检索结果-南通市图书馆

隐性营养不良性大疱性表皮松解症患者体内的维生素和微量金属元素水平

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 27-27页

作者： Ingen-Housz-Oro S. Blanchet-Bardon C. Vrillat m. Dubertret L. 马慧群 Department of Dermatology Centre Hospitalier Victor Dupouy 69 rue du Lieutenant Col Prud'hon 95107 Argenteuil Cedex France

Background. In recessive dystrophic epidermolysis bullosa (RDEB), a good nutr itional balance is necessary to obtain healing of the chronic wounds. However, i nvolvement of the oral mucosa and oesophagus stenosis may be responsible for sev ere nutritional deficiencies. Objective. In order to propose an adapted nutritio nal management, we studied the vitamin and trace metal status of 14 RDEB patient s. methods. Height and weight were measured. Plasma levels of albumin, iron, fer ritin, calcium, parathyroid hormone (PTH), folates, vitamins C, D, B12, A, E, B1 , B6, PP and B2, zinc, selenium, carnitine and copperweremeasured. Results. most patients had a significant growth retardation. We found iron, vitamin D, C, B6, PP, zinc and selenium deficiencies in 36- 70% of the patients, without clini cal expression, except in one case. Vitamin B1, 12, B2, A/RBP, E/lipids and carn itine were normal. The three patients with gastrostomy feeding had better growth but still a protein deficiency and sometimes vitamin C, B6, PP, zinc and carnit ine deficiencies. Conclusion. Vitamin and trace metal deficiencies are frequent in RDEB, even in patients receiving gastrostomy feeding, and often go unrecogniz ed. Regular nutritional evaluation is necessary. Dietary advice and supplements should be given. Enteral feeding by gastrostomy should be discussed in early chi ldhood.

关键词：营养不良性微量金属元素甲状旁腺激素口腔黏膜食管狭窄胃造口术肠道喂养营养治疗肉毒碱营养评价

全谷物饲喂对母羊生产性能、胴体特性和肉质的影响

在线全文

学校读者我要写书评

暂无评论

饲料博览 2016年第3期 58-58页

作者： Fruet A P B Stefanello F S Júnior A G R Souza A N m Tonetto C J N?rnberg J L

为评估牧草饲喂和全谷物饲喂对牧场母羊生产性能、胴体特性及肉质的影响,随机挑选波耳沃斯母羊41只,分成6组:RY组(饲喂黑麦牧草)、RYgo组(饲喂黑麦牧草和燕麦)、RYGm组(饲喂黑麦牧草和玉米)、Gm组(全玉米)、go组(全燕麦)和GS组(全高粱)... 详细信息

为评估牧草饲喂和全谷物饲喂对牧场母羊生产性能、胴体特性及肉质的影响,随机挑选波耳沃斯母羊41只,分成6组:RY组(饲喂黑麦牧草)、RYgo组(饲喂黑麦牧草和燕麦)、RYGm组(饲喂黑麦牧草和玉米)、Gm组(全玉米)、go组(全燕麦)和GS组(全高粱)。试验结束后,对母羊进行屠宰发现,Gm组和GS组的平均日增重较高,go组的屠宰率较低,不同组间的母羊在肉的红色指数、色泽度、p H、蒸煮损失和嫩度方面差异较小。对牧场母羊肉质的主成分分析、C18:2n-6变量值、色泽度、n-6/n-3、硫代巴比妥酸反应活性物质(TBARS)含量、总脂质含量、明度、泛黄指数等指标进行评定发现,试验中饲喂牧草能促进母羊肉中共轭亚油酸和n-3脂肪酸的积累,但降低TBARS含量,而使脂质稳定。

关键词：肉质羊脂肪酸高谷物日粮黑麦草

采用意大利多中心前瞻性研究以评估16层及64层mDCT对计划行冠状动脉造影病人的阴性预测值(NImISCAD-意大利冠心病无创性多中心性研究)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2009年第4期32卷 402-402页

作者： R. marano F. De Cobelli I. Floriani C. Becker C. Herzog m. Centonze 王卿（译）李威（校） Department of Bioimaging and Radiological Sciences Institute of Radialosy ＂A. Gemelli＂ Hospital - Catholic University L.go A Gemelli 8 00168 Rome Italy. 不详

这是一项多中心的前瞻性研究．通过应用不同制造商生产的mDCT设备,对计划行选择性冠状动脉造影（CA）的病人行mDCT检查以对其诊断冠心病（CAD）的价值进行评估。2004年7月-2006年6月间．在20所国家医院前瞻性地征集了367例病人。对于每... 详细信息

这是一项多中心的前瞻性研究．通过应用不同制造商生产的mDCT设备,对计划行选择性冠状动脉造影（CA）的病人行mDCT检查以对其诊断冠心病（CAD）的价值进行评估。2004年7月-2006年6月间．在20所国家医院前瞻性地征集了367例病人。对于每种类型的mDCT（≥16层）,CT检查均采用标准化／优化的扫描方案,并且与2周内进行的定量冠状动脉造影比较。共有284例病人（81％）应用16层mDCT进行检查,66例病人（19％）应用64层mDCT进行检查。初步分析采用院内／院外的方法,评估对1例病人的阴性预测值（NPV）。

关键词：多层螺旋CT 冠心病心脏CT

Crohn病病人小肠外科切除术后的CT肠成像检查和PEG-CT检查:CT的结果及与内镜检查结果的关系

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2009年第6期 604-604页

作者： L.m.minordi A.Vecchioli G.Poloni L.Bonomo I.De Vitis L.Bonomo 余丽芳 Department of Bio-Imaging and Radiological Sciences Catholic UniversityL.go Agostino Gemelli 800168 RomeItaly

研究目的在于评价多层CT扫描诊断Crohn病(CD)病人回结肠切除术后复发的准确性,并与内镜检查对比。34例病人均行内镜和多层CT检查,其中21例病人服用聚乙烯糖溶液,13例病人经由鼻胃管导入甲基纤维素溶液。CT检查评价以下几种征象:肠壁增... 详细信息

研究目的在于评价多层CT扫描诊断Crohn病(CD)病人回结肠切除术后复发的准确性,并与内镜检查对比。34例病人均行内镜和多层CT检查,其中21例病人服用聚乙烯糖溶液,13例病人经由鼻胃管导入甲基纤维素溶液。CT检查评价以下几种征象:肠壁增厚、靶

关键词：内镜检查小肠 PEG-CT Crohn 病人

溶酶体酸化可增强吞噬性星形胶质细胞的消化功能

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

神经损伤与功能重建 2015年第5期10卷 425-425页

作者： Kelly R.monk m.Laura Feltri Carla Taveggia Camilla Lv Claire H.mitchell martin Simonsson Anna Erlandsson 唐颖馨 Department of Neuroscience Uppsala University Uppsala University Hospital Department of Anatomy and Cell Biology University of Pennsylvania Department of Physiology University of Pennsylvania SciL ife Lab and Department of Computer Science Electrical & Space Engineering Lulea University of Technology Department of Public Health and Caring Sciences Uppsala University Rudbeck Laboratory

低效的溶酶体降解是多种脑部疾病发展的中心环节,但其具体机制及参与的细胞种类仍不清楚。既往研究显示,星形胶质细胞大量吞噬死亡的细胞,但将这些吞噬的物质储存在细胞内而不是进行降解。本研究对星形胶质细胞降解消化功能减弱的原因... 详细信息

低效的溶酶体降解是多种脑部疾病发展的中心环节,但其具体机制及参与的细胞种类仍不清楚。既往研究显示,星形胶质细胞大量吞噬死亡的细胞,但将这些吞噬的物质储存在细胞内而不是进行降解。本研究对星形胶质细胞降解消化功能减弱的原因进行研究,并探索增强星形胶质细胞降解消化功能的方法。结果显示,长期存在于吞噬泡周围的肌动环阻碍了溶酶体的吞噬溶解作用。此外,Rab27a蛋白可以通过Nox2减少溶酶体的酸化,而星形胶质细胞高表达Rab27a蛋白,阻碍抗原呈递。本研究还发现,Nox2与星形胶质细胞摄取的物质共定位,且表达主要组织相容性复合体II,提示这可能影响星形胶质细胞内的抗原呈递。使用酸化纳米粒子对星形胶质细胞溶酶体进行长时间的酸化处理,能增加星形胶质细胞对所摄取物质和死亡细胞的消化。但随着酸化时间的延长,星形胶质细胞的消化能力再次回复到较低水平,提示随着酸化作用的增强,细胞的对抗酸化的通路也相应增强了。

关键词： Nox2 消化星形胶质细胞溶酶体纳米粒子 pHrodo 染料吞噬作用

Refined families of Dothideomycetes:orders and families incertae sedis in Dothideomycetes

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2020年第6期105卷 17-318页

作者： Sinang Hongsanan Kevin D.Hyde Rungtiwa Phookamsak Dhanushka N.Wanasinghe Eric H.C.mcKenzie V.Venkateswara Sarma Robert Lücking Saranyaphat Boonmee Jayarama D.Bhat Ning-Guo Liu Danushka S.Tennakoon Dhandevi Pem Anuruddha Karunarathna Shu-Hua Jiang Gareth E.B.Jones Alan J.L.Phillips Ishara S.manawasinghe Saowaluck Tibpromma Subashini C.Jayasiri Diana Sandamali Ruvishika S.Jayawardena Nalin N.Wijayawardene Anusha H.Ekanayaka Rajesh Jeewon Yong-Zhong Lu Chayanard Phukhamsakda Asha J.Dissanayake Xiang-Yu Zeng Zong-Long Luo Qing Tian Kasun m.Thambugala Dongqin Dai milan C.Samarakoon K.W.Thilini Chethana Damien Ertz mingkwan Doilom Jian-Kui(Jack)Liu Sergio Pérez-Ortega Ave Suija Chanokned Senwanna Subodini N.Wijesinghe mekala Niranjan Sheng-Nan Zhang Hiran A.Ariyawansa Hong-Bo Jiang Jin-Feng Zhang Chada Norphanphoun Nimali Ide Silva Vinodhini Thiyagaraja Huang Zhang Jadson D.P.Bezerra Ricardo miranda-gonzález AndréAptroot Hiroyuki Kashiwadani Dulanjalee Harishchandra Emmanuël Sérusiaux Pranami DAbeywickrama Dan-Feng Bao Bandarupalli Devadatha Hai-Xia Wu Kwang Hee moon Cecile Gueidan Felix Schumm Digvijayini Bundhun Ausana mapook Jutamart monkai Chitrabhanu S.Bhunjun Putarak Chomnunti Satinee Suetrong Napalai Chaiwan monika C.Dayarathne Jing Yang Achala R.Rathnayaka Jian-Chu Xu Jiesheng Zheng Gang Liu Yao Feng Ning Xie Guangdong Provincial Key Laboratory for Plant Epigenetics Shenzhen Key Laboratory of Microbial Genetic EngineeringCollege of Life Science and OceanographyShenzhen UniversityShenzhen 518060People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand CAS Key Laboratory for Plant Diversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Centre for mountain Futures(CmF) Kunming Institute of BotanyKunming 650201YunnanPeople’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50002Thailand Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China World Agroforestry Centre East and Central Asia132 Lanhei RoadKunming 650201YunnanPeople’s Republic of China manaaki Whenua-Landcare Research Private Mail Bag 92170AucklandNew Zealand Fungal Biotechnology Lab Department of BiotechnologySchool of Life SciencesPondicherry UniversityKalapetPondicherry 605014India School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Botanischer Garten und Botanisches museum Freie Universität BerlinKönigin-Luise-Straße 6-814195 BerlinGermany 13128/1-J Azad Co-Op Housing SocietyCurcaP.O.Goa Velha 403108India Faculty of Agriculture Natural Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of C

Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et *** 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern *** this paper,we provide a refined updated document on orders and families incertae sedis of *** family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological *** also provide phylogenetic trees for each *** this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological *** new order,Catinellales,and four new families,Catinellaceae,morenoinaceae Neobuelliellaceae and Thyrinulaceae are *** genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,macroconstrictolumina,Pseudobogoriella,and Schummia)are *** new species(Acrospermum urticae,Bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different *** new combinations are also provided in this paper.

关键词： Abrothallales Ascrospermales Asterinales Botryosphaeriales Catinellales Cladoriellales Collemopsidiales Dyfrolomycetales Eremithallales Eremomycetales Jahnulales Kirschsteiniotheliales Lembosinales Lichenotheliales microthyriales minutisphaerales monoblastiales murramarangomycetales new family new genera new order new species Parmulariales Patellariales Phaeotrichales Phylogeny Stigmatodiscales Strigulales Superstratomycetales Taxonomy Trypetheliales Tubeufiales Valsariales Venturiales Zeloasperisporiales

发育中的小鼠海马星形胶质细胞功能性合胞体的产生

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

神经损伤与功能重建 2023年第3期18卷 F0003-F0003页

作者：杜一星(编译) Department of Neuroscience Ohio State University Wexner Medical Center Department of Neurology Shanghai 10th Hospital of Tongji University School of Medicine Department of Physiology Tongji Medical College Department of Neurology Wuhan First Hospital

越来越多的证据表明星形胶质细胞在脑功能中起着等电位合胞体的作用。原生质星形胶质细胞通过以下方面获得了这种在功能上超越单细胞水平的能力:进化为海绵状形态、细胞质连接成合胞体,以及表达高密度的K+电导。然而,围生期新生星形胶... 详细信息

越来越多的证据表明星形胶质细胞在脑功能中起着等电位合胞体的作用。原生质星形胶质细胞通过以下方面获得了这种在功能上超越单细胞水平的能力:进化为海绵状形态、细胞质连接成合胞体,以及表达高密度的K+电导。然而,围生期新生星形胶质细胞中并不存在这些细胞/功能特征。由此我们提出了一个基本问题,即在发育中的大脑中功能性合胞体是何时形成的。我们的结果表明,海马CA1区的星形胶质细胞的海绵状形态及其空间组织均在出生后第15天达到稳定水平。在功能上,星形胶质细胞在出生11 d即开始统一表达成熟水平的被动K+电导。我们使用合胞体等电位来监测星形胶质细胞合胞体的成熟。在出生1 d小鼠的非偶联星形胶质细胞中,用Na+电极溶液([Na+]p)替代内源性K+导致了生理膜电位(Vm)以及goldman-Hodgkin-Katz(GHK)方程预测的外向K+电导的完全消除。随着发育过程中更多的星形胶质细胞通过缝隙连接相互耦合,[Na+]p诱导的生理Vm和向外的K+电导的损失逐渐由邻近的星形胶质细胞所补偿。到出生后15 d,在所有[Na+]p记录的星形胶质细胞中均出现稳定建立的合胞体等电位(-73 mV)和完全补偿的外向K+电导。因此,鉴于单个合胞体在解剖和功能上用于合胞体内K+平衡功能建立的发育时间框架,星形胶质细胞合胞体在出生15 d的小鼠海马体中可全面行使其功能。

关键词： K+电导星形胶质细胞电耦合缝隙连接合胞体等电位

FAIR Principles:Interpretations and Implementation Considerations

在线全文

学校读者我要写书评

暂无评论

Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet melanie Courtot merce Crosas michel Dumontier Chris T.Evelo Carole goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara magagna PetermcQuilton Natalie meyers Annalisa montesanti mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn mark Thompson Andra Waagmeester Tobias Weigel mark D.Wilkinson Egon L.Willighagen Peter Wittenburg marco Roos Barend mons Erik Schultes Leiden University medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UmC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EmBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic go FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges