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Potential mechanisms of hepatitis B virus induced liver injury

World Journal of Gastroenterology 2014年第35期20卷 12462-12472页

作者： Mohd suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri King Fahd Medical Research Center King Abdul Aziz University Department of Medicine University of Colorado Health Sciences Center at Fitzsimons IQ Institute of Infection and Immunity Special Infectious Agents Unit-Biosafety Level 3 King Fahd Medical Research CenterKing Abdul Aziz University Medical Laboratory Technology Department Faculty of Applied Medical Sciences King Abdul Aziz University

Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular *** histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal *** potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral *** viral and cellular factors that contribute to liver injury are discussed in this *** injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and *** consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of *** identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury.

关键词： Hepatitis B virus Hepatitis B virus genotype Hepatocellular carcinoma Woodchuck hepatitis virus Ground squirrel hepatitis virus Peripheral blood mononuclear cells Interferon regulatory factor 7 Interleukin-1 receptor-associated kinase 4 TNF receptor-associated factor 3

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Arthroscopic Subacromial Decompression for Small and Medium Size Tears of Rotator Cuff without Tendon Repair

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Open Journal of Clinical Diagnostics 2014年第4期4卷 243-246页

作者： suhail Karkabi Nahum Rosenberg Shoulder Service Rambam-Human Health Campus Haifa Israel

According to our previous clinical impression, we hypothesized that patients who had symptomatic rotator cuff tendon tear in a diamemter below 3 cm would benefit from arthroscopic subacromial decompression only, without the need for the repair of the thorn tendon. From 1998 to 2003, 160 patients (168 shoulders) had arthroscopic subacromial decompression for impingement syndrome with a torn rotator cuff without repairing the tear of the cuffs (120 males and 40 females). The average patient age was 64 years and the average follow up was 30 months. At follow up, 96 patients (60%) had full recovery;55 patients (35%) had residual low grade shoulder pain on effort and 7 patients (5%) had poor outcome. In the last group of patients with unsatisfactory outcome, the postoperative Constant score was only 64 points. In 95% of patients, the average Constant score values raised from average preoperative value of 62 to postoperative average score of 82. According to these results, there is an indication that in patients in the seventh decade of life or older with symptomatic rotator cuff tear, pain relief and good shoulder function can be achieved by more conservative approach of subacromial decompression alone, providing a clear diagnosis that the diameter of the tear in the supraspinatus and infraspinatus tendons is below 3 cm.

关键词： Impingement Syndrome Arthroscopic Subacromial Decompression Rotator Cuff Tear

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Probabilistic Failure Analysis of Composite Beams for Optimum Ply Arrangements under Ballistic Impact

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Journal of Aerospace Science and Technology 2015年第1期1卷 36-47页

作者： Shivdayal Patel suhail Ahmad Puneet Mahajan Department of Applied Mechanics Indian institute of Technology Delhi New Delhi 110016 India

The probabilistic analysis takes into consideration an effect of scatter in elastic and strength properties of composite beam, and velocity of impactor. The damage model is implemented in the FE （finite element） code by a VUMAT （user-defined subroutine）. The inter ply failure is modeled using cohesive surfaces between the plies. Dynamic response is obtained using explicit time domain integration approach. SFEA （stochastic finite element analysis） is used to study the initiation of fiber failure analysis due to ballistic impact. SFEA provided the critical stress input in the limit state which is computationally solved using reliability software. The random variation in these properties is used for determining statistics of stress in the lamina. These are compared to the random strengths in the limit state function and probability failure surface is obtained by using GPRSM （Gaussian process response surface method）. GPRSM is used to predict the Pf （probability of failure） for different ply lay-ups arrangement. The Pf of Chang-Chang initiation of fiber failure for simply supported composite beams with symmetric cross ply lay-ups are （88.9%, 1.47% and 58.1%） greater than the anti-symmetric cross ply, symmetric angle ply and anti-symmetric angle ply, respectively. Sensitivity analysis is also carried out for symmetric cross ply arrangements.

关键词： Ballistic impact composite stochastic finite elements limit state function probability of failure.

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Deep Reinforcement Learning Based Unmanned Aerial Vehicle (UAV) Control Using 3D Hand Gestures

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Computers, Materials & Continua 2022年第9期72卷 5741-5759页

作者： Fawad Salam Khan Mohd Norzali Haji Mohd Saiful Azrin B.M.Zulkifli Ghulam E Mustafa Abro suhail Kazi Dur Muhammad Soomro Faculty of Electrical and Electronics(FKEE) Universiti Tun Hussein Onn MalaysiaParit Raja81756Malaysia Department of Electrical&Electronic Engineering Universiti Teknologi PETRONASSeri Iskandar32610Malaysia Faculty of Engineering Science and Technology Isra UniversityHyderabad71000Pakistan Department of Innovation CONVSYS(Pvt)Ltd.44000IslamabadPakistan

The evident change in the design of the autopilot system produced massive help for the aviation industry and it required frequent *** learning delivers appropriate outcomes when considering a continuous environment where the controlling Unmanned Aerial Vehicle(UAV)required maximum *** this paper,we designed a hybrid framework,which is based on Reinforcement Learning and Deep Learning where the traditional electronic flight controller is replaced by using 3D hand *** algorithm is designed to take the input from 3D hand gestures and integrate with the Deep Deterministic Policy Gradient(DDPG)to receive the best reward and take actions according to 3D hand gestures *** UAV consist of a Jetson Nano embedded testbed,Global Positioning System(GPS)sensor module,and Intel depth *** collision avoidance system based on the polar mask segmentation technique detects the obstacles and decides the best path according to the designed reward *** analysis of the results has been observed providing best accuracy and computational time using novel design framework when compared with traditional Proportional Integral Derivatives(PID)flight *** are six reward functions estimated for 2500,5000,7500,and 10000 episodes of training,which have been normalized between 0 to−*** best observation has been captured on 2500 episodes where the rewards are calculated for maximum *** achieved training accuracy of polar mask segmentation for collision avoidance is 86.36%.

关键词： Deep reinforcement learning UAV 3D hand gestures obstacle detection polar mask

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On the 2-Domination Number of Complete Grid Graphs

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Open Journal of Discrete Mathematics 2017年第1期7卷 32-50页

作者： Ramy Shaheen suhail Mahfud Khames Almanea Department of Mathematics Faculty of Science Tishreen University Lattakia Syria

A set D of vertices of a graph G = (V, E) is called k-dominating if every vertex v ∈V-D is adjacent to some k vertices of D. The k-domination number of a graph G, γk (G), is the order of a smallest k-dominating set of G. In this paper we calculate the k-domination number (for k = 2) of the product of two paths Pm × Pn for m = 1, 2, 3, 4, 5 and arbitrary n. These results were shown an error in the paper [1].

关键词： k-Dominating Set k-Domination Number 2-Dominating Set 2-Domination Number Cartesian Product Graphs Paths

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西非与南美东部的关联盆地的对比——基于构地质学和地层学的分析

西非与南美东部的关联盆地的对比——基于构地质学和地层学的分析

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作者： Ahmed suhail 浙江大学

学位级别：硕士

In this work, the main evidence and conclusions regarding the geological links between the basins of South American margin （Espirito Santos basin, Pelotas basin ＆ Colorado basin） with the conjugate margin of Western African （Kwanza basin, Walvis basin ＆ Orange basin） Many research works have been done in both margins of South Atlantic and Western African like sedimentation history and tectonic evolution. However, there are some cognition needs to be unified, and some geologic problems need to be further researched, such as the deposition of salt, extension of the basin, and the sedimentation history along the comparative *** basins were formed during the breakup of Gondwana, while the South Atlantic Ocean started to open during the Late Cretaceous at ca.131.7Ma, the sedimentation history between the Late Jurassic and present are broadly similar on both margins, where these basins are filled with the Cretaceous, Tertiary and the Quaternary sediments. However, the sediment of the Late Jurassic only deposit at Colorado basin in South American margin and at Kwanza basin and Orange basin in Western African margin. Sedimentation proceeded from the deposition of continental pre- and syn-rift facies, through syn-rift lacustrine, the turbiditic and transgressive shales, to shallow marine carbonates and evaporitic units before the deposition of a post rift marine transgressive and regressive *** the opening of the South Atlantic Ocean there were some major events （i.e, the Parana ＆ Etendeka volcanic plume, salt deposition before the opening of South Atlantic）, these events at these two margins could be well matched. Tectonically, South Atlantic Ocean are divided into four major segments from South to North:the Falkland segment, the South segment, the Central segment and the Equatorial segment. South Atlantic Ocean contains two kinds of passive margins which are the thick crust volcanic margin and the thin-crust non-volcanic margin. The volcanic passive ma

关键词：盆地地质运动板块构造南大西洋西非地区南美地区

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第十二届全国量子光学学术会议

作者： M．suhail Zubairy Department of Physics Texas A&M University College StationTexas 77843USA

We consider a two-photon correlated emission laser as a source of an entangled radiation with a large number of photons in each mode. The system consists of three-level atomic schemes inside a doubly resonant cavity. We study the dynamics of this system in the presence of cavity losses, concluding that the creation of entangled states with photon numbers up to tens of thousands seems achievable.

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Time Evolution of the Lamb Shift

Time Evolution of the Lamb Shift

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第十四届全国量子光学学术会议

作者： M.suhail Zubairy Institute for Quantum Studies and Department of Physic Texas A＆M UniversityCollege StationTexas 77843

＜正＞The time evolution of the Lamb shift that accompanies the real photon emission is studied for the first time. The investigation of the explicit time-dependence of the Lamb shift becomes possible because the self-energy of the free electron,which is divergent,is subtracted from the Hamiltonian after a unitary ***

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McGill Brisbane Symptom Score for patients with resectable pancreatic head adenocarcinoma

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World Journal of Gastroenterology 2014年第34期20卷 12226-12232页

作者： Mohammed H Jamal suhail A R Doi A James Moser Sinziana Dumitra Jad abou Khalil Eve Simoneau Prosanto Chaudhury Adedayo A Onitilo Peter Metrakos Jeffrey S Barkun Hepato-biliary Pancreatic and Liver Transplant SurgeryMcGill University Health CenterMontreal QCH3A 1A1Canada Department of Surgery Kuwait Medical SchoolKuwait CityKuwait 24923Kuwait Clinical Epidemiology Unit School of Population HealthUniversity of QueenslandBrisbane QLD4006Australia Department of Surgery Harvard Medical SchoolBeth Israel Deaconess HospitalBostonMA 02215United States Marshfield Clinic Research Foundation Marshfield ClinicMarshfieldWI 54449United States Division of General Surgery Department of SurgeryRoyal Victoria HospitalQuébec H3A 1A1Canada

AIM: To evaluate the ability of the McGill Brisbane Symptom Score (MBSS) to predict survival in resectable pancreatic head adenocarcinoma (PHA) patients.

关键词： Pancreatic neoplasms Pancreatic adenocarcinoma Whipple procedure Prognosis Survival study Chemotherapy

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基于神经网络的心脏图像分割

基于神经网络的心脏图像分割

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作者： suhail Ahmed Rajpar 北京交通大学

学位级别：硕士

目前,心血管疾病是人类非意外死亡的主要原因之一,发病率较高,没有固定的发病规律。现在,心血管疾病逐渐向年轻人发展,并始终威胁着人类的健康生活。心脏是心血管系统的中枢器官,获得心脏的生理信息是心血管疾病诊断和治疗的关键。CT成... 详细信息

目前,心血管疾病是人类非意外死亡的主要原因之一,发病率较高,没有固定的发病规律。现在,心血管疾病逐渐向年轻人发展,并始终威胁着人类的健康生活。心脏是心血管系统的中枢器官,获得心脏的生理信息是心血管疾病诊断和治疗的关键。CT成像技术因其具有成像速度快、成像清晰等优点,已经成为心脏检查的常用手段。CT图像分割对心血管疾病的诊断和治疗具有重要意义。然而,心脏是一个实体器官,常见的断层图像序列很难完全显示心脏的生理信息,而对于计算机辅助诊断,介入治疗引导,心脏手术和其他技术通常需要一个完整的心脏解剖学信息。医学图像的三维可视化是发掘心脏解剖学信息的主要手段,而图像分割是实现人体器官视觉化的数据基础。对于心脏图像的分割,国内外研究人员提出了各种不同的分割方法,但大多数算法都侧重于对心房和心室的分割,难以满足整个心脏分割的要求。同时,由于心脏搏动和血流的影响,心脏CT图像容易产生伪影、边界弱化等问题,影响到心壁分割效果。此外,传统的人工分割方法需要大量医务人员的经验,并且分割的效率较低。因此,在医学图像处理领域,自动心脏分割一直是一个具有挑战性的热点问题。基于医学图像的分割和识别,本文提出了一种基于神经网络和图像显著性的新方法。该方法主要基于心脏图像和其他组织切片之间的显著差异,并且在心脏CT图像序列中,相邻片之间具有很高的相似性。本文的主要内容和创新如下:1.利用视觉显著性技术实现基于CT图像的心脏分割。利用图像显著性检测算法对CT图像进行计算,并利用显著性图像对原始CT图像进行分割,获得完整的心脏图像。进一步将分割任务分解为两部分:定位和分割,利用卷积神经网络和叠加去噪声自编码网络实现定位和分割。首先,根据卷积神经网络具有的优秀的图像分类和目标识别性能,构建卷积神经网络来实现图像中心脏的定位功能。然后,对原始心脏CT图像进行切割,并通过定位结果去除部分非目标区。此外,构造一个叠加去噪声自编码器,并通过人工划分图像来完成对CT图像中心脏组织的分类和识别的训练。2.将该分割算法的结果与人工分割结果进行了比较,并得到这两种结果的定量评价。最后利用体绘制和面绘制进行了三维可视化。本文通过对CT图像的特点和现有的心脏分割算法的分析,将心脏分割任务分解为两部分,并提出了一种基于神经网络和图像显著性的分割算法。主要内容如下:第一章,引言。介绍了本文的研究背景、目的和意义,以及国内外心脏图像分割的研究现状,并比较了现有的心脏分割算法和心脏分割的特点。最后,简要介绍了本文的主要内容,和总体结构。第二章,介绍了 CT图像分割算法。详细介绍了研究中涉及的基本算法和基本概念等知识。本文提出了基于图像显著性和神经网络的两种分割方法,并对这两种算法的分割性能进行了验证。本章也详细介绍了一些算法的概念和原理,包括CT图像处理技术的技术理论及其相关的基本概念,如卷积神经网络、图像显著性以及在分割过程中叠加去噪声的自编码等。第三章,基于视觉显著性的心脏分割。本章详细介绍了一种基于视觉显著性的分割算法,并利用显著性图像对原始的CT图像进行分割。在医学图像分割和处理中,人们只对图像的一部分感兴趣。这部分称为前景或目标,通常对应于图像中具有特殊属性的区域。因此,有必要将目标与图像分离以进行进一步的分析。图像分割技术是将图像分割成几个具有统一特征的区域,以便将感兴趣的图像区域与复杂图像内容分离开来。视觉注意力机制是包括人类在内的灵长类动物所拥有的重要属性。它可以帮助人们在许多图像信息中找到重要或感兴趣的对象,忽略其他不重要的内容,减少信息处理量的计算。因此,将视觉注意力机制引入到图像分割中可以显著提高图像分割的效率。实现基于神经网络的心脏分割方法。将心脏图像分割任务分解为两部分:定位和分割。并利用卷积神经网络和叠加去噪声自编码网络实现。如何利用计算机技术从图像中准确地分割目标区域一直是医学图像处理领域的研究挑战。由于医学图像不可避免地受到环境噪声、局部身体效应和组织运动等现象的干扰,与自然环境中的光学成像和其他问题相比,它们不可避免地具有边缘模糊、灰度分布不均匀、对比度低等特点。CT图像作为一种医学图像,图像分割也将受到上述因素的影响。为了实现图像的自动分割,减少分割的难度,提高分割的精度,本文将分割算法分解为两部分:定位和分割。针对心脏定位的问题,采用卷积神经网络定位法。针对定位后的心脏图像分割,采用叠加降噪的自编码神经网络来实现。在定位和分割的实验中,神经网络的训练效果对训练集的数量具有很强的鲁棒性。为了解决这一问题,本文采用了去噪声的自编码方法,对卷积核进行预训练,从而提高了训练集图像的数量。实验结果表明,经过训练的卷积网络对心脏CT图像具有良好的识别效果,能够准确地获得心脏位置。通过叠加去噪声自编码网络训练二进制图像,可以很好地与SF分割方法进行比较。最终的分割图像完

关键词： CT图像心脏分割神经网络卷积神经网络叠加去噪自编码器

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