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Effectiveness of Liu-zi-jue exercise on coronavirus disease 2019 in the patients: a randomized controlled trial

Journal of Traditional Chinese Medicine 2022年第6期42卷 997-1005页

作者： ZHU Qingguang ZHANG Shuaipan LI Jingxian sun wuquan CHENG Wei ZHAN Chao CHENG Yanbin FANG Lei FANG Min Department of Tuina Yue yang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China School of Human Kinetics University of OttawaOttawa K1V7P8Canada Department of Tuina Huangshi Hospital of Traditional Chinese MedicineHuangshi cityHubei 435000China School of Acupuncture-Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE: The aim of this study was to examine the effect of Liu-zi-jue exercise on the respiratory symptoms, quality of life, and mental health of patients with mild coronavirus disease 2019(COVID-19). METHODS: A single-center randomized controlled trial was conducted with 104 patients with mild COVID-19. The patients were randomly assigned to the Liu-zi-jue plus conventional therapy group and conventional therapy group. The outcome measures included Modified Borg Dyspnea Scale(MBDS) score, Patient Health Questionnaire-9(PHQ-9) score, Fatigue Scale-14(FS-14), respiratory symptoms, and vital signs. Data were collected on the first and sixth days of hospitalization and on the discharge day. RESULTS: Repeated-measures ANOVA revealed that the whole scales all showed a downward trend in the two groups(all P < 0.05). The results of single-group effect suggested that the whole scale score in the intervention group was significantly lower than that in the control group at the sixth day of hospitalization. Compared with the control group, only the MBDS, expectoration, and FS-14 scores showed significantly lower scores at the discharge day(P < 0.001, P = 0.011, P = 0.002). Comparison within the group showed that all the variables were significantly different at the three time points with a decreasing trend(P < 0.05), except for the PHQ-9 and expectoration scores(P = 0.331, 0.052). All patients’ vital signs remained within a stable normal range throughout the hospital stay. CONCLUSION: The results suggested that Liu-zi-jue exercise as a complementary and alternative therapy showed beneficial effects on improving the symptoms(shortness of breath, fatigue, and cough), quality of life, and mental health of patients with mild COVID-19.

关键词： COVID-19 Liu-zi-jue exercise respiratory symptom physical and mental health randomized controlled trial

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Effect of Chinese massage(Tui Na) on isokinetic muscle strength in patients with knee osteoarthritis

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Journal of Traditional Chinese Medicine 2016年第3期36卷 314-320页

作者： Zhu Qingguang Li Jianhua Fang Min Gong Li sun wuquan Zhou Nan Department of Physical Therapy with Chinese Massage Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine

OBJECTIVE: Chinese massage(Tui Na) is one of the most popular Traditional Chinese Medicine remedies for knee osteoarthritis(OA). Several studies have subjectively evaluated the effect of Chinese massage on knee OA through self-assessment questionnaires; however, very few studies have objectively assessed the effect by measuring knee muscle strength. The purpose of this study was to assess the efficacy of Chinese massage in improving knee extensor and flexor muscle strength in patients with knee OA.METHODS: Thirty patients with knee OA received Chinese massage therapy three times per week for 2 weeks. Patients completed pre- and post-treatment Visual Analogue Scale(VAS) pain questionnaires, and pre- and post-treatment knee muscle strength was evaluated using the Biodex Multi-Joint System 3. Isokinetic muscle strength measurements were performed at 60 degrees/s and 180 degrees/s. The peak torque(PT), peak torque/body weight(PT/BW), total work(TW), average power(AP), hamstring/quadriceps(H/Q), and range of motion(ROM) values were recorded separately for flexors and extensors.RESULTS: Chinese massage therapy significantly improved knee pain as assessed by the VAS in patients with knee OA(P < 0.05). Post-treatment values were significantly greater than pre-treatment values in the extensor muscles for PT(right P =0.013, left P = 0.001), PT/BW(right P = 0.008, left P =0.001) and TW(right P = 0.036, left P = 0.004) at 60 degrees/s. The AP increased significantly after treatment in the flexor muscles in the right knee(P =0.009) and the extensor muscles in the left knee(P = 0.001). There were no significant differences in pre- and post-treatment ROM and H/Q at 60 degrees/s and 180 degrees/s.CONCLUSION: Chinese massage therapy decreased pain and may improve extensor muscle strength in patients with knee OA, but does not appear to improve ROM.

关键词：肌力患者按摩骨关节炎等速中国骨性关节炎中医治疗

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Gait analysis of patients with knee osteoarthritis before and after Chinese massage treatment

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Journal of Traditional Chinese Medicine 2015年第4期35卷 411-416页

作者： Zhu Qingguang Fang Min Gong Li Jiang Shuyun sun wuquan Li Jianhua Li Yong Department of Physical Therapy with Chinese Massage Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Research Institute of Chinese Massage Shanghai Academy of Traditional Chinese Medicine

The objective of this study was to evaluate the effectiveness of Chinese massage therapy in patients with knee osteoarthritis(OA) by measuring lower-limb gait parameters. We recruited 20 women with knee OA,who then underwent Chinese massage therapy three times per week for 2 weeks. The patients underwent gait evaluation using a six-camera infrared motion analysis system. They completed Western Ontario and Mc Master Universities Osteoarthritis Index questionnaires before and after treatment. We calculated the forward speed,step width,step length,total support time percentage,initial double support time percentage,and single support time percentage. We also measured the angles at the knee,hip,and ankle during the stance phase of walking. The results showed statistically significant mean differences in knee pain relief,alleviation of stiffness,and physical function enhancement after therapy(P < 0.05). The patients gained significantly faster gait speed,greater step width,and increased total support time percentage after the Chinese massage therapy(P < 0.05). There were no significant differences in the range of motion or initial contact angles of the knee,hip,or ankle during the stance phase of walking. We concluded that Chinese massage is a beneficial complementary treatment and an alternative therapy choice for patients with knee OA for short-term pain relief. Chinese massage may improve walking ability for these patients.

关键词：骨性关节炎替代治疗步态分析膝关节患者运动分析骨关节炎行走能力

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中医推拿■法的上肢关节运动角度特征分析

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医用生物力学 2024年第3期39卷 463-468页

作者：陈金田周鑫单一鸣朱清广孙武权上海中医药大学附属岳阳中西医结合医院推拿科上海200437 上海市中医药研究院推拿研究所上海200437

目的研究推拿医生■法操作中肩、肘、腕关节的运动学及关节协调性变化。方法应用Vicon三维运动捕捉系统采集10名初学组和10名熟练组推拿医生■法操作的运动学数据,比较两组在推拿■法操作中肩、肘、腕关节的运动模式差异。结果初学... 详细信息

目的研究推拿医生■法操作中肩、肘、腕关节的运动学及关节协调性变化。方法应用Vicon三维运动捕捉系统采集10名初学组和10名熟练组推拿医生■法操作的运动学数据,比较两组在推拿■法操作中肩、肘、腕关节的运动模式差异。结果初学组与熟练组■法操作时,肘关节活动角度无显著差异(P>0.05),其主要差异为腕关节屈伸和肩关节内收外展角度不同,熟练组较初学组■法操作时肩关节内收外展活动角度显著更小(P<0.05),熟练组腕关节掌屈最大角度显著大于初学组(P<0.05)。结论 ■法的运动学特征主要为腕关节屈伸,肘关节和肩关节旋转,■法操作主要是前臂旋转与腕关节屈伸的复合运动,熟练组的“沉肩”操作要领掌握更好。

关键词：中医推拿 ■法运动学关节角度

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Possible mechanism underlying analgesic effect of Tuina in rats may involve piezo mechanosensitive channels within dorsal root ganglia axon

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Journal of Traditional Chinese Medicine 2018年第6期38卷 834-841页

作者： Song Pengfei Lin Zhigang Zhu Qingguang Jiang Shichao Zhang Hao Cheng Yanbin sun wuquan Wu Zhiwei Zhou Xin Lv Zhizhen Fang Min Department of Tuina YueYang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Fujian University of Traditional Chinese Medicine Subsidiary Rehabilitation Hospital Fuzhou 350003China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Research Institute of Tuina Shanghai Academy of Traditional Chinese MedicineShanghai 200437China

OBJECTIVE: To demonstrate the analgesic effect of Tuina mainly from mechanically sensitive ion channels in peripheral myelinated nerve fibers.METHODS: A total of 40 healthy and pathogen-free adult male Sprague-Dawley rats were used in the study [weight:(220.0 ± 1.4) g, Shanghai Slac Laboratory Animal Co., Ltd., Shanghai, China; license No. Shanghai ICP 05033115]. The rats were housed in cages with free access to water and food in a temperature-controlled room [(22 ± 1) ℃] and12-h/12-h light-dark cycle. Thirty-two rats were randomly divided into five groups: naive, sham, chronic compression of dorsal root ganglion(CCD), Tuina(7 d) and Tuina(21 d). CCD rat model was established via unilateral DRG compression by"L"liked steel bar. Chinese Tuina treatment was accepted once per day. Behavior monitoring of paw withdrawal threshold(PWT) and paw withdrawal latency(PWL) were tested. The expression of Piezo1 and Piezo2 in myelinated nerve fiber were analyzed by immunohistochemistry and Western-blotting.RESULTS: There was a high expression of Piezo2 and a low expression of Piezo1 in the naive and CCD groups. In contrast, the expression of Piezo2 was down regulated and Piezo1 was increased after a period of Tuina. There was significant difference(P ≤ 0.05) between the groups.CONCLUSION: Our findings suggest that Tuina therapy can increase the expression of Piezo2 and decrease the expression of Piezo1 in the test rats.The different changes in the expressions of Piezo1 and Piezo2 may play an important role in alleviating CCD-induced allodynia and hyperalgesia.

关键词： Tuina Ganglia spinal Hyperalgesia Mechansensitiveion channels

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中医推拿揉法核心要素的生物力学特征

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中华中医药杂志 2024年第4期39卷 1753-1756页

作者：石梦妮孙武权吴志伟周鑫房敏朱清广上海中医药大学附属岳阳中西医结合医院上海200437 上海中医药研究院中医推拿研究所上海200437 上海中医药大学附属曙光医院上海201203

目的:研究中医推拿揉法有力、均匀、柔和、深透核心要素生物力学特征。方法:分别选取推拿初学者与熟练者纳入初学组及熟练组,每组10人,采用手套动态压力分布测量系统收集拇指揉法及掌根揉法各3 min力学参数,分析最大压力、峰值压强、压... 详细信息

目的:研究中医推拿揉法有力、均匀、柔和、深透核心要素生物力学特征。方法:分别选取推拿初学者与熟练者纳入初学组及熟练组,每组10人,采用手套动态压力分布测量系统收集拇指揉法及掌根揉法各3 min力学参数,分析最大压力、峰值压强、压力时间积分(FTI)、压强时间积分(PTI)等10项参数。结果:熟练组拇指揉法和掌根揉法波峰差值均显著低于初学组(P<0.01,P<0.05),拇指揉法除波峰差值外的所有力学参数均显著高于初学组(P<0.05,P<0.01),掌根揉法最大压力、平均压力、压力极差、PTI、FTI、频率均显著高于初学组(P<0.05,P<0.01)。结论:熟练组揉法最大压力、平均压力均大;压力波峰差值小、波形均匀,力量输出稳定、动作变形幅度小;FTI、PTI均大,力的累计效应大体现了中医推拿揉法有力、均匀、柔和、深透核心要素的生物力学特征。

关键词：推拿揉法核心要素生物力学压力压强

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推拿联合塞来昔布治疗腰椎间盘突出症的疗效观察

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世界中医药 2024年第10期19卷 1460-1463页

作者：陈金田周鑫李建华朱清广单一鸣房敏孙武权上海中医药大学附属岳阳中西医结合医院上海200437 上海市中医药研究院推拿研究所上海200437 上海中医药大学附属曙光医院上海201203

目的:观察推拿手法联合塞来昔布治疗腰椎间盘突出症的临床疗效,为临床应用提供可靠循证医学证据。方法:选取2021年3月至2022年1月上海中医药大学附属岳阳中西医结合医院推拿科就诊的腰椎间盘突出症患者80例作为研究对象,按照随机数字表... 详细信息

目的:观察推拿手法联合塞来昔布治疗腰椎间盘突出症的临床疗效,为临床应用提供可靠循证医学证据。方法:选取2021年3月至2022年1月上海中医药大学附属岳阳中西医结合医院推拿科就诊的腰椎间盘突出症患者80例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组40例。观察组采用推拿联合塞来昔布治疗;对照组单纯口服塞来昔布治疗,干预周期为4周。测量的结果变量包括视觉模拟评分(VAS)、简化McGill疼痛问卷简表(SF-MPQ)和Oswestry残疾指数(ODI)。结果:观察组有效率显著高于对照组(P<0.01);2组都能显著降低患者疼痛评分(P<0.001),但观察组疗效更优(P<0.001);2组都能显著降低患者ODI功能障碍指数(P<0.01),观察组疗效更优(P<0.01)。结论:推拿手法结合塞来昔布治疗腰椎间盘突出症在缓解腰部疼痛、改善腰椎功能方面,优于单纯口服塞来昔布治疗。

关键词：腰椎间盘突出症推拿塞来昔布疼痛评分功能障碍指数临床疗效

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眼周穴位推拿结合耳穴按压干预儿童轻度近视临床研究

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山东中医杂志 2024年第6期43卷 608-612页

作者：曾亮顾尤黄帅胡嘉威周小晓董晓薇潘国良孙武权上海市浦东医院/复旦大学附属浦东医院上海201399 华东师范大学第一附属中学上海200086 上海中医药大学附属岳阳中西医结合医院上海200437

目的:观察眼周穴位推拿结合耳穴按压干预儿童轻度近视的效果。方法:将60例小学3、4年级轻度近视儿童按随机数字表法分为观察组与对照组各30例。观察组采用眼周穴位推拿结合耳穴按压(《亮晶晶眼操》)干预,同时配合耳穴贴敷,对照组采用非... 详细信息

目的:观察眼周穴位推拿结合耳穴按压干预儿童轻度近视的效果。方法:将60例小学3、4年级轻度近视儿童按随机数字表法分为观察组与对照组各30例。观察组采用眼周穴位推拿结合耳穴按压(《亮晶晶眼操》)干预,同时配合耳穴贴敷,对照组采用非接触眼保健操干预。两组均每天干预2次,每周干预5 d(周一至周五),共干预12周。比较两组儿童干预前后的裸眼视力、屈光度、眼轴长度,计算干预前后屈光度差值、眼轴长度差值,并评价临床疗效。结果:干预后,观察组儿童裸眼视力、屈光度、眼轴长度较干预前无明显变化(P>0.05);对照组儿童裸眼视力较干预前下降(P<0.05),屈光度、眼轴长度较干预前上升(P<0.05);观察组儿童裸眼视力优于对照组(P<0.01)。观察组干预前后屈光度差值、眼轴长度差值小于对照组(P<0.05)。干预后,观察组疗效优于对照组(P<0.01)。结论:眼周穴位推拿结合耳穴按压不能有效提升轻度近视儿童的裸眼视力、降低屈光度及眼轴长度,但能防控裸眼视力下降,延缓屈光度及眼轴长度增长。

关键词：眼周穴位推拿耳穴按压耳穴贴敷儿童轻度近视正光穴承泣穴

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Organic thin-film transistors and related devices in life and health monitoring

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Nano Research 2024年第2期17卷 426-444页

作者： Chenfang sun Tie Wang Tianjin Key Laboratory of Drug Targeting and Bioimaging Life and Health Intelligent Research InstituteTianjin University of TechnologyTianjin 300384China

The early determination of disease-related biomarkers can significantly improve the survival rate of patients.Thus,a series of explorations for new diagnosis technologies,such as optical and electrochemical methods,have been devoted to life and health monitoring.Organic thin-film transistor(OTFT),as a state-of-the-art nano-sensing technology,has attracted significant attention from construction to application owing to the merits of being label-free,low-cost,facial,and rapid detection with multi-parameter responses.Nevertheless,interference from non-specific adsorption is inevitable in complex biological samples such as body liquid and exhaled gas,so the reliability and accuracy of the biosensor need to be further improved while ensuring sensitivity,selectivity,and stability.Herein,we overviewed the composition,mechanism,and construction strategies of OTFTs for the practical determination of disease-related biomarkers in both body fluids and exhaled gas.The results show that the realization of bio-inspired applications will come true with the rapid development of high-effective OTFTs and related devices.

关键词： organic thin-film transistors biosensors biomarkers organic bioelectronics organic semiconductors healthcare

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Pretreating and normalizing metabolomics data for statistical analysis

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Genes & Diseases 2024年第3期11卷 188-205页

作者： Jun sun Yinglin Xia Division of Gastroenterology and Hepatology Department of MedicineDepartment of Microbiology/ImmunologyUIC Cancer CenterUniversity of Illinois ChicagoJesse Brown VA Medical Center Chicago(537)ChicagoIL 60612USA Division of Gastroenterology and Hepatology Department of MedicineUniversity of Illinois ChicagoChicagoIL 60612USA

Metabolomics as a research field and a set of techniques is to study the entire small molecules in biological samples.Metabolomics is emerging as a powerful tool generally for pre-cision medicine.Particularly,integration of microbiome and metabolome has revealed the mechanism and functionality of microbiome in human health and disease.However,metabo-lomics data are very complicated.Preprocessing/pretreating and normalizing procedures on metabolomics data are usually required before statistical analysis.In this review article,we comprehensively review various methods that are used to preprocess and pretreat metabolo-mics data,including MS-based data and NMR-based data preprocessing,dealing with zero and/or missing values and detecting outliers,data normalization,data centering and scaling,data transformation.We discuss the advantages and limitations of each method.The choice for a suitable preprocessing method is determined by the biological hypothesis,the characteristics of the data set,and the selected statistical data analysis method.We then provide the perspective of their applications in the microbiome and metabolome research.

关键词： Data centering and scaling Data normalization Data transformation Missing values MS-Baseddata preprocessing NMRData preprocessing Outliers Preprocessing/pretreatment

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