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SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

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World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep K Dabla Dharmsheel Shrivastav Swapan Gupta Manisha Yadav subhash Yadav Bidhan chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

Effect of tool rotational speed on the particle distribution in friction stir welding of AA6092/17.5 SiCp-T6 composite plates and its consequences on the mechanical property of the joint

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Defence Technology（防务技术） 2020年第2期16卷 381-391页

作者： Uttam Acharya Barnik Saha Roy subhash chandra Saha Department of Mechanical Engineering National Institute of Technology AgartalaBarjalaJiraniaWest Tripura799046India

This study investigates the effect of tool rotational speed(TRS)on particle distribution in nugget zone(NZ)through quantitative approach and its consequences on the mechanical property of friction stir welded joints of AA6092/17.5 SiCp-T6 composite.6 mm thick plates are welded at a constant tool tilt angle of 2°and tool traverse speed of 1 mm/s by varying the TRS at 1000 rpm,1500 rpm and 2000 rpm with a taper pin profiled *** analysis shows large quantity of uniformly shaped smaller size SiC particle with lower average particle area which are homogeneously distributed in the *** fragmentation of bigger size particles has been observed because of abrading action of the hard tool and resulting shearing effect and severe stress generation due to the rotation of *** particles occupy maximum area in the matrix compared to that of the base material(BM)due to the redistribution of broken particles as an effect of *** migration of particles towards the TMAZ-NZ transition zone has been also encountered at higher TRS(2000 rpm).The microhardness analysis depicts variation in average hardness from top to bottom of the NZ,minimum for 1500 rpm and maximum for 2000 *** impact strength at 1000 rpm and 1500 rpm remains close to that of BM(21.6 J)while 2000 rpm shows the accountable *** maximum joint efficiency has been achieved at 1500 rpm(84%)and minimum at 1000 rpm(68%)under tensile *** analysis shows mixed mode of failure for BM,1000 rpm and 1500 rpm,whereas 2000 rpm shows the brittle mode of failure.

关键词： Friction stir welding Aluminium matrix composite Tool rotational speed Particle distribution Mechanical property

Chemical characteristics of trace metals in PM10 and their concentrated weighted trajectory analysis at Central Delhi,India

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Journal of Environmental Sciences 2017年第5期29卷 184-196页

作者： subhash chandra Monika J.Kulshrestha Ruchi Singh Nahar Singh CSIR-National Physical Laboratory New Delhi 110012 India. Academy of Scientific and Innovative Research (AcSIR) CSIR - National Physical Laboratory (CSIR-NPL) Campus New Delhi 110012 India Present address: Shriram Institute for Industrial Research Delhi 110007 India.

Trace metals associated with PM10 aerosols and their variation during day and nighttime as well as during different seasons have been studied for the year 2012. PCA analysis suggested5 PCs,which accounted for 86.8% cumulative variance. PC1 accounted for 30% with a significant loading of metals of anthropogenic origin,while PC2 showed 28% variance with the loading of metals of crustal origin. These trace metals showed seasonal distinct day and night time characteristics. The concentrations of Cu,Pb,and Cd were found to be higher during nighttime in all the seasons. Only Fe was observed with significantly higher mean concentrations during daytime of all seasons except monsoon. The highest mean values of Cu,Cd,Zn,and Pb during post-monsoon might be attributed to winds advection over the regions of waste/biomass burning and industrial activities in Punjab and Haryana ***,concentration weighted trajectory analysis suggested that metals of crustal origin were contributed by long-range transport while metals of anthropogenic and industrial activities were contributed by regional/local source regions.

关键词： Trace metals Potential source regions Backward trajectory Principal component analysis

Temporal variation of solar flare index during solar cycles 21–24

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Research in Astronomy and Astrophysics 2021年第3期21卷 21-33页

作者： Soumya Roy Amrita Prasad subhash chandra Panja Sankar Narayan Patra Department of Applied Electronics and Instrumentation Engineering Haldia Institute of TechnologyHaldiaMidnapore(E)-721657West BengalIndia Department of Mechanical Engineering Jadavpur UniversityKolkata-700032West BengalIndia Department of Instrumentation and Electronics Engineering Jadavpur UniversityKolkata-700106West BengalIndia

The present investigation attempts to quantify the temporal variation of Solar Flare Index(SFI)with other activity indices during solar cycles 21-24 by using different techniques such as linear regression,correlation,cross-correlation with phase lag-lead,*** Solar Activity Indices(SAI)considered in this present study are Sunspot Number(SSN),10.7 cm Solar Radio Flux(F10.7),Coronal Index(CI)and MgⅡCore-to-Wing Ratio(MgⅡ).The maximum cycle amplitude of SFI and considered SAI has a decreasing trend from solar cycle 22,and cycle 24 is the weakest solar cycle among all other *** SFI with SSN,F10.7,CI and MgⅡshows hysteresis during all cycles except for solar cycle 22 where both paths for ascending and descending phases are intercepting each other,thereby representing a phase reversal.A positive hysteresis circulation exists between SFI and considered SAI during solar cycles 22 and 23,whereas a negative circulation exists in cycles 21 and *** has a high positive correlation with coefficient values of 0.92,0.94,0.84 and 0.81 for SSN,F10.7,CI and MgⅡ*** to crosscorrelation analysis,SFI has a phase lag with considered SAI during an odd-number solar cycle(solar cycles21 and 23)but no phase lag/lead during an even-numbered solar cycle(solar cycles 22 and 24).However,the entire smoothed monthly average SFI data indicate an in-phase relationship with SSN,F10.7 and MgⅡ,and a one-month phase lag with *** presence of those above characteristics strongly confirms the outcomes of different research work with various solar indices and the highest correlation exists between SFI and SSN as well as F10.7 which establishes that SFI may be considered as one of the prime activity indices to interpret the characteristics of the Sun’s active region as well as for more accurate short-range or long-range forecasting of solar events.

关键词： Methods:data analysis Methods:statistical Sun:activity Sun:flares Sun:general

Chaos and Periodicities in Solar Flare Index from Kandilli Observatory during 1976–2014

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Research in Astronomy and Astrophysics 2020年第7期20卷 177-186页

作者： Soumya Roy Amrita Prasad Koushik Ghosh subhash chandra Panja Sankar Narayan Patra Department of Applied Electronics and Instrumentation Engineering Haldia Institute of TechnologyHaldiaMidnapore(E)-721657West BengalIndia Department of Mechanical Engineering Jadavpur UniversityKolkata-700032West BengalIndia Department of Mathematics University Institute of TechnologyThe University of BurdwanBurdwan-713104West BengalIndia Department of Instrumentation and Electronics Engineering Jadavpur UniversityKolkata 700106West BengalIndia

The Solar Flare Index is regarded as one of the most important solar indices in the field of solarterrestrial research. It has the maximum effect on Earth of all other solar activity indices and is being considered for describing the short-lived dynamo action inside the Sun. This paper attempts to study the short as well as long-term temporal fluctuations in the chromosphere region of the Sun using the Solar Flare Index. The daily Solar Flare Index for Northern, Southern Hemisphere and Total Disk are considered for a period from January 1976 to December 2014(total 14 245 days) for chaotic as well as periodic *** 0–1 test has been employed to investigate the chaotic behavior associated with the Solar Flare *** test revealed that the time series data is non-linear and multi-periodic in nature with deterministic chaotic features. For periodic analysis, the Raleigh Power Spectrum algorithm has been used for identifying the predominant periods within the data along with their confidence score. The well-known fundamental period of 27 days and 11 years along with their harmonics are well affirmed in our investigation with a period of 28 days and 10.77 years. The presence of 14 days and 7 days periods in this investigation states the short-lived action inside the Sun. Our investigation also demonstrates the presence of other mid-range periods including the famous Rieger type period which are very much confirming the results obtained by other authors using various solar activity indicators.

关键词： chaos method:data analysis Sun:activity Sun:flares Sun:fundamental parameters Sun:rotation

Panic disorder in COVID-19 patients admitted in a tertiary care hospital in South India

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Asian Pacific Journal of Tropical Medicine 2022年第8期15卷 379-380页

作者： Lakshmi KP subhash chandra Dipu Thareparambil Sathyapalan Kudrat Jain Department of Psychiatry Amrita Institute of Medical sciences and Research CentreKochiKeralaIndia Department of General Medicine Amrita Institute of Medical sciences and Research CentreKochiKeralaIndia

COVID-19 has led to an increase in psychiatric disorders,stress,trauma and suicidal *** published in the Lancet in 2021 have identified anxiety disorder as the most frequently diagnosed psychiatric disorder in COVID-19 survivors[1].Fear conditioning and hyper-vigilance towards abnormal breathing patterns attributable to COVID-19 or not,can act as etiological and maintenance factors of panic,and hence we should expect an onset or aggravation of panic disorder in COVID-19[2].

关键词： admitted patients hence

Fatal Delftia acidovorans infection in an immunocompetent patient with empyema

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 923-924页

作者： Sadia Khan Sujatha Sistla Rahul Dhodapkar subhash chandra Parija Department of Microbiology JIPMER Puducherry-60500 India

Delftia acidovorans(earlier known as Comamonas acidovorans) is an aerobic,non-fermentative, Cram negative rod,classified in the Pseudomonas rRNA homology Group *** of isolation of the organism from serious infections like central venoug catheter associated bacleremia. corneal ulcers,otitis media *** microbiologists can identify this organism based on an orange indole *** reaction demonstrates the organism's ability to produce anthranilic acid from tryptophan on addition of Kovac's reagent;which gives the media its characteristic "pumpkin orange" *** we report the isolation of this organism from the Endotracheal tube aspirate of a 4 year old *** the increasing use of invasive devices,it has become important to recognize these non fermentative gram negative bacilli as emerging source of infection even in immunocompetent individuals.

关键词： Delftia acidovorans Comamonas acidovorans Orange indole

Larvicidal activity of Dregea volubilis and Bombax malabaricum leaf extracts against the filarial vector Culex quinquefasciatus

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Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 436-441页

作者： Emdad Hossain Anjali Rawani Goutam chandra subhash C.mandal Jayanta Kumar Gupta Pharmacy College AzamgarhItauraPO:ChandeshwarAzamgarh 276128Uttar PradeshIndia Department of Zoology Mosquito Research UnitParasitology LaboratoryThe University of BurdwanBurdwan 713104West BengalIndia Department of Pharmaceutical Technology Jadavpur UniversityKolkata 700032India

Objective:To analyze the larvicidal activity of two plant leaf powder and leaf-extracts, Dregea volubilis and Bombax malabaricum against Culex ***:The larvicidal bioassay was done for powdered leaves of Dregea volubilis and Bombax malabaricum individually and their methanol extracts against first-,second-,third- and fourth-instar larval forms of Culex *** rate was recorded after 24,48 and 72 h of postexposure. LC50 and LG90 values were calculated at different time intervals for third instar larvae. Results:All the graded concentration（0.1%,0.2%,0.3%,0.4%,0.5%） of powdered leaves showed significant（P 50 values were 56.97 ppm and 48.85 ppm,respectively after 24 h of *** is no mortality of non-target organism such as Chironomous circumdatus,Oreochromis niloticus niloticus and Diplonichus annulatum within 72 h of post exposure to 0.1%,0.2%,0.3%crude powdered leaves and methanolic extracts of both the two individual plants under the laboratory *** results of preliminary qualitative phytochemical analysis of both the plants revealed the presence of many bioactive principles such as steroids,tannins,flavonoids,triterpenoids,saponins,etc. that may be responsible for their bio-control ***:The results have shown potential and eco-friendly use of both plant extracts against larva of Culex quinquefasciatus for the first time.

关键词： Bombax malabaricum Culex quinquefasciatus Dregea volubilis Larvicidal activity

Identification,synthesis and characterization of an unknown process related impurity in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS,~1H,^(13)C and ~1H-~1H COSY NMR

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Journal of Pharmaceutical Analysis 2014年第5期4卷 339-344页

作者： Saji Thomas Saroj Kumar Paul subhash chandra Joshi Vineet Kumar Ashutosh Agarwal Dharam Vir Analytical Research Department Jubilant Life Sciences Ltd.R&D CentreC-26Sector-59NoidaUttar Pradesh 201301India Chemical Research Department Jubilant Life Sciences Ltd.R&D CentreC-26Sector-59NoidaUttar Pradesh 201301India

A new impurity was detected during high performance liquid chromatographic （HPLC） analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer （LC/ESI-IT/MS） analysis. Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using 1H, 13C nuclear magnetic resonance spectrometry （NMR）, 1H-1H correlation spectro-scopy （COSY） and infrared spectroscopy （IR）. Based on the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.

关键词： Eslicarbazepine acetate Characterization LC/ES I-IT/MS NMR Impurity