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Asian Journal of Andrology 2007年第5期9卷 690-696页

作者： Karina Zitta Martin Albrecht stephan weidinger Artur Mayerhofer Frank Koehn Department of Dermatology and Allergy Technical University Munich Biedersteiner Strasse 29 Munich 80802 Germany Institute of Anatomy Ludwig-Maximilians-University Biedersteiner Strasse 29 Munich 80802 Germany

Aim： To investigate mechanisms of tryptase-induced reduction of sperm motility and explore whether epidermal growth factor receptor （EGF-R） and protease activated receptor 2 （PAR-2）- associated pathways are involved. Methods： Fresh semen was collected from healthy donors （n = 15）. Semen parameters and quality were assessed in accordance with the World Health Organization （WHO） criteria. Swim-up sperm were fixed and subjected to immunocytochemistry and immunoelectronmicroscopy with specific antibodies directed against PAR-2 and EGF-R. Protein extractions from swim-up spermatozoa were analyzed by Western blotting with antibodies for both receptors. Motility of spermatozoa was evaluated by computer-assisted semen analysis. Results： Immunocytochemistry found PAR-2 and EGF-R in approximately 30% of examined human ejaculated spermatozoa. Both receptors were localized in the plasma membrane. Like tryptase, the PAR-2 synthetic agonist SLIGKV reduced sperm motility, and this effect was inhibited by application of two specific EGF-R pathway blockers （AG1478 and PD168393）. Conclusion： The observed reduction of sperm motility by tryptase through the PAR-2 receptor involves EGF-R pathways.

关键词： spermatozoa motility epidermal growth factor receptor protease activated receptor

Genome-wide association study detects novel risk locus psoriasis

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Genome-wide association study detects novel risk locus psori...

Wnt/β-catenin signaling in heart regeneration

中华医学会第16次全国皮肤性病学术年会

作者： stephan weidinger Eva Buchert David Ellinghaus Philip E.Stuart Rajan P.Nair Sophie Debrus John V.Raelson Manfred Kunz Proton Rahman Dafna Gladman Christian Gieger H.Erich Wichmann Tom H.Karlsen Dieter Kabelitz Goncalo R.Abecasis James T.Elder Stefan Schreiber Michael Weichenthal Andre Franke Institute of Clinical Molecular Biology Christian-Albrechts-University24105 KielGermany Department of Dermatology and Allergy Technische Universitt Mnchen80802 MunichGermany Department of Dermatology University of MichiganAnn ArborMI 48109USA Christian-Albrechts-University 24105 KielGermany

Psoriasis is a complex polygenic disease characterized by epidermal proliferation,altered keratinocyte differentiation and chronic *** recently new insights into the genetic architecture of psoriasis were obtained,many susceptibility loci remain to be *** here present a genome-wide association analysis of 2,339,118 single nucleotide polymorphisms in 472 psoriasis patients and 1146

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Cell Regeneration 2015年第1期4卷 20-31页

作者： Gunes Ozhan Gilbert weidinger Izmir Biomedicine and Genome Center(iBG-izmir) Dokuz Eylul UniversityInciralti-Balcova35340 IzmirTurkey Department of Medical Biology and Genetics Dokuz Eylul University Medical SchoolInciralti-Balcova35340 IzmirTurkey Institute for Biochemistry and Molecular Biology Ulm UniversityAlbert-Einstein-Allee 1189081 UlmGermany

The ability to repair damaged or lost tissues varies significantly among *** regenerative ability of the heart is clinically very relevant,because adult teleost fish and amphibians can regenerate heart tissue,but we mammals ***,heart regeneration is possible in neonatal mice,but this ability is lost within 7 days after *** zebrafish and neonatal mice,lost cardiomyocytes are regenerated via proliferation of spared,differentiated *** some cardiomyocyte turnover occurs in adult mammals,the cardiomyocyte production rate is too low in response to injury to regenerate the ***,mammalian hearts respond to injury by remodeling of spared tissue,which includes cardiomyocyte ***/β-catenin signaling plays important roles during vertebrate heart development,and it is re-activated in response to cardiac *** this review,we discuss the known functions of this signaling pathway in injured hearts,its involvement in cardiac fibrosis and hypertrophy,and potential therapeutic approaches that might promote cardiac repair after injury by modifying Wnt/β-catenin *** of cardiac remodeling by this signaling pathway appears to vary depending on the injury model and the exact stages that have been ***,conflicting data have been published regarding a potential role of Wnt/β-catenin pathway in promotion of fibrosis and cardiomyocyte *** addition,the Wnt inhibitory secreted Frizzled-related proteins(sFrps)appear to have Wnt-dependent and Wnt-independent roles in the injured ***,while the exact functions of Wnt/β-catenin pathway activity in response to injury still need to be elucidated in the non-regenerating mammalian heart,but also in regenerating lower vertebrates,manipulation of the pathway is essential for creation of therapeutically useful cardiomyocytes from stem cells in ***,a detailed understanding of the in vivo role of Wnt/β-catenin signaling in injure

关键词： Wnt Beta-catenin Cardiomyocyte sFrp Regeneration Heart Fibrosis Hypertrophy Zebrafish

Geomorphic Processes, Rock Quality and Solid Waste Management—Examples from the Mt. Everest Region of Nepal

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Journal of Water Resource and Protection 2015年第16期7卷 1921-1308页

作者： Eva Posch Rainer Bell Johannes Thomas weidinger Thomas Glade Department of Geography and Geology University of Salzburg University of Salzburg Salzburg Austria Department of Geography University of Vienna Vienna Austria ERKUDOK Institute K-Hof Museums Gmunden Austria

Sagarmatha National Park and Buffer Zone (SNPBZ) in the Everest region in Nepal is among the most popular destinations for trekking tourism in Nepal. The dramatic growth of the tourism industry has increased pressures on the environment and the National Park is heavily affected by the rapidly growing waste issue. Besides, major mass movements play an important role in the Himalaya and have been observed in SNPBZ. Also, seasonal monsoon floods, debris flows, rock falls, landslides and the creation of glacial lake outburst floods are frequently occurring in the region. This paper explores the reciprocal interactions between the geo-environment and solid waste management in Everest’s SNPBZ. Therefore, geological characteristics and geomorphological processes, especially the two large rockslides in Lukla and Khumjung, as well as their consequences for rock quality, climatic and hydrologic conditions, are analyzed and simultaneously connected to the rapidly growing tourism-induced waste issue. Rockslide material shows high porosity and permeability. Thus, we argue that rockslide facies are particularly vulnerable to contamination by waste water and washed out agricultural fertilizers, which pose threats to the population especially in Namche Bazaar but probably also in Lukla. Also, the landfill sites are often affected by geomorphological processes and may consequently contaminate surface and ground water. Results highlight that regional infrastructure planning of landfill sites often collides with the natural features of the geo-environment and often causes harm to human health and the environment. The implications of the results can be applied to similar areas (such as Marsyandi Valley, Kali Gandaki Valley) with special geological characteristics and rapidly growing waste issues.

关键词： Sagarmatha National Park and Buffer Zone Rock Slide Facies Hydrogeology Landfills Tourism-Impact

An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2694-2708页

作者： Mirja Harms Monica MWHabib Simona Nemska Antonella Nicolò Andrea Gilg Nico Preising Pandian Sokkar Sara Carmignani Martina Raasholm Gilbert weidinger Gönül Kizilsavas Manfred Wagner Ludger Ständker Ashraf HAbadi Hassan Jumaa Frank Kirchhoff Nelly Frossard Elsa Sanchez-Garcia Jan Münch Institute of Molecular Virology Ulm University Medical CenterUlm 89081Germany Department of Pharmaceutical Chemistry Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo 11835Egypt Laboratoire D'Innovation Thérapeutique UMR7200 CNRS/Universitéde Strasbourg and LabEx MEDALISFacultéde PharmacieIllkirch 67412France Institute of Immunology Ulm University Medical CenterUlm 89081Germany Core Facility Functional Peptidomics Ulm University Medical CenterUlm 89081Germany Center of Medical Biotechnology University of Duisburg-EssenDuisburg 47057Germany Max-Planck-Institute for Coal Research Düsseldorf 45470Germany Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkam 603103India Max-Planck-Institut für Molekulare Physiologie Dortmund 44227Germany Institute of Biochemistry and Molecular Biology Ulm UniversityUlm 89081Germany Max Planck Institute for Polymer Research Mainz 55128Germany

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases.A natural fragment of serum albumin,named EPI-X4,has previously been identified as endogenous peptide antagonist and inverse agonist of CXCR4 and is a promising compound for the development of improved analogues for the therapy of CXCR4-associated *** generate optimized EPI-X4 derivatives we here performed molecular docking analysis to identify key interaction motifs of EPI-X4/*** rational drug design allowed to increase the anti-CXCR4 activity of *** EPI-X4 derivative JM#21 bound CXCR4 and suppressed CXCR4-tropic HIV-1 infection more efficiently than the clinically approved small molecule CXCR4 antagonist ***-X4 JM#21 did not exert toxic effects in zebrafish embryos and suppressed allergen-induced infiltration of eosinophils and other immune cells into the airways of animals in an asthma mouse ***,topical administration of the optimized EPI-X4 derivative efficiently prevented inflammation of the skin in a mouse model of atopic ***,rationally designed EPIX4 JM#21 is a novel potent antagonist of CXCR4 and the first CXCR4 inhibitor with therapeutic efficacy in atopic *** clinical development of this new class of CXCR4 antagonists for the therapy of atopic dermatitis,asthma and other CXCR4-associated diseases is highly warranted.

关键词： CXCR4 antagonist Asthma Allergy Inflammation Atopic dermatitis

Geomorphologic and Hydrogeologic Characteristics of Populated Rockslide Deposits (Sagarmatha National Park, Khumbu Himal, Nepal)

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Journal of Water Resource and Protection 2015年第13期7卷 1038-1048页

作者： Joachim Gö tz Johannes Thomas weidinger Stefan Kraxberger Anne-Lise Hennecke Johannes Buckel Basanta Raj Adhikari Department of Geography and Geology University of Salzburg Salzburg Austria Erkudok-Institute K-Hof-Museums of Gmunden Gmunden Austria Department of Civil Engineering Tribhuvan University Kathmandu Nepal

Surface morphology and internal composition of large rockslide deposits have been frequently studied, but their hydrogeologic conditions and consequences for (drinking) water quality and quantity on such deposits are largely unknown. In this study we provide first information on this critical relationship for two large rockslide deposits in the Khumbu Himal (Nepal), which are at the same time the main settlement areas in the region. In the first step, we investigated the Lukla and the Namche-Khumjung rockslides with respect to their dimensions and internal composition based on orthophotos and digital elevation models, geomorphologic field mapping, and the analysis of rockslide outcrops. Secondly, we studied their hydrogeologic characteristics by means of spring water mapping, sampling and analyses. As a consequence of the fragmented and highly shattered rockslide material, both deposits are characterized by 1) effective infiltration, 2) short residence times of percolating water and 3) by only small amounts of available spring water and surface runoff at all. Human activity on the studied rockslide deposits can therefore be described as an ambivalent relationship: On the one hand, the rockslide deposits provide a gentle topography and the only available areas for extensive settlements and agriculture in the steep upper DudhKosi catchment;On the other hand, their internal composition accounts for water scarcity—a critical issue for the local population demanding for adaptation strategies, especially in the light of the ever—increasing trekking and expedition tourism in the region.

关键词： Khumbu Himal Geomorphologic and Hydrogeologic Mapping Rockslide Morphology Rockslide Hydrology Water Scarcity

强调材料——清华大学核能技术研究院花园的再设计

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中国园林 2007年第2期23卷 11-12页

作者： Jurgen weidinger 李文玺朱育帆德国Juergen weidinger景观设计事务所

1 设计意识核能研究院花园再设计的项目证明了朱育帆在本设计中的一个偏好的原发点：材料意识和对材料精确性的把握。从这种材料意识出发，他的设计赋予了这个地点一种新的愉悦氛围，甚至是对当代中国风景园林境遇的一种注释。

关键词：核能技术再设计研究院材料清华大学花园设计意识风景园林

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利用多相钢成形加工技术生产新型座椅部件

现代制造 2013年第27期 50-52页

作者： Markus Kaupper Marion Merklein Peter weidinger

在汽车制造领域中，开发和实．现一套经济的轻结构设计制造方案，在降低汽车油耗、减少有害气体排放和充分利用资源方面有着重要的战略意义。因此，合适的材料选择、汽车零部件的结构设计和加工工艺方法等在产品生产过程中是密切相关的... 详细信息

在汽车制造领域中，开发和实．现一套经济的轻结构设计制造方案，在降低汽车油耗、减少有害气体排放和充分利用资源方面有着重要的战略意义。因此，合适的材料选择、汽车零部件的结构设计和加工工艺方法等在产品生产过程中是密切相关的；只有这样，

关键词：汽车零部件加工技术生产过程多相钢轻结构设计座椅成形有害气体排放

用微扰角相关技术研究Nb-H系统的无序-有序相

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低温物理学报 1987年第1期 5-9页

作者：盛虞琴,E.Recknagel,A.weidinger 上海交通大学应用物理系德意志联邦共和国康斯坦茨大学物理系德意志联邦共和国康斯坦茨大学物理系

用微扰角相关技术对Nb-H系统的无序-有序相进行了研究。测量了Nb-H晶格内放射性探查原子181Hf位置上在不同温度下的电场梯度。实验发现,我们确定的Nb-H系统的无序-有序相的相转变温度和***等的相图及***等用电子显微镜研究得出的十分一... 详细信息

用微扰角相关技术对Nb-H系统的无序-有序相进行了研究。测量了Nb-H晶格内放射性探查原子181Hf位置上在不同温度下的电场梯度。实验发现,我们确定的Nb-H系统的无序-有序相的相转变温度和***等的相图及***等用电子显微镜研究得出的十分一致。还发现,对[H]/[Nb]=0.81的样品当温度低于90k时存在一种新的有序相。

关键词：有序相变 Nb-H 角相关微扰技术研究

在中等海拔高度(1700m)下代谢综合征患者血流介导的血管舒张短暂受损

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 35-36页

作者： Frick M. Rinner A. Mair J. F.weidinger 孙凯 Division of Cardiology Innsbruck Medical UniversityAnichstrasse 35A-6020 InnsbruckAustria

Background: The influence of moderate altitude on the cardiovascular system in patients with metabolic syndrome has not been investigated sufficiently, yet. T he aim of this study was to assess the effect of acute and mid-term exposure to moderate altitude(1700 m) on endothelial function in patients with metabolic sy ndrome. Methods: Flow-medi-ated(FMD) and nitroglycerin-mediated vasodilation( NMD) were assessed in 18 patients with coronary risk factors on 5 occasions:(1) at location A(576 m),(2) on the first day at moderate altitude(location B, 1700 m),(3) after 3 weeks at moderate altitude,(4) and(5) again at location A(6 and 1 6 weeks after the stay at moderate altitude, respectively). In addition, markers of lipid metabolism, serum erythropoietin and endothelin were measured. Results : FMD on the first day at moderate altitude was similar compared to baseline FMD at location A(7.0±3.3 vs. 7.4±4.6%; NS). A 3-week stay at moderate altitude was associated with a significant reduction in FMD(7.4±4.6 vs. 3.8±2.5%; p< 0.05) despite a decrease in baseline diameter(4.5±0.3 vs. 4.3±0.4 mm; p< 0.05) . Six weeks after returning to location A, FMD was still reduced compared to bas eline(4.3±2.8%; p< 0.05) and after further 16 weeks, FMD returned to baseline values(5.5±3.5%). However, metabolic parameters improved significantly. In contrast, NMD and endo thelin levels remained unchanged. Conclusion: In patients with metabolic syndrom e, a sojourn of 3 weeks at moderate altitude leads to a prolonged, but reversibl e impairment of FMD. The discrepancy to improvement of other cardiovascular and metabolic parameters requires further investigation.

关键词：血管舒张功能代谢综合征海拔高度血流介导中等血清促红细胞生成素短暂硝酸甘油介导