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Journal of Geological Resource and Engineering 2014年第1期2卷 39-54页

作者： Elena A. Kalinina William J. Peplinski Vincent c. Tidwell David B. hart Sandia National Laboratories Albuquerque 87185 NM USA

The cLM （community Land Model） simulates major physical processes at the land surface and in the shallow subsurface and calculates the parameters that are then used as the inputs into the atmospheric model. The major goal of this study was to identify the parameters that have greatest impacts on these inputs and thus, the greatest potential to impact the climate in Arctic environment. Another goal was to identify the limitations in representing different physical processes and to determine whether these limitations restrict the ability of cLM to predict the distribution of energy at the land surface. The focus of this analysis is on the vegetation and soil models. The analysis was conducted for a grid cell near Fairbanks, Alaska. A range of hydrogeologic and thermal soil properties and vegetation characteristics was defined for the vegetation and soil parameters. Multiple cLM sensitivity runs were performed. The sensitivity cases that produced noticeable differences either between the mean soil temperatures or/and between ground temperatures were the cases related to the LAI （leaf area index）, SAI （stem area index）, and soil moisture （shallow water table conditions）. These results were explained based on the analysis of the net radiation partitioning at the land surface.

关键词： Soil moisture soil temperature vegetation properties ground heat latent heat sensible heat.

ciprofloxacin 对生殖道致病微生物的作用

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国际泌尿系统杂志 1985年第6期05卷 269-270页

作者： c Anthony hart 李崇贤

提要:作者对喹啉羧酸,ciprofloxacin在试管内对各种生殖道致病微生物的作用进行了测定。分离出的35株淋球菌中的每一株,包括一些能产生β-内酰胺酶的和对四环素有抗药性的菌株,在0.01mg/l的浓度中被抑制,大多数Gardnerella Vaginalis菌... 详细信息

提要:作者对喹啉羧酸,ciprofloxacin在试管内对各种生殖道致病微生物的作用进行了测定。分离出的35株淋球菌中的每一株,包括一些能产生β-内酰胺酶的和对四环素有抗药性的菌株,在0.01mg/l的浓度中被抑制,大多数Gardnerella Vaginalis菌株在1mg/1的浓度中被抑制,但有三种分离出的菌株的最低抑制浓度为8mg/l或更高。7种沙眼衣原体的每一种在2mg/l的浓度中完全被抑制,而各种衣原体在这种浓度时需长时间(72小时)与ciprofloxacin接触才被抑制。

关键词：生殖道抗菌作用淋球菌淋病奈瑟氏球菌沙眼衣原体衣原体属 ciprofloxacin 致病微生物病原微生物

抗生素耐药性是否日趋严重?该问题由来已久,但我们仍可有所作为

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英国医学杂志中文版 1998年第2期1卷 51-52页

作者： c A hart 王爱霞 Professor of medical microbiology University of Liverpool PO Box 147 Liverpool L69 3GA

虽然"抗生素时代"始于1928年,当时弗莱明发现了真菌中点青霉的作用,但是,直至1940年才研制出相当纯的、可以用于治疗人类疾病的青霉素。不幸的是,在前些年已有关于一种β内酰胺酶(青霉素酶)可以使青霉素失活的报道。

关键词：抗生素耐药性青霉素酶 β内酰胺酶人类疾病点青霉弗莱明新型抗生素抗微生物制剂金黄色葡萄球菌肠球菌

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PFA-fixed Hsp6Osp-loaded dendritic cells as a vaccine for the control of mouse experimental allergic encephalomyelitis

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cellular & Molecular Immunology 2014年第2期11卷 169-174页

作者： Feng Liu Hui Zheng Yuanyuan Qi Xue Wang Jianjun Yang Miaomiao Han hart Zhang Hong Jiang These authors contributed equally to this work.

We have shown that Hsp6Osp-loaded immature dendritic cells （Dc/sp） can protect mice from the induction of experimental allergic encephalomyelitis （EAE） by inducing Qa-l-restricted cD8＋ T regulatory （Treg） cells. The binding half-life between Qa-1 and Hsp6Osp is particularly short and leads to an unstable Qa- l/peptide complex that significantly decreases the efficacy of this vaccination. To prevent Qa-l/Hsp6Osp complex dissociation, we utilized paraformaldehyde （PFA） fixation to stabilize the formation of the Qa-l/Hsp6Osp complex and maximize the function of Dc/sp as a vaccine to control autoimmune diseases. compared with the non-fixed Dc/sp, the fixed Dc/sp （FDc/sp） showed an enhanced ability to activate Qa-l-restricted Hsp6Osp-specific cD8＋T cells in vitro and prevented EAE in vivo. Importantly, the FDc/sp maintained immune activity following cryopreservation for I week or after storage for 72 h at 4 ~c. These results indicate that PFA fixation can sustain or increase the efficacy of Dc/sp by improving the stability of the Qa-l/Hsp6Osp complex on the surface of the Dc/sp. In addition, PFA fixation creates a time window for Dc/sp storage, transport and application. Our d^tn ~u^p__~t ~ nnt^nti^l clinic^l ..~e nf FDcI^n ~ ~ vnccine fnr the nr^v~ntinn and treatment of autnimm.n~_ di_~_~__

关键词： autoimmune disease dendritic cells Hsp6Osp PFA fixation Qa-l-restricted cD8+ T cells

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集成注入逻辑(I~2L)

电子计算机动态 1974年第5期 26-34页

作者： c.M.hart A.Slob 刘恩荣

引言集成逻辑电路制造技术的不断改进,起初着手于旨在较短延迟时间方面的成就。然而到1970年前后,速度可能提高的程度事实上已达到某种极限,因而现在的趋势是朝着提高每块芯片上门电路数目的方向发展。对于希望象单个单元那样制作多门... 详细信息

引言集成逻辑电路制造技术的不断改进,起初着手于旨在较短延迟时间方面的成就。然而到1970年前后,速度可能提高的程度事实上已达到某种极限,因而现在的趋势是朝着提高每块芯片上门电路数目的方向发展。对于希望象单个单元那样制作多门电路的一些应用来说,这种大规模集成(LSI)的形式将构成一种改进。如要LSI 能成为一种切实可行的建议,逻辑电路就必须满足三个重要条件。首先,基本“积木式单元”(buildingblocks)必须有简单而紧凑的结构,以便将尽可能多的单元容纳在单块芯片上。其次,应按速度适当且芯片功耗不过大的原则设计电路,这就意味着门延时τ与门功耗D 之乘积τD(这一要求的测定因数)必须足够小,第三,制造

关键词：基极电流集电极电流 I~2L 晶体管电路

Machine-learned multi-system surrogate models for materials prediction

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npj computational Materials 2019年第1期5卷 702-707页

作者： chandramouli Nyshadham Matthias Rupp Brayden Bekker Alexander V.Shapeev Tim Mueller conrad W.Rosenbrock Gábor csányi David W.Wingate Gus L.W.hart Department of Physics and Astronomy Brigham Young UniversityProvoUT 84602USA Fritz Haber Institute of the Max Planck Society Faradayweg 4–614195 BerlinGermany Skolkovo Institute of Science and Technology Skolkovo Innovation CenterBuilding 3Moscow 143026Russia Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Engineering Laboratory University of CambridgeTrumpington StreetCambridge CB21PZUK computer Science Department Brigham Young UniversityProvoUT 84602USA citrine Informatics 702 Marshall StreetRedwood CityCA 94063USA

Surrogate machine-learning models are transforming computational materials science by predicting properties of materials with the accuracy of ab initio methods at a fraction of the computational *** demonstrate surrogate models that simultaneously interpolate energies of different materials on a dataset of 10 binary alloys(Agcu,AlFe,AlMg,AlNi,AlTi,coNi,cuFe,cuNi,FeV,and NbNi)with 10 different species and all possible fcc,bcc,and hcp structures up to eight atoms in the unit cell,15,950 structures in *** find that the deviation of prediction errors when increasing the number of simultaneously modeled alloys isction errors of formation enthalpy with relative errors of<2.5% for all systems.

关键词： alloys prediction coNi

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用决策论选择布置强震仪的建筑物

国外地震工程 1981年第2期 49-55页

作者： G.c.hart c.Rojahn 谢礼立

加里福尼亚州在1971年制定了一项法令,要建立一项全州性的强震观测计划,以确保本州的强震仪在分布上应有足够的科学根据。这项法令规定强震仪应设置在具有代表性的地质环境和结构上,还

关键词：自然状态仪器强震仪森特埃尔地震仪音分建筑物概率期望决策者决策个体震中距地震基本参数赋值圣贝纳迪诺圣安娜奥克斯纳德阿纳海决策论

Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3

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chinese Medical Journal 2014年第8期127卷 1523-1529页

作者： Song Yuping Shi Jingli Wu Ying hart chong Zou Junjie Shi Yongquan Liu Zhimin Department of Endocrinology Changzheng Hospital Second Military Medical University Shanghai 200003 China

Background SIRT3 is an important regulator in cell metabolism, and recent studies have shown that it may be involved in the pharmacological effects of metformin. However, the molecular mechanisms underlying this process are unclear. Methods The effects of SIRT3 on the regulation of oxidative stress and insulin resistance in skeletal muscle were evaluated in vitro. Differentiated L6 skeletal muscle cells were treated with 750 pmol/L palmitic acid to induce insulin resistance. SIRT3 was knocked down and overexpressed in L6 cells. SIRT3, nuclear factor kappa-light-chain-enhancer of activated B cells （NF-KB） p65, c-Jun N-terminal kinase 1 （JNK1）, and superoxide dismutase 2 （SOD2） were evaluated by Western blotting. Results Over expression of SIRT3 increased glucose uptake and decreased ROS production in L6-1R cells as well as in L6 cells. Knock-down of SIRT3 induced increased production of ROS while decreased glucose uptake in both L6 and L6- IR cells, and these effects were reversed by N-acetyI-L-cysteine （NAc）. Metformin increased the expression of SIRT3 （1.5- fold） and SOD2 （2-fold） while down regulating NF-KB p65 （1.5-fold） and JNK1 （1.5-fold）. Knockdown of SIRT3 （P〈0.05） reversed the metformin-induced decreases in NF-KB p65 and JNK1 and the metformin-induced increase in SOD2 （P〈0.05）. conclusions Upregulated SIRT3 is involved in the pharmacological mechanism by which metformin promotes glucose uptake. Additionally, SIRT3 may function as an important regulator of oxidative stress and a new alternative approach for targeting insulin resistance-related diseases.

关键词： metformin SIRT3 insulin resistance oxidative stress nuclear factor-kB p65

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集成注入逻辑为双极型LSI提供了新方向

计算机研究与发展 1975年第4期 23-31页

作者： c. M hart A. Slob 胡祥森

集成注入逻辑,这种双极型基片设计的新方法正以其高密度、毫微秒级的延迟以及微瓦的功耗等优良性能引起全世界逻辑设计者们的关注。最引人关切的是I2L出色的门的布局,它从根本上消除了耗费面积和功率的电流源以及晶体管-晶体管逻辑中的... 详细信息

集成注入逻辑,这种双极型基片设计的新方法正以其高密度、毫微秒级的延迟以及微瓦的功耗等优良性能引起全世界逻辑设计者们的关注。最引人关切的是I2L出色的门的布局,它从根本上消除了耗费面积和功率的电流源以及晶体管-晶体管逻辑中的负载电阻。由于这一简化,使得一个高产量的单片上能放到3,000个门或者10,000个存储单元,而且,速度-功耗积可降到0.13微微焦耳的惊人程度,要比现在的TTL好得多。因此,若门的工作速度与TTL相等,则几千个这种门的总功耗还不大于今天100个门的

关键词：电流增益基极 TTL 接口电路电流源输出电流双极型 LSI 收集极晶体管逻辑逻辑摆幅

An Essential Oil Blend Decreases Methane Emissions and Increases Milk Yield in Dairy cows

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Open Journal of Animal Sciences 2019年第3期9卷 259-267页

作者： Kenton J. hart Hefin G. Jones Kate E. Waddams Hilary J. Worgan Beatrice Zweifel c. Jamie Newbold Institute of Biological Environmental and Rural Sciences (IBERS) Aberystwyth University Aberystwyth Ceredigion UK caltech crystalyx Siloth Cumbria UK Agolin SA Switzerland Scotland’s Rural college Kings Buildings Edinburgh UK

This study was conducted to investigate the effect of a commercial essential oil (EO) additive on milk production and methane (cH4) emissions from dairy cows. Early lactation Holstein-Friesian dairy cows were fed grass, whole crop wheat and corn silage total mixed ration. cows were allocated to one of two experimental treatments: control (no additive, cON) or 1 g/head/day of EO. cows were housed in a free stall barn, split into two pens for the duration of the experiment. Two gas data loggers units used to measure cH4 emissions were provided per pen for the duration of the 22 week-long study. Milk yield was determined daily, and milk components were analyzed every two weeks. cH4 was recorded continuously, and daily values were tabulated. Body weight and body condition score were determined at the start and bi-weekly. Results were analyzed as a randomized complete block trial. In total, 149 cows participated in the study (76 cON, 73 EO). Milk yields were greater (P cON, 31.2 EO) with no change in milk component concentrations. Milk component concentrations were unaffected (P > 0.05) by treatment. Yields of fat, protein, lactose, and solids were higher for EO fed cows (P 4 output was reduced with the EO compared to the cON treatment (411 g/day vs 438 g/day;13.8 g/L of milk vs 17.2 g/L of milk, P cts of treatment on reproductive performance or the occurrence of mastitis. Feeding EO to dairy cows reduced cH4 emissions whilst also increasing performance.

关键词： Dairy cows Essential Oils Methane Milk Yield