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Risk assessment model for endpoints of ischemic stroke: A study protocol for a registry study

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Journal of Traditional Chinese Medicine 2018年第6期38卷 936-942页

作者： Zhang Yin Liu Yue Wang Guiqian sun shuailing Gao Yang Xie Yanming Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Center for Evidence-Based Chinese Medicine School of Chinese Medicine Beijing University of Chinese Medicine

OBJECTIVE: To evaluate the risk of ischemic stroke endpoints by establishing risk assessment models that combine Traditional Chinese Medicine(TCM)and modern medicine ***/DESIGN: The proposed study is a registry-based participant survey conducted in seven hospitals nationwide in China. After obtaining informed consent, 3000 patients diagnosed with ischemic stroke will be recruited. One-year follow-ups will be performed on-site in hospitals and by telephone to track endpoint events. Comparative analysis of the prevalence of endpoint events and other TCM or modern medicine features in different groups will be conducted using frequency analysis and χ2tests, and the results will be expressed as composition ratios. Comparative analysis of quantitative scores and related patterns or symptoms will be conducted using a rank-sum test. Correlation analysis of endpoint events and TCM or modern medicine factors will be performed using a multivariate Cox proportional hazard ***: Previous reports have described modern medicine indicator-based risk assessment models for ischemic stroke endpoint events, but no such studies have included TCM features. Our new risk assessment model combines TCM and modern medicine indicators and thus has the potential to facilitate early warning, early intervention, and early control of ischemic stroke endpoint events.

关键词： Stroke Medicine,Chinese traditional Secondary prevention Endpoint determination Risk assessment Protocol Registry study

Jinye Baidu granule for wind-warmth lung-heat disease(heat in the lung-wei)： protocol for a randomized, double-blind, parallel, controlled trial

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Journal of Traditional Chinese Medicine 2017年第5期37卷 621-628页

作者： Jiang Junjie Zhang Yin Xie Yanming Li Yuan sun shuailing Zhang Yili Wang Shuo Zhu Yong Qi Wensheng Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Emergency Department Guanganmen Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing 100053 China Department of Pneumology Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Beijing 100010 China Intensive Care Unit Guanganmen Hospital Affiliated to China Academy of Chinese Medical SciencesBeijing 100053 China

OBJECTIVE: To observe the curative effect of Jinye Baidu granule in the treatment of fever and swollen and sore throat caused by wind-warmth lung-heat disease(heat in the lung-wei) to further identify the ***: This randomized, double-blind, parallel, controlled trial will include patients with acute upper respiratory infection and wind-warmth lung-heat disease(heat in the lung-wei). Patientswith serious bacterial infection(white blood cell count > 12 × 10~9, neutrophils > 80%) will be excluded. Patients will be divided into three categories(blocks) according to their condition: fever only, a swollen and sore throat, and combined fever plus a swollen and sore throat. Patients within each of the three blocks will be further divided into a treatment group and a control group via stratified blocked randomization. The treatment group will be treated with Jinye Baidu granule, and the control group will be treated with Fufang Shuanghua granule. The primary outcome measure will be body temperature recovery time for patients with fever, throat symptom score for patients with a swollen and sore throat, and body temperature recovery time and throat symptom score for patients with combined fever plus a swollen and sore throat. Routine blood testing, urine testing, liver function, kidney function and ECG data of all patients will be collected as safety indices before and after enrollment, and adverse events will be recorded during the whole trial ***: This study protocol will include stratified block analysis according to patients' symptoms, and identify the accurate clinical indications of Jinye Baidu granule. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment.

关键词： Syndrome of wind heat invading lung and stomach Respiratory tract infections Randomized controlled trial Clinical protocols Jinye Baidu granule

正弦激励下三磁铁磁悬浮动力吸振器的被动减振性能研究

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Acta Mechanica Sinica 2023年第5期39卷 160-172页

作者：陈潇雨冷永刚孙菲苏徐昆孙帅令许俊杰 School of Mechanical Engineering Tianjin UniversityTianjin300350China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin300350China School of Foreign Languages Tianjin UniversityTianjin300350China

本本文设计了一种新型的三磁铁磁悬浮动力吸振器(TMSDVA),并进行了建模和测试首先建立了TMSDVA悬臂梁减振系统的等效动力学模型.基于等效磁化电流理论,建立了非线性磁悬浮力的计算模型,并分析了非线性磁悬浮力的特征.然后用Runge-Kutta... 详细信息

本本文设计了一种新型的三磁铁磁悬浮动力吸振器(TMSDVA),并进行了建模和测试首先建立了TMSDVA悬臂梁减振系统的等效动力学模型.基于等效磁化电流理论,建立了非线性磁悬浮力的计算模型,并分析了非线性磁悬浮力的特征.然后用Runge-Kutta方法求解系统在正弦激励下的动力学响应.通过对仿真结果的分析发现,适当调整TMSDVA的阻尼系数不仅可以降低TMSDVA的减振效果对激励幅值的敏感性,还可以整体提高TMSDVA的减振效果.最后通过实验验证了理论分析的正确性.综合来看,TMSDVA在工程结构的被动减振方面具有潜在应用价值.

关键词： Triple-magnet magnetic suspension dynamic vibration absorber Damping Excitation amplitude Passive vibration reduction Sinusoidal excitation

《温病条辨》中寒湿病的辨治及方剂性味配伍规律探析

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中国中医基础医学杂志 2023年第4期29卷 533-535页

作者：孙帅玲马晓北中国中医科学院中医基础理论研究所北京100700 中国中医科学院研究生院北京100700

《温病条辨》一书对寒湿病的病名、病因、病机、病位、辨证纲领、治法、方药性味配伍等内容进行全面、系统的总结,建立了一套辨治寒湿病的完整体系。吴鞠通认为,寒湿之病乃由内外之邪合而为病,其病机为寒湿伤阳,病位涉及上中下三焦,其... 详细信息

《温病条辨》一书对寒湿病的病名、病因、病机、病位、辨证纲领、治法、方药性味配伍等内容进行全面、系统的总结,建立了一套辨治寒湿病的完整体系。吴鞠通认为,寒湿之病乃由内外之邪合而为病,其病机为寒湿伤阳,病位涉及上中下三焦,其中以中焦脾胃居多,其兼证、变证繁多。对于该病的治疗,吴鞠通善用性味配伍理论,在寒湿病辨治中最常用的方剂性味配伍方法为苦辛法,临床常根据其病位、病机、治法等不同进行具体运用。通过探析吴鞠通辨治寒湿之病,为现代临床寒湿所致之病的辨治提供了新思路。

关键词：寒湿温病条辨吴鞠通性味配伍苦辛法

Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

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Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai sun Fengge SU He sun State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

New perspectives on deep carbon cycling

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Science China Earth Sciences 2024年第8期67卷 2411-2422页

作者： Weidong sun Center of Deep Sea Research Key Laboratory of Ocean Observation and ForecastingInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The proto-atmosphere serves as a crucial starting point for the carbon *** based on atmospheric data from Mars and Venus suggest that Earth's proto-atmosphere contained>110 bar of CO_(2)and>2.6 bar of *** protoatmosphere had over 1000 bar of water vapor during the magma ocean stage,assuming the proto-ocean had a volume of two oceans of *** this stage both water and carbon dioxide were in a supercritical state at the magma-atmosphere *** serpentinization reactions occurred due to rock-water interaction,producing abundant ***,nitrogen is reduced to ammonia,and carbon dioxide to methane,forming carbonate *** proto-atmosphere dominated by methane,ammonia,and hydrogen formed a significant amount of amino acids through *** process is essential not only to the origin of life,but also to the early carbon-nitrogen cycle on *** the Hadean eon,a large amount of CO_(2)was sequestered as carbonate and organic ***,it mainly entered the deep mantle through mantle overturn or *** the mantle transition zone,carbonate undergoes“Redox freezing”,where carbonate is reduced to diamond through oxidation of ferrous iron in the *** the lower mantle,Fe^(2+)undergoes disproportionation reactions,forming Fe^(3+)and metallic *** these,Fe^(3+)mainly resides in bridgmanite,thereby increasing the oxygen fugacity of the lower mantle,while metallic iron falls to the Earth's *** distribution of carbon in the mantle is crucial for deep carbon *** density curves of diamond and mantle peridotite melt intersect at the bottom of the mantle transition zone(about 660 km).This density crossover leads to the accumulation of diamond during the magma ocean *** materials such as subducting slabs enter the lower mantle,compensatory upwelling of lower mantle material *** enters the upper mantle,decomposes,releasing Fe^(3+)ions and oxidizes diamond

关键词： Carbon cycling Proto-atmosphere Amino acids Subduction initiation Passive margin subduction Atmospheric carbon dioxide

Fossil Equidae in the Linxia Basin with Biostratigraphic and Paleozoogeographic Significance

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 1-9页

作者： sun Boyang Key Laboratory of Vertebrate Evolution and Human Origins of the Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

The Linxia Basin is characterized by an abundance of Cenozoic sediments,that contain exceptionally rich fossil *** are abundant in the Linxia Basin,the fossil record of equids in this region including 16 species that represent 10 *** comparison to other classic late Cenozoic areas in China,the Linxia Basin stands out,because the fauna and chronological data accompanying Linxia equids render them remarkably useful for *** anchitheriines in the region,such as Anchitherium and Sinohippus,represent early equids that appeared in the late stages of the middle and late Miocene,*** the equines,most species of Chinese hipparions have been identified in the Linxia Basin and some species of the genera Hipparion and Hippotherium have FAD records for ***,Equus eisenmannae is one of the earliest known species of Equus in the Old World and is well-represented at the Longdan *** species with precise geohistorical distributions can serve as standards for high-resolution chronological units within this *** at the eastern margin of the Tibetan Plateau and subject to considerable uplift,the Linxia Basin has served as a biogeographic transition area for equids throughout the late Cenozoic.

关键词： Equidae Cenozoic biostratigraphy paleozoogeography Linxia Basin

Achieving simultaneously high conversion and high selectivity for light olefins directly producing from syngas

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Science China Chemistry 2024年第3期67卷 753-754页

作者： Yuhan sun Shanxi Research Institute Huairou Research LaboratoryTaiyuan 030032China Institute of Carbon Neutrality ShanghaiTech UniversityShanghai 201210China

The activity and selectivity are two primary indexes of a successful catalyst for chemical reactions. However,achieving a high activity and a high selectivity simultaneously is a long-standing challenge in catalysis, the socalled activity-selectivity trade-off. In the article recently published in Science, a research team led by Prof.

关键词： selectivity simultaneous catalysis

ONE-PARAMETER FINITE DIFFERENCE METHODS AND THEIR ACCELERATED SCHEMES FOR SPACE-FRACTIONAL SINE-GORDON EQUATIONS WITH DISTRIBUTED DELAY

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Journal of Computational Mathematics 2024年第3期42卷 705-734页

作者： Tao sun Chengjian Zhang Haiwei sun School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China Department of Mathematics University of MacaoMacaoChina

This paper deals with numerical methods for solving one-dimensional(1D)and twodimensional(2D)initial-boundary value problems(IBVPs)of space-fractional sine-Gordon equations(SGEs)with distributed *** 1D problems,we construct a kind of oneparameter finite difference(OPFD)*** is shown that,under a suitable condition,the proposed method is convergent with second order accuracy both in time and *** implementation,the preconditioned conjugate gradient(PCG)method with the Strang circulant preconditioner is carried out to improve the computational efficiency of the OPFD *** 2D problems,we develop another kind of OPFD *** such a method,two classes of accelerated schemes are suggested,one is alternative direction implicit(ADI)scheme and the other is ADI-PCG *** particular,we prove that ADI scheme can arrive at second-order accuracy in time and *** some numerical experiments,the computational effectiveness and accuracy of the methods are further ***,for the suggested methods,a numerical comparison in computational efficiency is presented.

关键词： Fractional sine-Gordon equation with distributed delay One-parameter finite difference methods Convergence analysis ADI scheme PCG method