Synthesis,characterization,and antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt

作     者：Xueqi SUN Jingjing ZHANG Yingqi MI Qin MIAO Wenqiang TAN Qing LI Zhanyong GUO Xueqi SUN;Jingjing ZHANG;Yingqi MI;Qin MIAO;Wenqiang TAN;Qing LI;Zhanyong GUO

作者机构：Key Laboratory of Coastal Biology and Bioresource UtilizationYantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Journal of Oceanology and Limnology》 (海洋湖沼学报（英文）)

年 卷 期：2022年第40卷第1期

页      面：284-295页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：Supported by the National Key R&D Program of China(No.2019YFD0900705) the Key Deployment Projects of the Marine Science Research Center of the Chinese Academy of Sciences(No.COMS2020J04) the Natural Science Foundation of Shandong Province of China(No.ZR2019BD064) 

主　　题：antioxidant activity carboxymethyl chitosan derivative sulfonium salts structural characteristics/synthesis 

摘      要：To improve the solubility and bioactivity of chitosan,a new class of carboxymethyl chitosan derivatives possessing sulfonium salts was successfully designed and synthesized,including Methyl sulfi de carboxymethyl chitosan(MCMCS),Ethyl sulfi de carboxymethyl chitosan(ECMCS),Propyl sulfi de carboxymethyl chitosan(PCMCS),and Butyl sulfi de carboxymethyl chitosan(BCMCS).To determine the structure of the new class of the derivatives,methods of the Fourier transform infrared spectroscopy(FT-IR),^(1)H nuclear magnetic resonance spectrometer(^(1)H NMR),and^(13)C nuclear magnetic resonance spectrometer(^(13)C NMR)were ***,the antioxidant activity of the derivatives for three types of free radicals,i.e.,hydroxyl radical,superoxide radical,and 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical was evaluated in *** addition,the L929 cells were adopted to test the cytotoxicity of chitosan and its derivatives by CCK-8 *** class of the carboxymethyl chitosan derivatives showed a strong scavenging ability against the three free radicals at 1.6 mg/mL,with scavenging rate of over 70%and some up to 100%.At this high rate,the overall cell viability in the toxicity test reached more than 80%,indicating that the synthetic derivative had a little *** results show that the introduction of carboxymethyl group to chitosan increased the water-solubility of chitosan,and the combination of sulfonate ions with diff erent chain lengths further enhanced the antioxidant activity of ***,the sulfonium-containing carboxymethyl chitosan derivatives had excellent bioactivity with good application prospects in food,biomedicine,and medical fi elds.