Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China:an observational cohort study

作     者：Jingya Jia Qiuying Zhu Luojia Deng Guanghua Lan Andrew Johnson Huanhuan Chen Zhiyong Shen Jianjun Li Hui Xing Yuhua Ruan Jing Li Hui Lu Sten H.Vermund Jinhui Zhu Han-Zhu Qian Jingya Jia;Qiuying Zhu;Luojia Deng;Guanghua Lan;Andrew Johnson;Huanhuan Chen;Zhiyong Shen;Jianjun Li;Hui Xing;Yuhua Ruan;Jing Li;Hui Lu;Sten H. Vermund;Jinhui Zhu;Han-Zhu Qian

作者机构：SJTU-Yale Joint Center for Biostatistics and Data ScienceShanghai Jiao Tong UniversityShanghaiChina Department of Bioinformatics and BiostatisticsSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina Guangxi Key Laboratory of Major Infectious Disease Prevention Control and Biosafety Emergency ResponseGuangxi Center for Disease Control and PreventionNanningChina Groton SchoolGrotonMAUSA State Key Laboratory of Infectious Disease Prevention and Control(SKLID)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina School of Public HealthYale UniversityNew HavenCTUSA 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2022年第11卷第1期

页      面：27-33页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China Guangxi Natural Science Foundation Project(Grants 2020GXNSFAA159020) Guangxi Key Laboratory of AIDS Prevention Control and Translation[ZZH2020010] Guangxi Bagui Honor Scholarship,and Chinese State Key Laboratory of Infectious Disease Prevention and Control 

主　　题：Hepatitis C virus Hepatitis B virus HIV Antiretroviral therapy Mortality Retrospective cohort 

摘      要：Background:Antiretroviral therapy(ART)has reduced mortality among people living with HIV(PLWH)in China,but co-infections of hepatitis B virus(HBV)and hepatitis C virus(HCV)may individually or jointly reduce the effect of *** study aimed to evaluate the impacts of HBV/HCV coinfections on treatment drop-out and mortality among PLWH on ***:A retrospective cohort study analysis of 58,239 people living with HIV(PLWH)who initiated antiretroviral therapy(ART)during 2010-2018 was conducted in Guangxi Province,*** were from the observational database of the National Free Antiretroviral Treatment *** proportional hazard models were fitted to evaluate the effects of baseline infection of HBV or HCV or both on death and treatment attrition among ***:Our study showed high prevalence of HBV(11.5%),HCV(6.6%)and HBV-HCV(1.5%)*** overall mortality rate and treatment attrition rate was 2.95[95%confidence interval(CI):2.88-3.02]and 5.92(95%CI:5.82-6.01)per 100 person-years,*** with HIV-only patients,HBV-co-infected patients had 42%higher mortality[adjusted hazard ratio(a HR)=1.42;95%CI 1.32-1.54],HCV-co-infected patients had 65%higher mortality(a HR=1.65;95%CI:1.47-1.86),and patients with both HCV and HBV co-infections had 123%higher mortality(a HR=2.23;95%CI:1.87-2.66).Conclusions:HBV and HCV coinfection may have an additive effect on increasing the risk of all-cause death among PLWH who are on *** is suggested that there is need for primary prevention and access to effective hepatitis treatment for PLWH.