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Current Medical Science 2021年第4期41卷 722-728页

作者： Yun LI Hong-ying YU Kao-chuang ZHAO Xu-hong DING Yi huANG su-ping hu Han-xiang NIE Department of Respiratory and Critical Medicine Renmin Hospital of Wuhan UniversityWuhan430060China

Objective To observe effects of medication use on small airway function,airway inflammation and acute exacerbations in patients with clinically controlled *** Forced expiratory flow over the middle half of the forced expiratory curve(FEF25%–75%),percentage of eosinophil,concentrations of eosinophil cationic protein(ECP)and interleukin(IL)-5 in induced sputum were assessed in patients with clinically controlled asthma who were given oral anti-inflammatory agents alone or in combination with inhaled therapy and inhaled therapy ***,acute exacerbations were compared between two groups during the 24-week follow-up *** FEF25%–75%in 43 patients with clinically controlled asthma given oral anti-inflammatory agents alone or in combination with inhaled therapy was significantly higher than that in 49 patients given inhaled therapy ***,the percentage of eosinophils and levels of IL-5 and ECP in patients with clinically controlled asthma given oral anti-inflammatory agents alone or in combination with inhaled therapy were significantly lower than those in patients given inhaled therapy ***,the patients with clinically controlled asthma given inhaled therapy were likely to have more acute exacerbation than the patients given oral anti-inflammatory agents alone or in combination with inhaled therapy during the 24-week follow-up *** Systemic anti-inflammatory agents may have a greater effect on parameters reflecting small airway patency and reducing acute exacerbations,presumably secondary to reduction in airway inflammation.

关键词： asthma clinical control small airways airway inflammation acute exacerbation

Interleukin-12 was not involved in promotion of T helper cell differentiation induced by theophylline

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Acta Pharmacologica Sinica 2004年第12期25卷 100-104页

作者： Jiong YANG1, Wei GUO, Han-xiang NIE, su-ping hu Departmentof Respiratory Disease, Renmin Hospital, Wuhan University, Wuhan 430060, China Department of Respiratory Disease Renmin Hospital Wuhan University Wuhan 430060

AIM: To investigate the effect of theophylline on the naive T cell differentiation and the probable role of interleukin- 12 (IL-12). METHODS: Naive cord blood T cells were treated with theophylline 10 mg/L for 3 d after stimulation with PHA 100 mg/L. Differentiation of Tcells was analyzed by flow cytometry. Theophylline 10 mg/L and IL-12- mAb 0.025 mg/L were added in cord blood mononuclear cell (CBMC) cultures primed with LPS 1 mg/L to detect the levels of IL-12 and IL-12P40. The whole blood cultures were obtained from twelve health volunteers with or without administration of theophylline (200 mg). Cytokines were measured by enzyme linked immuno-sorbent assay. REsuLTS: Theophylline promoted T helper 1 (Th1) cells differentiation from naive T cells (21.9 %±10.3 % vs 9.4 %±5.6 %, Psubjects (19±11 ng/L vs 31±15 ng/L and 92±13 ng/L vs 196±49 ng/L, P<0.01). CONCLUSION: Theophylline promoted the differentiation of Th1 cells. IL- 12 seemed not to be involved in this process.

关键词： asthma theophylline helper inducer T lymphocytes Th1 cells Th2 cells interleukin-12

Application of Inflammatory Markers in Induced Sputum in Stable Chronic Obstructive Pulmonary Disease Patients with Positive Bronchodilation Tests

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Current Medical Science 2019年第4期39卷 560-567页

作者： Xu-xue GUO Ni-shan DENG Qian-hui CHEN Hong-ying YU Xu-hong DING su-ping hu Han-xiang NIE Department of Respiratory Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Positive bronchodilation (BD) tests can be noticed in some stable chronic obstructive pulmonary disease (COPD) *** characteristics of airway inflammation in this entity remain *** study aimed to identify the characteristics of airway inflammation in stable COPD patients with positive BD *** airway inflammation was assessed in 88 patients with stable COPD using the examination of induced sputum in the aftermath of lung function and BD *** counts and the levels of molecular markers including eosinophil cationic protein (ECP),myeloperoxidase (MPO),interleukin-5 (IL-5),and IL-8 were assayed by Wright's stain,Immuno-CAP system,and ELISA,*** the 88 patients with stable COPD,20 (22.7%) showed positive BD *** values of eosinophils (4.7%±3.4%) and ECP (90.1±41.6 ng/mL) in induced sputum in stable COPD patients with positive BD tests were markedly elevated as compared with those in stable COPD patients with negative BD tests or in healthy controls (all Psupernatant was significantly decreased in stable COPD patients with positive BD tests as compared with the patients with asthma (12.5±7.8 vs.48.2±26.0 ng/mL;P0.05).Moreover,the values of neutrophils (61.8%±15.1%),MPO (574.0±111.8 ng/mL),and IL-8 (32.6±13.4 ng/mL) in induced sputum in stable COPD patients with positive BD tests were significantly higher than those in asthmatics or normal controls (all P0.05).The stable COPD patients with positive BD tests may present not only eosinophilic airway inflammation but also neutrophilic airway inflammation.

关键词： airway inflammation bronchodilation tests chronic obstructive pulmonary disease induced sputum

The Clinical Role of Changes of Maximum Expiratory Flow at 25%and 50%of Vital Capacity before and after Bronchodilator Reversibility Test in Diagnosing Asthma

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Current Medical Science 2020年第4期40卷 677-682页

作者： Xu-xuc GUO Xiao-fan LIU Ai-ling WANG Qian-hui CHEN Shuo CHEN Ni-shan DENG Rui-yun LI Xu-hong DING su ping hu Han-xiang NIE Department of Respiratory&Critical Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Pulmonary and Critical Care Medicine The Central Hospial of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Nursing Department Wuhan University School of Health SciencesWuhan 430071China

summary:Changes of maximum expiratory flow at 25%and 50%of vital capacity(MEF2s and MEFso,respectively),and predominant parameters indicating small airways function in asthmatics before and after bronchodilator(BD)reversibility test have been less *** study aimed to investigate the clinical role of changes of MEF2s and MEFso before and after BD reversibility test in diagnosing *** expiratory volume in the first second(FEV),MEF2s,and MEFso were measured before and after BD reversibility test in 207 asthmatic patients using standard *** healthy individuals were enrolled as *** operating characteristic(ROC)curve was used to assess the diagnostic accuracy of reversibility of MEF2s and MEFgo before and after BD reversibility test(OMEF 2s%and AMEF so%,respectively)in diagnosing *** these functional criteria,AMEF2;%and 0MEFs%≥25%performed the best diagnostic *** sensitivity,specificity,and accuracy of AMEF 25%≥25%as an objcctive diagnostic test for asthma were 63.29%,87.50%,and 67.21%,and of AMEFs0%≥25%were 79.23%,85.00%,and 80.16%,*** area under the ROC curve of the indicators was 0.8203 and 0.9104,*** contrast,an increase in FEV≥12%and 200 mL demonstrated a sensitivity of 62.32%,specificity of 82.50%,and accuracy of 65.59%in diagnosing *** changes of MEF2s and MEFso before and after BD reversibility test may be of additional value in the clinical diagnosis of asthma,with cutoff values of 25%being the most.

关键词： asthma bronchodilator reversibility test maximum expiratory flow at 25%of vital capacity maximum expiratory flow at 50%of vital capacity

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng su Yanfang huang Bingbing Liu hu sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia su Jia‑Min hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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模拟核弹头核查中能谱遮盖技术的概念研究

物理学报 2001年第8期50卷 1405-1408页

作者：刘素萍胡广春龚建郝樊华向永春中国工程物理研究院核物理与化学研究所绵阳621900

建立了一套基于局域网的核弹头核查系统 .系统的硬件组成为 :一台网络服务器、两台个人计算机和一台便携式高纯锗γ谱仪 .系统的软件 (能谱遮盖软件 )包括核查方软件、被核查方软件两个模块 ,它们都采用交互式人机对话 ,通过局域网进行... 详细信息

建立了一套基于局域网的核弹头核查系统 .系统的硬件组成为 :一台网络服务器、两台个人计算机和一台便携式高纯锗γ谱仪 .系统的软件 (能谱遮盖软件 )包括核查方软件、被核查方软件两个模块 ,它们都采用交互式人机对话 ,通过局域网进行通讯 .核查中 ,探测器所采集的高分辨γ射线能谱需要经过被核查方软件的防泄密处理后 ,才能以遮盖能谱或文字显示方式发送给核查方终端 .能谱遮盖的原则是 ,对核查方要求核查的能段 ,核查方软件必须提供真实、客观的显示 ;而对其他能段 ,可根据被核查方对“敏感信息”的认识 ,作适当的遮盖处理 .文字显示方式则是直截了当地回答核查对象是“铀弹”、“钚弹”或“非核弹” .利用能谱遮盖软件对模拟核弹头进行了类型识别和能谱遮盖实验 .实验结果表明 ,所建立的基于局域网的核弹头核查系统具有识别模拟核弹头类型和在核查中保护敏感信息泄漏的功能 ,特别值得指出的是 ,核查结果文字显示方式具有较好的防泄密功能 ,有助于提高核查可信度 .实验同时也暴露了该系统的一些不足点 ,如系统组件过多 ,集成度不够 ;

关键词：核弹头核查 γ射线能谱能谱遮盖

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi Lian Kang hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

Strategies for achieving fast-charge and high-voltage polymer-based solid-state lithium metal batteries

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Science China Chemistry 2025年

作者： Zitian Lin sucheng Liu Ce Cui Wuhua Liu Yufeng su huiyu Song Li Du Jianqiang hu Zhiming Cui Guangdong Provincial Key Laboratory of Fuel Cell Technology School of Chemistry and Chemical Engineering South China University of Technology

Solid-state polymer electrolytes hold the potential for market application due to the combination of advantageous properties,such as flexibility,ease of processing and low ***,the sluggish ion transport and poor high-voltage stability pose significant challenges for the practical application of polymer-based solid-state lithium metal batteries (SSLMBs).Therefore,the design and development of polymer-based SSLMBs toward fast-charge and high-voltage is of great significance in high-energydensity ***,this review deeply analyzes the mechanism of ion transport and anti-oxidation of polymer-based solidstate ***,we also systematically and comprehensively summarize the factors that affect ionic conductivity and the electrochemical ***,we outline the solution strategies for simultaneously enhancing both ionic conductivity and high-voltage ***,we discuss the main challenges and the future prospects of polymer-based SSLMBs for further *** is hoped that this review can provide both advances and fundamentals to the research community and pave the way for the development of SSLMBs

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Fabrication and Mechano-sensing Characteristics of Bending Polypyrrole Actuator

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 240-245页

作者： CHEN Jinyou hu Wei School of Automotive Engineering Hunan Financial&Industrial Vocational-technical CollegeHengyang 421002China College of Mechanical and Electrical Engineering Hunan Agricultural UniversityChangsha 410128China

To prepare a conductive polymer actuator with decent performance,a self-built experimental platform for the preparation of polypyrrole film is *** of the essential goals is to examine the mechanical characteristics of the actuator in the presence of various combinations of process parameters,combined with the orthogonal test method of"four factors and three levels".The bending and sensing characteristics of actuators of various sizes are methodically examined using a self-made bending polypyrrole *** functional relationship between the bending displacement and the output voltage signal is established by studying the characteristics of the actuator sensor subjected to various degrees of *** experimental results reveal that the bending displacement of the actuator tip almost exhibits a linear variation as a function of length and *** the voltage reaches 0.8 V,the bending speed of the actuator tends to be ***,the mechanical properties of the self-assembled polypyrrole actuator are verified by the design and fabrication of the microgripper.

关键词： conductive polymer polypyrrole mechanical characteristics actuators sensing characteristics