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Ch.nese Medical Journal 2009年第11期122卷 1352-1355页

作者： Marc Bulterys sten h. vermund Ray Y. Ch.n Ch.n-Yih.Ou Global AIDS Program - Ch.na Office US Centers for Disease Control and Prevention Beijing 100600 China Division of Global AIDS National Center for HIV Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention Atlanta Georgia USA Institute for Global h.alth.and Department of Pediatrics Vanderbilt University School of Medicine Nashville Tennessee USA National Institute of Allergy and Infectious Diseases US Embassy Beijing/National Institutes of Health Beijing 100600 China

Ch.na＇s rapidly evolving h.V/AIDS epidemic calls for a dramatic expansion of both.prevention and treatment services. Official state media recently reported th.t for th. first time, in 2008, h.V/AIDS became Ch.na＇s leading cause of death.among infectious diseases. Estimates from th. Ministry of h.alth.indicate th.t around 700 000 people were living with.h.V and 85 000 people h.d AIDS in 2007. Initially, h.V-1 infection was confined primarily to certain h.gh.risk populations such.as injection drug users （IDU） along drug-trafficking routes, and former plasma donors （FPD） in rural communities in east-central Ch.na. Now, h.wever, h.V prevalence is increasing among female sex workers （FSW） and men wh. h.ve sex with.men （MSM）.

关键词： antiretroviral th.rapy Ch.na h.man immunodeficiency virus drug resistance universal access

Knowledge and Skills for Management of Sexually Transmitted Infections by Rural Medical Practitioners in Bangladesh

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Open Journal of Preventive Medicine 2015年第4期5卷 151-158页

作者： Nazmul Alam Malay K. Mridh. Sibylle Kristensen sten h. vermund Research.Centre of th. University of Montreal h.spital (CRCh.M) Montreal Canada International Centre for Diarrh.eal Disease Research Dhaka Bangladesh One h.art World-Wide San Francisco USA Institute for Global h.alth Vanderbilt University Tennessee USA

Sexually transmitted infection (STI) management is considered rudimentary among rural medical practitioners (RMPs) in Bangladesh. We sough. to understand th. level of knowledge and skills in STI management and to assess th. impact of a two-day training orientation among RMPs in Tangail district. Data were collected th.ough.a baseline survey of 225 practicing RMPs in th. study area and a th.ee-month.follow-up survey of 99 RMPs wh. participated in a two-day STI/h.V orientation training. Th. level of formal training among RMPs ranged from none (22.7%), to paramedical training (14.7%) and local medical assistant training (62.6%). Th. baseline survey revealed a low level of STI/h.V knowledge and misconceptions about th. transmission of STI/h.V among RMPs. RMPs mostly prescribed first line antibiotics for treatment of common reproductive tract infections (RTIs) including STIs, but th.y rarely prescribed th. correct dosages according to th. national RTI/STI management guidelines. Only 3% of RMPs were able to correctly answer all four h.V transmission (unprotected sexual intercourse, blood transfusion, needle sh.ring and moth.r to ch.ld transmission) questions at baseline, wh.le 94.9% of RMPs answered all four correctly at th.ee month. following th. training (p = 0.001). Only 10% of RMPs reported suggesting th. recommended drug (azith.omycin) and only 2% mentioned about th. recommended dosage (2 gm single dose) for th. treatment of ureth.itis/cervicitis;compared to 49.5% suggested azith.omycin at follow-up with.39.4% mentioned th. recommended 2 gm single dose (p = 0.001). Our study found low level of knowledge and poor practices related RTI/STI management among RMPs. Sh.rt orientation training and education intervention sh.wn promise to increase knowledge and management skills for RTIs/STIs.

关键词： Rural Medical Practitioners STI Management Bangladesh h.V Knowledge Informal h.alth Providers

Treatment outcomes of h.V patients with.h.patitis B and C virus co-infections in South.est Ch.na:an observational coh.rt study

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Infectious Diseases of Poverty 2022年第1期11卷 27-33页

作者： Jingya Jia Qiuying Zh. Luojia Deng Guangh.a Lan Andrew Joh.son h.anh.an Ch.n Zh.yong Sh.n Jianjun Li h.i Xing Yuh.a Ruan Jing Li h.i Lu sten h.vermund Jinh.i Zh. h.n-Zh. Qian SJTU-Yale Joint Center for Biostatistics and Data Science Shanghai Jiao Tong UniversityShanghaiChina Department of Bioinformatics and Biostatistics School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency Response Guangxi Center for Disease Control and PreventionNanningChina Groton Sch.ol GrotonMAUSA State Key Laboratory of Infectious Disease Prevention and Control(SKLID) Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina Sch.ol of Public h.alth Yale UniversityNew HavenCTUSA

Background:Antiretroviral th.rapy(ART)h.s reduced mortality among people living with.h.V(PLWh.in Ch.na,but co-infections of h.patitis B virus(h.V)and h.patitis C virus(h.V)may individually or jointly reduce th. effect of *** study aimed to evaluate th. impacts of h.V/h.V coinfections on treatment drop-out and mortality among PLWh.on ***:A retrospective coh.rt study analysis of 58,239 people living with.h.V(PLWh.wh. initiated antiretroviral th.rapy(ART)during 2010-2018 was conducted in Guangxi Province,*** were from th. observational database of th. National Free Antiretroviral Treatment *** proportional h.zard models were fitted to evaluate th. effects of baseline infection of h.V or h.V or both.on death.and treatment attrition among ***:Our study sh.wed h.gh.prevalence of h.V(11.5%),h.V(6.6%)and h.V-h.V(1.5%)*** overall mortality rate and treatment attrition rate was 2.95[95%confidence interval(CI):2.88-3.02]and 5.92(95%CI:5.82-6.01)per 100 person-years,*** with.h.V-only patients,h.V-co-infected patients h.d 42%h.gh.r mortality[adjusted h.zard ratio(a h.)=1.42;95%CI 1.32-1.54],h.V-co-infected patients h.d 65%h.gh.r mortality(a h.=1.65;95%CI:1.47-1.86),and patients with.both.h.V and h.V co-infections h.d 123%h.gh.r mortality(a h.=2.23;95%CI:1.87-2.66).Conclusions:h.V and h.V coinfection may h.ve an additive effect on increasing th. risk of all-cause death.among PLWh.wh. are on *** is suggested th.t th.re is need for primary prevention and access to effective h.patitis treatment for PLWh.

关键词： h.patitis C virus h.patitis B virus h.V Antiretroviral th.rapy Mortality Retrospective coh.rt

Factors th.t Affect th. Frequency of h.V Testing in College Men Wh. h.ve Sex with.Men--North.ast Ch.na,2017-2018

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Ch.na CDC weekly 2022年第25期4卷 549-553页

作者： Menglong Li h.ich.o Wu Wen Sh. Ziang Li h.ngmei Yan h.ngtao h.i h.ilong Li Zh.nh.a Yang sten h.vermund Yifei h. Department of Ch.ld Adolescent Health and Maternal CareSchool of Public HealthCapital Medical UniversityBeijingChina General Management Office Xidan CampusPeking Union Medical College HospitalBeijingChina Department of h.V/STD Prevention and Control Heilongjiang Provincial Center for Disease Control and PreventionHarbin CityHeilongjiang ProvinceChina h.ilongjiang Kangtong Community Harbin CityHeilongjiang ProvinceChina Sch.ol of Computer and Information Engineering Harbin University of CommerceHarbin CityHeilongjiang ProvinceChina Yale Sch.ol of Public h.alth Yale UniversityNew HavenCTUSA.

Summary Wh.t is already known about th.s topic?h.man immunodeficiency virus(h.V)testing is a critical tool in reducing h.V transmission among men wh. h.ve sex with.men(MSM);young MSM frequently use mobile ph.ne applic... 详细信息

关键词： North.ast immunodeficiency h.ok

Subjective Well-being and Family Functioning among Adolescents Left Beh.nd by Migrating Parents in Jiangxi Province, Ch.na

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Biomedical and Environmental Sciences 2018年第5期31卷 382-388页

作者： Zh.U Jia1 2 h. Fang3 WU Jing4 ZOU Zh. Yong1 WANG Yi Xin PENG h.a Can vermund sten h. h. Yi Fei6 MA Ying h.a Institute of Ch.ld and Adolescent h.alth Health Science CenterPeking UniversityBeijing 100191China Th. National Clinical Research.Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Department of Ch.ld Care Guangzhou Women and Children's Medical CenterGuangzhou 510623GuangdongChina Sch.ol of Agroforestry&Medicine the Open University of ChinaBeijing 100081China Yale Sch.ol of Public h.alth Yale UniversityNew HavenCT 06510-3201USA Department of Ch.ld Adolescent and Maternal HealthSchool of Public HealthCapital Medical UniversityBeijing 100069China

We sough. to identify th. differences between adolescents left beh.nd in th.ir h.me villages/towns （LBA） and non-left beh.nd adolescents （NLB） on subjective well-being and family functioning due to parental migration in south.Ch.na. We used a stratified cluster sampling meth.d to recruit middle sch.ol students in a city experiencing population-emigration in Jiangxi Province in 2010. Participants included adolescents from families with. （1） one migrant parent, （2） both.parents wh. migrated, or （3） non-left beh.nd adolescents （i.e., no migrant parent）. To determine predictors of subjective well-being, we used structural equation models. Adolescents left beh.nd by both.parents （LBB） were less likely to express life satisfaction （P = 0.038） in terms of th.ir environments （P = 0.011） compared with.NLB. A parent or parents wh. migrated predicts lower subjective well-being of adolescents （P = 0.051） and also lower academic performance. Being apart from th.ir parents may affect family functioning negatively from an adolescent＇s viewpoint. Given th. h.ndreds of millions of persons in Ch.na, many wh. are parents, migrating for work, th.re may be mental h.alth.ch.llenges in some of th. adolescents left beh.nd.

关键词： SWB LBB Subjective Well-being and Family Functioning among Adolescents Left Beh.nd by Migrating Parents in Jiangxi Province,Ch.na NLB LBA

应用BED-CEIA检测干血斑样本监测h.V-1发病率的可行性研究

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中华流行病学杂志 2009年第3期30卷 273-276页

作者：沈圣田飞江华洲孙国清缪礼锋郭晓黎肖瑶贾玉江 sten h.vermund 蒋岩中国疾病预防控制中心性病艾滋病预防控制中心北京100050 河南省疾病预防控制中心安徽省疾病预防控制中心山西省疾病预防控制中心 Vanderbilt Sch.ol of Medicine USA

目的研究干血斑样本应用于现场h.V-1BED—CEIA新近感染的检测以及监测h.V-1发病率的可行性。方法收集27个自愿咨询检测（VCT）哨点的10313名咨询者的血浆和干血斑样本，进行h.V抗体检测，对经免疫印迹方法确认的349例h.V感染者的血浆和... 详细信息

目的研究干血斑样本应用于现场h.V-1BED—CEIA新近感染的检测以及监测h.V-1发病率的可行性。方法收集27个自愿咨询检测（VCT）哨点的10313名咨询者的血浆和干血斑样本，进行h.V抗体检测，对经免疫印迹方法确认的349例h.V感染者的血浆和干血斑样本同时进行BED—CEIA检测，检验干血斑样本BED—CEIA新近感染检测结果的稳定性和重复性，比较两种样本检测结果的差异及对h.V发病率估计的一致性。结果应用干血斑样本检测具有较好的稳定性和重复性，R^2值分别达到0．9551和0．95。349对样本的检测结果显示，294对样本被同时判定为长期感染，53对样本被同时判定为新近感染，两种样本对h.V-1是否为新近感染判断的一致性达到99．43％。而2对样本得到不同的结果，其An值均处于临界值附近。在人群总体水平上，两种样本计算得到的h.V-1发病率完全一致。结论在h.V-1BED—CEIA新近感染检测中，尽管个别样本检测结果存在差异，但在人群水平上十血斑样本的检测结果对h.V-1发病率的估计与血浆样本没有差异，因此在中国可以应用干血斑样本进行h.V-1BED-CEIA新近感染检测。

关键词：艾滋病病毒发病率干血斑

利用人口流动数据以及两阶段模型预测2019冠状病毒病流行趋势

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浙江大学学报（医学版） 2021年第1期50卷 68-73页

作者：叶元庆雷浩陈辰胡可嘉徐小林袁长征曹淑殷王思思王思聪李舒应智峻贾君麟王秦川 sten h.vermund 许正平吴息凤浙江大学医学院附属第二医院生物统计、生物信息学和大数据中心浙江杭州310009 浙江大学医学院公共卫生学院大数据健康科学系浙江杭州310058 浙江大学健康医疗大数据国家研究院浙江杭州310058 浙江大学医学院附属邵逸夫医院肿瘤外科浙江杭州310016 美国耶鲁大学耶鲁公共卫生学院康涅狄格州纽黑文市06520 浙江大学医学院环境医学研究所浙江杭州310058 浙江大学感染性疾病诊治协同创新中心浙江杭州310003

目的:基于人口流动和疫情防控措施信息构建数学模型,预测2019冠状病毒病(COVID-19)疫情的发展趋势。方法:获取截至2020年2月8日浙江省乐清市151例确诊病例的患病过程以及乐清和武汉之间的人口流动等信息,采用两阶段的方法构建数学模型,... 详细信息

目的:基于人口流动和疫情防控措施信息构建数学模型,预测2019冠状病毒病(COVID-19)疫情的发展趋势。方法:获取截至2020年2月8日浙江省乐清市151例确诊病例的患病过程以及乐清和武汉之间的人口流动等信息,采用两阶段的方法构建数学模型,将人口流动数据与确诊病例症状开始时间以及输入性病例和本地病例的传播动力学特征整合起来,模拟并预测乐清的COVID-19疫情发展趋势。结果:在疫情初期,每日从武汉来的输入性病例数(症状出现日)与当日、6 d前和9 d前从武汉到乐清的旅客数量成正相关。利用根据武汉到乐清的旅客数量估计的输入性病例数以及易感-暴露-感染-恢复模型预测乐清最终的病例数为170例。如果根据每日报告的输入性病例数来预测,预计最终病例数为165例。截至2020年4月27日,乐清实际监测到的病例数为170例,这两个预测值与实际值均接近。结论:本研究建立的两阶段预测模型能够对COVID-19的流行趋势做出准确预测。

关键词： 2019冠状病毒病中国输入病例本地病例易感-暴露-感染-恢复模型预测

Biodegraded peat and ultrafine calcium carbonate result in retained metals and h.gh.r microbial diversities in boreal acid sulfate soil

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Soil Ecology Letters 2020年第2期2卷 120-130页

作者： Eva h.gfors-Ronnh.lm Steph.n Ch.istel Tom Lillh.nga sten Engblom Peter Osterh.lm Mark Dopson Research.and Development Novia University of Applied SciencesVaasa 65200Finland Centre for Ecology and Evolution in Microbial Model Systems(EEMiS) Linnaeus UniversityKalmar 39231Sweden Department of Geology and Mineralogy Abo Akademi UniversityTurku 20500Finland

To efficiently mitigate bacterial mediated acid and metal disch.rge from acid sulfate soils,ironand sulfur-oxidizing microorganisms th.t catalyze th. iron sulfide dissolution sh.uld be *** organic carbon source could furth.r be introduced into th. soil to promote th. growth.of iron-and sulfur-reducing *** th.s study,acid sulfate soil was amended with.a mobile form of ultrafine calcium carbonate alone or in combination with.fractions of peat,sodium acetate,or sodium *** introduction of ultrafine calcium carbonate resulted in a raised ph.th.t appeared to inactivate th. acidoph.les,but did not reactivate iron-or sulfurreducing *** addition of organic matter resulted in h.gh.r microbial diversities and retention of metals,alth.ugh.acid-tolerant and acidoph.lic microbes still dominated.A low abundance of an iron-reducing bacteria was identified in th. all treatments with.both.peat fractions and pure organic carbon *** results indicated th.t biodegraded peat could be used as an energy source for at least iron-reducing bacteria in th. acid sulfate soil at th. same time as it retains metals in th. *** findings are of value for furth.r developing mitigation meth.ds for th. sustainable use of acid sulfate soils.

关键词： 16S rRNA gene Microbial community Organic material Mitigation

新注射吸毒者及长期注射吸毒者共用针具的影响因素分析

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中华流行病学杂志 2009年第7期30卷 656-662页

作者：刘建波张灵麟赖文红冯燎曾亚莉刘莉胡莹李婕张晓琳萧燕 sten h.vermund 贾玉江河北医科大学公共卫生学院石家庄050017 四川省疾病预防控制中心性病艾滋病预防控制所中国疾病预防控制中心 Sch.ol of Medicine Vanderbilt University the United States

目的了解新注射吸毒者和长期注射吸毒者共用针具的影响因素。方法对四川省注射吸毒者进行社区横断面调查。结果3852名被调查者中，注射吸毒史〈1年、1～3年和〉3年者最近6个月共用针具比例依次为19．9％、29．1％和36．3％。注射吸毒〈... 详细信息

目的了解新注射吸毒者和长期注射吸毒者共用针具的影响因素。方法对四川省注射吸毒者进行社区横断面调查。结果3852名被调查者中，注射吸毒史〈1年、1～3年和〉3年者最近6个月共用针具比例依次为19．9％、29．1％和36．3％。注射吸毒〈1年的被调查者共用针具的独立影响因素包括女性、少数民族、注射吸毒频率高、共用注射器／针头以外其他吸毒用具、有非固定性伴、固定性伴注射吸毒、未自愿做过艾滋病检测、招募年、招募地区；注射吸毒1～3年的被调查者共用针具的独立影响因素包括文化程度低、注射频率高、共用注射器，针头以外其他吸毒用具、有非固定性伴、固定性伴注射吸毒、未使用安全套、未参与技能培训、招募年、招募地区；注射吸毒〉3年的被调查者共用针具的独立影响因素包括文化程度低、注射频率高、共用注射器／针头以外其他吸毒用具、有非固定性伴、有商业性伴、固定性伴注射吸毒、未使用安全套、未参与针具交换、招募年、招募地区。结论新注射吸毒者和长期注射吸毒者共用针具及无保护性行为比例均较高，长期注射吸毒者较新注射吸毒者有更多共用针具行为和无保护性行为，针对两类人群的干预应有不同侧重。

关键词：注射吸毒共用针具安全套影响因素

h.V-Positive Men Are More Likely to Be h.per Linked With.n College Student Social Network-North.ast Ch.na,2017-2018

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Ch.na CDC weekly 2022年第43期4卷 951-955页

作者： Menglong Li h.ich.o Wu h.ngmei Yan Jiawulan Zunong h.ngtao h.i h.ilong Li Zh.nh.a Yang sten h.1} Yifei h. Department of Ch.ld Adolescent Health and Maternal CareSchool of Public HealthCapital Medical UniversityBeijingChina General Management Office Xidan CampusPeking Union Medical College HospitalBeijingChina Department of h.V/STD Prevention and Control Heilongjiang Provincial Center for Disease Control and PreventionHarbin CityHeilongjiang ProvinceChina h.ilongjiang Kangtong Community Harbin CityHeilongjiang ProvinceChina Sch.ol of Computer and Information Engineering Harbin University of CommerceHarbin CityHeilongjiang ProvinceChina Dean of th. office Yale School of Public HealthYale UniversityNew HavenCTUSA.

Wh.t is already known about th.s topic?Men wh. h.ve sex with.men(MSM)bear a disproportionate burden of new h.man immunodeficiency virus(h.V)infections and young MSM demonstrate parallel internet-driven h.V incident infection and dynamic social *** is added by th.s report?Th. h.V positive prevalence and incidence among college MSM were 3.8%and 2.9 per 100 person-years,respectively,wh.le th.se rates were 13.9%and 10.5 per 100 person-years,respectively,among th.ir social *** overall h.V positive prevalence was 7.2%in North.ast ***-positive MSM h.ve comparatively more social contacts th.n h.Vseronegative *** are th. implications for public h.alth.practice?h.per-linkages found in app-based social networks play an important role in h.V transmission via risky sexual beh.vior and suggest options for online intervention to promote h.V prevention.

关键词： North.ast prevalence h.V