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下肢慢性静脉功能不全严重程度与超声结果的关系

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影像科学与光化学 2024年第3期42卷 269-275页

作者：刘志强米雨汪轶亭孙功能安徽医科大学附属巢湖医院介入血管科安徽巢湖238000 安徽医科大学附属巢湖医院超声医学科安徽巢湖238000

目的:探讨下肢静脉功能不全的患者临床严重程度与超声检查结果的关系。方法:选取2022年1月至2023年6月在我院住院就诊的下肢静脉功能不全的285例患者,对所有患者的超声检查进行回顾,并依据临床、病因、解剖-病理(CEAP)分级、静脉临床严... 详细信息

目的:探讨下肢静脉功能不全的患者临床严重程度与超声检查结果的关系。方法:选取2022年1月至2023年6月在我院住院就诊的下肢静脉功能不全的285例患者,对所有患者的超声检查进行回顾,并依据临床、病因、解剖-病理(CEAP)分级、静脉临床严重程度评分(VCSS)和HASTI评分来评估患者的临床严重程度。结果:通过回顾性分析285例患者(463条患肢),研究发现重度静脉功能不全的风险与年龄、体质量指数(Bmi)和糖尿病相关。超过60%的患肢有大隐静脉反流,有54.86%的患肢有穿支静脉反流,大隐静脉反流和穿支静脉反流与静脉功能不全的严重程度显著相关,重度静脉功能不全的患肢大隐静脉、小隐静脉、穿支静脉直径均显著高于轻中度,重度静脉功能不全的患肢大隐静脉反流时间、穿支静脉反流时间、股静脉反流时间显著大于轻中度。大隐静脉直径、穿支静脉直径和反流时间与VCSS和HASTI评分成正相关。结论:重度慢性静脉功能不全的超声阳性检出率更高,结果可作为静脉功能不全严重程度的客观评价指标。

关键词：慢性静脉功能不全 CEAP分级彩色多普勒超声静脉反流

不同强度电针对大鼠脊髓背角广动力神经元伤害性放电的抑制作用

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针刺研究 2024年第5期49卷 448-455页

作者：于清泉袁咪孙小月张妮楠王晓宇宿杨帅张知云景向红中国中医科学院针灸研究所北京100700

目的:观察不同强度电针对大鼠脊髓背角广动力(WDR)神经元伤害性电活动的作用,探讨电针在脊髓背角水平调控伤害性信号的效应特征。方法:采用多通道在体电生理技术记录25只正常雄性SD大鼠脊髓背角WDR神经元的电活动,在神经元的足底感受野(... 详细信息

目的:观察不同强度电针对大鼠脊髓背角广动力(WDR)神经元伤害性电活动的作用,探讨电针在脊髓背角水平调控伤害性信号的效应特征。方法:采用多通道在体电生理技术记录25只正常雄性SD大鼠脊髓背角WDR神经元的电活动,在神经元的足底感受野(RF)给予连续高强度电刺激诱发神经元的windup,而后于大鼠同侧“足三里”穴区进行不同强度(1 mA或2 mA)的电针(EA1 mA、EA2 mA)干预10 min,刺激频率为2 Hz/15 Hz,然后再次以相同条件诱发WDR神经元的windup。比较不同强度电针干预前后,WDR神经元伤害性放电成分的总数量及windup现象的变化。结果:EA1 mA和EA2 mA均显著减少了WDR神经元Aδ和C成分及后放电的数量(P<0.01,P<0.001),且EA2 mA对C成分的抑制率显著高于EA1 mA(P<0.05);EA1 mA和EA2 mA干预减弱了WDR神经元的windup现象(P<0.05,P<0.01),且EA2 mA的效应要强于EA1 mA(P<0.05)。EA1 mA和EA2 mA作用于WDR神经元的非感受野(non-RF)和RF均明显减少了其Aδ成分、C成分和后放电的数量(P<0.05,P<0.01);对于WDR神经元windup现象,EA2 mA作用于non-RF和RF均能发挥显著的抑制作用(P<0.01,P<0.05),而EA1 mA只有作用于non-RF时才能显著抑制(P<0.01)。结论:电针可以抑制大鼠脊髓背角WDR神经元的伤害性电活动,抑制效应与EA干预的强度和部位直接相关,2 mA的抑制效应要强于1 mA。

关键词：电针刺激强度镇痛伤害性信号广动力神经元

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Radio Communication Scenarios in 5G-Railways

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中国通信:英文版 2023年第9期20卷 235-246页

作者： Ruisi He Bo Ai Zhangdui Zhong mi Yang Chen Huang Ruifeng Chen Jianwen Ding Hang mi Zhangfeng Ma Guiqi sun Changzhu Liu State Key Lab of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China Institute of Computing Technology China Academy of Railway SciencesBeijing 100081China College of Information Engineering Shaoyang UniversityShaoyang 422000China National Research Center of Railway Safety Assessment Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Railway Industry of Broadband Mobile Information Communications Beijing Jiaotong UniversityBeijing 100044China Beijing Engineering Research Center of High-speed Railway Broadband Mobile Communications Beijing Jiaotong UniversityBeijing 100044China

With the rapid development of railways,especially high-speed railways,there is an increasingly urgent demand for new wireless communication system for *** the mature 5G technology as an opportunity,5G-railways(5G-R)have been widely regarded as a solution to meet the diversified demands of railway wireless *** the design,deployment and improvement of 5GR networks,radio communication scenario classification plays an important role,affecting channel modeling and system performance *** this paper,a standardized radio communication scenario classification,including 18 scenarios,is proposed for *** paper analyzes the differences of 5G-R scenarios compared with the traditional cellular networks and GSM-railways,according to 5G-R requirements and the unique physical environment and propagation *** proposed standardized scenario classification helps deepen the research of 5G-R and promote the development and application of the existing advanced technologies in railways.

关键词： 5G-R scenario classification smart rail-ways

3D-Printed Bio-inspired Multi-channel Cathodes for Zinc–air Battery Applications

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Journal of Bionic Engineering 2022年第4期19卷 1014-1023页

作者： Xin Men Zhiyuan Li Wei Yang mi Wang Song Liang Hang sun Zhenning Liu Guolong Lu Key Laboratory of Bionic Engineering(ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun 130022JilinPeople's Republic of China Engineering College Changchun Normal UniversityChangchun 130032People's Republic of China

It is of great significance to enhance mass transfer and improve active surface area in cathodes for zinc–air batteries(ZABs),which promote oxygen reduction reaction(ORR)efficiency and power *** has endowed some tissues with special structures to have efficient mass transfer properties and high active surface *** an important mass transfer part of trees,xylem contains massive long and partially aligned channels,which provides numerous“passageway”and high active surface area for plants to facilitate the efficient transport of oxygen and inorganic *** multi-channel structures give an important insight to develop high efficient air ***,3D-printed bio-inspired multi-channel cathodes(BMCs),inspired by xylem structures,have been developed for high-performance ZABs via 3D *** of bionic cathode contribute to forming a continuous supply of oxygen from *** a result,massive tri-phase boundary regions,where ORR happens,are formed inside of ***,the 3D-printed metal-based framework can facilitate electron transfer during ORR *** from the multi-channel framework,the assembled ZABs with BMC-600 show excellent electrochemical performances in terms of the high power density of 170.1 mW cm^(−2) and a high open-circuit voltage of 1.51 ***,BMCs provide a potential alternative as promising cathode for metal-air batteries.

关键词： Zinc-air battery Bio-inspired 3D printing Mass transfer

天然气地下储气库智能化建设关键技术及其发展趋势

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石油与天然气地质 2024年第2期45卷 581-592页

作者：糜利栋曾大乾刘华郭艳东李彦峰李遵照孙旭东张广权鲁春华王佩弦中国石化石油勘探开发研究院北京100026 山西能源学院山西太原030600 中国石化大连石油化工研究院辽宁大连116045 中国石化石油工程技术研究院北京100026

中国储气库在数字化转型和智能化建设方面已经取得了重要成果,储气库智能化建设发展了油气藏-井筒-管网一体化耦合模拟和数字孪生等关键技术。搭建了智能储气库云平台框架,采用“数据+平台+应用”的建设模式,充分利用数据中心、物联网... 详细信息

中国储气库在数字化转型和智能化建设方面已经取得了重要成果,储气库智能化建设发展了油气藏-井筒-管网一体化耦合模拟和数字孪生等关键技术。搭建了智能储气库云平台框架,采用“数据+平台+应用”的建设模式,充分利用数据中心、物联网和工业互联网等新型基础设施,支撑各业务板块管理、研究、生产和服务等需求。储气库智能化建设研发了储气库信息化管理平台、储气库一体化综合管理平台、基于数字孪生一体化仿真的决策系统和储气库全生命周期数字化平台。智能储气库未来建设将重点发展地质体数字孪生、高精度建模、可视化动态展示、智能运营、实时智能风险预警、工业软件国产化以及北斗卫星导航系统、卫星互联网等新技术。

关键词：数字孪生协同优化工业物联网地理信息系统智能储气库天然气

基于蒽[2,3⁃b]苯并呋喃为核心的高效长寿命蓝光材料

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发光学报 2024年第1期45卷 86-93页

作者：王小伟孙军袁江波张宏科毛涛王晨何海晓田密刘凯鹏杨丹丹李江楠西安瑞联新材料股份有限公司陕西西安710077

设计合成了一种以蒽[2,3-b]苯并呋喃为核心的新型化合物,通过给体咔唑基团修饰得到化合物2-(蒽[2,3-b]苯并呋喃-3-基)-9-苯基-9H-咔唑(ABPCz)。经过掺杂器件研究,ABPCz可以实现蓝光发射,最大电流效率为8.79 cd/A,最大外量子效率为7.8%,C... 详细信息

设计合成了一种以蒽[2,3-b]苯并呋喃为核心的新型化合物,通过给体咔唑基团修饰得到化合物2-(蒽[2,3-b]苯并呋喃-3-基)-9-苯基-9H-咔唑(ABPCz)。经过掺杂器件研究,ABPCz可以实现蓝光发射,最大电流效率为8.79 cd/A,最大外量子效率为7.8%,CIE(0.17,0.23),峰值光谱448 nm,在476 nm处有较强的肩峰,在1000 cd/m2初始亮度下测试器件LT90(亮度衰减到初始亮度的90%)寿命达到153 h。结果表明,蒽[2,3-b]苯并呋喃经过咔唑基修饰可以得到高效、长寿命的蓝光器件,这为设计开发高性能蓝光材料提供了一个新途径。

关键词：有机电致发光蒽[2,3-b]苯并呋喃蓝光荧光材料

Synthesis,characterization,and antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt

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Journal of Oceanology and limnology 2022年第1期40卷 284-295页

作者： Xueqi sun Jingjing ZHANG Yingqi mi Qin miAO Wenqiang TAN Qing LI Zhanyong GUO Key Laboratory of Coastal Biology and Bioresource Utilization Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

To improve the solubility and bioactivity of chitosan,a new class of carboxymethyl chitosan derivatives possessing sulfonium salts was successfully designed and synthesized,including Methyl sulfi de carboxymethyl chitosan(MCMCS),Ethyl sulfi de carboxymethyl chitosan(ECMCS),Propyl sulfi de carboxymethyl chitosan(PCMCS),and Butyl sulfi de carboxymethyl chitosan(BCMCS).To determine the structure of the new class of the derivatives,methods of the Fourier transform infrared spectroscopy(FT-IR),^(1)H nuclear magnetic resonance spectrometer(^(1)H NMR),and^(13)C nuclear magnetic resonance spectrometer(^(13)C NMR)were ***,the antioxidant activity of the derivatives for three types of free radicals,i.e.,hydroxyl radical,superoxide radical,and 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical was evaluated in *** addition,the L929 cells were adopted to test the cytotoxicity of chitosan and its derivatives by CCK-8 *** class of the carboxymethyl chitosan derivatives showed a strong scavenging ability against the three free radicals at 1.6 mg/mL,with scavenging rate of over 70%and some up to 100%.At this high rate,the overall cell viability in the toxicity test reached more than 80%,indicating that the synthetic derivative had a little *** results show that the introduction of carboxymethyl group to chitosan increased the water-solubility of chitosan,and the combination of sulfonate ions with diff erent chain lengths further enhanced the antioxidant activity of ***,the sulfonium-containing carboxymethyl chitosan derivatives had excellent bioactivity with good application prospects in food,biomedicine,and medical fi elds.

关键词： antioxidant activity carboxymethyl chitosan derivative sulfonium salts structural characteristics/synthesis

联合CT特征和病理预测结直肠癌脉管侵犯的初步研究

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中国医学计算机成像杂志 2024年第2期30卷 218-223页

作者：王咪孙金兵付婷婷陈光强陆志华张卫国苏州大学附属独墅湖医院苏州大学医学中心苏州市独墅湖医院放射科苏州215125 苏州大学附属常熟医院常熟市第一人民医院普外科苏州大学附属第二医院影像科

目的:探讨联合CT特征和常规病理指标预测结直肠癌(CRC)脉管侵犯(LVI)的价值。方法:回顾性收集310例CRC患者资料,按照6∶4的比例纳入训练组(186例)和验证组(124例)。对可能影响LVI的因素采用单因素分析和多因素logistic回归分析,以明确影... 详细信息

目的:探讨联合CT特征和常规病理指标预测结直肠癌(CRC)脉管侵犯(LVI)的价值。方法:回顾性收集310例CRC患者资料,按照6∶4的比例纳入训练组(186例)和验证组(124例)。对可能影响LVI的因素采用单因素分析和多因素logistic回归分析,以明确影响LVI阳性的独立危险因素,并建立回归模型。采用受试者工作特征曲线评估训练组和验证组的预测效能。结果:单因素分析发现训练组中肿瘤T分期、N分期、肿瘤分化程度、肿瘤沉积、肠梗阻、瘤周脂肪浸润类型在LVI阳性与阴性组间差异具有统计学意义(P<0.05)。多因素logistic回归分析发现训练组中T3、T4期、N2期、线样及结节样瘤周脂肪浸润类型是脉管侵犯的独立危险因素。训练组logistic回归模型预测LVI阳性的灵敏度为79.7%、特异度为61.7%,曲线下面积为0.787。该模型在验证组中预测LVI阳性的灵敏度为82.2%、特异度为67.1%,曲线下面积为0.783。结论:T分期、N分期及瘤周脂肪浸润类型有助于预测CRC患者LVI是否阳性。

关键词：结直肠癌脉管侵犯计算机体层成像

Liraglutide Suppresses Myocardial Fibrosis Progression by Inhibiting the Smad Signaling Pathway

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Current Medical Science 2023年第5期43卷 955-960页

作者： Wen sun Hong mi De-ying HE Wen LI Yi-yan SONGYANG Department of Geriatrics Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of Traditional Chinese Medicine Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China Department of Emergency Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Pharmacy Renmin Hospital of Wuhan UniversityWuhan 430060China

Objective Liraglutide is a commonly used hypoglycemic agent in clinical practice,and has been demonstrated to have protective effects against the development of cardiovascular ***,its potential role in myocardial fibrosis remains *** present study aims to assess the impact of liraglutide on the activation of cardiac *** Primary rat adult fibroblasts were isolated,cultured,and randomly allocated into 4 groups:control group,transforming growth factor beta1(TGFβ1)stimulation group,liraglutide group,and TGFβ1+liraglutide *** activation was induced by TGFβ*** proliferation activity was assessed using the CKK-8 kit,and cellular activity was determined using the MTT *** transcrition-quantitative polymerase chain reaction(RT-qPCR)was utilized to quantify the level of collagen transcription,immunofluorescence staining was performed to detect the expression level of type III collagen andα-smooth muscle protein(α-SMA),and immunoblotting was conducted to monitor alterations in signal *** The addition of 10,25,50 and 100 nmol/L of liraglutide did not induce any significant impact on the viability of fibroblasts(P>0.05).The rate of cellular proliferation was significantly higher in the TGFβl stimulation group than in the control ***,the treatment with 50 and 100 nmol/L of liraglutide resulted in the reduction of TGFβl-induced cell proliferation(P<0.05).The RT-qPCR results revealed that the transcription levels of type I collagen,type III collagen,andα-SMA were significantly upregulated in the TGFβl stimulation group,when compared to the control group(P<0.05).However,the expression levels of these aforementioned factors significantly decreased in the TGFβl+liraglutide group(P<0.05).The immunofluorescence staining results revealed a significant increase in the expression levels of type III collagen andα-SMA in the TGFβl stimulation group,when compared to the control group(P<0.05).However,these exp

关键词： liraglutide myocardial fibrosis TGFβl smad