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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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j.urnal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion spencer j.Allen Stephanie M.Ntoukas Gordon j.Bell j.ssica McNeil Qinggang Wang Margaret L.McNeely j.ff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau j.hn R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adj.sted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(p<0.001),poor sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(p<0.001),and multiple symptoms(p<0.001).VO_(2peak)demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

Himalayan Tectonics:Preface

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Geoscience Frontiers 2019年第3期10卷 791-792页

作者： Kyle Larson Christopher j. spencer Tectonics and Geodynamics Earth Environmental and Geographical Sciences IKBSAS University of British Columbia Earth Dynamics Research Group The Institute for Geoscience Research (TIGeR) Department of Applied Geology Curtin University

The Himalayan-Tibetan orogen system serves as the modern paradigm for understanding convergence-related processes in orogenic belts. The advancements made studying the region have been applied to other ancient orogenic belts leading not only to a better understanding of their development, but also of secular changes in collisional processes. As more advanced methodologies are introduced and utilized in geological research, the type, scale, and quality of data available enable quantification of geological processes not previously possible. These complex and robust datasets now form the core of many of the research proj.cts undertaken across the Himalaya and continue to provide unprecedented insight into the myriad different aspects of the evolution of the collisional system.

关键词： Himalayan-Tibetan system evolution

A Study of the TPS Based Beam-Matching Concept for Medical Linear Accelerators at a Tertiary Hospital

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International j.urnal of Medical Physics, Clinical Engineering and Radiation Oncology 2024年第1期13卷 16-25页

作者： Ntombela N. Lethukuthula Rovetto j. Nicolas Nethwadzi C. Lutendo Mpumelelo Nyathi Department of Radiation Oncology Steve Biko Academic Hospital Pretoria South Africa Department of Medical Physics University of Pretoria Pretoria South Africa Department of Medical Physics Sefako Makgatho Health Sciences University Ga-Rankuwa South Africa

The flexibility in radiotherapy can be improved if patients can be moved between any one of the department’s medical linear accelerators (LINACs) without the need to change anything in the patient’s treatment plan. For this to be possible, the dosimetric characteristics of the various accelerators must be the same, or nearly the same. The purpose of this work is to describe further and compare measurements and parameters after the initial vendor-recommended beam matching of the five LINACs. Deviations related to dose calculations and to beam matched accelerators may compromise treatment accuracy. The safest and most practical way to ensure that all accelerators are within clinical acceptable accuracy is to include TPS calculations in the LINACs matching evaluation. Treatment planning system (TPS) was used to create three photons plans with different field sizes 3 × 3 cm, 10 × 10 cm and 25 × 25 cm at a depth of 4.5 cm in Perspex. Calculated TPS plans were sent to Mosaiq to be delivered by five LINACs. TPS plans were compared with five LINACs measurements data using Gamma analyses of 2% and 2 mm. The results suggest that for four out of the five LINACs, there was generally good agreement, less than a 2% deviation between the planned dose distribution and the measured dose distribution. However, one specific LINAC named “Asterix” exhibited a deviation of 2.121% from the planned dose. The results show that all of the LINACs’ performance were within the acceptable deviation and delivering radiation dose consistently and accurately.

关键词： Radiotherapy Beam-Matching Linear Accelerator Dosimetry

"Miles wide and miles deep"-Exploring the depth and breadth of geoscience during the first ten years of Geoscience Frontiers

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Geoscience Frontiers 2019年第3期10卷 1219-1221页

作者： Christopher j. spencer Nick M.W.Roberts Damian Nance The Institute of Geoscience Research (TIGeR) School of Earth and Planetary Sciences Curtin University NERC Isotope Geosciences Laboratory British Geological Survey Department of Geological Sciences Ohio University Department of Geology and Geophysics Yale University

When early explorers first crossed the Platte River in what is now Nebraska (USA), it was said the river was “a mile wide and an inch deep”(Mokler, 1923;Smith, 1971). This phrase was used to describe not only the difficulty in crossing the river but also in navigating its length. The trouble with a river being too wide is the risk that it won’t provide the depth necessary to be useful. The same thing can be said of multidisciplinary scientific j.urnals. While a j.urnal can claim to be multidisciplinary, there is a risk of it being so broad that its articles can only engage the reader at a superficial level. Nothing could be further from the truth with Geoscience Frontiers. Over the past ten years, this j.urnal has successfully navigated the wide breadth of geoscience while providing a level of depth and detail that rivals discipline-specific j.urnals.

关键词： engage its was can past be is now

Chromatic Mapping of Partial Discharge Signals

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高电压技术 2013年第10期39卷 2532-2540页

作者： M. Ragaa G. R. j.nes A. G. Deakin j. W. spencer Northern Powergrid Castleford WF 10 5DS UK Department of Electrical Engineering and Electronics Centre for Intelligent Monitoring Systems University of Liverpool Liverpool L69 3G J UK

This contribution describes the use of chromatic techniques for quantifying signatures of partial discharges(PD).A brief description of the basis of chromatic monitoring is given along with explanations of how the approach may be applied for addressing signals produced by *** test data from several sources for different types of PDs,operating conditions and geometries have been subj.cted to the chromatic *** include a point-plane gap,a sphere in a liquid and treeing in a *** changes in PD signals have been investigated as a function of the amplitude of the alternating voltage producing the PD,the time duration before full electrical breakdown and for different forms of *** of the chromatic processing of these data are presented in the form of a number of chromatic maps relating to different quarter cycles of the alternating voltage producing the *** results show the potential of the chromatic techniques for indicating the likelihood of full electrical breakdown and for distinguishing between certain forms of PDs.A summary of the chromatic processing procedures is presented for producing chromatic maps and for adaptation in further exploring PD signal features.

关键词：局部放电信号 PD信号映射交流电压彩色地图测试数据几何形状操作条件

Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 B from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： j.a-Qi Wang Xiao-j.n j.ang j.e Zheng Hanna Kellermann Arno Riffeser Liang Wang Karen A.Collins Allyson Bieryla Lars A.Buchhave steve B.Howell Elise Furlan Eric Girardin j.ao Gregorio Eric j.nsen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-j.an Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanj.ng Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinj.ang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lij.ang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(j.,and a very low mass companion star with a mass of about 96.5±1.5 Mj.TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Obj.cts of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041Rj.and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(j. and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

Visualising data distributions with kernel density estimation and reduced chi-squared statistic

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Geoscience Frontiers 2017年第6期8卷 1247-1252页

作者： C.j.spencer C.Yakymchuk M.Ghaznavi Earth Dynamics Research Group The Institute of Geoscience ResearchDepartment of Applied GeologyCurtin UniversityPerthAustralia Department of Earth and Environmental Sciences University of WaterlooWaterlooCanada David R.Cheriton School of Computer Science University of WaterlooWaterlooCanada

The application of frequency distribution statistics to data provides obj.ctive means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret *** commonly used tools are the kernel density estimation and reduced chi-squared statistic used in combination with a weighted *** to the wide applicability of these tools,we present a j.va-based computer application called KDX to facilitate the visualization of data and the utilization of these numerical tools.

关键词： Data visualisation Kernel density estimation Reduced chi-squared statistic Mean square weighted deviation Geostatistics

Strategies towards statistically robust interpretations of in situ U-Pb zircon geochronology

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Geoscience Frontiers 2016年第4期7卷 581-589页

作者： Christopher j.spencer Christopher L.Kirkland Richard j.M.Taylor The Institute of Geoscience Research(TIGeR) Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Centre for Exploration Targeting-Curtin Node Department of Applied GeologyWestern Australian School of MinesCurtin UniversityWA 6102Australia Australian Research Council Centre of Excellence for Core to Crust Fluid SystemsPerthWA 6102Australia

Zircon U-Pb geochronology has become a keystone tool across Earth science, arguably providing the gold standard in resolving deep geological time. The development of rapid in situ analysis of zircon （via laser ablation and secondary ionization mass spectrometry） has allowed for large amounts of data to be generated in a relatively short amount of time and such large volume datasets offer the ability to address a range of geological questions that would otherwise remain intractable （e.g. detrital zircons as a sedi- ment fingerprinting method）. The ease of acquisition, while bringing benefit to the Earth science com- munity, has also led to diverse interpretations of geochronological data. In this work we seek to refocus U -Pb zircon geochronology toward best practice by providing a robust statistically coherent workflow. We discuss a range of data filtering approaches and their inherent limitations （e.g. discordance and the reduced chi-squared; MSWD）. We evaluate appropriate mechanisms to calculate the most geologically appropriate age from both 238U/206pb and 207pb/206pb ratios and demonstrate the cross over position when chronometric power swaps between these ratios. As our in situ analytical techniques become progressively more precise, appropriate statistical handing of U-Pb datasets will become increasingly pertinent.

关键词： Zircon Geochronology U-Pb Geostatistics MSWD

Timescales of geological processes: Preface

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Geoscience Frontiers 2019年第1期10卷 1-3页

作者： Andrew Putnis Christopher j.spencer Tom Raimondo The Institute for Geoscience Research School of Earth and Planetary Science Curtin University School of Natural and Built Environments University of South Australia

*** One of the maj.r challenges in Geoscience is to understand how the formation and evolution of the Earth System are governed by timescales-that is,how the various geological processes that continue to contribute to its present-day structure and composition operated in the deep *** traditional view of such processes refers to events that occur at immense spatial scales and over hundreds of millions of years,constrained in most cases by the ages of rocks determined using isotopic dating methods or the fossil ***,the modern view of geological processes has increasingly acknowledged that their durations can be significantly shorter than previously thought possible,or indeed detectable without recent analytical *** are a prime example of rapid,high energy and episodic events that have a profound effect on subsequent processes such as metamorphism,fluid transport,and ore formation e the evidence of which is written in microstructures,compositional zoning,and P-T *** studies have also revealed that the reaction rates between fluids and rocks can be extremely rapid relative to geological *** has led to the notion that geological processes are not necessarily continuous over millions of years but may,in fact,be sporadic,with long periods where essentially no reactions take place punctuated by periods of intense activity.

关键词： In Preface Timescales of geological processes