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NADPH oxidase 4(NOX4)as a biomarker and therapeutic target in neurodegenerative diseases

Neural Regeneration Research 2024年第9期19卷 1961-1966页

作者： Napissara Boonpraman sun Shin yi BK21 four Program Department of Medical SciencesSoonchunhyang UniversityAsanSouth Korea Department of Biomedical Laboratory Science Soonchunhyang UniversityAsanSouth Korea iConnectome Co.Ltd.CheonanSouth Korea

Diseases like Alzheimer’s and Parkinson’s diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential therapeutic touchstone and indicative marker for these ailments. This in-depth review brings to light distinct features of NADPH oxidase 4, responsible for generating superoxide and hydrogen peroxide, emphasizing its pivotal role in activating glial cells, inciting inflammation, and disturbing neuronal functions. Significantly, malfunctioning astrocytes, forming the majority in the central nervous system, play a part in advancing neurodegenerative diseases, due to their reactive oxygen species and inflammatory factor secretion. Our study reveals that aiming at NADPH oxidase 4 within astrocytes could be a viable treatment pathway to reduce oxidative damage and halt neurodegenerative processes. Adjusting NADPH oxidase 4 activity might influence the neuroinflammatory cytokine levels, including myeloperoxidase and osteopontin, offering better prospects for conditions like Alzheimer’s disease and Parkinson’s disease. This review sheds light on the role of NADPH oxidase 4 in neural degeneration, emphasizing its drug target potential, and paving the path for novel treatment approaches to combat these severe conditions.

关键词： Alzheimer’s disease astrocytes mitochondrial dysfunction myeloperoxidase NADPH oxidase 4 NADPH oxidase 4 inhibitors neurodegenerative diseases osteopontin Parkinson’s disease reactive oxygen species

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Evaluation of water management on arsenic methylation and volatilization in arsenic-contaminated soils strengthened by bioaugmentation and biostimulation

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Journal of Environmental Sciences 2024年第3期137卷 515-526页

作者： Peng Chen yi Liu Guo-Xin sun State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under fooded conditions. However,no attempt was done to explore As methylation and volatilization under non-fooded conditions. Herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with strawderived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440(GE P. putida). Under fooded conditions, the application of biochar(BC), rice straw(RS)and their combination(BC+RS) increased total As in porewater. However, these effects were greatly attenuated under non-fooded conditions. Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization,and the promotion percentage under non-fooded conditions were significantly higher than that under fooded conditions. The combined GE P. putida and RS showed the highest efficiency in As methylation(88 μg/L) and volatilization(415.4 μg/(kg·year)) in the non-fooded soil with moderate As contamination. Finally, stepwise multiple linear regression analysis presented that methylated As, DOC and p H in porewater were the most important factors contributing to As volatilization. Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-fooded conditions.

关键词： Arsenic methylation Arsenic volatilization Water management Straw incorporation Bioaugmentation

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Navigating the safe operation of high-voltage cathodes:Challenges and strategies

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Nano Research 2024年第10期17卷 8694-8705页

作者： Yue sun Changjian Zuo yi-Chun Lu Electrochemical Energy and Interfaces Laboratory Department of Mechanical and Automation EngineeringThe Chinese University of Hong KongHong Kong 999077China

Lithium-ion batteries play a crucial role in storing energy for renewable sources and electric vehicles,yet face challenges related to insufficient energy *** the working-voltage of cathodes is promising to boost the energy density of batteries by increasing both the output voltage and capacity of cathode,which however could compromise life cycle and *** review provides a comprehensive summary of essential factors governing pathways of cathode-induced thermal runaway,including electrolyte decomposition,phase transitions,and crosstalk-induced *** and electrolyte modifications aimed at mitigating parasitic reactions and preventing crosstalk were also *** review concludes with insights into the future application of these strategies,providing a comprehensive perspective on the realization of high-energy and safe batteries.

关键词： battery safety high-voltage cathode lithium-ion battery thermal runaway

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Ytterbium modified birnessite MnO_(2) for improving deep oxidation of toluene

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Journal of Rare Earths 2024年第4期42卷 668-675页

作者： Linjiang sun Yan Cheng Yujie Liu Can yi Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu611756China

A series of rare earth metals modified birnessite manganese dioxides(RE-Mn)was synthesized by hydrothermal method and their catalytic degradation of toluene was ***-Mn shows the best toluene oxidation activity with the conversion of T50%and T99%at 196 and 226℃,*** physiochemical characterizations identified that the high catalytic performance and excellent stability of Yb-Mn are mainly associated with its higher molar ratios of Mn^(4+)/Mn^(3+),more lattice oxygen(Olatt),and better mobility of surface adsorbed oxygen(O_(ads)).Moreover,it is confirmed that introduction of Yb into birnessite MnO_(2) facilitates the production of acetic acid at lower *** results can aid the design of high-efficiency manganese oxide catalysts for the catalytic combustion of VOCs.

关键词： Manganese oxide Rare earth metal doping Toluene Catalytic combustion

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Two-dimensional semiconductor heterostructures for photocatalytic CO_(2)conversion

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Science China Chemistry 2024年第8期67卷 2434-2447页

作者： Yang Wu Mingyu Wu Yongfu sun yi Xie Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of ChinaHefei 230026China

The CO_(2)reduction into carbon-contained fuel via solar energy offers the powerful tools to realize the zero-emission carbon *** to the intriguing features of the two-dimensional(2D)heterostructures,it is susceptible to modulate the electronic structure as well as the surface geometry for optimizing the photocatalytic CO_(2)*** this perspective,we surveyed the fundamental insights of 2D semiconductor heterostructures,involving the fabrication strategies and classification of the 2D semiconductor ***,we have detailly discussed the overview of 2D semiconductor heterostructure for optimizing CO_(2)photocatalytic influenced factors,including the solar energy utilization,photogenerated carriers separation,and redox reaction ***,we showed the significant advantages of 2D heterostructures in elevating CO_(2)photoreduction performance,focusing on activity,selectivity and *** analyzing the limitations and developments,we ended by putting forward insights into the further researches about the CO_(2)photocatalysts and reactor design,even industrial applications.

关键词： two-dimensional semiconductor heterostructures photocatalysis CO_(2)conversion

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A GMDA clustering algorithm based on evidential reasoning architecture

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Chinese Journal of Aeronautics 2024年第1期37卷 300-311页

作者： Haibin WANG Xin GUAN Xiao yi Shuangming LI Guidong sun Naval Aviation University Yantai 264001China Unit 92941 of PLA Huludao 125001China Institute of Systems Engineering Beijing 100082China

The traditional clustering algorithm is difficult to deal with the identification and division of uncertain objects distributed in the overlapping region,and aimed at solving this problem,the Evidential Clustering based on General Mixture Decomposition Algorithm(GMDA-EC)is ***,the belief classification of target cluster is carried out,and the sample category of target distribution overlapping region is ***,on the basis of General Mixture Decomposition Algorithm(GMDA)clustering,the fusion model of evidence credibility and evidence relative entropy is constructed to generate the basic probability assignment of the target and achieve the belief division of the ***,the performance of the algorithm is verified by the synthetic dataset and the measured *** experimental results show that the algorithm can reflect the uncertainty of target clustering results more comprehensively than the traditional probabilistic partition clustering algorithm.

关键词： Evidential clustering Credal partition Evidential reasoning Mixed decomposition Gaussian mixture model

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Exploring changes of precipitation extremes under climate change through global variable-resolution modeling

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Science Bulletin 2024年第2期69卷 237-247页

作者： Wei sun Jian Li Rucong Yu Nina Li yi Zhang State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Tibetan Plateau Meteorology China Meteorological AdministrationChengdu 610072China Department of Atmospheric Science Yunnan UniversityKunming 650091China National Meteorological Center China Meteorological AdministrationBeijing 100081China 2035 Future Laboratory PIESAT Information Technology Co.Ltd.Beijing 100105China

Understanding the responses of precipitation extremes to global climate change remains limited owing to their poor representations in models and complicated interactions with multi-scale *** we take the record-breaking precipitation over China in 2021 as an example,and study its changes under three different climate scenarios through a developed pseudo-global-warming(PGW)experimental framework with 60-3 km variable-resolution global ensemble *** to the present climate,the precipitation extreme under a warmer(cooler)climate increased(decreased)in intensity,coverage,and total amount at a range of 24.3%-37.8%(18.7%-56.1%).With the help of the proposed PGW experimental framework,we further reveal the impacts of the multi-scale system interactions in climate change on the precipitation *** the warmer climate,large-scale water vapor transport converged from double typhoons and the subtropical high marched into central China,enhancing the convective energy and instability on the leading edge of the transport *** a result,the mesoscale convective system(Mcs)that directly contributed to the precipitation extreme became stronger than that in the present *** the contrary,the cooler climate displayed opposite changing characteristics relative to the warmer climate,ranging from the large-scale systems to local environments and to the *** summary,our study provides a promising approach to scientifically assess the response of precipitation extremes to climate change,making it feasible to perform ensemble simulations while investigating the multi-scale system interactions over the globe.

关键词： Precipitation extreme Climate change Pseudo-global-warming experiment Variable-resolution modeling Multi-scale system interaction

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Ultralow friction PTFE/PEEK heterolayer:A new solid lubrication approach toward simplicity

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Friction 2024年第1期12卷 120-135页

作者： Wei sun Jiaxin YE Qingrui SONG yi FENG Xiaojun LIU School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China

Tribological applications of polytetrafluoroethylene(PTFE)are often limited by technological complexity to overcome its poor wear ***,a PTFE/polyetheretherketone(PEEK)heterolayer(HL)was proposed and evaluated as a new solid lubrication ***-on-disk tribometry found the lowest friction coefficient(μ)of 0.031 and ultralow wear for the PEEK/HL under typical *** friction coefficient of the HL surpasses those of the state-of-the-art polymeric coatings/composites by at least 200%,and approaches that of highly lubricated *** investigations revealed multi-length physical and chemical heterogeneity of the HL that best facilitates a tribofilm with high subsurface stability and surface *** technological simplicity and robustness of the HL’s high lubricity make it a promising new type of solid lubrication toward greater reliability and longevity.

关键词： ultralow friction anti-wear polytetrafluoroethylene(PTFE) heterolayer(HL)

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Liquid-metal microgrid stretchable electronics based on bionic leaf veins with ultra-stretchability and high conductivity

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Rare Metals 2024年第6期43卷 2747-2757页

作者： Xi-Di sun Jun-Yang An yi-Qi sun Xin Guo Jing Wu Jiang-Bo Hua Meng-Rui Su yi Shi Li-Jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China

Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare *** devices can be seamlessly integrated with human ***,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical ***,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex *** systems are ultra-high tensile(800%tensile strain),environmentally stable(20 days)and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture *** the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm)with the system interconnects for a stretchable and wearable light source.

关键词： Stretchable electronics Liquid metal Stretchable conductor Vein Bionicist electronics

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Parallel Computing Based Solution for Reliability-constrained Distribution Network Planning

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1147-1158页

作者： Yaqi sun Wenchuan Wu yi Lin Hai Huang Hao Chen State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua UniversityChengduChina State Grid Fujian Electric Power Co.Ltd. FuzhouChina

The main goal of distribution network(DN)expan-sion planning is essentially to achieve minimal investment con-strained by specified reliability *** reliability-constrained distribution network planning(RcDNP)problem can be cast as an instance of mixed-integer linear programming(MILP)which involves ultra-heavy computation burden espe-cially for large-scale *** this paper,we propose a parallel computing based solution method for the RcDNP *** RcDNP is decomposed into a backbone grid and several lateral grid problems with ***,a parallelizable aug-mented Lagrangian algorithm with acceleration method is devel-oped to solve the coordination planning *** lateral grid problems are solved in parallel through coordinating with the backbone grid planning ***-Seidel iteration is adopted on the subset of the convex hull of the feasible region constructed by *** mild conditions,the opti-mality and convergence of the proposed method are *** tests show that the proposed method can significant-ly reduce the solution time and make the RcDNP applicable for real-worldproblems.

关键词： Distribution network expansion planning reliability parallel computing

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