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Arginine methylation by PRMT6 as a novel stemness and metabolic regulator in hepatocellular carcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 12-12页

作者： stephanie ma School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Objective:Arginine methylation is a common posttranslational modification that plays pivotal roles in signal ***,its function in human diseases is poorly *** methyltransferase 6(PRMT6)belongs to the type I PRMT enzyme... 详细信息

关键词： Arginine methylation PRMT6

Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

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Cancer Communications 2023年第8期43卷 951-955页

作者： Hoi-Hin Kwok Huiyu Li Jiashuang Yang Junyang Deng Nerissa Chui-Mei Lee Timmy Wing-Kuk Au Alva Ko-Yung Sit Michael Kuan-Yew Hsin stephanie Kwai-Yee ma LydiaWai-Ting Cheung Luc Girard Junya Fujimoto Ignacio Ivan Wistuba Boning Gao John Dorrance Minna David Chi-Leung Lam Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong SARP.R.China Nancy B.and Jake L.Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexasUSA Cardiothoracic Surgical Department Queen Mary HospitalHong Kong SARP.R.China School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARP.R.China Department of Translational Molecular Pathology Division of Pathology/Lab MedicineUniversity of Texas MD Anderson Cancer CenterHoustonTexasUSA

Dear Editor,Non-small cell lung carcinoma(NSCLC)accounts for more than 85%of all lung cancers[1].Lung adenocarcinomas(ADCs)arising from never-smokers have been frequently found to be associated with oncogenic driver mutations,including anaplastic lymphoma kinase(ALK)*** microtubule-associated protein-like 4(EML4)is the most common fusion partner of the ALK gene[2].Tyrosine kinase inhibitors(TKIs)are currently the first-line treatment for advanced EML4-ALKrearranged lung ADC.

关键词： lung adenocarcinoma Lung

The association of diet quality and physical activity with cardiovascular disease and mortality in 85,545 older Australians:A longitudinal study

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Journal of Sport and Health Science 2024年第6期13卷 841-850页

作者： Ding Ding Joe Van Buskirk stephanie Partridge Philip Clare Edward Giovannucci Adrian Bauman Nicole Freene Robyn Gallagher Binh Nguyen Sydney School of Public Health Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia Charles Perkins Centre the University of SydneyCamperdownNSW 2006Australia Sydney Local Health District CamperdownNSW 2050Australia School of Health Sciences Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia National Drug and Alcohol Research Centre UNSW SydneySydneyNSW 2052Australia Departments of Nutrition and Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Faculty of Health University of CanberraCanberraACT 2617Australia Susan Wakil School of Nursing and Midwifery the University of SydneyCamperdownNSW 2050Australia

Background:A quality diet and an active lifestyle are both important cornerstones of cardiovascular disease(CVD)***,despite their interlinked effects on metabolic health,the 2 behaviors are rarely considered jointly,particularly within the context of CVD *** examined the independent,interactive,and joint associations of diet and physical activity with CVD hospitalization,CVD mortality,and all-cause ***:CVD-free Australian participants aged 4574 years(n=85,545)reported physical activity,diet,sociodemographic,and lifestyle characteristics at baseline(20062009)and follow-up(20122015),and data were linked to hospitalization and death registries(03/31/2019 for CVD hospitalization and all-cause mortality and 12/08/2017 for CVD mortality).Diet quality was categorized as low,medium,and high based on meeting dietary *** activity was operationalized as(a)total moderate-to-vigorous physical activity(MVPA)as per guidelines,and(b)the composition of MVPA as the ratio of vigorous-intensity physical activity(VPA)to total *** used a left-truncated cause-specific Cox proportional hazards model using time-varying ***:During a median of 10.7 years of follow-up,6576 participants were admitted to the hospital for CVD and 6581 died from all causes(876 from CVD during 9.3 years).A high-quality diet was associated with a 17%lower risk of all-cause mortality than a low-quality diet,and the highest MVPA category(compared with the lowest)was associated with a 44%and 48%lower risk of CVD and all-cause mortality,*** interactions between diet and physical activity were *** all outcomes,the lowest risk combinations involved a high-quality diet and the highest MVPA *** for total MVPA,some VPA was associated with further risk reduction of CVD hospitalization and all-cause ***:For CVD prevention and longevity,one should adhere to both a healthy d

关键词： Diet Physical activity Cardiovascular disease Mortality Cohort studies

Beautysaur Organics美妆旗舰店

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现代装饰 2020年第8期 185-187页

作者： Lorène Faure Kenny Kinugasa-Tsui Pauline Paradis Lelia Ku stephanie ma Jemima Lai 舒禹(编译) 无不详 Bean Buro

本项目是有机护肤美容品牌Beautysaur Organics的旗舰店设计,店面位于香港尖沙咀新的K11 MUSEA购物中心。Beautysaur Organics的线上商店经营得非常成功,他们现在的诉求是需要一家能组织活动的线下实体旗舰店,帮助他们以充实的实体形象... 详细信息

本项目是有机护肤美容品牌Beautysaur Organics的旗舰店设计,店面位于香港尖沙咀新的K11 MUSEA购物中心。Beautysaur Organics的线上商店经营得非常成功,他们现在的诉求是需要一家能组织活动的线下实体旗舰店,帮助他们以充实的实体形象吸引更多顾客,向公众介绍最新的护肤产品。在设计之初,为了更好地提升线下实体店的客户体验,设计团队首先分析了目标客户的相关统计数据,以及其他竞争对手品牌的店铺布局,在与客户一起进行了各项研究后,设计团队才开展了店铺的设计。空间内所使用的不同的材料和颜色形成了有趣的对比,进入店面时,一侧的金属墙板上展示了一系列的产品,另一面墙上则是弧形展示柜,目的在于吸引顾客浏览店铺内的产品。

关键词：购物中心护肤美容客户体验护肤产品展示柜目标客户设计团队尖沙咀

The influence of fire frequency on the abundance of maerua subcordata in the Serengeti National Park, Tanzania

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Journal of Plant Ecology 2012年第4期5卷 400-406页

作者： Ayron M.Strauch stephanie Eby Department of Biology Tufts University163 Packard AvenueMedfordMA 02155USA Department of Ecology and Evolutionary Biology 106A Guyot HallPrinceton UniversityPrincetonNJ 08544USA Present address:Department of Ecology and Evolutionary Biology Yale UniversityPO Box 208106165 Prospect StreetNew HavenCT 06520-8106USA

Aims Invasive species alter the composition and function of communities,threatening the conservation of important ecosystems *** savanna ecosystems,fire plays a key role by modifying biogeochemical cycles and shaping the composition and structure of vegetation *** many studies have examined the long-term effects of fire frequency on grassland communities,few studies have examined the relationship between fire regime and woody species *** The Serengeti ecosystem is an ecologically and economically valuable natural resource in East Africa whose conservation is currently threatened by a variety of factors,including invasive *** determined the abundance of maerua subcordata,a noxious woody shrub,in three different regions of the Serengeti National Park,*** then examined the influence of fire frequency,developed through the use of 7 years of Moderate Resolution Imaging Spectroradiometer(MODIS)imagery,on *** *** Findings In all regions,burned transects had significantly greater abundances of *** compared to unburned ***,the number of times each transect burned from 2000 to 2006 had a significant positive effect on the abundance of *** and the number of years since a transect last burned had a significant negative relationship with *** results are particularly important as this species provides little forage value and is potentially toxic to wildlife and *** studies are needed to determine the ecological consequences of increasing *** abundance,as the potential expansion of noxious shrubs into protected areas of important conservation status is of serious concern.

关键词： Serengeti fire savanna maerua subcordata MODIS

Species diversity of thrips (Thysanoptera) in selected avocado orchards from Mexico based on morphology and molecular data

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Journal of Integrative Agriculture 2018年第11期17卷 2509-2517页

作者： Daniel Bravo-Perez ma. Teresa Santillbn-Galicia Roberto M. Johansen-Naime Hector Gonzalez-Hernandez Obdulia L. Segura-Leon Daniel L, Ochoa-martinez stephanie Guzman-Valencia Posgrado en Fitosanidad-Entomologia y Acarologia Colegio de Postgraduados Km 36.5 Carretera Mexico-Texcoco Montecillo Texcoco Estado de Mexico 56230 Mexico Instituto de Biologia de la Universidad Nacional Autonoma de Mexico (IBUNAM) Circuito exterior s/n Ciudad Universitaria Coyoacan Ciudad de Mexico 04510 Mexico Posgrado en Fitosanidad-Fitopatologia Colegio de Postgraduados Km 36.5 Carretera Mexico-Texcoco Montecillo Texcoco Estado de Mexico 56230 Mexico

Avocado is one of the most important crops in the world, and Mexico is the largest producer of this fruit. Several insect pests affect its production, and thrips are amongst the most important. A key step in the design of control methods is accurate species identification. Despite this, formal reports on species diversity of thrips in Mexico are very scarce. Morphological identification can sometimes be time-consuming and inconclusive. Therefore, we explored the species diversity of thrips in Mexican avocado orchards （Michoacan state） based on partial sequences of the mitochondrial gene cytochrome oxidase subunit I （COl）. Forty-four specimens were analysed, which represented approximately 8% of all individuals collected from five localities distributed in three Municipalities. All specimens were analysed using the COl marker, and specimens within the genera Frankliniella were also analysed using a marker within the D2 domain of the 28S （28SD2） nuclear ribosomal DNA. Molecular identifications were confirmed using morphological taxonomy. Overall, six genera were found （Neohydatothrips, Scirtothrips, Frankliniella, Arorathrips, Caliothrips and Leptothrips）. AII genera contained only one species, except Frankliniella, for which there were six species. Data from the two molecular markers suggest the existence of cryptic species within Mexican F. occidentalis populations.

关键词： molecular taxonomy morphological identification cytochrome oxidase subunit I 28S nuclear ribosomal DNA.

Prevalence and methodologies for detection,characterization and subtyping of Listeria monocytogenes and *** in foods and environmental sources

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Food Science and Human Wellness 2017年第3期6卷 97-120页

作者： Jin-Qiang Chena Patrick Regan Pongpan Laksanalamai stephanie Healey Zonglin Hua Winchester Engineering Analytical Center(WEAC)HFR-NE460Office of Regulatory AffairsUS Food and Drug Administration109 Holton StreetWinchesterMA 01890USA MD DHMH Laboratories Administration Division of MicrobiologyRoom 5281770 Ashland Ave.BaltimoreMD 21205USA

Listeria monocytogenes,one of the most important foodborne pathogens,can cause listeriosis,a lethal disease for ***,which is closely related to ***,is also widely distributed in nature and infects mainly warm-blooded ruminants,causing economic ***,there are high priority needs for methodologies for rapid,specific,cost-effective and accurate detection,characterization and subtyping of *** and *** in foods and environmental *** this review,we(A)described *** and ***,world-wide incidence of listeriosis,and prevalence of various *** strains in food and environmental sources;(B)comprehensively reviewed different types of traditional and newly developed methodologies,including culture-based,antigen/antibody-based,LOOP-mediated isothermal amplification,matrix-assisted laser desorption ionization-time of flight-mass spectrometry,DNA microarray,and genomic sequencing for detection and characterization of *** in foods and environmental sources;(C)comprehensively summarized different subtyping methodologies,including pulsed-field gel electrophoresis,multi-locus sequence typing,ribotyping,and phage-typing,and whole genomic sequencing *** subtyping of *** strains from food and environmental sources;and(D)described the applications of these methodologies in detection and subtyping of *** in foods and food processing facilities.

关键词： Foodborne pathogens Listeria monocytogenes Listeria ivanovii Molecular characterization Subtyping

PCR-based methodologies for detection and characterization of Listeria monocytogenes and Listeria ivanovii in foods and environmental sources

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Food Science and Human Wellness 2017年第2期6卷 39-59页

作者： Jin-Qiang Chen stephanie Healey Patrick Regan Pongpan Laksanalamai Zonglin Hu Winchester Engineering&Analytical Center(WEAC) HFR-NE460Office of Regulatory AffairsUS Food and Drug Administration109 Holton StreetWinchesterMA 01890USA MD DHMH Laboratories Administration Division of MicrobiologyRoom 5281770 Ashland Ave.BaltimoreMD 21205USA

Listeria monocytogenes is an important foodborne pathogen responsible for listeriosis,a fatal *** is widely distributed in various foods and environmental *** this review,we focused on addressing PCR-based technologies,including conventional PCR,qPCR and droplet digital PCR(ddPCR).Specifically,we described(a)conventional PCR and mono-,duplex-and multiplex-qPCR methodologies;(b)development and applications of gene HlyA-,Iap-,PrfA–and SsrA-based conventional and qPCR assays as well as PCR assays targeting newly identified gene targets for specific detection of ***;differentiation of viable from dead *** by qPCR in conjugation with propidium monoazide pretreatment;PCR-based serotype identification of *** isolates;PCR-based detection of ***,infecting ruminants,differentiation of *** from other Listeria species;and sigB-gene based PCR identification of Listeria spp;(c)applications of ddPCR in detection of ***;and(d)application of qPCR assays in detection and subtyping of *** in milk and dairy products;meats,meat products and meat-processing environment;and seafood,seafood products and processing *** goal was to provide a relatively comprehensive overview of PCR-based methodologies available in detection,characterization and subtyping of various strains of *** in foods and environmental sources.

关键词： Foodborne pathogens Listeria monocytogenes Listeria ivanovii qPCR

A bipolar verdazyl radical for a symmetric all-organic redox flow-type battery

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Journal of Energy Chemistry 2019年第7期28卷 52-56页

作者： Grant D.Charlton stephanie M.Barbon Joe B.Gilroy C.Adam Dyker Department of Chemistry University of New BrunswickFredericton E3B 5A3New BrunswickCanada Department of Chemistry and the Centre for Advanced materials and Biomaterials Research(CAMBR) The University of Western OntarioLondon N6A 5B7OntarioCanada

A symmetric all-organic non-aqueous redox flow-type battery was investigated employing the neutral small molecule radical 3-phenyl-1,5-di-p-tolylverdazyl,which can be reversibly oxidized and reduced in one-electron processes,as the sole charge storage *** voltammetry of the verdazyl radical in 0.5 M tetrabutylammonium hexa fluoro phosphate(TBAPF6)in acetonitrile revealed redox couples at-0.17 V and-1.15 V ***+/Ag,leading to a theoretical cell voltage of 0.98 *** the dependence of peak currents on the square root of the scan rate,diffusion coefficients on the order of 4 x 10 6 cm2 s-1 were *** performance was assessed in a static cell employing a Tokoyuma AHA anion exchange membrane,with 0.04 M verdazyl as catholyte and anolyte in 0.5 M TBAPF6 in acetonitrile at a current density of 0.12 ma *** coulombic efficiencies were good(94%-97%)throughout the experiment,the capacity faded gradually from high initial values of 93%of the theoretical discharge capacity to 35%by the 50th *** and energy efficiencies were 68%and 65%,*** analysis by cyclic voltammetry revealed that decomposition of the active material with cycling is a leading cause of cell degradation.

关键词： All-organic redox flow battery Energy storage Verdazyl radicals Organic radical Coin cell