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Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator

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Microsystems & Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon Srinivas Merugu Jaibir Sharma Amit Lal Eldwin J.ng Yul Koh Joshua E.-Y.lee Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMEMS Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves(GFWs)generated by a membrane acoustic waveguide actuator(MAWA).By harnessing the potential of GFWs,cavity-agnostic advanced particle manipulation functions are achieved,unlocking new avenues for microfluidic systems and lab-on-a-chip *** localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising *** traditional acoustofluidic technologies,the GFWs propagating on the MAWA’s membrane waveguide allow for cavity-agnostic particle manipulation,irrespective of the resonant properties of the fluidic ***,the acoustofluidic functions enabled by the device depend on the flexural mode populating the active region of the membrane *** demonstrations using two types of particles include in-sessile-droplet particle transport,mixing,and spatial separation based on particle diameter,along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS *** experiments emphasize the versatility and potential applications of the MAWA as a microfluidic platform targeted at lab-on-a-chip development and showcase the MAWA’s compatibility with existing microfluidic systems.

关键词： waveguide fluid cavity

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Inferior vena cava reconstruction in extended right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 533-534页

作者： Karin ky Ho Sui Ling Sin Kin Pan Au Henry HY lee Daniel TL Chan Albert Chan Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Surgery Yan Chai Hospital7 Yan Chai StreetHong KongChina State Key Laboratory of Liver Research(Li Ka Shing Faculty of Medicine The University of Hong Kong)102 Pok Fu Lam RoadHong KongChina

To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.

关键词： invasion vena Liver

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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUng sun KIM YUN sun lee SEUng MYUng DOng HYO JUng KIM DA EUN lee HYEON WOOng KAng MYEOng JIN KIM JOON SEOng PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

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Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering Management 2024年第1期11卷 79-91页

作者： Lebing WAng Jian Gang JIN Lijun sun Der-Horng lee School of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUC Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. Conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

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Amelioration of habitat since the early Holocene contributed to the origin of agriculture in the farming-pastoral zone of northern China

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Science China Earth Sciences 2024年第8期67卷 2535-2546页

作者： Xin JIA Zhiping ZHAng Yonggang sun Runqi JIAng Shuangwen YI Wei CHEN Jue sun Guoqiang LI Shuzhi WAng Enrui LI Xiaonong HU Qingchun BAO Harry F.lee Huayu LU Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Schlool of History and Culture Chifeng UniversityChifeng 024000China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Institute of Archaeology Chinese Academy of Social SciencesBeijing 100710China Ulanqab Museum Ulanqab 012000China The Institute of Cultural Relics and Archaeology Hohhot 010011China Department of Geography and Resource Management The Chinese University of Hong KongHong Kong 999077China Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China School of Geography Nanjing Normal UniversityNanjing 210023China Institute of Environmental Archaeology Nanjing Normal UniversityNanjing 210023China

The origin of agriculture in the farming-pastoral zone of northern China remains in *** central region of the Inner Mongolia Plateau is located in the core area of the farming-pastoral zone;thus,it is a critical region for exploring the origin of the dryland farming system in northern *** study selected the Yumin Site and Banan Site,which belong to the Yumin Culture-the beginning of Neolithic culture in Inner Mongolia-as the research *** on the quartz optically stimulated luminescence(OSL)dating on the sedimentary sections from the Yumin site(YM)and Banan site(BN1 and BN2),the Holocene chronology framework of each section was *** that,by identifying carbonized grains in the Yumin site and the multi-proxy analysis of each section,we investigated the relationship between the origin of agriculture and climate change in this *** results revealed that the timing of the origin of agriculture recorded in the Yumin site lagged behind the timing of a significant increase of precipitation during the early Holocene but coincided with the timing of a significant increase of vegetation around 8.4 *** phenomenon was further confirmed by the published high-resolution paleoenvironmental records from the surrounding area of the Yumin *** propose that with the gradual amelioration of hydrothermal conditions since the beginning of the Holocene,the regional ecosystem had been improved,resulting in the gradual conversion of the land surface from infertile sand to organic-rich soil,providing an appropriate environmental foundation for the origin of dryland farming in northern China around 8.4 *** study highlighted that the“accumulative environmental effects”during the early Holocene played a vital role in the origin of agriculture in northern China and provided a reference for agricultural management in the context of future climate change.

关键词： Origin of agriculture Accumulative environmental effects Yumin Culture Northern China Holocene

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An update on hormonal regulation of early embryo-fallopian tube interactions: insights for improvements of assisted reproductive technology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku Suranga P. ng Ernest H. Y. Yeung William S. B. lee Kai-Fai Department of Obstetrics and Gynaecology LKS Faculty of Medicine 3. The University of Hong Kong 4. Hong Kong SAR 999077 5. China

Human fallopian tubes (FTs) play important roles in the whole reproductive process. FTs are the site for the final maturation of gametes, fertilization, transport of preimplantation embryos, and early embryonic development before entering the uterus. All these functions are critical in the establishment of a successful pregnancy. When the embryo is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring cells. Therefore, the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of pregnancy. This review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal communications. Moreover, we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

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CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim Yu sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu lee Brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

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Unravelling the role of the combined effect of metallic charge transfer channel and SiO_(x) overlayer in the Zr/Si-Fe_(2)O_(3):Au:SiO_(x) nanorod arrays to boost photoelectrochemical water splitting

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Journal of Energy Chemistry 2024年第3期90卷 370-379,I0009页

作者： Tae Sik Koh Periyasamy Anushkkaran Love Kumar Dhandole Mahadeo A.Mahadik Weon-Sik Chae Hyun Hwi lee sun Hee Choi Jum Suk Jang Division of Biotechnology SafetyEnvironment and Life Science InstituteCollege of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54896Republic of Korea Department of Integrative Environmental Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Extreme Materials Research Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Hematite(α-Fe_(2)O_(3)) based photoanodes have been extensively studied due to various intriguing features that make them viable candidates for a photoelectrochemical(PEC) water splitting ***,we propose a Zr-doped Fe_(2)O_(3) photoanode decorated with facilely spin-coated Au nanoparticles(NPs) and microwave-assisted attached Si co-doping in conjunction with a SiO_(x) overlayer that displayed a remarkable photocurrent density of 2.01 mA/cm^(2) at 1.23 V *** kinetic dynamics at the photoelectrode/-electrolyte interface was examined by employing systematic electrochemical *** Au NPs played a dual role in increasing PEC water ***,the Schottky interface that was formed between Au NPs and Zr-Fe_(2)O_(3) lectrode ensured the prevention of electron flow from the photoanode to the metal,increasing the number of available charges as well as suppressing surface charge ***,Au extracted photoholes from the bulk of the Zr-Fe_(2)O_(3) and transported them to the outer SiO_(x) overlayer,while the SiO_(x) overlayer efficiently collected the photoholes and promoted the hole injection into the ***,Si co-doping enhanced bulk conductivity by reducing bulk charge transfer resistance and improving charge carrier *** study outlines a technique to design a metallic charge transfer path with an overlayer for solar energy conversion.

关键词： Hematite Microwave attachment Au nanoparticles SiO_(x) overlayer Water splitting

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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah lee Ang-Lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling ng Jing Feng Kong Yik-Ling Chew Kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(Png cardiovascular health(Png status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(Pngs underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

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Enhancing Identity Protection in Metaverse-Based Psychological Counseling System

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Computers, Materials & Continua 2024年第1期78卷 617-632页

作者： Jun lee Hanna lee Seong Chan lee Hyun Kwon Department of Game Software Hoseo UniversityAsan-si31499Korea Yatav Enter Seoul04799Korea Department of Artificial Intelligence and Data Science Korea Military AcademySeoul01805Korea

Non-face-to-face psychological counseling systems rely on network technologies to anonymize information regard-ing client ***,these systems often face challenges concerning voice data leaks and the suboptimal communication of the client’s non-verbal expressions,such as facial cues,to the *** study proposes a metaverse-based psychological counseling system designed to enhance client identity protection while ensuring efficient information delivery to counselors during non-face-to-face *** proposed systemincorporates a voicemodulation function that instantlymodifies/masks the client’s voice to safeguard their ***,it employs real-time client facial expression recognition using an ensemble of decision trees to mirror the client’s non-verbal expressions through their avatar in the metaverse *** system is adaptable for use on personal computers and smartphones,offering users the flexibility to access metaverse-based psychological counseling across diverse *** performance evaluation of the proposed system confirmed that the voice modulation and real-time facial expression replication consistently achieve an average speed of 48.32 frames per second or higher,even when tested on the least powerful smartphone ***,a total of 550 actual psychological counseling sessions were conducted,and the average satisfaction rating reached 4.46 on a 5-point *** indicates that clients experienced improved identity protection compared to conventional non-face-to-face metaverse counseling ***,the counselor successfully addressed the challenge of conveying non-verbal cues from clients who typically struggled with non-face-to-face psychological *** proposed systemholds significant potential for applications in interactive discussions and educational activities in the metaverse.

关键词： Metaverse counseling system face tracking identity protection

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