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Suicide risk in juvenile open angle glaucoma patients

International Journal of Ophtha.mology(English edition) 2024年第10期17卷 1880-1886页

作者： Hye-Jeong Seong sukyoung Jung Sooyeon Choe Department of Ophtha.mology Chungnam National University HospitalDaejeon 35015Republic of Korea Department of Ophtha.mology Chungnam National University College of MedicineDaejeon 35015Republic of Korea Department of Health Care Policy Research Korea Institute for Health and Social AffairsSejong 30147Republic of Korea

AIM:To investigate the association between juvenile open angle glaucoma(JOAG)and mental health among ***:This study used nationally representative data from the 8th Korea National Health and Nutrition Examination Survey(KNha.ES)*** diagnosis followed the International Society of Geographical and Epidemiological Ophtha.mology criteria based on glaucomatous structural defects,visual field defects,corrected vision,and intraocular *** outcomes,suicidal beha.iors,psychiatric counseling,and depression were evaluated through mental health *** ratios(ORs)with 95%confidence intervals(CIs)were estimated using logistic regression models,adjusting for ***:Among 7090 participants,3446 met the inclusion criteria for analysis,and 88(2.6%)were diagnosed with open angle glaucoma(OAG).After adjusting for age,sex,and best-corrected visual acuity(VA),participants with OAG were revealed to ha.e significantly higher odds of suicidal beha.iors(i.e.,ideation,planning,or attempts)compared with those without OAG(OR:2.70;95%CI:1.12-6.54;P=0.028).This association remained significant after further adjustments for socioeconomic status,lifestyle factors,and presence of chronic conditions(P=0.031 and 0.035,respectively).However,there was no significant difference for the other two outcomes,psychiatric counseling and *** age-stratified analysis revealed a stronger association between OAG and suicidal beha.iors in younger JOAG participants(ha. in older OAG participants(≥40y;OR:3.80 vs 2.22;95%CI:0.79-18.22 vs 0.56-8.80,respectively).CONCLUSION:OAG patients show a higher risk of suicidal beha.iors tha. those without glaucoma particularly in JOAG patients.

关键词： glaucoma juvenile open angle glaucoma suicide suicidal beha.ior

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Intracellular zinc signaling via Kruppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

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Genes & Diseases 2024年第4期11卷 24-27页

作者： Seongho Cha.Chongtae Kim Myeongwoo Jung Seungyeon Ryu sukyoung ha. Wook Kim Eun Kyung Lee Department of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Institute for Visual Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Molecular Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pancreaticβcells caused by zinc deficiency is related to the pathogenesis of diabetes.1 Impaired zinc homeostasis in diabetes is associated with reduced zinc transporters.2 Down-regulation of HuD,an es... 详细信息

关键词： βcell homeostasis zinc

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Helping People and Cha.ging the World with CS

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计算机教育 2024年第3期 17-19页

作者： sukyoung Ryu School of Computing Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-gu Daejeon 34141Korea

Wha. should academic institutions be doing in order to benefit students,the community at large,and society in the new era?Particularly,as computing is impacting all aspects of human society,it also brings many cha.lenges and opportunities for the academic departments of computer *** of these cha.lenges include the increasing impact of software on society,issues involving privacy and data abuse,and ethical issues concerning *** addressing these cha.lenges,the Korea Advanced Institute of Science and Technology(KAIST)leverages its position as an educator in order to train the future computing workforce to be more aware of these *** achieve this goal,KAIST mainly adopts three strategies:Combining science&technology and humanities together;putting academy and industry together;training software experts while making them understand people and the world.

关键词： Computing KAIST Privacy and data abuse Ethical issues

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Summer extreme precipitation patterns and synoptic-scale circulation precursors over the Tibetan Plateau

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Science China Earth Sciences 2024年第5期67卷 1625-1638页

作者： Zhiyuan DING Yao ha.Zhong ZHONG College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory for Virtual Geographic Environment School of Geography ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Collaborative Innovation Center for Climate Cha.ge School of Atmospheric SciencesNanjing UniversityNanjing 210023China

In the context of global warming,the extreme summer precipitation over the Tibetan Plateau(TP)ha. cha.ged *** this study,the summer(June–August)extreme precipitation on the TP was classified into three spatial types by applying the K-means clustering method to the Third Pole Region long time-series high-resolution(1/30°)precipitation dataset(TPHi Pr,1979–2020).The cha.acteristics of the circulation anomalies and precursors corresponding to the extreme precipitation on the TP in summer during 1979–2020 were *** results showed tha. the summer extreme precipitation of the TP can be categorized into northwestern(NW),southeastern(SE),and southern Himalayan(HS)types based on extreme precipitation *** NW and SE types are mainly influenced by anomalous signals in the mid-to-high latitude regions upstream of them,whereas the HS type is controlled by the localized subtropical anomalous *** the 8th day before the onset of the NW type,an anomalous cyclone was observed in the western Atlantic Ocean(60°W,50°N),which triggered the west-to-east quasi-latitudinal propagation of Rossby *** the onset day of the NW type,the upper troposphere showed positive-negative-positive geopotential height anomalies along the latitudinal 40°N from the Caspian Sea,the western part of Xinjiang,to the northeastern *** entered from the Arabian Sea along the southeastern edge of the anomalous cyclone on the southwestern TP and converged in the northwestern *** to the NW type,the precursors of the SE type appeared at higher latitudes and were more *** the 8th day before the onset of the SE type,an anomalous cyclone occurred near Greenland(60°W,70°N)and excited Rossby waves propagating *** the onset day of the SE type,the upper troposphere showed negative-positive-negative geopotential height anomalies across Eurasia from the Ural Mountains and the Iranian Plateau to the northern TP in the northwest-southeast directi

关键词： Tibetan Plateau Summer extreme precipitation Atmospheric circulation anomaly Precursor Teleconnection wave train

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Integrated strategies on cobalt phosphides-based electrocatalysts for efficient hydrogen evolution reaction

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Tungsten 2024年第3期6卷 488-503页

作者： Tha.h Dam Mai ha.Huu Do Faculty of Mecha.ical Engineering and Technology Ho Chi Minh City University of Industry and Trade VKTech Research Center NTT Hi-Tech Institute Nguyen Tat Thanh University

The development of cost-effective and durable hydrogen evolution reaction(HER) electrocatalysts plays a vital role in dealing with the issues related to carbon dioxide *** phosphide-based nanomaterials are evaluated as promising advocates for HER due to high catalytic activities,good stability,and rich *** review commences with an exploration of the synthetic pathways of CoP,including solid-pha.e,solution-pha.e along with electrochemical ***,the mecha.ism of hydrogen formation is expressed thoroughly,after which various integrated strategies of morphology engineering with doping,assisted highly conductive materials,and construction of heterostructure were introduced for ***,burdensome tasks and possible guidance for the advancement of CoP-based nanomaterials were discussed for hydrogen production.

关键词： Cobalt phosphides Nanomaterials Electrocatalysts Hydrogen evolution reaction

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Wearable Triboelectric Nanogenerators Based on Printed Polyvinylidene Fluoride Films Incorporated with Cobalt-Based Metal-Organic Framework for Self-Powered Mobile Electronics

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Energy & Environmental Materials 2024年第4期7卷 396-403页

作者： Myeong-Hyeon Kim Sang-Joon Park Tae-Jun ha Department of Electronic Materials Engineering Kwangwoon University

In this study,wearable triboelectric nanogenerators comprising bar-printed polyvinylidene fluoride (PVDF) films incorporated with cobalt-based metalorganic framework (Co-MOF) were *** enha.ced output performance of the TENCs was attributed to the pha.e transition of PVDF from α-crystals to β-crystals,as facilitated by the incorporation of the MOF.

关键词： bar printing pha.e transition polyvinylidene fluoride incorporated with cobalt-based metal–organic framework self-powered mobile electronics wearable triboelectric nanogenerators

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Hydrophobic tag tethering degrader as a promising paradigm of protein degradation:Past,present and future perspectives

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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： Si ha.Jiacheng Zhu Hua Xiang Guoshun Luo State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors ha.e dominated the pha.maceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology ha. captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach tha. is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mecha.ism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the cha.lenges tha. necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

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Nature-based Natural-ha.ard Preparedness:A Cross Section of Categorized Examples

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Journal of Environmental & Earth Sciences 2024年第1期6卷 33-44页

作者： Kyoo-Man ha Faculty of Resilience Rabdan AcademyAbu Dhabi114646UAE

Despite prevailing interests,no rigorous research ha. been conducted to examine the role of nature in natural-ha.ard *** systematic review aimed to describe how nature can reduce the impacts of natural ha.ards during the preparedness *** study focuses on the land,water,and air systems and on three types of stakeholders:international organizations,developed countries,and developing ***,it provides supplementary strategies,such as immediate actions,local engagement,and research and development,tha. the stakeholders should apply to enha.ce their nature-based natural-ha.ard *** suggest integrating costs and benefits analysis,local culture,societal cha.lenges,and environmental justice into the implementation of nature-based ***,this review outlines the framework of nature-based natural-ha.ard preparedness by discussing the relationship between nature and society.

关键词： Nature-based solutions Costs and benefits Land Integration Society

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A pipeline to cha.acterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-ha.Shin Hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 tha. confer tumor suppression ha.e been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

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Combined Insights from Leacha.e Structure and Microstructure Cha.acteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo ha.Hyo-Young JEONG Ju Hun LEE Hyun-Jung CHUNG Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice ha. become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leacha.e and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample ha. the highest total solids and amylopectin amount in the leacha.e. The amylopectin amount in the leacha.e differed significantly based on the targeted water content. Morphological cha.acterization revealed tha. the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural ha.dness of the AEC_58% sample was much higher tha. tha. of the other samples. The PSC_63% sample ha. the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leacha.e. Sensory cha.acterization showed tha. the PSC_63% sample ha. the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leacha.e and textural and sensory cha.acteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leacha.e multi-scale structure eating quality processing technology

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