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Comprehensive Mapping of Murine B cell Epitopes on Glycoprotein E2 from Eastern Equine Encephalitis Virus

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Comprehensive Mapping of Murine B cell Epitopes on Glycoprot...

A GMDA clustering algorithm based on evidential reasoning architecture

第八届全国免疫学学术大会

作者： ec sun J Zhao NH Liu T Yang QY Xu YL Qin YH Yang DL Wu Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Graduate School of Chinese Academy of Agricultural Sciences Beijing Institute of Microbiology and Epidemiology

Background and Aim:Eastern equine encephalitis(EEE) is a significant public health concern as its pathogen EEEV, a mosquito-borne virus, could cause both human and equine encephalitis with high case fatality *** E2 protein is one of the main immunogenic protein of EEEV and plays an important role in the protective immune *** there is no licensed vaccine or treatment for human infection other than supportive therapy so it is essential to develop therapeutics that effectively ameliorate or prevent diseases associated with *** there is no report about the determinate epitope map of EEEV E2 ***, we can develop and study on EEEV E2 protein-specific monoclonal antibodies(m Abs) and further identify the epitopes of the E2 *** and Results:In this study, 51 EEEV E2 protein-specific MAbs were prepared and *** also comprehensively mapped the E2 protein by pepscan with MAbs and antisera(polyclonal antibodies, PAbs) using Western blot and peptide ELISA.18 linear B cell epitopes that are targeted by murine antibody responses were *** them, there were 7 overlapping epitopes(E2-1,11+12,14,24,25,28,33) recognized by both MAbs and PAbs, 9 epitopes(E2-2,11,12,16,18,21,31,32,34) were only recognized by PAbs and 2 epitopes(E2-22,25+26), located at 211-226 aa and 248-259 aa, were only recognized by *** specificity identification of the epitopes corresponding with MAbs showed that there were 7 common epitopes of EEEV and 2 common epitopes of EEEV/*** among them, there were 4 EEEV antigenic complexspecific, EEEV subtype Ⅰ / Ⅱ / Ⅲ / Ⅳ(1-16 aa, 248-259 aa, 271-286 aa, 321-336aa) and 3 EEEV type-specific epitopes(subtype Ⅰ at 108-119 aa, subtype Ⅰ / Ⅱ / Ⅲ at 231-246 aa and subtype Ⅰ / Ⅳ at 211-226aa).The 2 common epitopes of EEEV/VEEV were at 131-146 aa and 241-256 ***:The MAbs of EEEV E2 protein prepared and different types of epitopes identified in our study will establish the foundation for th

关键词： EEEV E2 protein Monoclonal antibody Polyclonal antibody B-cell epitope mapping

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Chinese Journal of Aeronautics 2024年第1期37卷 300-311页

作者： Haibin WANG Xin GUAN Xiao YI Shuangming LI Guidong sun Naval Aviation University Yantai 264001China Unit 92941 of PLA Huludao 125001China Institute of Systems Engineering Beijing 100082China

The traditional clustering algorithm is difficult to deal with the identification and division of uncertain objects distributed in the overlapping region,and aimed at solving this problem,the Evidential Clustering based on General Mixture Decomposition Algorithm(GMDA-ec)is ***,the belief classification of target cluster is carried out,and the sample category of target distribution overlapping region is ***,on the basis of General Mixture Decomposition Algorithm(GMDA)clustering,the fusion model of evidence credibility and evidence relative entropy is constructed to generate the basic probability assignment of the target and achieve the belief division of the ***,the performance of the algorithm is verified by the synthetic dataset and the measured *** experimental results show that the algorithm can reflect the uncertainty of target clustering results more comprehensively than the traditional probabilistic partition clustering algorithm.

关键词： Evidential clustering Credal partition Evidential reasoning Mixed decomposition Gaussian mixture model

Design of low-alloying and high-performance solid solution-strengthened copper alloys with element substitution for sustainable development

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 826-832页

作者： Jiaqiang Li Hongtao Zhang Jingtai sun Huadong Fu Jianxin Xie Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Liaoning Academy of Materials Shenyang 110004China

Solid solution-strengthened copper alloys have the advantages of a simple composition and manufacturing process,high mechanical and electrical comprehensive performances,and low cost;thus,they are widely used in high-speed rail contact wires,electronic component connectors,and other *** the contradiction between low alloying and high performance is an important challenge in the development of solid solution-strengthened copper *** the typical solid solution-strengthened alloy Cu-4Zn-1Sn as the research object,we proposed using the element In to replace Zn and Sn to achieve low alloying in this *** new alloys,Cu-1.5Zn-1Sn-0.4In and Cu-1.5Zn-0.9Sn-0.6In,were designed and *** total weight percentage content of alloying elements decreased by 43%and 41%,respectively,while the product of ultimate tensile strength(UTS)and electrical conductivity(ec)of the annealed state increased by 14%and 15%.After cold rolling with a 90%reduction,the UTS of the two new alloys reached 576 and 627MPa,respectively,the ec was 44.9%IACS and 42.0%IACS,and the product of UTS and ec(UTS×ec)was 97%and 99%higher than that of the annealed state *** dislocations proliferated greatly in cold-rolled alloys,and the strengthening effects of dislocations reached 332 and 356 MPa,respectively,which is the main reason for the considerable improvement in mechanical properties.

关键词： element substitution copper alloy solid solution strengthening microstructure and performance

Sourcing the merits of 3D integrated air cathodes for highperformance Zn-air batteries by bubble pump consumption chronoamperometry

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Nano Research 2024年第8期17卷 6951-6959页

作者： Mengxuan Li Linfeng Yu Hai Liu Chuanyi Zhang Jiazhan Li Liang Luo Xiaoming sun State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

Zn-air batteries(ZABs)as a potential energy conversion system suffer from low power density(typically≤200 mW·cm^(−2)).Recently,three-dimensional(3D)integrated air cathodes have demonstrated promising performance over traditional twodimensional(2D)plane ones,which is ascribed to enriched active sites and enhanced diffusion,but without experimental ***,we applied a bubble pump consumption chronoamperometry(BPCC)method to quantitatively identify the gas diffusion coefficient(D)and effective catalytic sites density(ρec)of the integrated air cathodes for ***,the D andρec values can instruct consequent optimization on the growth of Co embedded N-doped carbon nanotubes(CoNCNTs)on carbon fiber paper(CFP)and aerophilicity tuning,giving 4 times D and 1.3 timesρec over the conventional 2D Pt/C-CFP *** a result,using the CoNCNTs with half-wave potential of merely 0.78 V ***(Pt/C:0.89 V ***),the superaerophilic CoNCNTs-CFP cathode-based ZABs exhibited a superior peak power density of 245 mW·cm^(−2) over traditional 2D Pt/C-CFP counterparts,breaking the threshold of 200 mW·cm^(−2).This work reveals the intrinsic feature of the 3D integrated air cathodes by yielding exact D andρec values,and demonstrates the feasibility of BPCC method for the optimization of integrated electrodes,bypassing trial-and-error strategy.

关键词： Zn-air batteries three-dimensional(3D)integrated air cathodes superaerophilic gas diffusion coefficient effective catalytic sites density

Impact of Sky Conditions on Net ecosystem Productivity over a “Floating Blanket” Wetland in Southwest China

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Advances in Atmospheric Sciences 2024年第2期41卷 355-368页

作者： Yamei SHAO Huizhi LIU Qun DU Yang LIU Jihua sun Yaohui LI Jinlian LI State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100029China Yunnan Meteorological Observatory Kunming 530100China College of Aviation Meteorology Civil Aviation Flight University of ChinaGuanghan 618307China Meteorological Bureau of Tengchong County Baoshan 679100China

Based on eddy covariance(ec) measurements during 2016–20, the effects of sky conditions on the net ecosystem productivity(NEP) over a subtropical “floating blanket ” wetland were investigated. Sky conditions were divided into overcast, cloudy, and sunny conditions. On the half-hourly timescale, the daytime NEP responded more rapidly to the changes in the total photosynthetic active radiation(PARt) under overcast and cloudy skies than that under sunny skies. The increase in the apparent quantum yield under overcast and cloudy conditions was the greatest in spring and the least in summer. Additionally, lower atmospheric vapor pressure deficit(VPD) and moderate air temperature were more conducive to enhancing the apparent quantum yield under cloudy skies. On the daily timescale, NEP and the gross primary production(GPP) were higher under cloudy or sunny conditions than those under overcast conditions across seasons. The daily NEP and GPP during the wet season peaked under cloudy skies. The daily ecosystem light use efficiency(LUE) and water use efficiency(WUE) during the wet season also changed with sky conditions and reached their maximum under overcast and cloudy skies, respectively. The diffuse photosynthetic active radiation(PAR_d) and air temperature were primarily responsible for the variation of daily NEP from half-hourly to monthly timescales, and the direct photosynthetic active radiation(PAR_b) had a secondary effect on NEP. Under sunny conditions, PAR_b and air temperature were the dominant factors controlling daily NEP. While daily NEP was mainly controlled by PAR_d under cloudy and overcast conditions.

关键词： diffuse radiation eddy covariance NEP controlling factors wetland path analysis

A novel silver-doped nickel oxide hole-selective contact for crystalline silicon heterojunction solar cells

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 93-101页

作者： Junfeng Zhao Xudong Yang Zhongqing Zhang Shengpeng Xie Fangfang Liu Anjun Han Zhengxin Liu Yun sun Wei Liu Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Engineering Research Center of Thin Film Photoelectronic TechnologyInstitute of Photoelectronic Thin Film Devices and Technology of Nankai University(Ministry of Education)Tianjin 300350China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 201800China

Based on its band alignment,p-type nickel oxide(NiO_(x))is an excellent candidate material for hole transport layers in crystalline silicon heterojunction solar cells,as it has a smallΔEV and largeΔec with crystalline ***,to overcome the poor hole selectivity of stoichiometric NiO_(x) due to its low carrier concentration and conductivity,silver-doped nickel oxide(NiO_(x):Ag)hole transport layers with high carrier concentrations were prepared by co-sputtering high-purity silver sheets and pure NiO_(x) *** improved electrical conductivity of NiO_(x) was attributed to the holes generated by the Ag^(+)substituents for Ni^(2+),and moreover,the introduction of Ag^(+)also increased the amount of Ni^(3+)present,both of which increased the carrier concentration in NiO_(x).Ag^(+)doping also reduced the c-Si/NiO_(x) contact resistivity and improved the hole-selective contact with NiO_(x).Furthermore,the problems of particle clusters and interfacial defects on the surfaces of NiO_(x):Ag films were solved by UV-ozone oxidation and high-temperature annealing,which facilitated separation and transport of carriers at the c-Si/NiO_(x) *** constructed c-Si/NiO_(x):Ag solar cell exhibited an increase in open-circuit voltage from 490 to 596 mV and achieved a conversion efficiency of 14.4%.

关键词： band alignment nickel oxide hole transport layer silver-doped nickel oxide UV-ozone

Microstructure and water-swelling mechanism of red-bed mudstone in the Xining region,Northeastern Tibetan Plateau

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2537-2551页

作者： Huan Guan Yong Ren Sixiang Ling Xiyong Wu Tao Yu Xian Li Sen Wang Chunwei sun School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China Faculty of Geosciences and Engineering Southwest Jiaotong UniversityChengdu611756China Moe Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China Guangzhou Metro Design and Research Institute Co Ltd. Guangzhou510010China Chengdu City Construction Investment Group Co Ltd. Chengdu610036China

This paper examines the effect of the microstructure and electrical conductivity(ec)on the swelling ratio and pressure in red-bed mudstone sampled from arid areas in the Xining region in the northeastern Tibetan Plateau.A series of laboratory tests,including swelling experiments,X-ray diffraction(XRD),and scanning electron microscope(SEM),was carried out for mechanical and microstructural *** coupled influence of the ec and microstructural parameters on the expansion ratio and pressure was investigated,and the weight coefficients were discussed by the entropy weight *** results revealed an increasing exponential trend in ec,and the maximum swelling speed occurred at an ec of approximately 10 μS/*** addition,a method for predicting the expansion potential is proposed based on the microstructure,and its reliability is verified by comparing with swelling experimental *** addition,according to the image analysis results,the ranges of the change in the clay minerals content(CMC),the fractal dimension(FD),the average diameter(AD)of pores,and the plane porosity(PP)are 23.75%-53%,1.08-1.17,7.53-22.45 mm,and 0.62%-1.25%,***,mudstone swelling is negatively correlated with the plane porosity,fractal dimension and average diameter and is linearly correlated with the clay mineral ***,the weight values prove that the microstructural characteristics,including FD,AD,and PP,are the main factors influencing the expansion properties of red-bed mudstones in the Xining *** on the combination of macro and micro-analyses,a quantitative analysis of the swelling process of mudstones can provide a better reference for understanding the mechanism of expansion behavior.

关键词： Mudstones Microstructure Swelling characteristics Electrical conductivity(ec) Scanning electron microscope Water-swelling

Highly efficient ternary organic solar cells with excellent open-circuit voltage and fill factor via precisely tuning molecular stacking and morphology

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Science China Chemistry 2024年第3期67卷 963-972页

作者： Dinghong sun Zhenyu Chen Jianfeng Zhang Wei Song Jingyu Shi Jintao Zhu Yuanyuan Meng Fei Jin Shuncheng Yang Ziyi Ge Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China Faculty of Material Science and Chemical Engineering Ningbo UniversityNingbo 315211China Zhejiang Provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology&EngineeringChinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049China Department of Chemical and Environmental Engineering University of Nottingham NingboNingbo 315100China

The micro-morphology and molecular stacking play a key role in determining the charge transport process and nonradiative energy loss, thus impacting the performances of organic solar cells(OSCs). To address this issue, a non-fullerene acceptor PhC6-IC-F with alkylbenzene side-chain, possessing optimized molecular stacking, complementary absorption spectra and forming a cascade energy level alignment in the PM6:BTP-ec9 blend, is introduced as guest acceptor to improve efficiency of ternary OSCs. The bulky phenyl in the side-chain can regulate crystallinity and optimizing phase separation between receptors in ternary blend films, resulting in the optimal phase separations in the ternary films. As a result, high efficiencies of 18.33% as photovoltaic layer are obtained for PhC6-IC-F-based ternary devices with excellent fill factor(FF) of 78.92%. Impressively, the ternary system produces a significantly improved open circuit voltage(V_(oc)) of 0.857 V compared with the binary device,contributing to the reduced density of trap states and suppressed non-radiative recombination result in lower energy loss. This work demonstrates an effective approach for adjusting the aggregation, molecular packing and fine phase separation morphology to increase V_(oc) and FF, paving the way toward high-efficiency OSCs.

关键词： alkylbenzene side-chain morphology regulation ternary blends organic solar cells

Dostarlimab in the treatment of mismatch repair deficient recurrent or advanced endometrial cancer

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Cancer Pathogenesis and Therapy 2024年第3期2卷 135-141页

作者： Siddhant Shukla Harsh Patel Shuzhen Chen Rainie sun Liuya Wei Zhe-Sheng Chen Institute for Biotechnology St.John's UniversityNew YorkNew York 11439United States Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's UniversityNew YorkNew York 11439United States School of Pharmacy Weifang Medical UniversityWeifangShandong 261053China Stuyvesant High School New YorkNew York 10282United States

Dostarlimab,a programmed death receptor-1(PD-1)-blocking IgG4 humanized monoclonal antibody,gained accelerated approval from the US Food and Drug Administration(FDA)in April 2021,and received a full approval in February *** was approved for treating adult patients with mismatch repair deficient(dMMR)recurrent or advanced endometrial cancer(ec)that progressed during or after prior treatment who have no other suitable treatment ***,we review the structure-based mechanism of action of dostarlimab and the results of a clinical study(GARNET;NCT02715284)to comprehensively clarify the efficacy and toxicity of the *** efficacy and safety of dostarlimab as monotherapy was assessed in a non-randomized,multicenter,open-label,multi-cohort trial that included 209 patients with dMMR recurrent or advanced solid tumors after receiving systemic *** received 500 mg of dostarlimab intravenously every three weeks until they were given four ***,patients received 1000 mg dostarlimab intravenously every six weeks until disease progression or unacceptable *** overall response rate,as determined by shrinkage in tumor size,was 41.6%(95%confidence interval[CI];34.9,48.6),with 34.7 months as the median response *** conclusion,dostarlimab is an immunotherapy-based drug that has shown promising results in adult patients with recurrent or advanced dMMR ***,its efficacy in other cancer subtypes,the development of resistance to monotherapy,and efficacy and safety in combination with other immunotherapeutic drugs have not yet been studied.

关键词： Dostarlimab PD-1 Immunotherapy Endometrial cancer Check-point inhibitor