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International Journal of Clinical Medicine（临床医学国际期刊） 2011年第3期

作者： Susanne habelt stephanie Korn Angelika Berger Jozef Bielek

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降脂药物治疗病人需住院肌溶解症的发生率

美国医学会杂志（中文版） 2006年第1期25卷 28-33页

作者： David J, Graham Judy A , Staffa Deborah shatin Susan E. Andrade stephanie D, Schech Lois La Grenade Jerry h. Gurwitz K. Arnold Chan Michael .J. Goodman Richard Platt 徐成斌（译） Office of Drug Safety Center for Drug Evaluation and Research Food and Drug Administration Rockvilte Md Center for health Care Policy and Evaluation Eden Prairie Minn Meyers Pdmary Care Institute Fallon Foundation and the University of Massachusetts Medical School Worcester Channing Laboratory Brigham and Wornen＇s Hospital and Harvard Medical School Department of Ambulatory Care and Prevention Harvard Pilgrim Health Care and Harvard Medical School Department of Epiderniology HarvardSchool of Public Health Boston Massi and HealthPartners Research Founda＇don Minneapolis Minn 不详

背景：在美国降脂药物已获广泛应用。但是对各种降脂药物发生肌溶解症的危险性目前尚缺乏可靠的估计。目的：对门诊情况下，不同他汀及贝特类药物（单用或联用）治疗病人肌溶解症的发生率进行估计。设计、地点及病人：根据全美11个卫生... 详细信息

背景：在美国降脂药物已获广泛应用。但是对各种降脂药物发生肌溶解症的危险性目前尚缺乏可靠的估计。目的：对门诊情况下，不同他汀及贝特类药物（单用或联用）治疗病人肌溶解症的发生率进行估计。设计、地点及病人：根据全美11个卫生保健计划申报数据建立不同他汀和贝特类用药起始队列。人选本队列的病例为1998年1月1h至2001年6月30日人组保健计划前至少用药180天的病人。人-时间按照单药治疗或他汀-贝特类联合治疗分类。主要结局指标：每治疗10000人一年肌溶解症的发生率、所需治疗例数以及发生肌溶解症的相对危险性。结果：在252460例采用降脂药物治疗的病人中，24例于治疗期间发生住院的肌溶解症。采用阿托伐他汀、普伐他汀或辛伐他汀单药治疗平均每10000人一年肌溶解症的发生率为0．44（95％可信区间[confidence interval，CI]，0．20～0．84）；西立伐汀为5．34（95％CI，1．46～13．68）；贝特类为2．82（95％CI，0．58—8．24；P=0．056）。未用药者（unexposed person—time）肌溶解症的发生率为0（95％CI，0—0．48，P=0．56）。阿托伐他汀、普伐他汀与一种贝特联川肌溶解症的发生率增至5．98（95％CI，0．72～216．0），西立伐他汀与叭特类联用增至1035（95％CI，389—2117）。每治疗1年，发现1例肌溶解症的所需治疗例数他汀单药治疗为2272例，采用他汀和贝特类联合治疗的年龄较大的糖尿病人为484例，采用西立伐他汀加贝特类治疗的病人为9．7到12．7例。结论：采用阿托伐他汀、普伐他汀及辛伐他汀单药治疗发生肌溶解症的危险相似而且很低；联合使用他汀及贝特类者危险增加，特别是在老年糖尿病病人。西立伐他汀联合贝特类每年治疗10例即可能有1例发生肌溶解症。

关键词：药物治疗糖尿病人降脂药物肌溶解发生率住院贝特类药物阿托伐他汀 interval 卫生保健计划

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa yugo Morita hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee stephanie P. hao Irvin Oh Chao Xie hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA Department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

Effect of SARS-CoV-2 infection on the liver

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World Journal of Virology 2023年第2期12卷 109-121页

作者： Adekunle Sanyaolu Aleksandra Marinkovic Abu Fahad Abbasi stephanie Prakash Risha Patidar Priyank Desai Martina Williams Abdul Jan Kareem hamdy Rachael Solomon Vyshnavy Balendra Maaz Ansari Omar Shazley Nasar Khan Rochelle Annan yashika Dixon Chuku Okorie Afolabi Antonio Department of Public health Federal Ministry of HealthAbujaNigeriaAbuja 0000FCTNigeria Department of Basic Medical Science Saint James School of MedicineThe Quarter 26400000Anguilla Department of Internal Medicine Loyola University Medical CenterMaywoodIllinoisIL 60153United States Department of Basic Medical Science American University of Saint Vincent School of MedicineSaint Vincent and the Grenadines 0000Saint Vincent and the Grenadines Department of Basic Medical Science Windsor University School of MedicineCayon 0000Saint Kitts and Nevis Department of Basic Medical Science Caribbean Medical University School of MedicineWillemstad 0000CuraçaoNetherlands Antilles Basic Medical Science Saint James School of MedicineSaint Vincent and the Grenadines 0000Saint Vincent and the Grenadines University of health Sciences Antigua School of Medicine PiccadillySt.John's Antigua Department of Science Union County CollegePlainfieldNew JerseyNJ 07016United States Department of Internal Medicine Lloydminster Regional HospitalLloydminster S9V 1Y5SaskatchewanCanada

There have been numerous concerns about the disease and how it affects the human body since the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic began in December *** impact of SARS-CoV-2 on the liver is being carefully investigated due to an increase in individuals with hepatitis and other liver illnesses,such as alcoholic liver ***,the liver is involved in the metabolism of numerous drugs used to treat comorbidities and coronavirus disease 2019(COVID-19).Determining how SARS-CoV-2 affects the liver and what factors place individuals with COVID-19 at a higher risk of developing liver problems are the two main objectives of this *** evaluation of the literature included research from three major scientific *** provide an update on the current impact of COVID-19 on the liver,data was collected and relevant information was incorporated into the *** more knowledge about the effect of the disease on the liver,better management and therapeutics can be developed,and education can ultimately save lives and reduce the long-term impact of the pandemic on our population.

关键词： Coronavirus COVID-19 SARS-CoV-2 Liver hepatic complications

Allogeneic and autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide conditioning therapy for relapsed/refractory non-hodgkin lymphoma

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Modern Chemotherapy 2013年第4期2卷 57-65页

作者： Neelima Vidula Andrew M. Evens Irene B. helenowski Borko Jovanovic Jane N. Winter Jayesh Mehta Seema Singhal stephanie F. Williams Olga Frankfurt Jessica K. Altman Joanne Monreal Leo I. Gordon Department of Preventive Medicine Northwestern University Chicago USA Division of hematology-Oncology Northwestern University Chicago USA Division of hematology-Oncology Northwestern University Chicago USA Division of hematology-Oncology The University of Massachusetts Medical School Worcester USA Division of hematology-Oncology University of California San Francisco USA

The optimal stem cell transplantation (SCT) conditioning therapy for relapsed/refractory non-hodgkin lymphoma (NhL) is not clearly defined. In a retrospective analysis, we examined 25 patients with “high risk” relapsed/refractory NhL who received busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP16) conditioning with autologous or allogeneic SCT. The majority of patients had aggressive histology and 52% had primary refractory NhL. Furthermore, 48% of patients had chemotherapy-resistant disease at the time of SCT. Fifty-six percent of patients underwent allogeneic SCT, while 44% had autologous SCT. The median engraftment time for neutrophils and platelets was 13.5 and 14 days, respectively. The 100-day treatment-related mortality (TRM) was 16%, while the 2-year non-relapse mortality (NRM) rate was also 16%. At a median follow-up of 15 months, the estimated 2-year disease-free survival (DFS) rate was 64% (95% confidence interval (CI): 36%-82%) and the estimated 2-year overall survival (OS) was 69% (95% CI: 40%-86%). Furthermore, the 2-year disease-specific survival (DSS) rate was 73% (95% CI: 40%-90%). Using Cox proportional hazard modeling, the International Prognostic Index at time of relapse predicted DFS and OS. Altogether, Bu/Cy/VP16 was associated with early TRM;however, late toxicities (including NRM) were uncommon resulting in relatively good survival rates in a high-risk relapsed/refractory NhL population.

关键词： Stem Cell Transplantation Busulfan Cyclophosphamide Etoposide Non-hodgkin Lymphoma

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新冠肺炎疫情下医疗机构的设计思考

中国医院建筑与装备 2022年第1期23卷 39-41页

作者：斯蒂芬妮·科斯特洛 B+h建筑师事务所

新冠肺炎疫情在众多国家肆虐,严重影响了全球经济、社会生态乃至人们的精神健康。与此同时,疫情对实体医疗环境以及相关体系所造成的影响同样不容小觑。从实体医疗环境层面上来看,大批量新冠肺炎患者的涌入致使众多医院从一开始就举步维... 详细信息

新冠肺炎疫情在众多国家肆虐,严重影响了全球经济、社会生态乃至人们的精神健康。与此同时,疫情对实体医疗环境以及相关体系所造成的影响同样不容小觑。从实体医疗环境层面上来看,大批量新冠肺炎患者的涌入致使众多医院从一开始就举步维艰,因为大多数医院的规模都不足以应对如此庞大的患者数量。预见到即将出现的庞大感染人群后,许多国家积极尝试,试图从体系层面解决这一问题.

关键词：感染人群肺炎患者患者数量医疗机构医疗环境疫情设计思考

Co-contaminants of microplastics in two seabird species from the Canadian Arctic

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Environmental Science and Ecotechnology 2022年第4期12卷 87-96页

作者： Roxana Sühring Julia E.Baak Robert J.Letcher Birgit M.Braune Amila de Silva Cody Dey Kim Fernie Zhe Lu Mark L.Mallory stephanie Avery-Gomm Jennifer F.Provencher Department of Chemistry and Biology Toronto Metropolitan University(formerly known as Ryerson University)350 Victoria StTorontoONM5B 2K3Canada Department of Natural Resource Science McGill UniversitySainte Anne de BellevueQuebecH9X 3V9Canada Environment and Climate Change Canada National Wildlife Research CentreCarleton UniversityRaven RoadOttawaOntarioK1A 0H3Canada Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Ecotoxicology&Wildlife health Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Institut des Sciences de la Mer de Rimouski Université du Québec à RimouskiRimouskiQuébecG5L 3A1Canada Department of Biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Through ingestion and subsequent egestion,Arctic seabirds can bioaccumulate microplastics at and around their colony breeding *** microplastics in Arctic seabirds have been well documented,it is not yet understood to what extent these particles can act as transport vehicles for plastic-associated contaminants,including legacy persistent organic pollutants(POPs),trace metals,and organic *** investigated the occurrence and pattern of organic and inorganic co-contaminants of microplastics in two seabird species from the Canadian Arctic-northern fulmar(Fulmarus glacialis)and black-legged kittiwake(Rissa tridactyla).We found that fulmars had higher levels of plastic contamination and emerging organic compounds(known to be plastic additives)than kittiwakes,whereas higher concentrations of legacy POPs were found in kittiwakes than the ***,fulmars,the species with the much larger foraging range(~200 km),had higher plastic pollution and overall contaminant burdens,indicating that birds may be acting as long-range transport vectors for plasticassociated *** results suggest a potential connection between plastic additive contamination and plastic pollution burdens in the bird stomachs,highlighting the importance of treating plastic particles and plastic-associated organic additives as co-contaminants rather than separate pollution issues.

关键词： Plastic contaminants Contaminants of emerging arctic concern Arctic Seabirds PFAS OPEs PBDEs Trace metals

Beautysaur Organics美妆旗舰店

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现代装饰 2020年第8期 185-187页

作者： Lorène Faure Kenny Kinugasa-Tsui Pauline Paradis Lelia Ku stephanie Ma Jemima Lai 舒禹(编译) 无不详 Bean Buro

本项目是有机护肤美容品牌Beautysaur Organics的旗舰店设计,店面位于香港尖沙咀新的K11 MUSEA购物中心。Beautysaur Organics的线上商店经营得非常成功,他们现在的诉求是需要一家能组织活动的线下实体旗舰店,帮助他们以充实的实体形象... 详细信息

本项目是有机护肤美容品牌Beautysaur Organics的旗舰店设计,店面位于香港尖沙咀新的K11 MUSEA购物中心。Beautysaur Organics的线上商店经营得非常成功,他们现在的诉求是需要一家能组织活动的线下实体旗舰店,帮助他们以充实的实体形象吸引更多顾客,向公众介绍最新的护肤产品。在设计之初,为了更好地提升线下实体店的客户体验,设计团队首先分析了目标客户的相关统计数据,以及其他竞争对手品牌的店铺布局,在与客户一起进行了各项研究后,设计团队才开展了店铺的设计。空间内所使用的不同的材料和颜色形成了有趣的对比,进入店面时,一侧的金属墙板上展示了一系列的产品,另一面墙上则是弧形展示柜,目的在于吸引顾客浏览店铺内的产品。

关键词：购物中心护肤美容客户体验护肤产品展示柜目标客户设计团队尖沙咀

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北美压裂用低密度支撑剂技术的进展

化工管理 2018年第31期 103-106页

作者：林厉军刘付臣黄降水白立涛 stephanie yu 尹从彬龚蔚周瀚 CNPC USA Corporation 美国德州中国石油休斯敦技术研究中心北京100000 中国石油集团工程技术研究院有限公司北京100000 中国石油川庆钻探工程公司井下作业公司四川成都610000

本文总结了北美最具代表性的七个低密度支撑剂产品,包括通过采用低密度材料制备,通过改变表面性能使得表面聚集气泡从而减低支撑剂的表观比重,或通过表面水溶性聚合物涂层溶胀以将表观比重降低,以及它们在现场运用中的情况。本文的目的... 详细信息

本文总结了北美最具代表性的七个低密度支撑剂产品,包括通过采用低密度材料制备,通过改变表面性能使得表面聚集气泡从而减低支撑剂的表观比重,或通过表面水溶性聚合物涂层溶胀以将表观比重降低,以及它们在现场运用中的情况。本文的目的是通过提供北美当前低密度支撑剂技术的概述以及现场应用的案例分析,促进对低密度支撑剂新技术的研发。

关键词：水力压裂低密度支撑剂滑溜水水溶性聚合物

Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement

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World Journal of Gastrointestinal Endoscopy 2014年第4期6卷 144-147页

作者： Mohammad F Ali Anik Patel stephanie Muller David Friedel Department of Internal Medicine Winthrop University Hospital Department of Gastroenterology Hepatology and NutritionWinthrop University Hospital Department of Pathology Winthrop University Hospital

We are reporting a rare case of a patient with primary(AL) amyloidosis presenting with an acute non-varicealupper gastrointestinal hemorrhage in the absence ofother systemic involvement. The case report involves a58-year-old woman with significant cardiac history andhereditary blood disorder who came in complaining ofabdominal pain and coffee-ground emesis for two *** tomography(CT) scan of the abdomen andpelvis with contrast revealed segmental wall thickeningof the proximal jejunum with hyperdense, heterog-enous luminal content. Similar findings were evident inthe left lower small bowel region, suspicious for smallbowel hematoma and the possibility of intraluminalclots. Esophagogastroduodenoscopy performed postresuscitation showed punctate, erythematous lesionsthroughout the stomach as well as regions of smallbowel mucosa that appeared scalloped, ulcerated, andhemorrhaged on contact. Despite initial treatment for immunostain-positive focal cytomegalovirus gastritis, follow-up esophagogastroduodenoscopy after two months continued to demonstrate friable and irregular duodenal mucosa hinting at a different underlying etiol-ogy. Pathology reports from analyses of biopsy samples highlighted infiltration and expansion of the lamina pro-pria and submucosa. Subsequent staining with congo red/crystal violet and appropriate subtyping established the diagnosis of AL(kappa)-type amyloidosis. The sig-nificance of this case lies in the fact that our patient did not have the typically seen diagnostic systemic involvements-namely of heart and kidneys-usually seen in primary(AL) amyloidosis patients. It was the persis-tent endoscopic findings and biopsy results which gave clues to the physicians regarding the possibility of an abnormal protein-deposition entity.

关键词： Primary amyloidosis AL amyloidosis Gastrointestinal hemorrhage Endoscopic finding Endo-scopic biopsy Upper gastrointestinal bleeding Amyloid deposition Gastric/intestinal mucosa Mucosal inflammation