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信息不对称下按需服务平台拥有不同类型代理人时的动态激励契约

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中国管理科学 2024年第5期32卷 241-253页

作者：孙中苗徐琪张艳芬东华大学旭日工商管理学院上海200051

针对信息不对称下按需服务平台同时拥有兼职与全职代理人时的动态激励问题,以平台服务商誉为状态变量,建立动态的委托代理模型,运用最优控制方法求解平台及代理人的均衡策略,通过参数分析和对比分析得到的研究结果表明:当平台由单一兼... 详细信息

针对信息不对称下按需服务平台同时拥有兼职与全职代理人时的动态激励问题,以平台服务商誉为状态变量,建立动态的委托代理模型,运用最优控制方法求解平台及代理人的均衡策略,通过参数分析和对比分析得到的研究结果表明:当平台由单一兼职或全职代理人转变为同时拥有两类代理人时,代理人的服务努力水平均会降低,平台对其激励强度应提高,平台向兼职代理人收取的担保金和向全职代理人提供的固定报酬随代理人对平台激励契约的敏感性而不同;且平台在三种模式下的最优服务努力投入并不相同。通过数值仿真发现,单一兼职代理人模式下按需平台收益最优,而全职代理人模式下按需平台的盈利能力最弱,同时拥有两类代理人模式时按需平台的收益次优。研究结论可为按需平台设计动态激励契约提供一定的参考。

关键词：共享经济动态激励契约兼职与全职代理人最优控制论委托代理模型

Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 794-803页

作者： Peng Chen Hai-Dong yang Jun-Jie Wang Zhen-Hua Zhu Hui-Min Zhao Xu-yuan yin yuan Cai Hong-LiangZhu Jia-Lin Fu Xin-Zhu Zhang Wen-Xi sun Li Hui Xiao-Bin Zhang Suzhou Medical College of Soochow University Suzhou 215123Jiangsu ProvinceChina Department of Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Psychiatry The Fourth People’s Hospital of LianyungangThe Affiliated Kangda College of Nanjing Medical UniversityLianyungang 222003Jiangsu ProvinceChina Research Center of Biological Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Neurology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina

BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6(IL-6)contributes to the pathophysiology of psychiatric ***,there was no study concerning the relationship between IL-6 concentrations and clinical features in the chronic phase of early-onset schizophrenia(EOS).AIM To investigate the relationship between serum IL-6 concentration and the clinical features of *** We measured serum IL-6 Levels from 74 patients with chronic schizophrenia,including 33 with age at onsetyears(EOS group)and 41 with onset≥21 years in[adult-onset schizophrenia(AOS)group],and from 41 healthy *** severities were evaluated using the Positive and Negative Syndrome Scale(PANSS).RESULTS Serum IL-6 concentrations were higher in both EOS and AOS groups than healthy controls(F=22.32,Py between EOS and AOS groups(P>0.05)after controlling for age,body mass index,and other *** symptom scores were higher in the EOS group than the AOS group(F=6.199,P=0.015).Serum IL-6 concentrations in the EOS group were negatively correlated with both total PANSS-negative symptom score(r=-0.389,P=0.032)and avolition/asociality subscore(r=-0.387,P=0.026).CONCLUSION Patients with EOS may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the ***-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients.

关键词： Early-onset schizophrenia Interleukin 6 Negative symptoms Avolition Asociality

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海口国际免税城项目结构设计

建筑科学 2024年第1期40卷 13-22页

作者：孙建超孙宁高杰许瑞姜鋆中国建筑科学研究院有限公司北京100013

本项目位于高烈度设防区,地震作用大,且项目地上建筑存在多项平面不规则。经充分对比分析,地上采用钢管混凝土框架+剪切型金属阻尼器结构,通过增加结构阻尼降低水平地震作用,大幅提升结构抗震性能。屋面主要采用大跨度单层网壳、局部悬... 详细信息

本项目位于高烈度设防区,地震作用大,且项目地上建筑存在多项平面不规则。经充分对比分析,地上采用钢管混凝土框架+剪切型金属阻尼器结构,通过增加结构阻尼降低水平地震作用,大幅提升结构抗震性能。屋面主要采用大跨度单层网壳、局部悬挑区域采用双层网壳的结构体系,并通过双非线性计算法进行整体稳定计算分析。本文主要介绍了本项目的结构体系及特点,明确了设计标准、参数选取、计算方法及关键技术措施等,旨在为同类项目的结构设计提供借鉴和参考。

关键词：金属阻尼器性能化设计单层网壳

有向根树上局部更新函数为NAND或NOR的广义并序动力系统的固定点

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Journal of Donghua University(English Edition) 2024年第2期41卷 214-220页

作者：孙彦文郑洁东华大学理学院上海201620

研究对象为有向根树上的广义并序动力系统,其局部更新函数为NAND或NOR。为了研究这类广义并序动力系统中的固定点的个数及状态,采用结构分析法和分类讨论法,得到了此类动力系统中关于固定点的确切结果。证明了这类广义并序动力系统中的... 详细信息

研究对象为有向根树上的广义并序动力系统,其局部更新函数为NAND或NOR。为了研究这类广义并序动力系统中的固定点的个数及状态,采用结构分析法和分类讨论法,得到了此类动力系统中关于固定点的确切结果。证明了这类广义并序动力系统中的固定点状态完全由有向根树中的自环决定。离散动力系统是数学建模的重要工具,该文可为离散动力系统的研究提供新的思路。

关键词：广义并序动力系统有向根树布尔函数固定点

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川渝传统谷物脱壳工具檑子设计研究

装饰 2024年第1期 98-102页

作者：孙虎冉秋艺西华大学四川工程职业技术大学

檑子是融合了传统土砻、木砻的制作方式的一种谷物脱壳农具。本文从设计学角度对川渝地区现存檑子的结构、功能、材质进行解析,并从人机工程学、力学及机械原理的角度分析其操作方式。在研究檑子设计的时空逻辑和作用物逻辑的基础上,将... 详细信息

檑子是融合了传统土砻、木砻的制作方式的一种谷物脱壳农具。本文从设计学角度对川渝地区现存檑子的结构、功能、材质进行解析,并从人机工程学、力学及机械原理的角度分析其操作方式。在研究檑子设计的时空逻辑和作用物逻辑的基础上,将其特点与木砻、土砻进行对比,从而解析檑子的改良逻辑。檑子作为民生设计的典型代表,反映了劳动者在长期的实践操作中根据使用反馈、总结继而发挥巧思的过程,其设计演进背后蕴含的设计逻辑包含了宜用、宜人的造物智慧,是传统农具流传千年仍在使用的根本原因之一。

关键词：檑子农具设计传统造物

Non-invasive imaging of pathological scars using a portable handheld two-photon microscope

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Chinese Medical Journal 2024年第3期137卷 329-337页

作者： yang Han yuxuan sun Feili yang Qingwu Liu Wenmin Fei Wenzhuo Qiu Junjie Wang Linshuang Li Xuejun Zhang Aimin Wang yong Cui Graduate School Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China College of Engineering Peking UniversityBeijing 100871China School of Chemical Biology and Biotechnology State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Department of Dermatology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Future Technology Peking UniversityBeijing 100871China Beijing Transcend Vivoscope Biotech Beijing 100085China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230001China Institute of Dermatology Anhui Medical UniversityHefeiAnhui 230001China School of Electronics Peking UniversityBeijing 100871China

Background:Pathological scars are a disorder that can lead to various cosmetic,psychological,and functional problems,and no effective assessment methods are currently *** and treatment of pathological scars are based on cutaneous manifestations.A two-photon microscope(TPM)with the potential for real-time non-invasive assessment may help determine the under-surface pathophysiological conditions in *** study used a portable handheld TPM to image epidermal cells and dermal collagen structures in pathological scars and normal skin in vivo to evaluate the effectiveness of treatment in scar ***:Fifteen patients with pathological scars and three healthy controls were *** was performed using a portable handheld *** indexes were extracted from two dimensional(2D)and three dimensional(3D)perspectives,including collagen depth,dermo-epidermal junction(DEJ)contour ratio,thickness,orientation,and occupation(proportion of collagen fibers in the field of view)of *** depth-dependent indexes were computed through the 3D second harmonic generation image and three morphology-related indexes from the 2D *** assessed index differences between scar and normal skin and changes before and after ***:Pathological scars and normal skin differed markedly regarding the epidermal morphological structure and the spectral characteristics of collagen *** indexes were employed to distinguish between normal skin and scar *** significant differences were found in average depth(t=9.917,Py be an auxiliary tool for scar treatment selection and assessing treatment efficacy.

关键词： Scars Two-photon microscope Two-photon excitation fluorescence Second harmonic generation microscopy

Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

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World Journal of Gastroenterology 2024年第38期30卷 4211-4220页

作者： Wei-Ling Zhang Jing sun Rong-Fang Huang yi Zeng Shu Chen Xiao-Peng Wang Jin-Hu Chen yun-Bin Chen Chun-Su Zhu Zai-Sheng ye you-Ping Xiao Department of Radiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Pathology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Gastric Surgery Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Epidemiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina

BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds ***2 overexpression occurs in approximately 15%-20%of advanced GC cases,directly affecting treatment-related ***-computed tomography(sCT)enables the quantification of material compositions,and sCT iodine concentration parameters have been demonstrated to be useful for the diagnosis of GC and prediction of its invasion depth,angioge-nesis,and response to systemic *** existing report describes the prediction of GC HER2 status through histogram analysis based on sCT iodine maps(IMs).AIM To investigate whether whole-volume histogram analysis of sCT IMs enables the prediction of the GC HER2 *** This study was performed with data from 101 patients with pathologically confirmed GC who underwent preoperative sCT *** parameters were extracted via sCT IM histogram analysis:The minimum,maximum,mean,standard deviation,variance,coefficient of variation,skewness,kurtosis,entropy,percentiles(1st,5th,10th,25th,50th,75th,90th,95th,and 99th),and lesion *** correlations of the parameters with the HER2 status and clinicopathological parameters were *** operating characteristic curves were used to evaluate the parameters’diagnostic *** Values for the histogram parameters of the maximum,mean,standard deviation,variance,entropy,and percentiles were significantly lower in the HER2+group than in the HER2–group(all Py with the HER2 status of tumor tissue(P=0.001 and 0.023,respectively).The 99th percentile had the largest area under the curve for GC HER2 status identification(0.740),with 76.2%,sensitivity,65.0%specificity,and 67.3%*** sCT IM histogram parameters correlated positively with the GC HER2 status(r=0.

关键词： Gastric cancer Spectral computed tomography Iodine map Histogram analysis

Effect of GnRH analogs in advanced male breast cancer:10-year experience from the Henan Breast Cancer Center and literature review

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Chinese Medical Journal 2024年第13期137卷 1623-1625页

作者： Mengwei Zhang Huimin Lyu Limin Niu Zhenzhen Liu Huiai Zeng Shengnan Zhao Jing Wang Huihui sun Min yan Department of Breast Disease Henan Breast Cancer CenterThe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China

To the Editor:Male breast cancer is relatively rare,accounting for just 1%of all breast cancer cases.[1]The management strategies for male breast cancer are mainly based on a limited number of retrospective studies and speculation based on female breast *** study presents a comprehensive account of a decade-long observation of male metastatic breast cancer(mMBC)in our *** Affiliated Cancer Hospital of Zhengzhou University database had records of 2853 advanced breast cancer cases that were treated from January 1,2010 to December 31,*** of the total number,18 cases were identified as *** analysis encompassed data about the treatment administered,the treatment’s effectiveness,and the patient’s survival *** present investigation entails a retrospective examination of our institution’s 10-year experience with patients diagnosed with mMBC and a comprehensive evaluation of relevant literature.

关键词： breast Cancer cancer

Expert consensus on the diagnosis and therapy of endo-periodontal lesions

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International Journal of Oral Science 2024年第3期16卷 381-389页

作者： Bin Chen yanan Zhu Minkui Lin yangheng Zhang yanfen Li Xiangying Ouyang Song Ge Jiang Lin yaping Pan yan Xu yi Ding Shaohua Ge Faming Chen Zhongchen Song Shaoyun Jiang Jiang sun Lijun Luo Junqi Ling Zhi Chen Lin yue Xuedong Zhou Fuhua yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Department of Endodontics Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province&Fujian Key Laboratory of Oral Diseases&Fujian Provincial Engineering Research Center of Oral Biomaterial School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Periodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina School and Hospital of Stomatology Zunyi Medical UniversityZunyiChina Department of Stomatology Beijing TongRen HospitalCapital Medical UniversityBeijingChina Department of Periodontics School and Hospital of StomatologyChina Medical UniversityShenyangChina Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Key Laboratory of Oral DiseasesNanjing Medical UniversityNanjingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Periodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Periodontology School and Hospital of StomatologyShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral Diseases JinanJinanChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of periodontologySchool of StomatologyThe Fou

Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing *** etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical ***,EPL-affected teeth require multidisciplinary therapy,including periodontal therapy,endodontic therapy and others,but there is still much debate about the appropriate timing of periodontal therapy and root canal *** compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EPL-affected teeth,this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence.

关键词： diagnosis periodontal lesions