检索结果-南通市图书馆

Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2016年第4期30卷 314-321页

作者： Yeong-Min Yoo su kil jang Gwang-Hoon Kim Jung-Youl Park Seong-Soo Joo Department of Biomedical Engineering College of Health ScienceYonsei UniversityWonjuGangwon-do 220-710Republic of Korea College of Life Science Gangneung-Wonju National UniversityGangneungGangwon-do 210-702Republic of Korea Industry-Academic Cooperation Foundation Hanbat National UniversityDaejeon 305-719Republic of Korea

Melatonin plays a critical role in regulating photoperiodic signals and has recently been shown to decrease immunosenescence with age. In this study, we examined whether melatonin activates T lymphocytes as major adaptive immune cells in in vitro and in vivo models. Splenocytes, CD4＋, and naive CD4 T lymphocytes were isolated from the spleen of BALB/c mice and the cell population patterns and mRNA profiles associated with T cell activation （CD28 and p21） and the melatonin receptor （MT1A and MT1B） were assessed. The T cell activation- related proteins Ki67 and Bcl2 were also evaluated to confirm the relationship between gene and protein levels. Our data clearly revealed that CD28, p21, MT 1 A, and MT 1B mRNA were highly expressed in the presence of melatonin. Co-culture of CD4＋ T lymphocyte and peritoneal macrophage 7 days after melatonin administration to young and aged mice significantly increased APRIL mRNA, suggesting induction or maintenance of T lymphocyte responses. We also found that the intracellular amount of Ki67 and Bcl2 proteins were significantly upregulated in aged CD4＋ T lymphocytes, suggesting enhancing T cell proliferation and ling-term maintenance of memory T cells. Taken together, we conclude that melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices in association with T lymphocytes and may be an attractive pharmacological candidate for aged and immunocompromised individuals.

关键词： melatonin aging CD4+ naive CD4 melatonin receptor

Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-Jeong jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** suMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-sung jang Maan Gee Lee Kyoungho suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

Machine Learning-Based Predictions on the Self-Heating Characteristics of Nanocomposites with Hybrid Fillers

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第6期71卷 4487-4502页

作者： Taegeon kil D.I.jang H.N.Yoon Beomjoo Yang Department of Civil and Environmental Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Korea School of Civil Engineering Chungbuk National UniversityCheongju28644Korea

A machine learning-based prediction of the self-heating characteristics and the negative temperature coefficient(NTC)effect detection of nanocomposites incorporating carbon nanotube(CNT)and carbon fiber(CF)is *** CNT content was fixed at 4.0 wt.%,and CFs having three different lengths(0.1,3 and 6 mm)at dosage of 1.0 wt.%were added to fabricate the *** self-heating properties of the specimens were evaluated via self-heating *** on the experiment results,two types of artificial neural network(ANN)models were constructed to predict the surface temperature and electrical resistance,and to detect a severe NTC *** present predictions were compared with experimental values to verify the applicability of the proposed ANN *** ANN model for data prediction was able to predict the surface temperature and electrical resistance closely,with corresponding R-squared value of 0.91 and 0.97,*** ANN model for data detection could detect the severe NTC effect occurred in the nanocomposites under the self-heating condition,as evidenced by the accuracy and sensitivity values exceeding 0.7 in all criteria.

关键词： Machine learning nanocomposites carbon fillers self-heating negative temperature coefficient

surgical intervention for acute pancreatitis in the COVID-19 era

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第31期10卷 11292-11298页

作者： Yu-jang su Tse-Hao Chen Toxicology Division Emergency DepartmentMacKay Memorial HospitalTaipei 10449Taiwan Department of Medicine MacKay Medical CollegeNew Taipei 252Taiwan Department of Nursing Yuanpei University of Medical TechnologyHsinChu 300Taiwan Department of Nursing MacKay Junior College of MedicineNursingand ManagementNew Taipei 25245Taiwan Emergency Medicine MacKay Memorial HospitalTaipei 10449Taiwan

Approximately 15%-19%of patients with severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)infections develop gastrointestinal *** pancreatitis(AP)has been reported in 0.1%of patients with coronavirus disease 2019(COVID-19).Biliary AP was most common(78.4%)before the COVID-19 pandemic;idiopathic AP is most common in patients with COVID-19(up to 57.1%).The number of emergency department presentations decreased by 23.3%during the pandemic and many governments made national recommendations to delay nonurgent endoscopic procedures,leading to decrements of 22%in combined esophagogastroduodenoscopy(EGD)and colonoscopy and 20%in EGD after the COVID-19 *** symptoms and signs of COVID-19-related AP are fever(63%),abdominal pain(58%),respiratory symptoms(40%),nausea and vomiting(39%),and headache(4%).Approximately 5-10%of patients develop necrotizing or hemorrhagic AP,and patients who required surgical intervention had a higher mortality *** to 2019,the rates of elective surgery decreased by 41.8%in 2020;including cholecystectomy(40.1%decrease)and pancreas(111.1%decrease).surgical volumes also decreased by 18.7%in 2020;device-assisted laparoscopic and robot-assisted procedures reduced by 45.4%and 61.9%during the COVID-19 Lockdown in 2020.

关键词： 2019-nCoV Complications COVID-19 Pancreatitis surgery

Minimum dose path planning for facility inspection based on the discrete Rao-combined ABC algorithm in radioactive environments with obstacles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第4期34卷 26-40页

作者： Kwon Ryong Hong su Il O Ryon Hui Kim Tae Song Kim jang su Kim Faculty of Energy Science Kim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea High-Tech Research&Development Centre Institute of Information TechnologyKim Il Sung UniversityPyongyangDemocratic People’s Republic of Korea

Workers who conduct regular facility inspections in radioactive environments will inevitably be affected by ***,it is important to optimize the inspection path to ensure that workers are exposed to the least amount of *** study proposes a discrete Rao-combined artificial bee colony(ABC)algorithm for planning inspection paths with minimum exposure doses in radioactive environments with *** this algorithm,retaining the framework of the traditional ABC algorithm,we applied the directional solution update rules of Rao algorithms at the employed bee stage and onlooker bee stage to increase the exploitation ability of the algorithm and implement discretion using the swap operator and swap *** increase the randomness of solution generation,the chaos algorithm was used at the initialization *** K-opt operation technique was introduced at the scout bee stage to increase the exploration ability of the *** path planning in an environment with complex structural obstacles,an obstacle detour technique using a recursive algorithm was *** evaluate the performance of the proposed algorithm,we performed experimental simulations in three hypothetical environments and compared the results with those of improved particle swarm optimization,chaos particle swarm optimization,improved ant colony optimization,and discrete Rao’s *** experimental results show the high performance of the proposed discrete Rao-combined ABC algorithm and its obstacle detour capability.

关键词： Minimum dose Path planning Nuclear facility inspection ABC algorithm Rao algorithms Swap sequence K-opt operation

Electrochemical characteristics of stainless steel using impressed current cathodic protection in seawater

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第4期19卷 930-934页

作者： Seok-Ki jang Min-su HAN Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University

Stainless steels such as STS 304,316 and 630 are frequently used as shaft materials in small fiber reinforced polymer(FRP) fishing *** the shaft material is exposed to a severely corrosive environment such as seawater,it should be protected using appropriate *** impressed current cathodic protection was used to inhibit corrosion in shaft *** anodic polarization,passivity was remarkably more evident in STS 316 stainless steel than in STS 304 and STS *** pitting potentials of STS 304,316,and 630 stainless steels were 0.30,0.323,and 0.260 V,*** concentration polarization due to oxygen reduction and activation polarization due to hydrogen generation were evident in the cathodic polarization trends of all three stainless *** 316 had the lowest current densities in all potential ranges,and STS 630 had the *** analysis showed that STS 316 was the most noble in the *** addition,the corrosion current density was the lowest for STS 316.

关键词：外加电流阴极保护 316不锈钢电化学特性海水腐蚀电流密度材料腐蚀阳极极化 STS

Examining global warming factors using self-organizing map and Granger causality network:a case from South Korea

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2023年第1期12卷 140-150页

作者： Thakur Dhakal Tae-su Kim Do-Hun Lee Gab-sue jang Department of Life Science Yeungnam UniversityGyeongsan 38541Republic of Korea National Institute of Ecology Seocheon 33657Republic of Korea

Background Understanding and patterning the possible causal variables of global warming is attributed to the development of effective prevention and mitigation strategies for climate ***,we aimed to pattern and visualize the possible causal variables of global warming and measure the causality between *** We patterned and visualized the time series(103 years,from 1918 to 2020)of global surface temperature(GTemp)data with the gross domestic product(GDP)per capita,human population(Pop),and carbon dioxide(CO_(2))emissions of South Korea using a self-organizing map(SOM)and examined the causable local feature of global warming using the Granger causality(GC)*** time-series data were trained and mapped in 4×4 SOM grids,and causality networks between variables were examined using multivariate Granger test *** SOM patterned 103 years of data,and a dominant cluster contained continuous time-series data from 2007 to ***,the CO_(2)emissions of South Korea were obtained as a predictable unidirectional causal variable for GTemp from GC *** on data from the past 34 years,significant causality(p-value=0.01)was observed with the integrated effect of Pop,GDP,and CO_(2)on *** This study patterned the time-series data using SOM and examined the causal relationship between variables using the GC *** study framework could be used as a reference by future scholars,ecologists,and the United Nations sustainable Development Goals.

关键词： Climate change Ecology Self-organizing map sustainable development goal Greenhouse gas

同方期刊数据库

Case Report:Congenital atresia of the left main coronary artery in an infant

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 539-541页

作者： su Ye SOHN Gi Young jang Byung Min CHOI Department of Pediatrics Korea University Hospital

Congenital atresia of the left main coronary artery is a rare occurrence, and surgical revascularizationbypass graft is required. We here report a rare case of congenital coronary anomaly in an infant. A lO-month-old male infant was admitted to the hospital with heart failure symptoms. Echocardiographic examinations revealed mitral valve regurgitation and ischemic changes of the anterolateral atresia of the left main coronary artery with a severe papillary muscle and chordae. Coronary angiography showed hypoplastic left anterior descending artery and a circumflex coronary artery. Unfortunately, sudden cardiac arrest occurred after catheterization and the infant did not recover despite of immediate cardiopulmonary resuscitation. Further studies are needed to find a newer diagnostic method to detect coronary anomaly in an infant, and coronary angiography, if necessary, has to be performed very carefully.

关键词： Conqenital heart disease Anomalous coronaries Infant