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γ"variant-sensitive deformation behaviour of Inconel 718 superalloy

Journal of Materials Science & Technology 2022年第31期126卷 169-181页

作者： r.Y.Zhang H.L.Qin Z.N.bi Y.T.Tang J.Araújo de Oliveira T.L.Lee C.Panwisawas S.Y.Zhang J.Zhang J.Li H.b.Dong Centre of Excellence for Advanced Materials Dongguan 523808China School of Engineering University of LeicesterUniversity RoadLeicester LE17RHUnited Kingdom beijing Key Laboratory of Advanced High Temperature Materials Central Iron and Steel Research InstituteBeijing 100081China Department of Materials University of OxfordParks RoadOxford OX13PHUnited Kingdom StressMap Engineering and Innovation DepartmentThe Open UniversityWalton HallMilton Keynes MK76AAUnited Kingdom ISIS Neutron Source Rutherford Appleton LaboratoryHarwell Science and Innovation CampusChiltonOxfordshire OX110QXUnited Kingdom School of Material Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Strengthening in Inconel 718 superalloy is derived from dislocation interaction withγ"precipitates,which exist in disk-shaped three possible orientation variants with their{100}habit plane normal to each *** interactions between dislocations andγ"precipitates vary according to theγ"orienta-tion variants,which makes the deformation behaviour complicated and difficult to reveal *** this work,γ"variant distributions of Inconel 718 samples were tailored by ageing heat treatment under either tensile or compressive ***γ"variant-sensitive deformation behaviours were then studied by in situ tensile tests via neutron diffraction at room *** is demonstrated that yield-ing first takes place in grains oriented withparallel to the loading *** identical lattice strain response to applied stress of both theγmatrix and theγ"precipitates was observed during yield-ing,suggesting that dislocations shearing through theγ"precipitates is predominant at this ***-ations in yield strength for samples with differentγ"variant distributions were observed,which can be attributed to different strengthening that arises from interactions between dislocation and differentγ"variants.

关键词： Ni-base superalloys Precipitation strengthening Neutron diffraction Lattice strains Plastic deformation

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MicrorNA-let-7a promotes E2F-mediated cell proliferation and NFKb activation in vitro

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Cellular & Molecular Immunology 2014年第1期11卷 79-93页

作者： Cristen b Chafin Nicole L regna David L Caudell Christopher M reilly Department of biomedical Sciences & Pathobiology Virginia-Maryland Regional College of Veterinary Medicine Virginia Polytechnic Institute and StateUniversity Blacksburg VA USA Department of Pathology/Comparative Medicine Wake Forest University Primate Center Wake Forest School ofMedicine Winston-Salem NC USA Edward Via College of Osteopathic Medicine Blacksburg VA USA

Epigenetic factors, including altered microrNA （mirNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）. MirNA-let-7a （let-7a） has been shown to directly alter cell cycle progression and proinflammatory cytokine production. Due to the crucial role of let-7a in cell division and inflammation, we investigated let-7a-mediated proliferation and NFKb translocation in J774A. 1 macrophages and MES 13 mesangial cells in vitro. In immune-stimulated cells transfected with let-7a, cell proliferation was significantly increased over time. There was a significant increase in the number of immune-stimulated cells in S and G2 phases. Immune-stimulated cells overexpressing let-7a had increased nuclear translocation of NFKb. bioinformatical analysis revealed that the E2F family, critical regulators of the G1-S transition, has potential binding sites for let-7a in their mrNA transcripts. Let-7a overexpression significantly increased the expression of the cell cycle activator E2F2 and increased retinoblastoma protein （rb） phosphorylation in immune-stimulated cells. The cell cycle inhibitor E2F5 was significantly decreased in let-7a-transfected cells that were immune-stimulated. bioinformatical analysis revealed E2F2 and NFKb are transcription factors predicted to regulate the let-7a promoter. We analyzed transcriptional regulation of let-7a by real-time rT-PCr using chromatin immunoprecipitation with E2F2 and NFKb antibodies. There was an increase in E2F2 and NFKb binding in DNA enriched for the let-7a promoter in immune-stimulated cells. Silencing E2F2 or NFKb significantly decreased let-7a expression and IL-6 production in immune-stimulated cells. Taken together, our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SLE.

关键词： cell proliferation E2F microrNA-let-7a NF~:b systemic lupus erythematosus

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Geochemistry and spectrometric prospection of younger granites and granitic pegmatites bearing uranium mineralization at *** El rakeb area, Central Eastern Desert, Egypt

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Acta Geochimica 2021年第4期40卷 575-601页

作者： Gehad M.Saleh bahaa M.Emad Ibrahim b.Abdel Kader Nuclear Materials Authority El MaadiP.O.Box 530CairoEgypt

The present study deals with the detailed field geology,mineralogy,geochemistry,and spectrometric prospection of rare metals and radioactive minerals associated with granitic pegmatites in the Gabal Um LassafAbu Dob-Um Atelia-Kadabora-Kab El rakeb area(LDAKK),which are situated in the central Eastern Desert of *** study area is composed of granodiorites and *** latter is dissected by granitic pegmatites with a discriminatory distribution of economically important mineralization(rare-metals and U-Th minerals).The granitic pegmatites display a zoning structure composed of feldspar-rich zones enveloping pockets of mica(mostly muscovite) and all zoning internal quartz ***,the monzogranite and granitic pegmatites are composed of potash-feldspar,albite,and quartz with a small amount of biotite and *** mineralogical investigation of the highly radioactive zones in the granitic pegmatite shows enrichment in kasolite,uranothorite,thorite,xenotime,columbite,zircon,bismuth,and ***,the granitic pegmatites are enriched with high field strength elements(HFSE;Zr,Nb,Th,and U) and ion lithophilic elements(LILE;rb,and Pb) and depleted in ba,Sr,and *** are strongly peralkaline to metalumainous except for two samples,which are *** are formed by partial melting of metagreywackes at *** studied granitic pegmatites could belong to the NYF family(Niobium-Yttrium-Fluorine family) according to the geochemistry of the trace *** studied granitic pegmatites show deep negative Eu anomaly and display a strong M-type tetrad effect of rare earth *** field spectroscopy measurements showed the localization of the radiometric anomalous associated with the granitic pegmatites,which are intruded in the granitic host *** eU and eTh contents reached up to 316 and 1367 ppm,*** and thorium occurrences in the investigated granitic pegmatites are related to magmatic(syngenetic)ori

关键词： Geochemistry Gabal Um Lassaf-Abu Dob-Um Atelia-Kadabora-Kab El rakeb area(LDAKK) Uranium rEE Egypt

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氯沙坦降低高血压病人的心血管病死率和病残率优于阿替洛尔

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新医学 2002年第10期33卷 588-588页

作者： Dahlf b Devereu rb Kjeldsen SE 王建国

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活性素的生殖生物学作用

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国外医学（妇产科学分册） 1992年第6期19卷 350-352页

作者： Dye rb 孔建国张师前

近年研究证实,卵巢的排卵不仅有 FSH 和 LH 控制,还有生物学控制。其中抑制素和活性素对排卵的控制是一种类似 FSH 的刺激和抑制作用。活性素来自两个结构相似、性质不同的14kDa-β亚单位(即βA 和βb 亚单位)。活性素在 FSH 诱导下有... 详细信息

近年研究证实,卵巢的排卵不仅有 FSH 和 LH 控制,还有生物学控制。其中抑制素和活性素对排卵的控制是一种类似 FSH 的刺激和抑制作用。活性素来自两个结构相似、性质不同的14kDa-β亚单位(即βA 和βb 亚单位)。活性素在 FSH 诱导下有重要的潜在活性,对性腺有调节作用。

关键词：活性素生殖生物学性腺

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Indentation Size Effect and Microhardness Study of β-Sn Single Crystals

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Chinese Physics Letters 2005年第12期22卷 3137-3140页

作者： O. SAHIN O. UZUN U. KOLEMEN b. DUZGUN N. UCAr Department of Physics Art and Science Faculty Suleyman Demirel University Isparta Turkey Department of Physics Art and Science Faculty Gaziosmanpasa University Tokat Turkey Department of Physics K. K. Education Faculty Ataturk-University Erzurum Turkey

The load dependence of apparent microhardness of β-Sn single crystals having different growth directions is investigated. The measurements are performed on （110） planes of these crystals in the load range from 10 to 50 mN. It is found that the degree of the microhardness anisotropy decreases for higher indentation test loads. The examined materials exhibit the behaviour of indentation size effect （ISE）, i.e., the apparent hardness increases with decreasing indentation load. Neither Meyer＇s law nor the proportional specimen resistance （PSr） model can fully explain the nonlinear variation of microhardness with load. Instead, preference is given to modified the PSr model based on the consideration of the effect of machining-induced residually stressed surface on the hardness measurement.

关键词： Microhardness

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Variability in distribution of major and trace elements in Lower Eocene siliceous sections of the Transuralian region, russia

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Acta Geochimica 2019年第2期38卷 262-276页

作者： P.V.Smirnov A.O.Konstantinov G.A.batalin b.I.Gareev Tyumen Industrial University Technische Universit?t Clausthal Kazan Federal University

This paper presents lithologic and geochemical data from the sequence of the Eocene Irbit formation siliceous rocks(Transuralian region) outcropping in a quarry in the Irbit deposit(thickness of 15 m) and in a large natural outcrop, belaya Gorka(thickness of 13 m). The data show that both outcrops are composed of diatomites and clayey diatomites, both characterized by a certain degree of lithologic heterogeneity around their chemical,granulometric, and mineralogical compositions;microstructural features; and degree of diatom preservation. The values of indices important for the classification of siliceous rocks and determination of prospects for their industrial application—SiO_2, Al_2O_3, Fe_2O_3, and clay fraction content—ranged from 66% to 77%, 7% to 14%,3.00% to 5.60%, and 23% to 50%, respectively. In all studied lithologic varieties, element abundances of V, Cr,Mn, Co, Ni, Cu, Zn, Ga, Ge, and Sb were two to three times higher than their respective abundances in the Earth's crust. This is probably related to these elements' involvement in the biological cycle and favorable conditions for transport. rb, Cs, ba, and Sr, as well as rare earth elements,are considered the most reliable indicators of lithologic and geochemical subdivision of a sequence of siliceous rocks,as they are associated mainly with clayey minerals. Variations in these indicators have recorded, with great probability, even short-term cycles and semi-cycles of silicasedimentation in the Transuralian region, as well as tectonic regime and involvement of terrigenous influx.

关键词： Diatomite Clayey diatomite Irbit formation Eocene Geochemical variability

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Effect of single walled carbon nanotubes on series resistance of rose bengal and Methyl red dye-based organic photovoltaic device

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Journal of Semiconductors 2018年第9期39卷 15-21页

作者： K.Chakraborty S.Chakraborty N.b.Manik Condensed Matter Physics research Centre Department of Physics Jadavpur University

The influence of single walled carbon nanotube（SWCNT）on the series resistanceof rose bengal（rb）and Methyl red（Mr）dye-based organic diodes has been *** has been revealed from experimental results that SWCNT has a significant effect on *** values of rs are measured from current–voltage（I–V）characteristics and also by utilizing the Cheung *** values from the Cheung method have been verified using H（I）–I plots for all dye-based *** extracted values using these two processes show a good consistency with each *** is observed that rs is reduced significantly by incorporating SWCNT for both *** estimated amounts of reduction of rs using SWCNT are 76.08%and 64.23%obtained from the I–V relationship whereas the value of rs shows a reduction of 83.5%and 67.1%when measured by using the Cheung method for rb and Mr dyes *** ideality factor and barrier height of the diodes have also been *** ideality factor has decreased with incorporation of SWCNT.A reduction in barrier height for the devices has also been observed in the presence of SWCNT.

关键词： SWCNT series resistance OPV barrier potential ideality factor

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ETV2 expression increases the efficiency of primitive endothelial cell derivation from human embryonic stem cells

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Cell regeneration 2015年第1期4卷 1-7页

作者： Anne G Lindgren Matthew b Veldman Shuo Lin Department of Molecular Cellular and Developmental biology University of California615 Charles E.Young Drive SouthLos AngelesCA 90095USA

background:Endothelial cells line the luminal surface of blood vessels and form a barrier between the blood and other tissues of the *** variant 2(ETV2)is transiently expressed in both zebrafish and mice and is necessary and sufficient for vascular endothelial cell *** of this gene in early zebrafish and mouse embryos results in ectopic appearance of endothelial *** expression of ETV2 in later development results in only a subset of cells responding to the ***:We have examined the expression pattern of ETV2 in differentiating human embryonic stem cells(ESCs)to determine when the peak of ETV2 expression *** show that overexpression of ETV2 in differentiating human ESC is able to increase the number of endothelial cells generated when administered during or after the endogenous peak of gene ***:Addition of exogenous ETV2 to human ESCs significantly increased the number of cells expressing angioblast genes without arterial or venous *** may be a viable solution to generate in vitro endothelial cells for use in research and in the clinic.

关键词： Human embryonic stem cells Endothelium ETV2 Differentiation

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Origin and geochemistry of Pan-African granitoid rocks in the Gabal Um Shomer area,Southwestern Sinai,Egypt

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Chinese Journal Of Geochemistry 2009年第2期28卷 125-135页

作者： E1-Tokhi M.M. Musallum A. Amin b.M. Geology Department College of ScienceUnited Arab Emirates UniversityUnited Arab Emirates

Geological, petrological and geochemical studies indicated that there are two distinct types of granitoid rocks: older quartz diorites to granodiorite assemblage and younger granitoids, the latter occurring in two phases. The older granitoids have a meta-aluminous chemistry and a calc-alkaline character, with high MgO, Fe2O3, TiO2, CaO, P2O5, Sr and low SiO2, K2O, and rb. Their major and trace elements data, together with low 87Sr/ 86Sr ratios (0.7029±0.0008) are indicative of I-type affinities. The second- and third-phase granitoids range from calc-alkaline to alkaline, respectively. The second-phase granitoids have a peraluminous chemistry and high Sr, ba, CaO, MgO, Al2O3 and Ti2O and low SiO2, K2O, Nb, Y and rb relative to the third-phase granitoids. The corundum normative nature and field observations suggested that it was formed by partial melting of the lower crust. The third-phase granitoids are alkaline in nature and characterized by higher SiO2, rb, Y, Nb and lower MgO, Sr and ba values than the younger granitoids (phase Ⅱ). They are A-type granitoids which were generated from below or within the existing continental crust.

关键词：花岗岩类岩石地球化学西奈半岛过铝质花岗岩起源西南埃及石英闪长岩

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