial activity(P<0.0l) was observed between the concentrations and time of *** chemical injury to erythrocytes was also carried out and it showed that there were no morphological changes in erythrocytes by the elhanolic extract of all the tested plant *** in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,***,saponins,triterpenoids,proteins, and lannins in the elhanolic extracts of tested ***:The elhanolic stem extracts of *** and *** possess lead compounds for the development of antiplasmodial drugs.

关键词： Antiplasmodial activity IC_(50) Medicinal plants Phytochemicals Plasmodium falciparum Achyranthes aspera Acalypha indica Jatropha glandulifera Phyllanthus amarus

Antibacterial activity of Ulva reticulata from southwest coast of Kanyakumari,India

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Journal of Coastal Life Medicine 2016年第3期4卷 246-247页

作者： sundaram ravikumar Lawrance Anburajan Balakrishnan Meena Centre for Marine Science and Technology Manonmaniam Sundaranar UniversityRajakkamangalam 629502Tamil NaduIndia

Objective:To evaluate the antibacterial activity of Ulva reticulata species collected from the Kanyakumari coast of India to determine their potential for ***:The algal extract was prepared using n-butanol for evaluating the antibacterial activity of Salmonella typhi,Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,Vibrio cholerae,Vibrio parahaemolyticus,Bacillus cereus and Listeria ***:It was observed that the n-butanolic extract of the seaweed powder of Ulva reticulata(25–100 mg/mL)exerted notable antibacterial activity against tested bacterial *** maximum antibacterial activity was exhibited against Escherichia coli and Bacillus cereus in all ***:The results obtained in the present investigation supported the traditional use of the seaweeds against various ***,further investigation has been carried out to elucidate the exact mechanism and isolation of active principle.

关键词： Ulva reticulata Antibacterial activity Kanyakumari

Characterization and screening of in vitro antimalarial and larvicidal activities of selected seaweeds from southeast coast of India against Plasmodium falciparum andAnopheles stephensi

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Journal of Coastal Life Medicine 2017年第6期5卷 242-248页

作者： Rajamani Sowmiya Govindasamy Balasubramani Paramasivam Deepak Dilipkumar Aiswarya sundaram ravikumar sundaramPrasannakumar Pachiappan Perumal Department of Biotechnology School of BiosciencesPeriyar UniversityPeriyar Palkalai NagarSalemTamil Nadu636011India Department of Oceanography and Coastal Area Studies School of Marine SciencesAlagappa UniversityThondi CampusRamanathapuramTamil Nadu623409India

Objective:To investigate the antimalarial and larvicidal activities of seaweeds against Plasmodium falciparum strain andAnopheles stephensi mosquito larva. Methods: The three different seaweeds,Jania rubens,Turbinaria ornata (T. ornata) and Ulva fasciata were collected from Southeast India. The seaweeds were extracted using hexane and ethyl acetate solvents and evaluated for their mosquito-larvicidal and antiplasmodial property. The bioactive compounds of the seaweed extract were studied by Fourier transform infrared spectroscopy and gas chromatography-mass spectrometry. Results:The hexane extract ofT. ornata (HTO) has shown significant inhibitory effects at the IC50 value 22.98 μg/mL, when compared to the positive control, chloroquine (12.32 μg/mL). The larvicidal activity of HTO on the fourth instar larvae of Anopheles stephensi was found to be effective with the LC50 and LC90 values (μg/mL) of 1.38 and 3.34. The Fourier transform infrared spectroscopy analysis ofHTO revealed the presence of alkenes, aromatics, amides and amines groups, whereas in gas chromatography-mass spectrometry, 11 different bioactive components were recorded. The bioactive component, hentriacontane in the HTO might be responsible for the recorded antiplasmodial and larvicidal activities. Conclusions:The finding of the present study reveals that the constituents of T. ornata have new sources of antimalarial and larvicidal agents in future.

关键词： Anopheles stephensi FT-IR GC-MS Plasmodium falciparum Turbinaria ornata