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Regional trends and petrologic factors inhibit global interpretations of zircon trace element compositions

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Geoscience Frontiers 2024年第5期15卷 300-307页

作者： Nick M.w.Roberts Christopher J.Spencer stephen Puetz C.Brenhin Keller Simon Tapster Geochronology and Tracers Facility British Geological SurveyNottingham NG125GGUK Department of Geological Sciences and Geological Engineering Queen’s UniversityKingstonOntarioCanada Atkinson Dr Suite 704HonoluluHI 96814USA Department of Earth Sciences Dartmouth CollegeHanoverNew HamphireUSA

The trace element composition of zircon reveals information about the melt that they are derived from,as such,detrital zircon trace element compositions can be used to interrogate melt compositions,and thus the evolution of the continental crust in time and ***,we present a global database of detrital zircon compositions and use it to test whether average global trends for five common petrogenetic proxies truly represent secular changes in continental *** demonstrate that the secular trend is broadly comparable across continental regions for Ti-in-zircon temperatures,but for other trace element ratios interrogated,secular trends are highly variable between continental *** trace element ratios result from multiple petrologic variables,we argue that these petrogenetic proxies can be overinterpreted if projected to global geologic *** particular,we caution against the interpretation of crustal thickness from trace elements in zircon,and we argue that our results negate current hypotheses concerning secular changes in crustal thickness.

关键词： Detrital zircon Trace elements Secular change Eu anomaly Crustal thickness

The replication crisis and its relevance to Earth Science studies:Case studies and recommendations

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Geoscience Frontiers 2024年第4期15卷 304-314页

作者： stephen J.Puetz Kent C.Condie Kurt Sundell Nick M.w.Roberts Christopher J.Spencer Slah Boulila Qiuming Cheng 475 Atkinson Dr Suite 704HonoluluHI 96814USA New Mexico Institute of Mining and Technology SocorroNM 87801USA Idaho State University PocatelloID 83209USA Geochronology and Tracers Facility British Geological SurveyKeyworthNottingham NG125GGUK Queen’s University Department of Geological Sciences and Geological EngineeringKingstonOntario K7L 3N6Canada Sorbonne Université CNRSInstitut des Sciences de la Terre ParisParisFrance State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China

Numerous scientific fields are facing a replication crisis,where the results of a study often cannot be replicated when a new study uses independent *** issue has been particularly emphasized in psychology,health,and medicine,as incorrect results in these fields could have serious consequences,where lives might be at *** other fields have also highlighted significant replication problems,the Earth Sciences seem to be an *** paucity of Earth Science research aimed at understanding the replication crisis prompted this ***,this work aims to fill that gap by seeking to replicate geological results involving various types of *** identify and discuss 11 key variables for replicating U-Pb age distributions:independent data,global sampling,proxy data,data quality,disproportionate non-random sampling,stratigraphic bias,potential filtering bias,accuracy and precision,correlating time-series segments,testing assumptions and divergent analytical methods,and analytical *** while this work primarily focuses on U-Pb age distributions,most of these factors(or variations of them)also apply to other geoscience ***,some of the discussions involve time-series consisting ofεHf,δ18O-zircon,14C,10Be,marineδ13C,and marineδ*** then provide specific recommendations for minimizing adverse effects related to these factors,and in the process enhancing prospects for replicating geological results.

关键词： Replication crisis Replicability Independent data Global time-series Globality index Filtered data

Non-canonical BRAF variants and rearrangements in hairy cell leukemia

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Oncology Research 2024年第9期32卷 1423-1427页

作者： stephen E.LANGABEER Cancer Molecular Diagnostics St.James’s HospitalDublinD08 W9RTIreland

Hairy cell leukemia(HCL)is an uncommon mature B-cell malignancy characterized by a typical morphology,immunophenotype,and clinical *** vast majority of HCL patients harbor the canonical BRAF V600E mutation which has become a rationalized target of the subsequently deregulated RAS-RAF-MEK-MAPK signaling pathway in HCL patients who have relapsed or who are refractory to front-line ***,several HCL patients with a classical phenotype display non-canonical BRAF mutations or *** include sequence variants within alternative exons and an oncogenic fusion with the IGH *** must be taken in the molecular diagnostic work-up of patients with typical HCL but without the BRAF V600E to include investigation of these uncommon ***,functional characterization,and reporting of further such patients is likely to provide insights into the pathogenesis of HCL and enable rational selection of targeted inhibitors in such patients if required.

关键词： Hairy cell leukemia BRAF Molecular diagnostics Targeted therapy

MethylGenotyper:Accurate Estimation of SNP Genotypes and Genetic Relatedness from DNA Methylation Data

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 43-54页

作者： Yi Jiang Minghan Qu Minghui Jiang Xuan Jiang Shane Fernandez Tenielle Porter Simon M.laws Colin L.Masters Huan Guo Shanshan Cheng Chaolong wang Ministry of Education Key Laboratory of Environment and Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Centre for Precision Health Edith Cowan UniversityPerthWA 6027Australia Collaborative Genomics and Translation Group School of Medical and Health SciencesEdith Cowan UniversityPerthWA 6027Australia Curtin Medical School BentleyWA 6102Australia The Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVIC 3052Australia Department of Occupational and Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Epigenome-wide association studies(EwAS)are susceptible to widespread confounding caused by population structure and genetic ***,kinship estimation is challenging in EwAS without genotyping ***,we proposed MethylGenotyper,a method that for the first time enables accurate genotyping at thousands of single nucleotide polymorphisms(SNPs)directly from commercial DNA methylation *** modeled the intensities of methylation probes near SNPs with a mixture of three beta distributions corresponding to different genotypes and estimated parameters with an expectation-maximization *** conducted extensive simulations to demonstrate the performance of the *** applying MethylGenotyper to the Infinium EPIC array data of 4662 Chinese samples,we obtained genotypes at 4319 SNPs with a concordance rate of 98.26%,enabling the identification of 255 pairs of close ***,we showed that MethylGenotyper allows for the estimation of both population structure and cryptic relatedness among 702 Australians of diverse *** also implemented MethylGenotyper in a publicly available R package(https://***/Yi-Jiang/MethylGenotyper)to facilitate future large-scale EwAS.

关键词： DNA methylation Genotype calling Genetic relatedness Population structure Epigenome-wide association study

Superexchange and charge transfer in the nickelate superconductor La_(3)Ni_(2)O_(7) under pressure

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 1-8页

作者： wéi wú Zhihui Luo Dao-Xin Yao Meng wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Recently, a bulk nickelate superconductor La_(3)Ni_(2)O_(7) is discovered at pressures with a remarkable high transition temperature T_(c)~ 80 K. Here, we study a Hubbard model with tight-binding parameters derived from ab initio calculations of La_(3)Ni_(2)O_(7),by employing large scale determinant quantum Monte Carlo and cellular dynamical mean-field theory. Our result suggests that the superexchange couplings in this system are comparable to that of cuprates. The system is a charge transfer insulator as the hole concentration becomes four per site at large Hubbard U. Upon hole doping, two low-energy spin-singlet bands emerge in the system exhibiting distinct correlation properties: while the one composed of the out-of-plane Ni-d_(3z^(2)-r^(2)) and O-p_(z) orbitals demonstrates strong antiferromagnetic correlations and narrow effective bandwidth, the in-plane singlet band consisting of the Ni-d_(x^(2)-y^(2)) and O-p_(x)/p_(y) orbitals is in general more itinerant. Over a broad range of hole doping, the doped holes occupy primarily the d_(x^(2)-y^(2)) and p_(x)/p_(y) orbitals, whereas the d_(3z^(2)-r^(2)) and p_(z) orbitals retain underdoped. we propose an effective t-J model to capture the relevant physics and discuss the implications of our result for comprehending the La_(3)Ni_(2)O_(7) superconductivity.

关键词： superconductivity nickelate superconductors Hubbard model superexchange charge transfer insulator quantum Monte Carlo

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： H.T.Jeong S.w.Lee w.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the HCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

Pervasive Attentive Neural Network for Intelligent Image Classification Based on N-CDE’s

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Computers, Materials & Continua 2024年第4期79卷 1137-1156页

作者： Anas w.Abulfaraj Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityRabigh21911Saudi Arabia

The utilization of visual attention enhances the performance of image classification *** attentionbased models have demonstrated notable performance,but many of these models exhibit reduced accuracy when confronted with inter-class and intra-class similarities and ***-Controlled Differential Equations(N-CDE’s)and Neural Ordinary Differential Equations(NODE’s)are extensively utilized within this ***’s possesses the capacity to effectively illustrate both inter-class and intra-class similarities and differences with enhanced *** this end,an attentive neural network has been proposed to generate attention maps,which uses two different types of N-CDE’s,one for adopting hidden layers and the other to generate attention *** distinct attention techniques are implemented including time-wise attention,also referred to as bottom N-CDE’s;and element-wise attention,called topN-CDE’***,a trainingmethodology is proposed to guarantee that the training problem is sufficiently *** classification tasks including fine-grained visual classification andmulti-label classification,are utilized to evaluate the *** proposedmethodology is employed on five publicly available datasets,including CUB-200-2011,ImageNet-1K,PASCAL VOC 2007,PASCAL VOC 2012,and MS *** obtained visualizations have demonstrated that N-CDE’s are better appropriate for attention-based activities in comparison to conventional NODE’s.

关键词： Differential equations neural-controlled DE image classification attention maps N-CDE’s

The quasi-Gramian solution of a non-commutative extension of the higher-order nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 51-61页

作者： H w A Riaz J Lin Department of Physics Zhejiang Normal UniversityJinhua 321004China

The nonlinear Schr?dinger(NLS)equation,which incorporates higher-order dispersive terms,is widely employed in the theoretical analysis of various physical *** this study,we explore the non-commutative extension of the higher-order NLS *** treat real or complex-valued functions,such as g_(1)=g_(1)(x,t)and g_(2)=g_(2)(x,t)as non-commutative,and employ the Lax pair associated with the evolution equation,as in the commutation *** derive the quasi-Gramian solution of the system by employing a binary Darboux *** soliton solutions are presented explicitly within the framework of *** visually understand the dynamics and solutions in the given example,we also provide simulations illustrating the associated ***,the solution can be used to study the stability of plane waves and to understand the generation of periodic patterns within the context of modulational instability.

关键词： integrable systems Darboux transformation solitons

Recent Advances in the Synthesis and Polymerization of New CO_(2)-Based Cyclic

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Chinese Journal of Chemistry 2024年第4期42卷 430-443页

作者： Matteo Lanzi Arjan w.Kleij Institute of Chemical Research of Catalonia(ICIQ) The Barcelona Institute of Science and Technology(BIST)Av.Països Catalans 1643007 TarragonaSpain Catalan Institute of Research and Advanced Studies(ICREA) Pg.Lluís Companys 2308010 BarcelonaSpain

Carbon dioxide can be converted into functional heterocycles known as cyclic carbonates,whose recent reactivity has been expanded towards the formation of tailor-made engineering *** minireview gives an overview of the most topical developments in this area with a special focus on the synthetic methods employed to prepare these CO_(2)based *** addition,their application potential in the area of polymer science using a variety of polymerization techniques is discussed that have in common the ring-opening of the carbonate *** perspectives are provided that provide impetus for the scientific communities aligning research to the use of sustainable processes for polymers from recyclable carbon sources such as CO_(2).

关键词： Carbon dioxide Cyclic carbonates Functional macromolecules Heterocycles Polycarbonates Recycling Ring opening polymerization