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The response to vedolizumab in chronic granulomatous disease-related inflammatory bowel disease

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Gastroenterology Report 2020年第5期8卷 404-406,I0003页

作者： Natasha Kamal Beatriz marciano Bryan Curtin Anna Strongin Suk See DeRavin Athos Bousvaros Christopher Koh Harry L.malech steven m.holland Christa Zerbe Theo Heller Digestive Disease Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Laboratory of Host Defenses National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA Division of Gastroenterology Hepatology and NutritionBoston Children’s HospitalBostonMAUSA Liver Disease Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Laboratory of Clinical Immunology and microbiology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA

Introduction Chronic granulomatous disease(CGD)is a rare immunodeficiency affecting approximately 1 in 200,000 people[1].Patients with CGD are unable to produce normal amounts of neutrophil superoxide and other phagocyte reactive oxygen *** a result,phagocytes have decreased microbicidal activity and patients develop recurrent bacterial and fungal infections.

关键词：慢性肉芽肿单抗治疗炎症性肠病 immunodeficiency

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青藏高原地表变暗与北极气候变化间的共振

Science Bulletin 2024年第3期69卷 367-374页

作者：汤舒畅朴世龙 David m.holland 阚飞汪涛姚檀栋李熙晨 Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China State Key Laboratory of Tibetan Plateau Earth System Resources and EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100085China Courant Institute of mathematical Sciences New York UniversityNew YorkNY 0711USA Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China

The Tibetan Plateau(TP)exerts a profound influence on global climate over million-year timescales due to its past ***,whether the ongoing climate changes over the TP,particularly the persistent reduction in its local albedo(referred to as“TP surface darkening”),can exert global impacts remains *** this study,a state-of-the-art coupled land–atmosphere global climate model has been employed to scrutinize the impact of TP darkening on polar climate *** indicate that the projected TP darkening has the potential to generate a stationary Rossby wave train,thereby modulating the atmospheric circulation in the high-latitudes of the Northern Hemisphere and instigating a dipole-like surface air temperature anomaly pattern around the Arctic *** additional experiment suggests that the projected Arctic warming may in return warm the TP,thus forming a bi-directional linkage between these two climate *** their association with vast ice reservoirs,the elucidation of this mechanism in our study is crucial in advancing our comprehension of Earth system climate projections.

关键词： Tibetan Plateau High-latitude Northern Hemisphere Arctic Climate change Albedo Surface darkening

青藏高原地表变暗与北极气候变化间的共振（英文）

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Science Bulletin 2024年第3期 367-374页

作者：汤舒畅朴世龙 David m.holland 阚飞汪涛姚檀栋李熙晨 Sino-French Institute for Earth System Science College of Urban and Environmental Sciences Peking University State Key Laboratory of Tibetan Plateau Earth System Resources and Environment Institute of Tibetan Plateau Research Chinese Academy of Sciences Courant Institute of mathematical Sciences New York University Institute of Atmospheric Physics Chinese Academy of Sciences

The Tibetan Plateau(TP) exerts a profound influence on global climate over million-year timescales due to its past uplift. However, whether the ongoing climate changes over the TP, particularly the persistent reduction in its local albedo(referred to as ‘‘TP surface darkening”), can exert global impacts remains elusive. In this study, a state-of-the-art coupled land–atmosphere global climate model has been employed to scrutinize the impact of TP darkening on polar climate changes. Results indicate that the projected TP darkening has the potential to generate a stationary Rossby wave train, thereby modulating the atmospheric circulation in the high-latitudes of the Northern Hemisphere and instigating a dipole-like surface air temperature anomaly pattern around the Arctic region. An additional experiment suggests that the projected Arctic warming may in return warm the TP, thus forming a bi-directional linkage between these two climate systems. Given their association with vast ice reservoirs, the elucidation of this mechanism in our study is crucial in advancing our comprehension of Earth system climate projections.

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Oxygen uptake response to switching stairs exercise by non-parametric modeling

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Control Theory and Technology 2024年第2期22卷 315-325页

作者： Hairong Yu Chenyu Zhang Kai Cao Hamzah m.Alqudah steven Weidong Su Key Laboratory of Child Development and Learning Science of ministry of Education and the School of Biological Science and medical Engineering Southeast UniversityNanjing210096JiangsuChina College of Artificial Intelligence and Big Data for medical Science Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117ShandongChina Faculty of Engineering and Information Technology University of Technology SydneyUltimoNSW2007Australia

Oxygen uptake plays a crucial role in the evaluation of endurance performance during exercise and is extensively utilized for metabolic assessment. This study records the oxygen uptake during the exercise phase (i.e., ascending or descending) of the stair exercise, utilizing an experimental dataset that includes ten participants and covers various exercise periods. Based on the designed experiment protocol, a non-parametric modeling method with kernel-based regularization is generally applied to estimate the oxygen uptake changes during the switching stairs exercise, which closely resembles daily life activities. The modeling results indicate the effectiveness of the non-parametric modeling approach when compared to fixed-order models in terms of accuracy, stability, and compatibility. The influence of exercise duration on estimated fitness reveals that the model of the phase-oxygen uptake system is not time-invariant related to respiratory metabolism regulation and muscle fatigue. Consequently, it allows us to study the humans’ conversion mechanism at different metabolic rates and facilitates the standardization and development of exercise prescriptions.

关键词： Non-parametric modeling Interval stair training exercise Kernel method.Cardiorespiratory response Oxygen uptake

SmILE soft X-ray Imager flight model CCD370 pre-flight device characterisation

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Earth and Planetary Physics 2024年第1期8卷 25-38页

作者： S.Parsons D.J.Hall O.Hetherington T.W.Buggey T.Arnold m.W.J.Hubbard A.holland Centre for Electronic Imaging the Open UniversityMilton KeynesMK76AAUK

Throughout the SmILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their *** order to understand the changes of the CCD370s within the soft X-ray Imager,an initial characterisation of the devices has been carried out to give a baseline performance *** CCDs have been characterised,the two flight devices and the flight spa *** has been carried out at the Open University in a bespo ke cleanroom measure ment *** results show that there is a cluster of bright pixels in the flight spa re which increases in size with tempe *** at the nominal ope rating tempe rature(-120℃) it is within the procure ment ***,the devices meet the specifications when ope rating at -120℃ in 6 × 6 binned frame transfer science *** se rial charge transfer inefficiency degrades with temperature in full frame *** any charge losses are recovered when binning/frame transfer is implemented.

关键词： CCD soft X-ray imager characterisation SmILE

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The CCD instrument background of the SmILE SXI

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： m.W.J.Hubbard O.Hetherington D.J.Hall T.W.Buggey S.Parsons T.Arnold A.holland C.Pagani S.Sembay Centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The ESA and CAS SmILE mission orbit is highly elliptical and will pass through multiple radiation *** Soft X-ray Imager(SXI)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the CCDs(Charge-Coupled Devices)that form the focal plane array of the SXI were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic Cosmic Rays(GCRs).It was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the GCRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

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Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine m Adler David O Carpenter steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： Davide mASSOCCHI Nora LECIS marco LATTUADA Davide SCAGLIA steven CHATTERTON Paolo PENNACCHI Department of mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDm).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

Thirteen years to get from b to a:one of the neglected isoforms of IL-37 enters the stage

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Cellular & molecular Immunology 2024年第2期21卷 201-202页

作者： steven X.Cho Ina Rudloff Andrew m.Ellisdon Claudia A.Nold-Petry marcel F.Nold Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Pediatrics Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia monash Newborn Monash Children’s HospitalMelbourneVICAustralia

Interleukin(IL)-37 is one of the few anti-inflammatory members of the predominantly pro-inflammatory IL-1 cytokine ***-37 possesses alarmin-like properties[1]and exerts its activities via intracellular[2]as well as cell surface receptor-dependent mechanisms,and the latter involves IL-1R8 and IL-18Rα[3].Because of its powerful and broad-spectrum“peacemaking”[4]functions,considerable efforts have been invested in developing IL-37-based anti-inflammatory therapeutics[5,6].

关键词： Interleukin neglected cytokine