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Familial nasopharyngeal carcinomas possess distinguished clinical characteristics in southern China

Chinese Journal of Cancer Research 2014年第5期26卷 543-549页

作者： Su-Mei Cao sui-hong chen Chao-Nan Qian Qing Liu Yun-Fei Xia State Key Laboratory of Oncology in South China and Department of Cancer Prevention Research Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China and Department of Nasopharyngeal Carcinoma Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China and Department of Radiation Oncology Sun Yat-Sen University Cancer Center

Objective： To compare clinical characteristics between familial nasopharyngeal carcinomas（NPCs） and sporadic NPCs in Guangdong province, China, a high-risk area.Methods： Between 1991 and 2001, 993 NPC patients treated at the Cancer Center of Sun Yat-Sen University in Guangdong were randomly selected as probands. Information about NPC among the probands＇ relatives and other information were obtained from a retrospective review of the patients＇ medical records. The patients were divided into sporadic NPC, low-frequency familial NPC（one NPC patient in addition to the proband in three generations）, and high-frequency familial NPC（2 or more additional NPC patients in three generations） groups. Pathological and clinical characteristics were compared among these groups.Results： Of the 993 patients, 131（13.2%） had a familial history of NPC. The average age at diagnosis was the lowest in the high-frequency familial NPC group（39 years; P=0.048）. Although the overall survival（OS）, distant metastasis-free survival（DMFS）, and disease-free survival（DFS） rates did not differ between familial and sporadic NPCs, the locoregional recurrence-free survival（LRFS） rate increased in the order sporadic NPCs, low-frequency familial NPCs, and high-frequency familial NPCs（P=0.009）, with 5-year rates of 70%, 83%, and 87%, respectively. Multivariate analysis showed that family history of NPC was an independent favorable prognostic factor for LRFS, with adjusted hazard ratio（a HR） of 0.548, 95% CI（0.342-0.878）. The high LRFS for familial NPCs was mainly noted among young, advanced-stage patients who received continuous radiation treatment.Conclusions： Genetic factors may play an important role in the etiology of high-frequency familial NPC and underlie the early age of onset and sensitivity to radiotherapy.

关键词： Nasopharyngeal carcinoma(NPC) familial clinical behavior

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Incidence trend of nasopharyngeal carcinoma from 1987 to 2011 in Sihui County,Guangdong Province,South China:an age-period-cohort analysis

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Chinese Journal of Cancer 2015年第8期34卷 350-357页

作者： Li-Fang Zhang Yan-Hua Li Shang-Hang Xie Wei Ling sui-hong chen Qing Liu Qi-hong Huang Su-Mei Cao Department of Cancer Prevention Research Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine School of Public Health Sun Yat-sen University Sihui Cancer Institute

Introduction:In the past several decades,declining incidences of nasopharyngeal carcinoma(NPC) have been observed in Chinese populations in hong Kong,Taiwan,Los Angeles,and Singapore.A previous study indicated that the incidence of NPC in Sihui County,South China remained stable until 2002,but whether age,diagnosis period,and birth cohort affect the incidence of NPC remains ***:Age-standardized rates(ASRs) of NPC incidence based on the world standard population were examined in both males and females in Sihui County from 1987 to *** regression analysis was conducted to quantify the changes in incidence trends.A Poisson regression age-period-cohort model was used to assess the effects of age,diagnosis period,and birth cohort on the risk of ***:The ASRs of NPC incidence during the study period were 30.29/100,000 for males and 13.09/100,000 for *** incidence of NPC remained stable at a non-significant average annual percent change of 0.2%for males and-1.6%for females throughout the entire period.A significantly increased estimated annual percent change of 6.8%(95%confidence interval,0.1%-14.0%) was observed from 2003 to 2009 for *** relative risk of NPC increased with advancing age up to 50-59 and decreased at ages >60 *** period effect curves on NPC were nearly flat for males and *** birth cohort effect curve for males showed an increase from the1922 cohort to the 1957 cohort and a decrease *** females,there was an undulating increase in the relative risk from the 1922 cohort to the 1972 ***:The incidence trends for NPC remained generally stable in Sihui from 1987 to 2011,with an increase from 2003 to *** relative risks of NPC increased in younger females.

关键词：队列分析中国人群发病率鼻咽癌广东省全国人民代表大会龄期回归分析

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Subtype distribution and long-term titer luctuation patterns of serum anti-Epstein–Barr virus antibodies in a non-nasopharyngeal carcinoma population from an endemic area in South China:a cohort study

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Chinese Journal of Cancer 2016年第9期35卷 447-454页

作者： Jin-Lin Du sui-hong chen Qi-hong Huang Shang-Hang Xie Yan-Fang Ye Rui Gao Jie Guo Meng-Jie Yang Qing Liu Ming-Huang hong Su-Mei Cao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China. Department of Cancer Prevention Research Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China. School of Public Health Sun Yat-sen UniversityGuang-zhou 510080GuangdongP.R.China. School of Public Health Guangdong Medical UniversityDongguan 523808GuangdongP.R.China. Sihui Cancer Institute Sihui 526200GuangdongP.R.China. Department of Clinical Trial Center Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China.

Background: Serum immunoglobulin A antibodies against Epstein–Barr virus(EBV), viral capsid antigen(VCA?Ig A) and early antigen(EA?Ig A), are used to screen for nasopharyngeal carcinoma(NPC) in endemic areas. However, their routine use has been questioned because of a lack of specificity. This study aimed to determine the distributions of different subtypes of antibody and to illustrate how the natural variation patterns affect the specificity of screening in non?NPC ***: The distribution of baseline VCA?IgA was analyzed between sexes and across 10?year age groups in 18,286 non?NPC participants using Chi square tests. Fluctuations in the VCA?IgA level were assessed in 1056 non?NPC participants with at least two retests in the first 5?year period(1987–1992) after the initial screening using the Kaplan–Meier ***: The titers of VCA?Ig A increased with age(P < 0.001). Using a previous serological definition of high NPC risk, nasopharyngeal endoscopy and/or nasopharyngeal biopsy would be recommended in 55.5% of the non?NPC partici?pants with an initial VCA?Ig A?positive status and in 20.6% with an initial negative status during the 5?year follow?up. However, seroconversions were common; 85.2% of the participants with a VCA?Ig A?positive status at baseline con?verted to negative, and all VCA?Ig A?negative participants changed to positive at least once during the 5?year follow?up. The EA?Ig A status had a high seroconversion probability(100%) from positive to negative; however, it had a low probability(19.6%) from negative to ***: Age? and sex?specific cutoff titer values for serum anti?EBV antibodies as well as their specific titer fluc?tuation patterns should be considered when defining high NPC risk criteria for follow?up diagnostics and monitoring.

关键词：病毒抗体波动模式鼻咽癌血清学中国南方地区队列研究亚型人群

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Surface engineering with ionic polymers on membranes for boron removal

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 61-69页

作者： Xiting Zhang chenyi Fang J Paul chen sui Zhang Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117576Singapore Department of Civil and Environmental Engineering National University of SingaporeSingapore 119260Singapore College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Removal of boric acid from seawater and wastewater using reverse osmosis membrane technologies is imperative and yet remains inadequately addressed by current commercial *** research efforts performed post-modification of reverse osmosis membranes to enhance boron rejection,which is usually accompanied by substantial sacrifice in water *** study delves into the surface engineering of low-pressure reverse osmosis membranes,aiming to elevate boron removal efficiency while maintaining optimal salt rejection and water *** were modified by the self-polymerization and co-deposition of dopamine and polystyrene sulfonate at varying ratios and *** surfaces became smoother and more hydrophilic after *** optimum membrane exhibited a water permeability of 9.2±0.1 L·m^(-2)·h^(-1)·bar^(-1),NaCl rejection of 95.8%±0.3%,and boron rejection of 49.7%±0.1% and 99.6%±0.3% at neutral and alkaline pH,*** water permeability is reduced by less than 15%,while the boron rejection is 3.7 times higher compared to the blank *** research provides a promising avenue for enhancing boron removal in reverse osmosis membranes and addressing water quality concerns in the desalination process.

关键词： membrane low-pressure reverse osmosis boron surface engineering

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Establishment of genome-editing system and assembly of a near-complete genome in broomcorn millet

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Journal of Integrative Plant Biology 2024年第8期66卷 1688-1702页

作者： Yang Liu Zixiang cheng Weiyao chen Chuanyin Wu Jinfeng chen Yi sui State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoologythe Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

The ancient crop broomcorn millet(Panicum miliaceum L.)is an indispensable orphan crop in semi-arid regions due to its short life cycle and excellent abiotic stress *** advantages make it an important alternative crop to increase food security and achieve the goal of zero hunger,particularly in light of the uncertainty of global climate ***,functional genomic and biotechnological research in broomcorn millet has been hampered due to a lack of genetic tools such as transformation and genome-editing ***,we successfully performed genome editing of broomcorn *** identified an elite variety,hongmi,that produces embryogenic callus and has high shoot regeneration ability in in vitro *** established an Agrobacterium tumefaciens-mediated genetic transformation protocol and a clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-mediated genome-editing system for *** these techniques,we produced herbicide-resistant transgenic plants and edited phytoene desaturase(Pm PDS),which is involved in chlorophyll *** facilitate the rapid adoption of hongmi as a model line for broomcorn millet research,we assembled a near-complete genome sequence of hongmi and comprehensively annotated its ***,our results open the door to improving broomcorn millet using biotechnology.

关键词： broomcorn millet CRISPR/Cas9 editing genome assembly herbicide resistance transformation system

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Inversion of O_(2) 1.27 μm nightglow emissions: A climatological analysis using satellite Limb-Viewed spectra and Harmonic analysis method

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Earth and Planetary Physics 2024年第4期8卷 632-640页

作者： YiYi sui YaJun Zhu QiuYu chen MaoSheng He JiYao Xu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China

This study employs a linear inversion algorithm to retrieve volume emission rates(VERs)of molecular O_(2) nightglow at 1.27μm,utilizing Limb-Viewed spectra obtained from the SCanning Imaging Absorption spectroMeter for Atmospheric for CHartographY(SCIAMACHY)payload on board the Envisat *** retrieved results are compared with VERs data from the SABER payload on the Thermosphere Ionosphere Mesosphere Energetics and Dynamics(TIMED)satellite,exhibiting *** will help to facilitate accurate revelation of spatial distribution and periodic variation in O_(2) *** are extracted monthly within the altitude range of 75-110 km from 2002 to 2012,yielding a climatology of spatial and temporal *** meridional structure exhibits two maxima,at the equator and at 45°*** August and October,the VERs exhibit a meridional bimodal structure,with the weaker one above the equator and the stronger one above 45°*** April,the VERs reach their annual ***,harmonic analysis reveals significant temporal variations on different *** emission shows characteristics of annual and semi-annual variation,and a non-linear long-term trend associated with solar cycle activity.

关键词： VERs O_(2)1.27μm nightglow SCIAMACHY

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A comprehensive review of the modeling of transport phenomenon in the flow channels of polymer electrolyte membrane fuel cells

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 123-161页

作者： Niyi Olukayode Shenrong Ye Mingruo Hu Yanjun Dai Rui chen Sheng sui Institute of Fuel Cell Shanghai Jiao Tong UniversityShanghai 200240China Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China Low Carbon Engineering Loughborough UniversityLoughborough Leicestershire LE113TUUK

Reactant gas and liquid water transport phenomena in the flow channels are complex and critical to the performance and durability of polymer electrolyte membrane fuel *** polymer membrane needs water at an optimum level for proton *** management involves the prevention of dehydration,waterlogging,and the cell’s subsequent performance decline and *** process requires the study and understanding of internal two-phase *** experimental visualization techniques are used to study two-phase flows in polymer electrolyte membrane fuel ***,the experiments have limitations in in situ measurements;they are also expensive and time *** contrast,numerical modeling is cheaper and faster,providing insights into the complex multiscale processes occurring across the components of the polymer electrolyte membrane fuel *** paper introduces the recent design of flow *** reviews the numerical modeling techniques adopted for the transport phenomena therein:the two-fluid,multiphase mixture,volume of fluid,lattice Boltzmann,and pressure drop ***,this work describes,compares,and analyses the models’approaches and reviews the representative results of some selected ***,the paper summarizes the modeling perspectives,emphasizing future directions with some recommendations.

关键词： two-phase flows numerical model flow channel polymer electrolyte membrane fuel cells water management

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Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma

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Cancer Communications 2018年第1期38卷 81-94页

作者： Meng-Jie Yang Jie Guo Yan-Fang Ye sui-hong chen Li-Xia Peng Chu-Yang Lin Ting Hu Shang-Hang Xie Chuan-Bo Xie Qi-hong Huang Yu-Qiang Lu Qing Liu Chao-Nan Qian Su-Mei Cao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Cancer Prevention Research Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China School of Public Health Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510060GuangdongP.R.China Department of Experimental Research Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Sihui Cancer Institute Sihui 526200GuangdongP.R.China

Background:The association of circulating inflammation markers with nasopharyngeal carcinoma(NPC)is still largely *** study aimed to comprehensively explore the relationship between circulating cytokine levels and the subsequent risk of NPC with a two-stage epidemiologic study in southern ***:The serum levels of 33 inflammatory cytokines were first measured in a hospital-based case-control study(150 NPC patients and 150 controls)using multiplex assay *** levels were categorized into two or more groups based on the proportion of sample measurements that was above the lower limit of *** ratios(ORs)and 95%confidence intervals(CIs)relating the serum marker concentration to the risk of NPC were computed by multivariable logistic regression *** associations were validated in 60 patients with NPC and 120 con-trols in a subsequent nested case-control study within a NPC screening *** interactions between serum cytokines and Epstein-Barr virus(EBV)relating to the risk of NPC were assessed using a likelihood ratio ***:The levels of serum macrophage inflammatory protein(MIP)-1αand MIP-1βin the highest categories were associated with a decreased risk of NPC in both the case-control study(MIP-1α:OR=0.49,95%CI=0.26-0.95;MIP-1β:OR=0.47,95%CI=0.22-1.00)and the nested case-control study(MIP-1α:OR=0.13,95%CI=0.03-0.62;MIP-1β:OR=0.20,95%CI=0.04-0.94),compared with those in the lowest ***,individuals with lower levels of these two cytokine markers who were EBV seropositive presented with a largely higher risk of NPC compared with patients with higher levels who were EBV seronegative in both the case-control study(MIP-1α:OR=16.28,95%CI=7.11-37.23;MIP-1β:OR=12.86,95%CI=5.9-28.05)and the nested case-control study(MIP-1α:OR=86.12,95%CI=10.58-701.03;MIP-1β:OR=115.44,95%CI=13.92-957.73).Conclusions:Decreased preclinical MIP-1αand MIP-1βlevels might be associated with a subsequently increased risk of NPC.

关键词： Nasopharyngeal carcinoma Prospective study Inflammatory cytokine Macrophage inflammatory protein Epstein-Barr virus

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Mixed H_(∞)/Passive Exponential Synchronization for Delayed Memristive Neural Networks with Switching Event-Triggered Control

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Journal of Systems Science & Complexity 2024年第1期37卷 294-317页

作者： WU Wenhuang GUO Lulu chen hong Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China Department of Control Science and Engineering Tongji UniversityShanghai 201804China

This paper is devoted to event-triggered synchronization of delayed memristive neural networks with H∞and passivity *** aim is to guarantee the exponential synchronization and mixed H∞and passivity control for memristive neural networks by using event-triggered ***,a switching system is constructed under the event-triggered control ***,by adopting a piece-wise Lyapunov functional,a sufficient condition is established for the exponential synchronization and mixed H_(∞)and passivity ***,an event-triggered controller design scheme is proposed using matrix decoupling ***,the effectiveness of the designed controller is exemplified by a numerical example.

关键词： Event-triggered control exponential synchronization memristive neural networks time delays.

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Equalizer Zero-Determinant Strategy in Discounted Repeated Stackelberg Asymmetric Game

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Journal of Systems Science & Complexity 2024年第1期37卷 184-203页

作者： chenG Zhaoyang chen Guanpu hong Yiguang Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Electrical Engineering and Computer Science KTH Royal Institute of Technology10044 StockholmSweden. Department of Control Science and Engineering Tongji UniversityShanghai 201804China Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 210201China

This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated Stackelberg asymmetric *** the leader-follower adversarial scenario,the strong Stackelberg equilibrium(SSE)deriving from the opponents’best response(BR),is technically the optimal strategy for the ***,computing an SSE strategy may be difficult since it needs to solve a mixed-integer program and has exponential complexity in the number of *** this end,the authors propose an equalizer ZD strategy,which can unilaterally restrict the opponent’s expected *** authors first study the existence of an equalizer ZD strategy with one-to-one situations,and analyze an upper bound of its performance with the baseline SSE *** the authors turn to multi-player models,where there exists one player adopting an equalizer ZD *** authors give bounds of the weighted sum of opponents’s utilities,and compare it with the SSE ***,the authors give simulations on unmanned aerial vehicles(UAVs)and the moving target defense(MTD)to verify the effectiveness of the proposed approach.

关键词： Discounted repeated Stackelberg asymmetric game equalizer zero-determinant strategy strong Stackelberg equilibrium strategy

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