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On breakthroughs and limits: Resolving structural fine-tuning of photosynthetic supercomplexes

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Molecular Plant 2024年第2期17卷 224-226页

作者： Eunchul Kim Marcel dann Division of Environmental Photobiology National Institute for Basic BiologySOKENDAlOkazaki 444-8585Japan Department of Basic Biology The Graduate University for Advanced StudiesSOKENDAlOkazaki 444-8585Japan Bio-Inspired Energy Conversion Technical University of DarmstadtSchnittspahnstraBe 1064287 DarmstadtGermany

Dynamic regulation of photosynthetic supercomplexes is a key strategy allowing plants to adjust their light-harvesting system in response to varying environmental light conditions(Bassi and Dall'Osto,2021).State transition(i.e.,acclimative re-distribution of peripheral antennae between photosystems[PSs]I and II)is one such regulation mechanism that maintains excitation balance between PSl and PSll.

关键词： complexes breakthrough maintain

“美美与共”的荒诞新谈:以《伊丽莎白·巴姆》与《秃头歌女》为比较中心

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戏剧（中央戏剧学院学报） 2023年第6期212卷 130-140页

作者：魏丹妮南京大学文学院

俄国剧作家丹尼尔·哈尔姆斯于20世纪20年代完成的先锋剧作《伊丽莎白·巴姆》在40余年后与尤奈斯库的《秃头歌女》产生强烈的美学共振,该文学现象不仅为“荒诞派戏剧”开辟新的阐释空间,亦推动对“荒诞”的认知边界。在二者的相互凝视... 详细信息

俄国剧作家丹尼尔·哈尔姆斯于20世纪20年代完成的先锋剧作《伊丽莎白·巴姆》在40余年后与尤奈斯库的《秃头歌女》产生强烈的美学共振,该文学现象不仅为“荒诞派戏剧”开辟新的阐释空间,亦推动对“荒诞”的认知边界。在二者的相互凝视中,被解放的语言以寓于自身的超越力量破除“荒诞”与“上帝”“理性”之间的二元对立,以“理性之外”的更高视角审视“荒诞”背后的生存危机。源自不同精神文化土壤的荒诞文本共同指向审美的敞开之域,无可限定的审美“空虚”充当弥合裂隙、承载差异的同一背景,现代主体对生存意义的想象返归源初的空白,不断重获新生。

关键词：荒诞派戏剧荒诞审美丹尼尔·哈尔姆斯尤金·尤奈斯库

Second-line therapy for advanced hepatocellular carcinoma with regorafenib or cabozantinib:Multicenter French clinical experience in real-life after matching

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1510-1527页

作者： Xavier Adhoute Marie De Matharel Laurent Mineur Guillaume Pénaranda dann Ouizeman Clemence Toullec Albert Tran Paul Castellani Armelle Rollet Valérie Oules HervéPerrier Si Nafa Si Ahmed Marc Bourliere Rodolphe Anty Department of Gastroenterology and Hepatology Hôpital Saint-JosephMarseille 13000France Department of Gastroenterology and Hepatology Hôpital Universitaire de l’ArchetNice 06000France Department of Oncology Institut Sainte-CatherineAvignon 84000France Department of Biostatistics AlphaBio LaboratoryMarseille 13000France

BACKGROUND Starting a second-line systemic treatment for hepatocellular carcinoma(HCC)is a common *** only therapeutic options in France are two broadspectrum tyrosine kinase inhibitors(TKIs),regorafenib(REG)and cabozantinib(CBZ),but no comparative real-life studies are *** To evaluate the progression-free survival(PFS)of patients treated with REG or CBZ,we investigated the disease control rate(DCR),overall survival(OS),and safety of both *** identify the variables associated with disease progression over *** A retrospective multicenter study was performed on the clinical data of patients attending one of three referral centers(Avignon,Marseille,and Nice)between January 2017 and March 2021 using propensity score *** and OS were assessed using the Kaplan-Meier *** analysis(MA)of progression risk factors over time was performed in matched-pair *** Fifty-eight patients 68(62-74)years old with HCC,Barcelona clinic liver cancer(BCLC)B/C(86%),Child-Pugh(CP)-A/B(24%)received REG for 3.4(1.4-10.5)mo as second-line *** patients 68(60-73)years,BCLC B/C(75%),CP-A/B(25%)received CBZ for 3.7(1.8-4.9)mo after first-line treatment with sorafenib[3(2-4)(CBZ)vs 4(2.9-11.8)mo(REG),P=0.0226].Twenty percent of patients received third-line *** matching,PFS and DCR were not significantly different after a median follow-up of 6.2(2.7-11.7)mo(REG)vs 5.2(4-7.2)mo(CBZ),P=*** was no difference in grade 3/4 toxicities,dose reductions,or *** OS of CP-A patients was 8.3(5.2-24.8)vs 4.9(1.6-11.7)mo(CP-B),P=*** MA of risk factors for progression over time identified C-reactive protein(CRP)>10 mg/L,neutrophil-to-lymphocyte ratio(NLR)>3,and aspartate aminotransferase(AST)>45 IU as predictive *** This multicenter indirect comparative study found no significant difference in PFS between REG and CBZ as second-line therapy for advanced *** levels of inflam

关键词： Hepatocellular carcinoma Regorafenib Cabozantinib C-reactive protein Neutrophillymphocyte ratio

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新鲜微播报

少年科普世界 2023年第12期 2-3页

作者： dann·Q 不详

蚁蜂长成熊猫样这只长得颇似蚂蚁的家伙,是一种独居性蜂类蚁蜂,它们没有翅膀,全身毛茸茸的,因为长相有几分熊猫样,所以又被叫做“熊猫蚂蚁”。

关键词：熊猫蚂蚁微播报蜂

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灾难医学动态救援推演模型与实例应用

工程管理科技前沿 2023年第1期42卷 61-68页

作者：周丹刘中民同济大学附属东方医院上海200120 同济大学医学院上海200092 同济大学灾难医学工程研究院上海200120

灾难事件的发生发展往往伴随着衍生、次生灾难的动态演化,并在医学救援的过程中进一步交叉、替换、叠加、扩大,从而形成灾难极其复杂的发展路径。本文首先对1990-2022年全球范围内40个特大城市中所发生的110个灾难案例逐一进行梳理,提... 详细信息

灾难事件的发生发展往往伴随着衍生、次生灾难的动态演化,并在医学救援的过程中进一步交叉、替换、叠加、扩大,从而形成灾难极其复杂的发展路径。本文首先对1990-2022年全球范围内40个特大城市中所发生的110个灾难案例逐一进行梳理,提炼分析各案例全生命周期的演化机理。接着,将决策实验室分析法与知识元理论相结合,以驱动灾难演化的核心影响因素作为情景信息的构成要素,构建用于灾难案例分析的情景要素表达模型。之后,创新地应用贝叶斯网络模型加以推演,形成灾难医学救援动态推演模型,从而分析灾难不同路径的演化概率。最后,将“8.12天津滨海新区爆炸事件”作为实例,对模型应用的合理性加以验证,构建形成可推广应用的灾难医学动态救援推演模型。

关键词：灾难医学应急救援案例研究情景推演模型应用

Spectral Characterization of Laser Induced Plasma from Titanium Dioxide

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Plasma Science and Technology 2007年第4期9卷 456-459页

作者： V.J.dann M.V.MATHEW V.P.N.NAMPOORI C.P.G.VALLABHAN V.M.NANDAKUMARAN P.RADHAKRISHNAN International School of Photonics Cochin University of Science and TechnologyCochin 22India Centre of Excellence in Lasers and Optoelectronic SciencesCochin University of Science and TechnologyCochin 22India International School of Photonics Cochin University of Science and TechnologyCochin 22India Centre of Excellence in Lasers and Optoelectronic Sciences Cochin University of Science and TechnologyCochin 22India

Optical emission from TiO2 plasma, generated by a nanosecond laser is spectroscopically analysed. The main chemical species are identified and the spatio-temporal distribution of the plasma parameters such as electron temperature and density are characterized based on the study of spectral distribution of the line intensities and their broadening characteristics. The parameters of laser induced plasma vary quickly owing to its expansion at low background pressure and the possible deviations from local thermodynamic equilibrium conditions are tested to show its validity.

关键词： laser induced plasma titanium dioxide optical emission spectroscopy local thermodynamic equilibrium

Stem cell transplantation and/or adenoviral glial cell line-derived neurotrophic factor promote functional recovery in hemiparkinsonian rats

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World Journal of Stem Cells 2021年第1期13卷 78-90页

作者： May-Jywan Tsai Shih-Chieh Hung Ching-Feng Weng Su-Fen Fan dann-Ying Liou Wen-Cheng Huang Kang-Du Liu Henrich Cheng Department of Neurosurgery Neurological InstituteNeurological InstituteTaipei 11217Taiwan Department of Medical Research National Yang Ming UniversityInstitute of Clinical MedicineTaipei 112Taiwan Integrative Stem Cell Center Department of OrthopaedicsChina Medical University HospitalTaichung 404Taiwan Institute of Biomedical Sciences Academia SinicaTaipei 11529Taiwan China Medical University Graduate Institute of Clinical Medical SciencesTaichung 404Taiwan Department of Medical Research and Education Taipei Veterans General HospitalStem Cell LaboratoryTaipei 112Taiwan Department of Life Science Institute of BiotechnologyHaulien 97401Taiwan Department of Neurosurgery Neurological InstituteTaipei 112Taiwan School of Medicine National Yang-Ming UniversityTaipei 112Taiwan Department of neurosurgery Neurological InstituteTaipei 112Taiwan Department of Neurosurgery Taipei Veterans General HospitalCenter for Neural RegenerationNeurological InstituteTaipei 112Taiwan

BACKGROUND Parkinson’s disease(PD)is a neurological disorder characterized by the progressive loss of midbrain dopamine(DA)*** marrow mesenchymal stem cells(BMSCs)can differentiate into multiple cell types including neurons and *** of BMSCs is regarded as a potential approach for promoting neural *** cell line-derived neurotrophic factor(GDNF)can induce BMSC differentiation into neuron-like *** work evaluated the efficacy of nigral grafts of human BMSCs(hMSCs)and/or adenoviral(Ad)GDNF gene transfer in 6-hydroxydopamine(6-OHDA)-lesioned hemiparkinsonian *** To evaluate the efficacy of nigral grafts of hMSCs and/or Ad-GDNF gene transfer in 6-OHDA-lesioned hemiparkinsonian *** We used immortalized hMSCs,which retain their potential for neuronal ***,preinduced hMSCs,or Ad-GDNF effectively enhanced neuronal connections in cultured *** vivo,preinduced hMSCs and/or Ad-GDNF were injected into the substantia nigra(SN)after induction of a unilateral 6-OHDA lesion in the nigrostriatal *** Hemiparkinsonian rats that received preinduced hMSC graft and/or Ad-GDNF showed significant recovery of apomorphine-induced rotational behavior and the number of nigral DA ***,DA levels in the striatum were not restored by these therapeutic *** hMSCs might reconstitute a niche to support tissue repair rather than contribute to the generation of new neurons in the injured *** The results suggest that preinduced hMSC grafts exert a regenerative effect and may have the potential to improve clinical outcome.

关键词： Stem cells Transplantation Parkinson’s disease Glial cell line-derived neurotrophic factor Adenovirus Neuroregeneration

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使用新的测井方法探测水平井中的裂缝

国外油气勘探 1991年第6期 111-114页

作者： Dennis dann 谢忠联

增加钻入裂缝储层的水平井钻井活动,需要新的和有效的测井技术来识别天然裂缝。探测和评价垂直裂缝系统对于制定完井方案以便提高水平井的生产能力是至关重要的。改善水平井的定向钻井和完井技术,得以对低孔隙度、低渗透率的储层进行工... 详细信息

增加钻入裂缝储层的水平井钻井活动,需要新的和有效的测井技术来识别天然裂缝。探测和评价垂直裂缝系统对于制定完井方案以便提高水平井的生产能力是至关重要的。改善水平井的定向钻井和完井技术,得以对低孔隙度、低渗透率的储层进行工业性开采。目前,水平钻井的费用是垂直钻井的1.6～3倍,而水平井的产量大约是常规井的2～5倍。人们为确定碳酸盐岩垂直井中的裂缝而做出了很大的努力。使用的测井技术包括各种电阻率、声波、自然伽马能谱、密度、中子、机械井径仪和其它测井仪。这些技术的

关键词：水平井裂缝测井方法

图形编辑程充中的一种有效修改,增量显示和Undo结构

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软件 1990年第8期11卷 605-623页

作者： dann.,RB 承雁