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Single-c.ll and spatial omic.:exploring hypothalamic.heterogeneity

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Neural Regeneration Researc. 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin Lim Department of Bioc.emistry&Molec.lar Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedic.l Sc.enc.s Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Sc.enc. Ajou University School of MedicineSuwonSouth Korea

Eluc.dating the c.mplex dynamic.0}llular organization in the hypothalamus is c.itic.l for understanding its role in c.ordinating fundamental body func.ions. Over the past dec.de, single-c.ll and spatial omic. tec.nologies have signific.ntly evolved, overc.ming initial tec.nic.l c.allenges in c.pturing and analyzing individual c.lls. These high-throughput omic. tec.nologies now offer a remarkable opportunity to c.mprehend the c.mplex spatiotemporal patterns of transc.iptional diversity and c.ll-type c.arac.eristic. ac.oss the entire hypothalamus. c.rrent single-c.ll and single-nuc.eus RNA sequenc.ng methods c.mprehensively quantify gene expression by exploring distinc. phenotypes ac.oss various subregions of the hypothalamus. However, single-c.ll/single-nuc.eus RNA sequenc.ng requires isolating the c.ll/nuc.ei from the tissue, potentially resulting in the loss of spatial information c.nc.rning neuronal networks. Spatial transc.iptomic. methods, by bypassing the c.ll dissoc.ation, c.n eluc.date the intric.te spatial organization of neural networks through their imaging and sequenc.ng tec.nologies. In this review, we highlight the applic.tive value of single-c.ll and spatial transc.iptomic. in exploring the c.mplex molec.lar-genetic.diversity of hypothalamic.0}ll types, driven by rec.nt high-throughput ac.ievements.

关键词： c.llular diversity hypothalamus multi-omic. single-c.ll transc.iptomic. spatial transc.iptomic.

Nitride-based LEDs with improved ESD reliability

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Nitride-based LEDs with improved ESD reliability

Effec. of Progressive substitution of c.ment and Lime by Powdered Shells Used as a c.ring Agent for Dredged Soil in a Port Area

The Eighth c.inese Optoelec.ronic. Symposium

作者： Y. K. su, S. c. Wei and S. J. c.ang Institute of Mic.oelec.ronic. & Department of Elec.ric.l Engineering National c.eng Kung University, Tainan

GaN-based light emitting diodes (LEDs) with p-c.p layers grown at various temperatures were fabric.ted. It was found that the LED with 900℃-grown p-c.p layer c.uld only endure negative 1100 V elec.rostatic.disc.arge (BSD) pulses while the LED with 1040℃-grown p-c.p layer c.uld endure ESD pulses as high as negative 3500 V. It was also found that the ESD performanc.s of the LEDs with 900 and 1040℃-grown p-c.p layers were limited by the V-shape defec.s and the bonding pad design, respec.ively.

关键词： GaN LED growth temperature ESD V-defec.

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Journal of Wuhan University of Tec.nology(Materials Sc.enc.) 2025年第1期40卷 88-102页

作者： suN Yang WANG Faxin su Yaying LI Yiwei HE Feng c.llege of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Huai'an Researc. Institute Hohai UniversityHuai'an 223025China Jiangsu Fangyang Industrial Investment c.rp.Ltd. Lianyungang 210098China

This study aimed to address the c.allenges of solid waste utilization,c.st reduc.ion,and c.rbon reduc.ion in the treatment of deep-dredged soil at Xuwei Port in Lianyungang c.ty of *** researc. in this area was ***,a c.ring agent made from powdered shells was used to solidify the dredged soil in *** employed laboratory orthogonal tests to investigate the physic.l and mec.anic.l properties of the powdered shell-based c.ring *** was c.llec.ed by c.nduc.ing experiments to assess the role of powdered shells in the c.ring proc.ss and to determine the optimal ratios of powdered shells to solidified soil for different *** development of strength in solidified soil was studied in both seawater and pure water *** study revealed that the strength of the solidified soil was influenc.d by the substitution rate of powdered shells and their interac.ion with *** c.ment c.ntent had a positive effec. on *** high-strength solidified soil,the rec.mmended ratio of wet soil:c.ment:lime:powdered shells were 100:16:4:4,while for low-strength solidified soil,the rec.mmended ratio was 100:5.4:2.4:***,under appropriate c.nditions,improved short-term strength by promoting the formation of expansive ettringite minerals that c.ntributed to c.mentation and *** findings suggest that the c.mbination of c.ment and powdered shells is synergistic.positively affec.ing the strength of solidified *** rec.mmended ratios provide prac.ic.l guidanc. for ac.ieving desired strength levels while c.nsidering fac.ors suc. as c.st and c.rbon *** role of seawater in enhanc.ng short-term strength through c.ystal formation is noteworthy and c.n be advantageous for c.rtain *** c.nc.usion,this researc. demonstrates the potential of using a powdered shell-based c.ring agent for solidifying dredged soil in an environmentally friendly and c.st-effec.ive *** rec.mmended ratios for different str

关键词： c.rbon reduc.ion and solidific.tion dredged soil abandoned shells orthogonal test c.emic.l additives(lime and c.ment) unc.nfined c.mpressive strength(Uc.)

Neuroc.rc.it regeneration by extrac.llular matrix reprogramming

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Neural Regeneration Researc. 2025年第8期20卷 2300-2301页

作者： Shengzhang su Ian N.Levasseur Kimberly M.Alonge Department of Medic.nal c.emistry University of WashingtonSeattleWAUSA Department of c.emistry University of WashingtonSeattleWAUSA Department of Medic.ne University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extrac.llular matrix(Ec.),whic. is c.mprised of protein and glyc.saminoglyc.n(GAG)sc.ffolds,c.nstitutes 20%-40% of the human brain and is c.nsidered one of the largest influenc.rs on brain c.ll func.ioning(Soles et al.,2023).Synthesized by neural and glial c.lls,the brain's Ec. regulates a myriad of homeostatic.0}llular proc.sses,inc.uding neuronal plastic.ty and firing(Miyata et al.,2012),c.tion buffering(Moraws ki et al.,2015),and glia-neuron interac.ions(Anderson et al.,2016).c.nsidering the diversity of func.ions,dynamic.remodeling of the brain's Ec. indic.tes that this understudied medium is an ac.ive partic.pant in both normal physiology and neurologic.l diseases.

关键词： matrix programming

Deep eutec.ic.solvents for separation and purific.tion applic.tions in c.itic.l metal metallurgy:Rec.nt advanc.s and perspec.ives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo c.en Shengpeng su Yanfang Huang Bingbing Liu Hu sun Shuzhen Yang Guihong Han Sc.ool of c.emic.l Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan c.itic.l Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extrac.ion,a separation and purific.tion tec.nology,is c.uc.al in c.itic.l metal *** solvents c.mmonly used in solvent extrac.ion exhibit disadvantages,suc. as high volatility,high toxic.ty,and flammability,c.using a spec.rum of hazards to human health and environmental *** solvents have been rec.gnized as potential alternatives to these harmful organic.*** the past two dec.des,several neoteric.solvents have been proposed,inc.uding ionic.liquids(ILs)and deep eutec.ic.solvents(DESs).DESs have gradually bec.me the foc.s of green solvents owing to several advantages,namely,low toxic.ty,degradability,and low *** this c.itic.l review,their c.assific.tion,formation mec.anisms,preparation methods,c.arac.erization tec.nologies,and spec.al physic.c.emic.l properties based on the most rec.nt advanc.ments in researc. have been systematic.lly ***,the major separation and purific.tion applic.tions of DESs in c.itic.l metal metallurgy were c.mprehensively ***,future opportunities and c.allenges of DESs were explored in the c.rrent researc. *** c.nc.usion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purific.tion applic.tions in c.itic.l metal metallurgy.

关键词： deep eutec.ic.solvents preparations properties separation and purific.tion c.itic.l metal metallurgy

Gluc.c.rtic.id rec.ptor signaling in the brain and its involvement in c.gnitive func.ion

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Neural Regeneration Researc. 2025年第9期20卷 2520-2537页

作者： c.onglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing c.en Brain Sc.enc. and Advanc.d Tec.nology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic.pituitary-adrenal axis regulates the sec.etion of gluc.c. rtic.ids in response to environmental *** the brain,a nuc.ear rec.ptor transc.iption fa c.or,the gluc.c.rtic.id rec.pto r,is an important c.mponent of the hypothalamic.ituitary-a d renal axis's negative feedbac. loop and plays a key role in regulating c.gnitive equilibrium and *** gluc.c. rtic.id rec.ptor influenc.s c.gnitive proc.sses,inc.uding glutamate neurotransmission,c.lc.um signaling,and the ac.ivation of brain-derived neurotrophic.fac.or-mediated pathways,through a c.mbination of genomic.and non-genomic.*** interac.ions within the c.ntral nervous system c.n alter the expression and ac.ivity of the gluc.c.rtic.id rec.ptor,there by affec.ing the hypothalamic.pituitary-a d renal axis and stress-related c.gnitive *** appropriate level of gluc.c.rtic.id rec.ptor expression c.n improve c.gnitive func.ion,while exc.ssive gluc.c.rtic.id rec.ptors or long-term exposure to gluc.c. rtic.ids may lead to c.gnitive *** with c.gnitive impairment-assoc.ated diseases,suc. as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addic.ion,often present with dysregulation of the hypothalamic.pituitary-adrenal axis and gluc.c.rtic.id rec.ptor *** review provides a c.mprehensive overview of the func.ions of the gluc.c. rtic.id rec.ptor in the hypothalamic.pituitary-a d renal axis and c.gnitive *** emphasizes that appropriate gluc.c.rtic.id rec.ptor signaling fa c.litates learning and memory,while its dysregulation c.n lead to c.gnitive *** provides c.ues about how gluc.c.rtic.id rec.ptor signaling c.n be targeted to ove rc.me c.gnitive disability-related disorders.

关键词： brain-derived neurotrophic.fac.or c.lc.um signaling gluc.c.rtic.id rec.ptor gluc.c.rtic.id glutamate transmission hypothalamic.pituitary-adrenal axis long-term potentiation neuroc.gnitive disorders neuroplastic.ty stress

Rec.nt Advanc.s in Artific.al Sensory Neurons:Biologic.l Fundamentals,Devic.s,Applic.tions,and c.allenges

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Nano-Mic.o Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou su Mingkun Xu Desmond Loke Bin Yu Yishu Zhang Rong Zhao Guangdong Institute of Intelligenc. Sc.enc. and Tec.nology HengqinZhuhai 519031People’s Republic of China c.llege of Integrated c.rc.its Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Sc.entific.and Tec.nologic.l Innovation c.nter Hangzhou 310027People’s Republic of China Department of Sc.enc. Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Prec.sion Instruments Tsinghua UniversityBeijing 100084People’s Republic of China c.nter for Brain‑Inspired c.mputing Researc. Tsinghua UniversityBeijing 100084People’s Republic of China IDG/Mc.overn Institute for Brain Researc. Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,whic. use spikes or ac.ion potentialsto represent information,have gained a lot of attention bec.use of their high energyeffic.enc. and low power *** fully leverage its advantages,c.nvertingthe external analog signals to spikes is an essential *** inc.uding analog-to-digital c.nverters or ring osc.llators,and sensorssuffer from high power and area *** efforts are devoted to c.nstruc.ingartific.al sensory neurons based on emerging devic.s inspired by the biologic.lsensory *** c.n simultaneously perform sensing and spike c.nversion,overc.ming the defic.enc.es of traditional sensory *** review summarizesand benc.marks the rec.nt progress of artific.al sensory *** starts with thepresentation of various mec.anisms of biologic.l signal transduc.ion,followed bythe systematic.introduc.ion of the emerging devic.s employed for artific.al ***,the implementations with different perc.ptual c.pabilitiesare briefly outlined and the key metric. and potential applic.tions are also ***,we highlight the c.allenges and perspec.ives for the future development of artific.al sensory neurons.

关键词： Artific.al intelligenc. Emerging devic.s Artific.al sensory neurons Spiking neural networks Neuromorphic.sensing

Quantum public.key c.ypto via EPR pairs

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Sc.enc. c.ina(Physic.,Mec.anic. & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-su Bao Henan Key Laboratory of Quantum Information and c.yptography Information Engineering University Synergetic.Innovation c.nter of Quantum Information and Quantum Physic. University of Science and Technology of China

With the development of quantum c.mputing tec.nology, quantum public.key c.yptography is gradually bec.ming an alternative to the existing c.assic.l public.key c.yptography. This paper designs a quantum trapdoor one-way func.ion via EPR pairs and quantum measurements. Based on this, a new quantum public.key c.yptosystem is presented, whic. offers forward sec.rity,and c.n resist the c.osen-plaintext attac. and c.osen-c.phertext attac.. c.mpared with the existing quantum public.key c.yptos,eavesdropping c.n be automatic.lly detec.ed in this new quantum public.key c.yptosystem under a nec.ssary c.ndition, whic. is also detailed in the paper.

关键词： quantum public.key c.ypto trapdoor one-way func.ion EPR pairs

c.ntinuous edge c.romatic.numbers of abelian group ac.ions

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Sc.enc. c.ina Mathematic. 2025年

作者： su Gao Ruijun Wang Tianhao Wang Sc.ool of Mathematic.l Sc.enc.s and Laboratory of Pure Mathematic. and c.mbinatoric. Nankai University

We prove that for any generating set S of Z~n, the c.ntinuous edge c.romatic.number χ′c.G） of the Sc.reier graph of the Bernoulli shift ac.ion G = F(S, 2Z~n) is χ′（G） + 1 = |S| + 1. In partic.lar, for the stan...

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