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Quantitative Autoradiographic Study on Receptor Regulation in the Basal Ganglia in Rat model of Levodopa-induced motor Complications

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Journal of Huazhong University of Science and Technology(medical Sciences) 2009年第2期29卷 156-162页

作者：徐岩张振涛秦开蓉 stella m.papa 曹学兵 Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Rehabilitation Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Neurology School of MedicineEmory University

In order to study neurotransmitter receptor regulation in the basal ganglia involved in the functional changes underlying levodopa-induced motor complications, quantitative autoradiography was used to observe receptor bindings of dopamine D1 and D2, N-methyl-D-aspartate （NmDA）, amino-3-hydroxy-5-methylisoxazole propionic acid （AmPA） and amino butyric acid （GABA） in the basal ganglia of rats that had unilateral nigrostriatal lesions and had been chronically treated with levodopa until motor complications developed. The rats were randomly assigned to three groups： normal, denervated and treatment-complicated groups. The results showed that response duration to levodopa became progressively shorter and abnormal involuntary movement （AIm） score was progressively increased during the course of levodopa treatment. Chronic treatment augmented D1 receptors more than denervation, and reduced D2 receptors that were also increased by dopamine denervation. Striatal NmDA receptors were substantially up-regulated in the treatment-complicated group. Levodopa treatment did not change receptors of nigral AmPA, pallidal GABA, and subthalamic GABA, which remained the same as that in denervation group. However, chronic treatment reversed the increase of nigral GABA receptors caused by the lesion. It was concluded that a shortening of response duration and AIm mimicked levodopa-induced motor complications of Parkinson＇s patients. These data suggested that up-regulation of dopamine D1 and NmDA receptors in the striatum leads to an imbalance of stimulation through the striatal output pathways, which is associated with levodopa-induced motor complications.

关键词： levodopa-induced motor complications Parkinson's disease glutamate receptors GABA receptors dopaminc receptors autoradiography

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Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates

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Neuroscience Bulletin 2015年第6期31卷 705-713页

作者： Arun Singh Claire A.Gutekunst Subramaniam Uthayathas John P.m.Finberg Klaus mewes Robert E. Gross stella m.papa Yair Feld Neuropharmacology and Neurologic Diseases Yerkes National Primate Research Center Department of Neurosurgery Emory University School of Medicine molecular Pharmacology Department Rappaport Faculty of Medicine Department of Neurology Emory University School of Medicine Gene Grafts Ltd

Recent studies have shown that fibroblast transplantation can modify the activity of basal ganglia networks in models of Parkinson＇s disease. To determine its effects on parkinsonian motor symptoms, we performed autologous dermal fibroblast transplantation into the internal pallidum （GPi） in two parkinsonian rhesus monkeys with stable levodopa- induced dyskinesias （LIDs）. Levodopa responses were assessed every week after transplantation for three months. A reduction of between 58% and 64% in total LIDs on the contralateral side was observed in both animals. No clear LID changes were observed on the ipsilateral side. These effects lasted the entire 3-month period in one monkey, but declined after 6-8 weeks in the other. The antiparkinsonian effects of levodopa did not diminish, The results of this pilot study indicate that fibroblast transplantation into the GPi may have beneficial effects on LIDs and warrant further investigation for potential therapeutic use.

关键词： globus pallidum autologous levodopa antiparkinsonian monkeys

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Non-equilibrium Statistic Features in Dissipative Heavy Ion Collision ^(27)Al+ ^(27)Al

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Chinese Physics Letters 1999年第12期16卷 876-878页

作者： WANG Qi LI Song-lin TIAN Wen-dong HU Peng-yun LU Jun F.Amorini m.Cabibb G.Cardellas P.Figuere A.musumarra m.papa G.pappalardo F.Rizzo S.Romano S.Tudisco B.Heusch Institute of modern Physics Chinese Academy of SciencesLanzhou 730000 Istituto Nazionale di Fisica Nucleare the Laboratorio Nazionale del SudItaly Istituto Nazionale di Fisica Nuclearr SezCataniaItaly Dipartimento di Fisica University Catania Italy Centre de Recherches Nucleaires StrasbourgFrance

The excitation functions of dissipative products have been measured in the reaction 27Al+27Al at incident energies from 114 to 127meV in steps of 200keV. Detection angles vary continuously from 10.4° to 57.4° in laboratory system. An angular coherent width more than 40° in center of mass is obtained. The results from the analysis of excitation functions with nonself-averaging are characterized by a quasi-periodic long-range energy structure embedded in the disorder Ericson fluctuation.

关键词： excitation equilibrium steps

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Acacia mangium Willd: benefits and threats associated with its increasing use around the world

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Forest Ecosystems 2019年第1期6卷 13-25页

作者： Lydie-stella Koutika David m.Richardson CRDPI Centre de Recherche sur la Durabilité et la Productivité des Plantations Industrielles Centre for Invasion Biology Department of Botany & Zoology Stellenbosch University

Background: Acacia mangium, a fast-growing tree native to parts of Indonesia, Papua New Guinea and Australia,has been cultivated outside its native environment and introduced into humid tropical lowland regions of Asia,South America and Africa over the last few decades. It is a multipurpose tree used in agroforestry, forestry and for restoration of degraded lands. It is also highly invasive in many regions where it has been introduced outside its native range. This paper reviews evidence of its obvious benefits and its negative impacts on ***: A literature review on Australian acacias and especially on A. mangium was undertaken to highlight both benefits and threats associated with their increasing worldwide use outside their native ***: Through N_2 fixed from the atmosphere, A. mangium improves soil fertility, especially by increasing N status and soil C accretion when introduced to N-limited areas; it thus has the potential to restore nutrient cycling in degraded systems. No studies have, however, been done to assess the effectiveness of A. mangium in restoring biodiversity of degraded lands. most Australian acacias have traits that facilitate invasiveness, and 23 species have been recorded as invasive to date. A. mangium has been reported as invasive in Asia, Indonesia, Pacific Islands,Indian Ocean Islands, southern Africa and Brazil. Research on other invasive Australian acacias in several parts of the world has elucidated the types of impacts that are likely in different types of ecosystems and key options for mitigating ***: A. mangium has the potential to restore nutrient cycling in degraded systems, but is highly invasive wherever it is planted. many parts of the world have a large invasion debt for this species. Experience with other invasive acacias around the world suggests a suite of interventions that could be used to reduce invasions and mitigate impacts. Careful risk assessments should be undertaken prior to

关键词： Biodiversity Biological invasions C sequestration Soil N status Tree invasions

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Impact of crystalline and amorphous iron-and aluminum hydroxides on mechanisms of phosphate adsorption and desorption

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Journal of Environmental Sciences 2018年第8期30卷 175-189页

作者： stella Gypser Florian Hirsch Anja m.Schleicher Dirk Freese Brandenburg University of Technology Cottbus-Senftenberg Faculty of Environment Process Engineering Biotechnology and Chemistry Department of Soil Protection and Recultivation Brandenburg University of Technology Cottbus-Senftenberg Faculty of Environment Process Engineering Biotechnology and Chemistry Department of Geopedology and Landscape Development German Research Centre for Geosciences Section 3.1 Inorganic and Isotope Geochchemistry

Fourier-transform infrared（FT-IR） spectroscopic experiments were carried out during phosphate adsorption on highly crystalline gibbsite, poorly crystalline 2-line-ferrihydrite and amorphous iron–aluminum–hydroxide mixtures in the molar ratio 1：0, 10：1, 5：1, 1：1, 1：5, 1：10 and 0：1. The OH stretching vibrational bands were utilized to analyze changes in structural and surface OH groups during adsorption, because the position of characteristic P／O vibrational bands can shift depending on reaction conditions, pH or adsorbed phosphate *** and desorption kinetics were studied at pH6 and different initial phosphate concentrations to achieve varying phosphate coverage on the mineral surfaces. For gibbsite the formation of AlHPO4 and Al2HPO4 can be assumed, while for ferrihydrite, a FeHPO4 or Fe2PO4 complex and the precipitation of FePO4 with longer equilibration time were ***2HPO4 or a Fe2PO4 surface complex was deduced for Fe-hydroxides, an AlH2PO4 surface complex was identified for Al-hydroxide, and both displayed either hydrogen bonds to neighboring hydroxyl groups or hydrogen bonds to outer-sphere complexes. Fe：Al-hydroxide mixtures with high Al ratios showed a low phosphate desorption rate, while ferrihydrite and the Fe：Al-hydroxide mixtures with high Fe ratios had almost negligible desorption rates. It was concluded that within the weakly associated amorphous FeO（OH） materials, FePO4 precipitated, which was bound by outer-sphere hydrogen bonds. With high Al ratios, desorption increased, which indicated weaker phosphate binding of both inner-sphere and outer-sphere complexes and hence, either no or minor quantities of precipitate. Ferrihydrite showed a more rigid structure and a lower extent of precipitation compared to amorphous Fe-hydroxide.

关键词： Phosphate Adsorption Desorption Surface complexation Precipitation FT-IR

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Clinical implications of microRNAs in liver cancer stem cells

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Chinese Journal of Cancer 2013年第8期32卷 419-426页

作者： stella Chai Stephanie ma Department of Clinical Oncology Li Ka Shing Faculty of Medicine The University of Hong Kong State Key Laboratory for Liver Research Li Ka Shing Faculty of Medicine The University of Hong Kong

The prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is often dismal, mainly due to late presentation, high recurrence rate, and frequent resistance to chemotherapy and radiotherapy. Accumulating evidence on the differential microRNA (miRNA) expression patterns between non-tumor and HCC tissues or between liver cancer stem cells (CSCs) and non-CSC subsets and the significant clinical implications of these differences suggest that miRNAs are a promising, non-invasive marker for the prognosis and diagnosis of the disease. This perspective article summarizes the current knowledge of miRNAs in liver CSCs and highlights the need for further investigations of the role of miRNAs in regulating liver CSC subsets for possible future clinical applications.

关键词：肝干细胞 microRNA 临床意义肝癌 miRNAs 肝细胞癌表达模式小RNA

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Epigenetics of human melanoma： promises and challenges

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Journal of molecular Cell Biology 2014年第5期8卷 356-367页

作者： Ahmad Besaratinia stella Tommasi Department of Preventive medicine Keck School of Medicine University of Southern California M/C 9603 Los Angeles CA 90033 USA

melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Although early-stage melanoma is highly curable, advanced-stage melanoma is refractory to treatment. This underscores the importance of prevention and early detection as well as the need to improve treatment and prognostication of human melanoma. Elucidating the underlying mechanisms of the initi- ation and progression of human melanoma can help identify potential targets of intervention for prevention, diagnosis, therapy, and prognosis of this disease. Aberrant DNA methylation and histone modifications are the best-established epigenetic mechanisms of carcinogenesis. The occurrence of epigenetic changes prior to clinical diagnosis of cancer and their reversibility through pharmaco-logic/genetic approaches offer a promising avenue for basic and translational research on human melanoma. Candidate gene（s） or genome-wide aberrant DNA methylation and histone modifications have been observed in human melanoma tumor tissues and cell lines, and correlated to cellular and functional characteristics and/or clinicopathologicai features of this malignancy. The present review summarizes the published researches on aberrant DNA methylation and histone modifications in connection with human melanoma. Representative studies are highlighted to set forth the current state of knowledge, gaps in the knowledgebase, and future directions in these epigenetic fields of research. Examples of epigenetic therapy applied for human melanoma in vitro, and the challenges of its in vivo application for clinical treatment of solid tumors are discussed.

关键词： aberrant DNA methylation epigenetic therapy histone modifications melanoma cell lines skin cancer

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manifestations of type 2 diabetes in corneal endothelial cell density,corneal thickness and intraocular pressure

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The Journal of Biomedical Research 2016年第1期30卷 46-51页

作者： stella Briggs Uchechukwu L Osuagwu Essam m AlHarthi Department of Optometry College of Health SciencesUniversity of BuraimiAl BuraimiSultanate of Oman Department of Optometry and Vision Sciences Institute of Health and Biomedical Innovation(Chronic Disease and Ageing)Queensland University of TechnologyBrisbaneQueenslandAustralia AlHokama Eye Specialist Center Riyadh 11427Saudi Arabia

We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（Dm）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized *** measured ECD,CCT and IOP of125 patients with type 2 Dm（mean age 57.1±11.5 years）and compared them with 90 age-matched *** parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for *** the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2Dm exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.

关键词： type 2 diabetes corneal endothelial cells central corneal thickness diabetes duration and control

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Genomic signatures of different adaptations to environmental stimuli between wild and cultivated Vitis vinifera L

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Horticulture Research 2018年第1期5卷 501-512页

作者： Annarita marrano Diego micheletti Silvia Lorenzi David Neale m.stella Grando Department of Genomics and Biology of Fruit Crops Research and Innovation CentreFondazione Edmund MachSan Michele all'Adige(TN)Italy Computational Biology Unit Research and Innovation CentreFondazione Edmund MachSan Michele all'Adige(TN)Italy Department of Plant Sciences University of CaliforniaDavisCA95616USA Center Agriculture Food Environment(C3A) University of TrentoSan Michele all'Adige(TN)Italy

The application of population genetic methods in combination with gene mapping strategies can help to identify genes and mutations selected during the evolution from wild plants to crops and to explore the considerable genetic variation still maintained in natural *** genotyped a grapevine germplasm collection of 44 wild(Vitis vinifera ***)and 48 cultivated(*** ***)accessions at 54 K single-nucleotide polymorphisms(SNPs)to perform a whole-genome comparison of the main population genetic *** analysis of Wright Fixation Index(FST)along the whole genome allowed us to identify several putative“signatures of selection”spanning over two thousand SNPs significantly differentiated between sativa and *** of these genomic regions included genes involved in the adaptation to environmental *** overall reduction of nucleotide diversity was observed across the whole genome within sylvestris,supporting a small effective population size of the wild ***’s D resulted positive in both wild and cultivated subgroups,which may indicate an ongoing balancing *** mapping for six domestication-related traits was performed in combination with population genetics,providing further evidence of different perception and response to environmental stresses between sativa and sylvestris.

关键词： crops Vitis vinifera

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STARD1:a new rising StAR in cholesterol-mediated hepatocarcinogenesis

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 910-912页

作者： Salvatore papa Concetta Bubici Wing-Kin Syn Leeds Institute of medical Research at St.James’ Faculty of Medicine and HealthUniversity of LeedsSt.James’University HospitalLeedsUK Centre for Genome Engineering and maintenance Department of Life SciencesCollege of HealthMedicine and Life SciencesBrunel University LondonUxbridgeUK Division of Gastroenterology and Hepatology Medical University of South CarolinaCharlestonSCUSA Section of Gastroenterology Ralph H.Johnson Veterans Affairs Medical CenterCharlestonSCUSA Department of Physiology Faculty of Medicine and NursingUniversity of the Basque CountryUniversidad del Pais Vasco/Euskal Herriko Unibertsitatea(UPV/EHU)LeioaSpain

Having cholesterol in our body is essential for living healthy,but too much can lead to serious health problems,including-but not limited to-heart attacks and strokes(1).Indeed,accumulating evidence points to cholesterol as a cancer risk factor especially in colon,rectal,prostatic and testicular cancer(2).Cholesterol is the most abundant sterol in animal tissues with many important functions that spans from simply maintaining cell membrane physical properties to the production of bile acids and biosynthesis of steroid *** the most part,cholesterol is synthetised de novo in the liver,but some is obtained from dietary *** synthesis of cholesterol takes place in the cytoplasm and the endoplasmic reticulum(ER)of hepatocytes(the major liver cell types)and starts with one molecule of acetyl-CoA.

关键词： cholesterol intake cancer

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