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Modelling the combined effect of surface roughness and topography on bacterial attachment

Journal of Materials Science & Technology 2021年第22期81卷 151-161页

作者： subash Bommu Chinnaraj Pahala Gedara Jayathilake Jack Dawson Yasmine Ammar Jose Portoles Nicholas Jakubovics Jinju Chen School of Engineering Newcastle UniversityNewcastle Upon TyneUK Department of Oncology University of OxfordUK School of Dental Sciences Newcastle UniversityNewcastle Upon TyneUK

Bacterial attachment is a complex process affected by flow conditions,imparted stresses,and the surface properties and structure of both the supporting material and the *** on the initial attachment of cells of the bacterium Streptococcus gordonii(***),an important early coloniser of dental plaque,to samples of stainless steel(SS)have been reported in this *** primary aim motivating this study was to establish what affect,if any,the surface roughness and topology of samples of SS would have on the initial attachment of cells of the bacterium *** material and bacterium were chosen by virtue of their relevance to dental implants and dental implant *** to bacterial attachment,surfaces become conditioned by the interfacing environment(salivary pellicle from the oral cavity for instance).For this reason,cell attachment to samples of SS pre-coated with saliva was also *** implementing the Extended Derjaguin Landau Verwey and Overbeek(XDLVO)theory coupled with convection-diffusion-reaction equations and the surface roughness information,a computational model was developed to help better understand the physics of cell *** roughness was modelled by reconstructing the surface topography using statistical parameters derived from atomic force microscopy(AFM)*** this computational model,the effects of roughness and surface patterns on bacterial attachment were examined quantitatively in both static and flowing fluid *** results have shown that rougher surfaces(within the sub-microscale)generally increase bacterial attachment in static fluid conditions which quantitatively agrees with experimental *** flow conditions,computational fluid dynamics(CFD)simulations predicted reduced convection-diffusion inside the channel which would act to decrease bacterial *** combined with surface roughness effects,the computational model also predicted that the surface top

关键词： Bacterial attachment XDLVO theory Computational modelling Surface topography Surface roughness

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Zero-DCE++Inspired Object Detection in Less Illuminated Environment Using Improved YOLOv5

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Computers, Materials & Continua 2023年第12期77卷 2751-2769页

作者： Ananthakrishnan Balasundaram Anshuman Mohanty Ayesha Shaik Krishnadoss Pradeep Kedalu Poornachary Vijayakumar Muthu subash Kavitha Centre for Cyber Physical Systems Vellore Institute of Technology(VIT)ChennaiTamil Nadu600127India School of Computer Science and Engineering Vellore Institute of Technology(VIT)ChennaiTamil Nadu600127India School of Information and Data Sciences Nagasaki UniversityNagasaki8528521Japan

Automated object detection has received the most attention over the *** cases ranging from autonomous driving applications to military surveillance systems,require robust detection of objects in different illumination ***-of-the-art object detectors tend to fare well in object detection during daytime ***,their performance is severely hampered in night light conditions due to poor *** address this challenge,the manuscript proposes an improved YOLOv5-based object detection framework for effective detection in unevenly illuminated nighttime ***,the preprocessing strategies involve using the Zero-DCE++approach to enhance lowlight *** is followed by optimizing the existing YOLOv5 architecture by integrating the Convolutional Block Attention Module(CBAM)in the backbone network to boost model learning capability and Depthwise Convolutional module(DWConv)in the neck network for efficient compression of network *** Night Object Detection(NOD)and Exclusively Dark(ExDARK)dataset has been used for this *** proposed framework detects classes like humans,bicycles,and *** demonstrate that the proposed architecture achieved a higher Mean Average Precision(mAP)along with a reduction in model size and total parameters,*** proposed model is lighter by 11.24%in terms of model size and 12.38%in terms of parameters when compared to baseline YOLOv5.

关键词： Object detection deep learning nighttime road scenes YOLOv5 DWConv Zero-DCE++ CBAM

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Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第4期13卷 156-164页

作者： Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra subash Chandra Parija Department of Pharmacology and Toxicology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Surgery and Radiology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia Department of Veterinary Anatomy and Histology College of Veterinary Sciences and Animal HusbandryOUATBhubaneswarIndia

Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in ***:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 ***,biochemical,electrocardiography,echocardiography,and histopathological examinations were ***:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated ***,it reduced peak systolic velocity and end-diastolic velocity while increasing heart *** trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin ***:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in ***,it can be further explored as a cardioprotective agent.

关键词： Arsenic trioxide Hesperidin Cardiotoxicity ECG CK-MB LDH

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Hydrochemistry of Rara Lake: A Ramsar lake from the southern slope of the central Himalayas,Nepal

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Journal of Mountain Science 2021年第1期18卷 141-158页

作者： KAPHLE Binija WANGJun-bo KAI Jin-lei LYU Xin-miao PAUDAYAL Khum Narayan ADHIKARI subash Key Laboratory of Tibetan Environment Changes and Land Surface Processes(TEL) Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Central Department of Geology Tribhuvan UniversityKritipurKathmandu 44600Nepal

High-altitude Himalayan lakes act as natural storage for environmental evidence related to climate change and environmental factors.A great number of lakes are distributed in the southern slope area of the central Himalayas;however,research concerning the hydrochemical processes of these lakes is still ***,we present a comprehensive study on the water chemistry of the lake waters and the inlet stream waters from Rara Lake in western Nepal based upon samples collected in November *** p H,dissolved oxygen,chlorophyll-aconcentration(chl-a),water temperature,electric conductivity(EC)and total dissolved solids(TDS)were measured in situ,and the concentrations of major ions(Ca^(2+),Mg^(2+),K^(+),Na^(+),Cl^(-),SO_(4)^(2-),and NO_(3)^(-))were analyzed in the *** results revealed that the water in Rara Lake is slightly alkaline,with p H values ranging from *** cations,in decreasing order of concentration in the lake water,are Ca^(2+)>Mg^(2+)>K^(+)>Na^(+)with average concentrations of20.64 mg·L^(-1),11.78 mg·L^(-1),1.48 mg·L^(-1) and 0.72 mg·L^(-1),respectively;the order and concentrations for the anions is HCO_(3)^(-)>SO_(4)^(2-)>Cl^(-)>NO_(3)^(-),with average concentrations of 122.15 mg·L-1,2.15 mg·L-1,0.46mg·L-1 and 0.55 mg·L-1,*** dominant cation and anion in the lake water are Ca2+and HCO3-and they account for 48.14%and 71.8%of the totals,*** range of lake water TDS is from 95mg·L^(-1) to 98 mg·L^(-1),with an average of 96.85 mg·L^(-1).The high ratio of(Ca^(2+)+Mg^(2+))to total cations and the low ratio of(Na^(+)+K^(+))to total cations indicate that Rara Lake receives ions from rock weathering,especially from carbonate ***,Gibbs boomerang diagrams and Piper diagrams also support the hydrochemistry of Rara Lake as being dominated by rock-weathering ***,other statistical analysis tools,such as Principal Component Analysis(PCA)and correlation strongly suggest the dominance of weather

关键词： Water quality profiling Major ions Rock weathering Anthropogenic Rara Lake Himalayas

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Neuroprotective effects of berry fruits on neurodegenerative diseases

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Neural Regeneration Research 2014年第16期9卷 1557-1566页

作者： Selvaraju subash Musthafa Mohamed Essa Samir Al-Adawi Mushtaq A.Memon Thamilarasan Manivasagam Mohammed Akbar Department of Food Science and Nutrition College of Agricultural and Marine Sciences Sultan Qaboos University Muscat Sultanate of Oman Ageing and Dementia Research Group Sultan Qaboos University College of Medicine and Health Sciences Sultan Qaboos University College of Veterinary Medicine Washington State University Department of Biochemistry and Biotechnology Annamalai University Section of Molecular Pharmacology and Toxicology Laboratory of Membrane Biochemistry and Biophysics National Institute on Alcohol Abuse and Alcoholism National Institutes of Health

Recent clinical research has demonstrated that berry fruits can prevent age-related neurodegenerative diseases and improve motor and cognitive functions. The berry fruits are also capable of modulating signaling pathways involved in inflammation, cell survival, neurotransmission and enhancing neuroplasticity. The neuroprotective effects of berry fruits on neurodegenerative diseases are related to phytochemicals such as anthocyanin, caffeic acid, catechin, quercetin, kaempferol and tannin. In this review, we made an attempt to clearly describe the beneficial effects of various types of berries as promising neuroprotective agents.

关键词： nerve regeneration berry fruit neurodegenerative disease neuroprotection Alzheimer'sdisease Parkinson's disease review neural regeneration

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Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine

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Journal of Pharmaceutical Analysis 2016年第5期6卷 341-344页

作者： Patitapabana Parida subash Chandra Mishra Subhashree Sahoo Ajit Behera Bibhukalyan Prasad Nayak Department of Biotechnology and Medical Engineering NIT Rourkela Odisha 769008 India Department of Metallurgical and Materials Engineering NIT Rourkela Odisha 769008 India Department of Pharmaceutics Kanakmanjari Institute of Pharmaceutical Sciences Rourkela Odisha 769015 India Department of Metallurgical and Materials Engineering IIT Kharagpur West Bengal 721302 India

This article introduced the work of ethylcellulose based polymeric microsphere loaded with nifedipine for reduction in frequency of administration with low solubility in aqueous medium and high rate of absorption in the stomach. The non-aqueous polymeric suspension was put dropwise into an aqueous medium containing polyvinyl alcohol as a surfactant for the synthesis of microsphere by solvent evaporation. The microspheres were characterized by different techniques, namely, XRD, SEM, and NMR. The formation of microspheres was confirmed by SEM. XRD analysis revealed the semi-crystallinity nature of microspheres. The NMR study indicated the presence of hetero-aromatic nucleus in the microsphere.

关键词： Nifedipine Microsphere Solvent evaporation Sustained release

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Ulipristal Acetate (UPA): An Alternative Option to Surgery for Uterine Fibroids in Reproductive Age: A Review

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Yangtze Medicine 2022年第1期6卷 1-11页

作者： subash Chandra Sharma Cunjian Yi Department of Gynecology and Obstetrics The First Affiliated Hospital of Yangtze University Jinzhou China

Uterine fibroids are common in females of reproductive age and substantially affecting fertility and quality of life. Current management strategies mainly involve surgical interventions. For treatment, options available are surgical and non-surgical, but the mode of management leans on several factors, such as severity of symptoms, patient’s age, myoma characteristics, desire to preserve uterus and fertility. Alternative approach to surgery for the treatment of symptomatic females with uterine myomas has been recognized. Ulipristal acetate (UPA) has been the first selective progesterone-receptor modulator (SPRM) approved for the pre-operative and long-term management of uterine fibroids. There are evidences promoting an important role for progesterone pathways in the pathophysiology of uterine fibroids which supports the use of ulipristal acetate. The availability of alternative choices to surgical intervention is very necessary especially for those willing to preserve uterus and fertility. One of the alternatives is with ulipristal acetate, which has been proven to treat fibroid symptoms effectively.

关键词： Myoma Females Uterine Fibroids Selective Progesterone Receptor Modulator (SPRM) Ulipristal Acetate (UPA)

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LCA studies for alkaline and enzyme catalyzed biodiesel production from palm oil

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Advances in Biological Chemistry 2012年第4期2卷 341-352页

作者： Pogaku Ravindra subash Saralan Rahmath Abdulla School of Engineering and Information Technology Universiti Malaysia Sabah Sabah Malaysia

The life cycle analysis of biodiesel production from palm oil (PO) involves 3 stages: 1) Cultivation;2) Oil Extraction and 3) Transesterification of PO. There are several different approaches to the production process. The enzyme catalyzed process, was investigated and its environmental performance was compared with the conventional alkali-catalyzed process by using life cycle analysis (LCA). The enzyme catalyzed process is found to be technically a simpler production process and offers the production of less environmentally damaging wastes.

关键词： Biodiesel Life Cycle Assessment (LCA) Enzyme Catalyzed Process

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中国西南部分地区小兽体表寄生虫分布及相关生态研究

中国西南部分地区小兽体表寄生虫分布及相关生态研究

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作者： subash GC 大理大学

学位级别：硕士

简介:在西方人群中进行的几项研究已经确定了疾病发作和进展的风险因素。风险因素识别提供了对视网膜病变典型特征的洞察,有助于临床判断、治疗和监测,以降低DR的频率和严重程度。该研究的目的是确定中国大理大学内科就诊的2型糖尿病患... 详细信息

简介:在西方人群中进行的几项研究已经确定了疾病发作和进展的风险因素。风险因素识别提供了对视网膜病变典型特征的洞察,有助于临床判断、治疗和监测,以降低DR的频率和严重程度。该研究的目的是确定中国大理大学内科就诊的2型糖尿病患者发生视网膜病变的危险因素。方法:该研究是一项横断面前瞻性描述性研究,于2017年9月至2021年9月期间对120名2型糖尿病患者进行。评估。单变量分析的主要目的是估计独立因素之间的关系并计算优势比。统计显着性定义为P值为0.05。结果:我们的研究发现,37.67%的2型糖尿病患者患有糖尿病视网膜病变,这与全球34.6%的患病率(范围15-51.2%)相当。我们的研究结果表明,高血压、体重指数异常、血糖水平升高、空腹胰岛素升高、稳态模型评估指数升高、纤维蛋白原水平升高、高密度脂蛋白降低、尿素和肌酐升高、尿酸升高和糖尿增加视网膜病变发展和进展的风险。在我们的研究中发现C肽水平、凝血参数和血脂参数是保护因素。结论:该研究发现了可改变和不可改变的风险因素以及糖尿病视网膜病变发展和进展的一些保护因素。

关键词：血糖肾脏脂质保护因子风险因素

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Large Riedel’s lobe and atrophic left liver in a donor-Accept for transplant or call off?

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World Journal of Transplantation 2020年第5期10卷 129-137页

作者： Yuhki Sakuraoka Rashmi Seth Amanda PCS Boteon Moira Perrin J Isaac Gowri subash Paolo Muiesan Andrea Schlegel The Liver Unit Queen Elizabeth University Hospital BirminghamBirmingham B152THUnited Kingdom Second Department of Surgery Dokkyo Medical UniversityTokyo 321-0293Japan NIHR Liver Biomedical Research Unit University Hospitals BirminghamBirmingham B152THUnited Kingdom

BACKGROUND In context of suboptimal liver utilisation,grafts with various risk factors are under consideration *** example,impaired vascularity with severe arterial calcifications and modified liver shapes are no longer contraindications and their use depends on the centre policy and experience of the surgical *** liver lobes represent a tongue-like liver shape with inferior projection in the right liver *** development modifications were initially described when patients developed a lesion and subsequently presented with *** here present the first case report in the literature,where such livers with anatomical variations were used for *** SUMMARY We describe here two cases of adult human liver transplantation,where we have accepted two donor livers with modified *** technical considerations for transplantation of such livers,found with enlarged right lobes,or Riedel shape,and hypo-trophic left lateral segment are *** recipients experienced immediate liver function and overall good outcomes with a minimum follow up of 1 *** also provide detailed pictures and outcome analysis in combination with a literature *** The utilisation of donor livers with modified shape,such as Riedel’s Lobe appears safe and will increase the donor pool.

关键词： Case report Anatomical variations Riedel’s lobe Liver utilization Liver transplantation

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