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AB014. What is the role of sildenafil in repairing retinopathy of prematurity?

Annals of Eye Science 2018年第1期 420-420页

作者： Alexandra Bélanger Shulin Li Annie Poon suna jung Palig Balian Zehra Khoja Ania Polosa Pierre Lachapelle Pia Wintermark Department of Pediatrics Division of Newborn MedicineMontréal Children’s HospitalMcGill UniversityMontréalQCCanada Department of Ophthalmology and Neurology-Neurosurgery Montréal Children’s Hospital-Research InstituteMcGill UniversityMontréalQCCanada

Background:Oxygen therapy provided to support the lungs of premature newborns often leads to damages to the retina called retinopathy of prematurity(ROP)and long-term visual *** treatments for ROP are invasive and aim at preventing further progression of the damages to the retina,but do not repair these *** goal is to investigate the therapeutic effect of sildenafil on retinal structure in a rat model of ***:Sprague-Dawley rats were exposed to hyperoxia(i.e.,80%oxygen)interrupted by three 0.5-hour periods of normoxia(i.e.,21%oxygen)(hyperoxic animals)per day or room air only(i.e.,21%oxygen)(control animals)from post-natal day 4(P4)to 14(P14).Pups were then housed in room ***(50 mg/kg)or vehicle was given per os twice daily after oxygen exposure(from P15 to P21).At P30,retinas were extracted,and *** retinal histology,eyes were stained with toluidine blue to measure the thicknesses of the different retinal *** was also performed to count the number of retinal ganglion cells and bipolar cells in the inner retina,as well as the number of astrocytes and microglia within the different retinal ***:Hyperoxia caused a reduction in thickness of the outer plexiform layer(OPL)and a decrease in the number of bipolar cells in some parts of the retina,compared to control animals(P<0.05);in addition,the number of microglia cells was significantly increased in the rats exposed to hyperoxia,compared to controls(P<0.05).Sildenafil improved OPL thickness in ROP animals,but did not change the number of bipolar *** hyperoxic rats treated with sildenafil,the number of microglia were similar to control *** number of retinal ganglion cells and astrocytes did not differ significantly between the ***:Treatment with sildenafil following oxygen exposure provided some recovery of the structure of the *** beneficial effect may be modulated by a decrease of inflammation within t

关键词： Neonates hyperoxia retinopathy of prematurity(ROP) neuroscience vision health

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Tuning the base properties of Mg–Al hydrotalcite catalysts using their memory effect

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Journal of Energy Chemistry 2020年第7期29卷 229-236,I0008页

作者： Dahye Kwon Ji Yeon Kang suna An Inchan Yang Ji Chul jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea

Herein,the relationship between the structure and base properties of Mg–Al hydrotalcite catalysts was comprehensively investigated in relation to heat treatment and rehydration processes,which are well known as memory effects of *** structure of Mg–Al hydrotalcites changed from layered double hydroxide(LDH)to mixed metal oxide and subsequently to a spinel structure during heat treatment,and it was returned from mixed metal oxide to a LDH structure by *** on various characterizations,we successfully proposed a detailed mechanism of memory *** also confirmed that the Mg–Al hydrotalcites had weak or strong base sites and that their base properties could be systematically tuned by heat treatment and *** prepared Mg–Al hydrotalcites were applied to a model reaction,isomerization of glucose to fructose,as base *** the catalysts tested,the rehydrated Mg–Al hydrotalcite efficiently produced fructose due to its appropriate base and structure *** finally concluded that the base sites of Mg–Al hydrotalcites can be designed as desired by heat treatment and ***,through systematic design of the base sites of Mg–Al hydrotalcites,these can be promising catalysts for various heterogeneous reactions over base catalysts,giving excellent catalytic performances.

关键词： Mg–Al hydrotalcite Structure Base properties Heat treatment Rehydration

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AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina

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Annals of Eye Science 2018年第1期 441-441页

作者： Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv suna jung Francois Duhamel Houda Tahiri Samy Omri Baraa Noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-Justine Universitéde MontréalMontréalQCCanada Department of Ophthalmology and Neurology-Neurosurgery Montréal Children’s Hospital-Research InstituteMcGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and ***,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in *** date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating ***,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−***:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J *** thicknesses of their choroid were evaluated by ***,Q-PCR,western blot and choroid sprout assay were *** vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for ***:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of *** the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their *** Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity ***:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the *** novel discovery sheds new light on the relationship between metabolism and epigenetic modification.

关键词： Subretina GPR81 epigenetic modification

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