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Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

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Journal of Integrative Medicine 2024年第2期22卷 126-136页

作者： Zhen-yu Ma Shu-ping Yang Ying li Tian-tian Xu Ya-lin Yang Hui-yong Yang Heng-bing li Le-jin Zhou Yong Diao su-yun li School of Medicine Huaqiao UniversityQuanzhou 362021Fujian ProvinceChina College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355Shandong ProvinceChina Second Clinical Medical College Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina

Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical ***,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been ***:This study was designed to evaluate the existing evidence and offer a comprehensive understanding of the associations between the use of RYR preparations and various adverse health *** strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,“red yeast rice,”“Xuezhikang,”and“Zhibitai”).Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this *** extraction and analysis:Two researchers independently extracted data using a standardized data collection table;any disagreements were resolved by consulting a third *** on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were *** associations’effect estimates were re-evaluated using random-effect ***:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were *** on A Mea surement Tool to Assess Systematic Reviews version 2,3(20%)and 12(80%)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible *** on the random-effect models,10(16.4%)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2%)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate trans

关键词： Red yeast rice Safety Adverse health outcomes Umbrella review Meta-analysis Systematic review

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Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： Xin-Yu liu liang Zhu su-yun Jie Bo-Geng li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(MTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-VL).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[M]_0/[I],linear polyvalerolactones(PVLs)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experiments were carried out to prove the"living"/controllable *** the NMR experiments were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVL

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金鱼草WAK/WAKL基因家族鉴定及抗核盘菌候选基因挖掘

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南方农业学报 2024年第1期55卷 24-36页

作者：杨冬梅夏文念宋佳怡杨洁严苍海苏芸丽汪仲毅胡慧贞西南林业大学园林园艺学院/云南省功能性花卉资源及产业化技术工程研究中心云南昆明650224

【目的】鉴定金鱼草细胞壁相关受体激酶(Wall-associated kinase,WAK)及类WAK蛋白(WAK-like kinases,WAKL)基因家族成员,并挖掘抗核盘菌的候选基因,为深入解析金鱼草抗核盘菌的WAK/WAKL分子调控机制提供理论参考。【方法】以拟南芥WAK/W... 详细信息

【目的】鉴定金鱼草细胞壁相关受体激酶(Wall-associated kinase,WAK)及类WAK蛋白(WAK-like kinases,WAKL)基因家族成员,并挖掘抗核盘菌的候选基因,为深入解析金鱼草抗核盘菌的WAK/WAKL分子调控机制提供理论参考。【方法】以拟南芥WAK/WAKL家族蛋白为参考序列,利用生物信息学方法从金鱼草基因组数据库中鉴定出WAK/WAKL基因家族成员,并对其理化性质、系统发育、基因结构、保守基序、顺式作用元件及共线性关系等进行预测分析,并通过转录组测序和实时荧光定量PCR对该家族基因在金鱼草抗感核盘菌材料中的表达模式进行分析。【结果】从金鱼草基因组中共鉴定出27个WAK/WAKL基因家族成员,其中WAK家族基因16个(AmWAK1~AmWAK16),WAKL家族基因11个(AmWAKL1~AmWAKL11),编码的氨基酸数量为615~1085个;理论等电点(pI)为4.94~8.69,绝大多数蛋白呈酸性;所有蛋白的总平均亲水性指数(GRAVY)值小于0,均为亲水性蛋白;大多数蛋白亚细胞定位于细胞质膜区域,少部分定位于细胞外、液泡、高尔基体和细胞核。27个WAK/WAKL基因家族成员不均匀地分布在金鱼草的8条染色体上,且与拟南芥WAK/WAKL家族基因存在7对共线性同源基因;基因启动子区域含有与防御和胁迫响应、茉莉酸甲酯响应及水杨酸响应等顺式作用元件。通过叶片离体接种核盘菌试验,筛选出抗性差异明显的易感病品种Am1和抗病品种Am6。有12个WAK/WAKL家族基因在金鱼草抗感材料中显著差异表达(P<0.05),有9个基因表达模式与转录组测序结果基本一致。这9个基因中,有5个基因(AmWAK7、AmWAKL2、AmWAKL8、AmWAK6和AmWAK13)在金鱼草的根、茎和叶组织中高表达,而剩余4个基因(AmWAK2、AmWAK8、AmWAK9和AmWAK12)在根、茎和叶中基本不表达。【结论】筛选出的27个金鱼草WAK/WAKL基因家族成员,具有相似的基因结构和蛋白功能结构域,其中AmWAK6、AmWAK7、AmWAK13、AmWAKL2和AmWAKL8为金鱼草抗核盘菌的关键候选基因,具有介导抗病的潜在功能。

关键词：金鱼草 WAK/WAKL基因家族鉴定核盘菌抗性转录组测序候选基因挖掘

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Advances in functional MRI research in bipolar disorder:from the perspective of mood states

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General Psychiatry 2024年第1期37卷 33-43页

作者： Yankun Wu yun-Ai su linlin Zhu Jitao li Tianmei Si Department of Clinical Psychopharmacology Peking University Sixth HospitalPeking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratoryof Mental Health(Peking University)National Clinical Research Centerfor Mental Disorders(Peking University Sixth Hospital)BeijingChina

Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and *** breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar ***,the pathophysiology underlying mood instability,mood switching and the development of extreme mood states is less well *** reviewpresents a comprehensive overviewof current evidence from functional MRI studies from the perspective of mood *** first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder,irrespective of the mood *** next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related ***,we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research.A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder.

关键词： anatomy bipolar functional

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基于Landsat影像的惠州海岸线近30年动态变化监测

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广州大学学报（自然科学版） 2024年第1期23卷 60-71页

作者：黄诗宁杨现坤董永宏苏丽云庄丹秀邱俊良惠州市自然资源局惠州市海洋信息(预报减灾)中心广东惠州516001 广州大学地理科学与遥感学院广东广州510006 帕多瓦大学土地环境农林学部意大利帕多瓦35020

广东省惠州市海岸线是我国南海海岸线的重要组成部分,其近30年的动态变化尚不明确。基于Google Earth Engine平台和1990—2020年的Landsat系列影像,该研究获取了惠州沿海1990—2020年改进的归一化差异水体指数(Modified Normalized Diff... 详细信息

广东省惠州市海岸线是我国南海海岸线的重要组成部分,其近30年的动态变化尚不明确。基于Google Earth Engine平台和1990—2020年的Landsat系列影像,该研究获取了惠州沿海1990—2020年改进的归一化差异水体指数(Modified Normalized Difference Water Index, MNDWI)和土地利用分布,提取了惠州市1990—2020年的海岸线,并分析其变化趋势。结果表明:(1)惠州市1990、2000、2010和2020年的海岸线长度分别为240.11、242.36、260.90和282.83 km。1990—2020年间,惠州海岸线的长度增加了42.72 km,增加主要发生在2000年之后。(2)1990—2020年,惠州2020年海岸线5 km缓冲区内,面积减少最多的是农用地,减少面积为146.47 km^(2),这主要受“退耕还林”政策和城镇扩张的影响;建设用地面积从20.40 km^(2)增加到135.46 km^(2),增加面积为115.06 km^(2)。(3)2010—2020年间惠州沿海开始出现蚝场,蚝场面积大约为10.28 km^(2)。

关键词：海岸线惠州 MNDWI

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Layered niobium carbide enabling excellent kinetics and cycling stability of li-Mg-B-H hydrogen storage material Layered niobium carbide enabling excellent kinetics

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Rare Metals 2024年第3期43卷 1153-1166页

作者： li-Wen Lu Hui Luo Guang-Xu li yun li Xin-Hua Wang Cun-Ke Huang Zhi-QiangLan Wen-Zheng Zhou Jin Guo Mohammad Ismail Hai-Zhen liu Guangxi Novel Battery Materials Research Center of Engineering Technology Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China State Key Laboratory of Featured Metal Materials and life-Cycle Safety for Composite Structures Nanning530004China School of Mechanical and Electrical Engineering Quzhou College of TechnologyQuzhou324000China Department of Materials Science and Engineering Zhejiang UniversityHangzhou310027China Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

The li-Mg-B-H composite(2liBH_(4)+MgH_(2))has a high capacity of 11.4 wt%as a hydrogen storage ***,the slow kinetics and poor cycling stability severely restrict its practical *** this work,a layered Nb_(2)C MXene was first synthesized and then introduced to tailor the kinetics and cycling stability of the li-Mg-B-H *** milled 2liH+MgB_(2)composites were initially hydrogenated to obtain the 2liBH_(4)+MgH_(2)*** 2liBH_(4)+MgH_(2)+5wt%Nb_(2)C can release 9.0 wt%H_(2)in 30 min at 400℃,while it is only 2.7 wt%for the undoped 2liBH_(4)+MgH_(2).The dehydrogenation activation energies of MgH_(2)and liBH_(4)are 123 and 154 kJ·mol^(-1)respectively for the 5 wt%Nb_(2)C-doped composite,lower than the undoped composite(164 and 165 kJ·mol^(-1)).The 2liBH_(4)+MgH_(2)+5 wt%Nb_(2)C possesses excellent cycling stability,with the reversible capacity only slightly reduced from 9.4 wt%for the 1st cycle to 9.3 wt%for the 20th ***_(2)C keeps stable in the composite and acts as an efficient catalyst for the li-Mg-B-H *** is believed that both the layered structure and the active Nb element contribu te to the enhanced hydrogen storage performances of the li-Mg-B-H *** work confirms that the Nb_(2)C MXene with layered stru cture has a significant enhancing impact on the li-Mg-B-H hydrogen storage materials,which is different from the bulk NbC.

关键词： Hydrogen storage lithium borohydride Magnesium hydride Nb_(2)C MXene

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Construction of electron rich Fe active sites by FeCu alloy anchoring on carbon nitride for photocatalytic nitrogen reduction

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Rare Metals 2024年第4期43卷 1570-1579页

作者： Gang Dong Cong Huang Fei-Yang Chen Xue-Qin liu Zhen li Xiao-li su Tao Zeng yun-Xia Chen Yi-Huang Chen Yang Wang School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen333403China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou325035China

Given the clean and inexhaustible solar energy from solar light,photocatalytic ammonia synthesis is extremely ***,high electron-hole recombination rates and insufficient active sites severely limited N2 photoreaction ***,we designed and fabricated FeCu alloy nanoparticles anchored on carbon nitride nanosheets with excellent photocatalyt ic ammonia synthesis *** a coupler between Fe and carbon nitride,Cu promotes the separation of photogenerated charge carriers in carbon nitride under solar light irradiation,and renters the semiconductor a forceful electron donor for the Fe active *** accumulated electrons at Fe sites furtherly facilitated the adsorption and activation of the molecular ***,the uniform dispersed FeCu alloy nanoparticles were on carbon nitride nanosheets enhanced the stability of photocataly tic nitrogen reduction reaction,making the artificial photocataly tic ammonia synthesis more sustainable for *** work highlights that a direct electron transfer channel can be used to regulate the photochemical nitrogen fixation network.

关键词： Photocatalytic N_2 fixation Carbon nitride FeCu alloy Active sites Hydrogenation pathway

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Mechanisms of fracture propagation from multi-cluster using a phase field based HMD coupling model in fractured reservoir

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Petroleum Science 2024年第3期21卷 1829-1851页

作者： yun-Jin Wang Bo Wang Hang su Tu Chang Ren-Cheng Dong li-Zhe li Wei-Yu Tang Ting-Xue Jiang Fu-Jian Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBejing2249China China University of Petroleum-Beijing at Karamay Karamay834000XinjiangChina China National Oil and Gas Exploration and Development Corporation Ltd. Beijing100034China University of Texas at Austin United States SINOPEC Research Institute of Petroleum Engineering Beijing100101China

Natural fractures(NFs)are common in shale and tight reservoirs,where staged multi-cluster fracturing of horizontal wells is a prevalent technique for reservoir *** NFs and stress interference are recognized as significant factors affecting hydraulic fracture(HF)propagation,the combined influence of these factors remains poorly *** address this knowledge gap,a novel coupled hydromechanical-damage(HMD)model based on the phase field method is developed to investigate the propagation of multi-cluster HFs in fractured *** comprehensive energy functional and control functions are established,while incorporating dynamic fluid distribution between multiple perforation clusters and refined changes in rock mechanical parameters during hydraulic *** HMD coupled multi-cluster HF propagation model investigates various scenarios,including single HF and single NF,reservoir heterogeneity,single HF and NF clusters,and multi-cluster HFs with NF *** results show that the HMD coupling model can accurately capture the impact of approach angle(θ),stress difference and cementation strength on the interaction of HF and *** criterion of the open and cross zones is not *** NF angle(a)is not a decisive parameter to discriminate the *** to the relationship between approach angle(θ)and NF angle(a),the contact relationship of HF can be divided into three categories(θ=a,θa).The connected NF can increase the complexity of HF by inducing it to form branch fracture,resulting in a fractal dimension of HF as high as2.1280 at angles of±45°.Inter-fracture interference from the heel to the toe of HF shows the phenomenon of no,strong and weak ***,under the influence of NFs,distant HFs from the injection can become dominant ***,as a gradually increases,inter-fracture stress interference becomes the primary factor influencing HF propagation,gradually superseding the dominance of NF

关键词： HMD coupling Phase field Natural fracture Flow distribution Hydraulic fracturing Inter-fracture interference

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Predict the evolution of mechanical property of Al-li alloys in a marine environment

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Defence Technology（防务技术） 2024年第1期31卷 557-566页

作者： Wei li lin Xiang Guang Wu Hongli Si Jinyan Chen Yiming Jin Yan su Jianquan Tao Chunyang Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100036China Chongqing Innovation Center Beijing Institute of TechnologyChongqing400044China First Research Institute of the Ministry of Public Security for PR China Beijing100036China Southwest Technology and Engineering Research Institute Chongqing400039China

The ocean is one of the essential fields of national defense in the future,and more and more attention is paid to the lightweight research of Marine equipment and *** study it is to develop a Machine learning(ML)-based prediction method to study the evolution of the mechanical properties of Al-li alloys in the marine *** obtained the mechanical properties of Al-li alloy samples under uniaxial tensile deformation at different exposure times through Marine exposure *** obtained the strain evolution by digital image correlation(DIC).The strain field images are voxelized using 2D-Convolutional Neural Networks(CNN)autoencoders as input data for Long Short-Term Memory(LSTM)neural ***,the output data of LSTM neural networks combined with corrosion features were input into the Back Propagation(BP)neural network to predict the mechanical properties of Al-li *** main conclusions are as follows:*** variation law of mechanical properties of2297-T8 in the Marine atmosphere is *** the increase in outdoor exposure test time,the tensile elastic model of 2297-T8 changes slowly,within 10%,and the tensile yield stress changes significantly,with a maximum attenuation of 23.6%.*** prediction model can predict the strain evolution and mechanical response simultaneously with an error of less than 5%.*** study shows that a CNN/LSTM system based on machine learning can be built to capture the corrosion characteristics of Marine exposure *** results show that the relationship between corrosion characteristics and mechanical response can be predicted without considering the microstructure evolution of metal materials.

关键词： Marine environment Al-li alloy Machine learning Corrosion

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Mass-produced and uniformly luminescent photochromic fibers toward future interactive wearable displays

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light(Science & Applications) 2024年第4期13卷 593-595页

作者： Yan li Yikai su Department of Electronic Engineering Shanghai Jiao Tong University200240 ShanghaiChina

Enabling flexible fibers with light-emitting capabilities has the potential to revolutionize the design of smart wearable interactive devices.A recent publication in light Science&Application,an interdisciplinary team of scientists led by ***-Qing Lu and *** Tao has realized a highly flexible,uniformly luminescent photochromic fiber based on a mass-produced thermal drawing *** overcomes the shortcomings of existing commercial lightdiffusing fibers,exhibiting outstanding one-dimensional linear illumination *** research team integrated controllable photochromic fibers into various wearable interaction interfaces,providing a novel approach and insights to enable human-computer interaction.

关键词： interaction fibers uniformly

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