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Modeling the effects of salt concentration on aqueous and organic electrolytes

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npj computational Materials 2023年第1期9卷 546-552页

作者： stephanie c.c.van der Lubbe Pieremanuele canepa Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Department of chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4117585 SingaporeSingapore Department of Electrical and computer Engineering and Texas center for Superconductivity University of HoustonHoustonTX 77204USA

Understanding the thermodynamic properties of electrolyte solutions is of vital importance for a myriad of physiological and technological *** mean activity coefficientγ±is associated with the deviation of an electrolyte solution from its ideal behavior and may be obtained by combining the Debye-Hückel(DH)and Born(B)***,the DH and B equations depend on the concentration and temperature-dependent static permittivity of the solutionεr(c,T)and the size of the solvated ions ri,whose experimental data is often not ***,we use a combination of molecular dynamics and density functional theory to predictεr(c,T)and ri,which enables us to apply the DH and B equations to any technologically relevant aqueous and nonaqueous electrolyte at any concentration and temperature of interest.

关键词： equations electrolyte apply

Application of serine integrases for secondary metabolite pathway assembly in Streptomyces

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Synthetic and Systems Biotechnology 2020年第2期5卷 111-119页

作者： Hong Gao Gabrielle Taylor stephanie K.Evans Paul c.M.Fogg Margaret c.M.smith Department of Biology University of YorkYorkYO105DDUnited Kingdom School of Health&Life Science Teesside UniversityMiddlesbroughTS13BA National Horizons centre Darlington campusTeesside UniversityDarlingtonDL11HG

Serine integrases have been shown to be efficient tools for metabolic pathway *** further improve the flexibility and efficiency of pathway engineering via serine integrases,we explored how multiple orthogonally active serine integrases can be applied for use in vitro for the heterologous expression of complex biosynthesis pathways in Streptomyces spp.,the major producers of useful bioactive natural *** results show that multiple orthogonal serine integrases efficiently assemble the genes from a complex biosynthesis pathway in a single in vitro recombination reaction,potentially permitting a versatile combinatorial assembly ***,the assembly strategy also permitted the incorporation of a well-characterised promoter upstream of each gene for expression in a heterologous *** results demonstrate how site-specific recombination based on orthogonal serine integrases can be applied in Streptomyces spp.

关键词： Serine integrase Pathway assembly Streptomyces Erythromycin

The inducible nitric oxide synthaseinhibitor 1400W as a potential treatment for retinal diseases

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Neural Regeneration Research 2021年第6期16卷 1221-1222页

作者： Sven Schnichels stephanie c.Joachim University Eye Hospital Tübingen Centre for OphthalmologyTübingenGermany Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

The overproduction of reactive oxygen species is defined as oxidative *** deprived oxygen supply in tissues is known as *** mechanisms contribute to the pathogenesis of several retinal diseases,like glaucoma,age-related macular degeneration(AMD),and retinal *** is a neurodegenerative disease defined by a progressive loss of retinal ganglion cells(RGcs)and their axons causing visual field defects,which ultimately leads to *** AMD pathogenesis is further characterized by soft drusen,it involves the retinal pigment epithelium and the Bruch’s membrane-choroid complex.

关键词： AMD diseases potential

Glaucoma-like damage induced by S100B injection is accompanied by microglial response

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Neural Regeneration Research 2022年第3期17卷 572-574页

作者： Teresa Tsai stephanie c.Joachim Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

Glaucoma is currently the second leading cause of blindness *** to aging societies the number of patients suffering from this disease will further increase in the next ***,glaucoma can remain asymptomatic until it is rather far progressed,hence about 10–50% of patients are unaware they suffer from this *** is a progressive optic neuropathy associated with changes at the optic nerve head.

关键词： S100B injection damage

Does HSP27 injection induce glaucoma damage in mice?

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Neural Regeneration Research 2024年第11期19卷 2347-2348页

作者： stephanie c.Joachim Sabrina Reinehr Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of *** good vision is crucial to maintaining mobility,independence,and mental *** can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.

关键词： HSP27 injection damage

Multifunctional resonant wavefront-shaping meta-optics based on multilayer and multi-perturbation nonlocal metasurfaces

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Light(Science & Applications) 2022年第9期11卷 2194-2206页

作者： stephanie cMALEK ADAM cOVERVIG ANDREA ALÙ NANFANG YU Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY 10027USA Photonics Initiative Advanced Science Research CenterCity University of New YorkNew YorkNY 10031USA Physics Program Graduate CenterCity University of New YorkNew YorkNY 10016USA

Photonic devices rarely provide both elaborate spatial control and sharp spectral control over an incoming *** optical metasurfaces,for example,the localized modes of individual meta-units govern the wavefront shape over a broad bandwidth,while nonlocal lattice modes extended over many unit cells support high quality-factor ***,we experimentally demonstrate nonlocal dielectric metasurfaces in the near-infrared that offer both spatial and spectral control of light,realizing metalenses focusing light exclusively over a narrowband resonance while leaving off-resonant frequencies *** devices attain this functionality by supporting a quasi-bound state in the continuum encoded with a spatially varying geometric *** leverage this capability to experimentally realize a versatile platform for multispectral wavefront shaping where a stack of metasurfaces,each supporting multiple independently controlled quasi-bound states in the continuum,molds the optical wavefront distinctively at multiple wavelengths and yet stay transparent over the rest of the *** a platform is scalable to the visible for applications in augmented reality and transparent displays.

关键词： spectrum resonant supporting

What to Eat:Evidence for Selective Autophagy in Plants

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Journal of Integrative Plant Biology 2012年第11期54卷 907-920页

作者： Brice E.Floyd stephanie c.Morriss Gustavo c.MacIntosh Diane c.Bassham Department of Genetics Development and Cell BiologyIowa State UniversityAmes IA 50011USA Department of Biochemistry Biophysics and Molecular BiologyIowa State UniversityAmes IAUSA

Autophagy is a macromolecular degradation pathway by which cells recycle their contents as a developmental process, housekeeping mechanism, and response to environmental stress. In plants, autophagy involves the sequestration of cargo to be degraded, transport to the cell vacuole in a doublemembrane bound autophagosome, and subsequent degradation by lytic enzymes.

关键词： Autophagy degradation stress vacuole.

clinical features and long-term outcomes of patients with colonic oligopolyposis of unknown etiology

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World Journal of Gastroenterology 2022年第48期28卷 6950-6961页

作者： Dan Feldman Linda Rodgers-Fouche stephanie Hicks Daniel c chung Division of Gastroenterology Massachusetts General HospitalBostonMassachusetts 02114United States center for cancer Risk Assessment Massachusetts General HospitalBostonMassachusetts 02114United States Division of Gastroenterology and center for cancer Risk Assessment Massachusetts General HospitalHarvard Medical SchoolBostonMassachusetts 02114United States

BAcKGROUND colonic adenomatous polyposis of unknown etiology(cPUE)is an adenomatous polyposis phenotype that resembles Familial Adenomatous Polyposis(FAP)even though no germline pathogenic variant is *** We sought to better characterize the clinical features and outcomes in a cohort of cPUE *** This is a retrospective case series of patients 18 years old or older with adenomatous oligopolyposis(between 10-100 adenomas)and negative genetic testing,identified through the Hereditary Gastrointestinal cancer Database at Massachusetts General Hospital,a tertiary academic referral center.A retrospective chart review was performed with a focus on demographics,alcohol and tobacco use,medication use,familial malignancy and polyp burden,genetic testing information,endoscopic surveillance data including the corresponding histopathology,colonic and extracolonic malignancies,mortality events,and their *** correlation and Pearson chi-square test(or Fisher's exact test)were used for continuous and categorical variables *** cPUE patients were primarily male(69%)and presented for genetic counseling at 63.7 *** 2 patients(2.9%)reported a first-degree relative with *** an average surveillance period of 12.3 years,0.5 colonoscopies per year were *** developed 2.3 new adenomas per year.4(5.7%)were diagnosed with colorectal cancer(cRc)at a mean age of 66 years,and 3 were diagnosed prior to the onset of oligopolyposis.7(10%)required colectomy due to advanced dysplasia or polyp *** respect to upper gastrointestinal manifestations,1 patient had a gastric adenoma,but there were no cases of gastric or small bowel *** surveillance,10(14%)patients died at a mean age of 72,and none were due to *** cPUE is distinct from familial adenomatous polyposis(FAP)syndrome and the use of FAP surveillance guidelines may result in unnecessarily frequent upper and lower endoscopies.

关键词： colonic polyposis of unknown etiology Multigene cancer panel colorectal cancer colectomy Surveillance Mortality

Dielectric metasurfaces for complete and independent control of the optical amplitude and phase

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Light(Science & Applications) 2019年第1期8卷 318-329页

作者： Adam c.Overvig Sajan Shrestha stephanie c.Malek Ming Lu Aaron Stein changxi Zheng Nanfang Yu Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY 10027USA center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA Department of computer Science Columbia UniversityNew YorkNY 10027USA

Metasurfaces are optically thin metamaterials that promise complete control of the wavefront of light but are primarily used to control only the phase of ***,we present an approach,simple in concept and in practice,that uses meta-atoms with a varying degree of form birefringence and rotation angles to create high-efficiency dielectric metasurfaces that control both the optical amplitude and phase at one or two *** opens up applications in computer-generated holography,allowing faithful reproduction of both the phase and amplitude of a target holographic scene without the iterative algorithms required in phase-only *** demonstrate all-dielectric metasurface holograms with independent and complete control of the amplitude and phase at up to two optical frequencies simultaneously to generate two-and three-dimensional holographic *** show that phaseamplitude metasurfaces enable a few features not attainable in phase-only holography;these include creating artifactfree two-dimensional holographic images,encoding phase and amplitude profiles separately at the object plane,encoding intensity profiles at the metasurface and object planes separately,and controlling the surface textures of three-dimensional holographic objects.

关键词： holographic phase complete