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Protein and energy concentrations of meat meal and meat and bone meal fed to pigs based on in vitro assays

Animal Nutrition 2021年第1期7卷 252-257页

作者： Hyunjun Choi Chang sik Won Beob Gyun kim Department of Animal Science and Technology Konkuk UniversitySeoul 05029Republic of Korea

The objective of this study was to develop equations for estimating ileal digestible crude protein(CP)and metabolizable energy(ME)contents of meat meal(MM)and meat and bone meal(MBM)as feed in-gredients for pigs based on in vitro *** ingredients were 4 sources of MM and 3 sources of *** and CP contents of the ingredients ranged from 3.8%to 33.1%and 46.8%to 82.9%(as-is basis),*** vitro ileal disappearance(IVID)of CP was determined and ileal digestible CP content was calculated by multiplying CP content by IVID of *** vitro total tract disappearance(IVTTD)of dry matter(DM)was determined and ME was calculated using gross energy,CP contents,and IVTTD of *** IVID of CP and IVTTD of DM ranged from 77.2%to 88.7%and from 82.7%to 92.4%,*** ileal digestible CP and ME contents ranged from 37.8%to 73.5%DM and 2,405 to 3,905 kcal/kg DM,*** contents were negatively correlated(P<0.001)with CP(r=-0.99),in vitro ileal digestible CP(r=-0.97),gross energy(r-1.00),in vitro digestible energy(r=-0.97),and adjusted ME(r=-0.97).The most fitting equations for ileal digestible CP and adjusted ME were:ileal digestible CP(%DM)=11.91-0.90×Ash(%DM)+0.74×IVID of CP(%)(R2=0.99)and adjusted ME(kcal/kg DM)=130.85-50.90×ash(%DM)+47.06×IVTTD of DM(%)(R2=0.99).To validate the accuracy of the prediction equations for ME,mean bias and linear bias were determined using a regression *** ME values of MM and MBM were in a good agreement with data obtained from animal ex-periments based on a statistically insignificant bias in the *** conclusion,ME concentrations of MM and MBM as swine feed ingredients can be calculated using ash concentration and in vitro disap-pearance of dry matter.

关键词： Animal offal Energy In vitro disappearance method Protein

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Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

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Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin kim Yong-Hee kim Myeong-Geun Oh Ki-Jung kim Sang-Eun Jung Ju-Hee Jin sun-Uk kim Kwan-sik Min Buom-Yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal

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Single-atom Pd catalyst anchored on Zr-based metal-organic polyhedra for Suzuki-Miyaura cross coupling reactions in aqueous media

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Nano Research 2021年第2期14卷 486-492页

作者： Seongsoo kim Seohyeon Jee Kyung Min Choi Dong-sik Shin Division of Chemical and Bioengineering Kangwon National UniversityGangwon-do 24341Republic of Korea Department of Chemical and Biological Engineering Sookmyung Womens University100 Cheongpa-ro 47-gilYongsan-guSeoul 04310Republic of Korea

The challenge for single-atom catalysts in various C-C cross coupling reaction exists in the development of solid supporting *** has been desired tofind a supporting material designed in molecular level to anchor a single-atom catalyst and provide high degree of dispersion and substrate access in aqueous ***,we prepared discrete cages of metal-organic polyhedra anchoring single Pd atom(MOP-BPY(Pd))and successfully performed a Suzuki-Miyaura cross coupling reaction with various substrates in aqueous *** was revealed that each tetrahedral cage of MOP-BPY(Pd)has 4.5 Pd atoms on average and retained its high degree of dispersion up to 3 months in *** coupling efficiencies of the Suzuki-Miyaura cross coupling reaction exhibited more than 90.0%for various substrates we have tested in the aqueous media,which is superior to those of the molecular Pd complex and metal-organic framework(MOF)anchoring Pd ***,MOP-BPY(Pd)was successfully recovered and recycled without performance degradation.

关键词： metal-organic polyhedra Suzuki-Miyaura cross coupling reaction structure characterization aqueous phase reaction high-degree of dispersion

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Solvent extraction and stripping of lithium ion from aqueous solution and its application to seawater

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Rare Metals 2016年第12期35卷 948-953页

作者： Gregorius Rionugroho Harvianto Seok-Hyeon kim Chang-sik Ju Department of Chemical Engineering Pukyong National University

For the development of lithium ion recovery process from seawater, a series of experimental researches were performed. Solvent extraction of lithium ion from aqueous solution using kerosene as solvent was proposed. Lithium ion is effectively extracted by thenoyltrifluoroace- tone-trioctylphosphine oxide （TTA-TOPO） in kerosene within 80 min. Extraction efficiency is severely influenced by stoichiometric parameters. Among the stoichiometric parameters, volume ratio of aqueous （A） to extraction （E） solution is the most influential parameter. After extrac- tion, lithium ion could be easily stripped from the extraction solution by acidic solutions. Stripping efficiency decreases with pH of acidic solutions, and the kind of acid does not affect the stripping efficiency. Extraction efficiency main- tains at more than 93 % even when the extraction solution is recycled three times. 65 % of lithium ion can be extracted from seawater by this solvent extraction process when magnesium ion is precipitated by NHaOH prior to solvent extraction process. Other metallic ions in seawater decrease the extraction efficiency of lithium ion.

关键词： Lithium Thenoyltrifluoroacetone Trioctylphosphine oxide Solvent extraction Stripping Recycling

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Recent applications of chemosensitivity tests for colorectal cancer treatment

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World Journal of Gastroenterology 2014年第44期20卷 16398-16408页

作者： Yong sik Yoon Jin Cheon kim Department of Surgery University of Ulsan College of Medicine Institute of Innovative Cancer Research and Asan Institute for Life Sciences Asan Medical Center

The evaluation of therapeutic efficacy is necessary to predict the outcome of patients with metastatic colorectal cancer(CRC). In these patients, there is a critical need for predictive chemosensitivity assays and biomarkers to optimize efficacy and minimize toxicity. The introduction of targeted agents has improved the progression-free survival and overall survival of patients with metastatic disease. However, approximately 50% of patients do not show a positive response to chemotherapy and the selection of patients likely to respond to a specific regimen remains challenging. Cell culturebased chemosensitivity tests use autologous viable tumor cells to evaluate susceptibility to specific agents in vitro and predict their direct effects. Adenosine triphosphate-based assays and methyl thiazolyl-diphenyltetrazolium bromide-based assays are used widely as sensitivity tests because of their short assay period, technical simplicity, and the requirement of small amount of specimen. Among protein- and gene-based chemosensitivity assays, assessment of KRAS mutation status predicts the response to epidermal growth factor receptor-targeted therapy in CRC patients. The validation of predictive and prognostic markers enables the selection of therapeutic regimens with optimal efficacy and minimal toxicity for each patient, which has been termed personalized treatment. This review summarizes currently available predictive and prognostic chemosensitivity tests for metastatic CRC.

关键词： Colorectal adenocarcinomas Colorectal cancer Chemotherapy In vitro assays Molecular targeted therapy Individualized therapy

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Intraductal papillary bile duct adenocarcinoma and gastrointestinal stromal tumor in a case of neurofibromatosis type 1

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World Journal of Gastroenterology 2018年第4期24卷 537-542页

作者： Jung Min Lee Jae Min Lee Jong Jin Hyun Hyuk Soon Choi Eun sun kim Bora Keum Yoon Tae Jeen Hoon Jai Chun Hong sik Lee Chang Duck kim Dong sik kim Joo Young kim Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Gastrointestinal Medical Instrument Research Korea University College of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University Anam Hospital Division of HBP Surgery and Liver Trans- plantation Department of Surgery Korea University College of Medicine Department of Pathology Korea University College of Medicine

We report our experience with a synchronous case of gastrointestinal stromal tumor(GIST) and intraductal papillary neoplasm of the bile duct(IPNB) in anelderly woman with neurofibromatosis type 1(NF-1). A 72-year-old woman presented with a 2-mo history of right upper abdominal pain unrelated to diet and indigestion. Fourteen years earlier, she had been diagnosed with NF-1, which manifested as café au lait spots and multiple nodules on the skin. Computed tomography(CT) revealed a multilocular low-density mass with septation, and mural nodules in the right hepatic lobe, as well as a 1.7-cm-sized well-demarcated enhancing mass in the third portion of the duodenum. The patient subsequently underwent right hepatectomy and duodenal wedge resection. We present here the first report of a case involving a synchronous IPNB and GIST in a patient with NF-1. Our findings demonstrate the possibility of various tumors in NF-1 patients and the importance of diagnosis at an early

关键词： Neurofibromatosis type 1 Intraductal papillary neoplasm of the bile duct Gastrointestinal stromal tumor Synchronous

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong Bae Taehyun Park Il Tae kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

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Persistent half-metallic ferromagnetism in a(111)-oriented manganite superlattice

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npj Computational Materials 2022年第1期8卷 727-734页

作者： Fabrizio Cossu Heung-sik kim Biplab Sanyal Igor Di Marco Department of Physics and Institute of Quantum Convergence and Technology Kangwon National UniversityChuncheon24341Korea Asia Pacific Center for Theoretical Physics Pohang37673Korea Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120UppsalaSweden Department of Physics POSTECHPohang37673Korea

We employ electronic structure calculations to show that a(111)-oriented(LaMnO_(3))_(12)∣(SrMnO_(3))_(6)superlattice retains a half-metallic ferromagnetic character despite its large *** link this behaviour to the strain and the octahedral connectivity between the *** also gives rise to breathing modes,which are coupled to charge and spin oscillations,whose components have a pure e_(g)*** interestingly,the magnetisation reaches its maximum value inside the LaMnO_(3)region and not at the interface,which is fundamentally different from what observed for the(001)*** inter-atomic exchange coupling shows that the magnetic order arises from the double-exchange mechanism,despite competing interactions inside the SrMnO_(3)***,the van Vleck distortions and the spin oscillations are crucially affected by the variation of Hund’s exchange and charge doping,which allows us to speculate that our system behaves as a Hund’s metal,creating an interesting connection between manganites and nickelates.

关键词： metallic exchange superlattice

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Soil compression influences the avoidance behavior of Allonychiurus kimi(Collembola)to cadmium and copper

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Pedosphere 2022年第3期32卷 487-494页

作者： Jino SON Yun-sik LEE Yongeun kim Kijong CHO OJeong Eco-Resilience Institute Korea UniversitySeoul 02841(Republic of Korea) Department of Environmental Science and Ecological Engineering Korea UniversitySeoul 02841(Republic of Korea) Institute of Environment and Ecology Korea UniversitySeoul 02841(Republic of Korea)

The behavior of soil organisms inhabiting soil pore spaces can be influenced by soil compression,which can affect their avoidance behavior to *** this study,we aimed to evaluate the effect of soil compression on the avoidance behavior of Allonychiurus kimi(Collembola)to heavy metals cadmium and ***,to assess the applicability of the avoidance test guideline of the International Organization for Standardization(ISO)developed for Folsomia candida,we investigated the avoidance behavior of *** to cadmium and copper in an artificial soil with a loose structure(bulk density of 0.25 g cm^(-3)),the porous texture of which was sufficiently loose to enable *** to move between pore *** effect of soil compression on the avoidance behavior of *** to both metals was evaluated in compressed soil(bulk density of 0.64 g cm^(-3))with a uniformly compressed soil surface,and avoidance behavior was investigated at 24-h intervals over a 120-h *** that *** is unable to burrow into compressed soil,the compressed soil test can minimize the effects of differences in soil factors,such as soil porosity and bulk density,on the behavior of this *** the artificial soil,a statistically significant avoidance behavior of *** was observed at cadmium and copper concentrations greater than 50 and 200 mg kg^(-1),respectively,thereby indicating the applicability of the ISO avoidance test guidelines for *** compared at the same exposure time point,the avoidance response to both metals in compressed soil was less sensitive than that in uncompressed *** addition,we observed differences in the effects of metals on avoidance response in the compressed soil over time,with the effect of cadmium increasing with time and the effect of copper showing the opposite ***,we found that soil compression can affect the avoidance behavior of *** to cadmium and copper,and we discussed the advantages and limitations of using compressed

关键词： behavioral endpoint ecotoxicity test habitat function heavy metal pollutant springtail

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Variation in dynamic deformation behavior and resultant yield asymmetry of AZ80 alloy with extrusion temperature

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Journal of Materials Science & Technology 2020年第11期42卷 225-236页

作者： Sang-Hoon kim Sang Won Lee Byoung Gi Moon Ha sik kim sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu702701South Korea Implementation Research Division Korea Institute of Materials ScienceChangwon51508South Korea

In this work,variation in the dynamic recrystallization(DRX)and dynamic precipitation behavior of AZ80 alloy during extrusion due to changes in extrusion temperature was investigated,and the resultant microstructure and yield asymmetry were *** the extrusion temperature increases from 250℃to 350℃,the primary DRX mechanism changes from twin-induced DRX to discontinuous DRX,resulting in an increase in the DRX area fraction and un DRXed grain *** addition,as the extrusion temperature rises,Mg17Al12 precipitation during extrusion decreases sharply throughout the extruded *** reduction in the compressive yield strength(CYS)with increasing extrusion temperature is more pronounced than it is for the tensile yield strength(TYS),which ultimately increases the yield asymmetry of the extruded *** higher extrusion temperature has less of an influence on the TYS due to the promotion of certain hardening *** the other hand,the greater reduction in the CYS is attributed to the increased fraction and size of regions in which{1012}twins predominantly form and the lower amount of precipitates,which effectively facilitates{1012}twinning.

关键词： Magnesium alloys Extrusion Recrystallization Precipitation Yield asymmetry

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