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Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition

Cancer Communications 2022年第4期42卷 360-364页

作者： Christian Schneeweis Zonera HassanKatja Ascherl Matthias Wirth stella koutsouli Felix Orben Lukas Krauß Carolin Schneider Rupert Ollinger Oliver HKrämer Roland Rad Maximilian Reichert Maria SRobles Dieter Saur Günter Schneider Medical Clinic and Polyclinic II Klinikum rechts der IsarTechnical University MunichMunich 81675Germany Department of Hematology Oncology and Tumor ImmunologyCharite-Universitatsmedizin BerlinCorporate Member of Freie Universitat BerlinHumboldt-Universitat zu Berlin and Berlin Institute of HealthBerlin 12203Germany Institute of Medical Psychology and Biomedical Center(BMC) Faculty of MedicineLMU MunichMunich 80336Germany Institute of Molecular Oncology and Functional Genomics TUM School of MedicineTechnical University MunichMunich 81675Germany Department of Toxicology University of Mainz Medical CenterMainz 55131Germany German Cancer Research Center(DKFZ)and German Cancer Consortium(DKTK) Heidelberg 69120Germany Center for Protein Assemblies(CPA) Technical University of MunichGarching 85747Germany Institute for Translational Cancer Research and Experimental Cancer Therapy Technical University MunichMunich 81675Germany Department of General Visceral and Pediatric SurgeryUniversity Medical Center GottingenGottingen 37075Germany

Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)remains a significant health problem with an increase in the incidence and a five-year survival rate of only 10%[1].The Phosphoinositide 3-kinase-protein kinase-B-mechanistic target of rapamycin(PI3K-AKT-mTOR)pathway is a driver pathway in PDAC and an important therapeutic target[2].We[3]and others[4–6]have demonstrated that the mTOR kinase is a therapeutic target in PDAC,and rationally designed mTOR inhibitor(mTORi)-based combination therapies are emerging[2].

关键词： rapamycin therapeutic adenocarcinoma

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Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio Ilaria Venezia Licia Pensabene Elisa Blasi Donato Rigante Paolo Mariotti Giuseppe stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

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Phosphorus release from vivianite and hydroxyapatite by organic and inorganic compounds

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Pedosphere 2020年第2期30卷 190-200页

作者： stella GYPSER Dirk FREESE Brandenburg University of Technology Cottbus-Senftenberg Faculty of EnvironmentProcess EngineeringBiotechnology and ChemistryDepartment of Soil Protection and RecultivationKonrad-Wachsmann-Allee 6Cottbus 03046Germany

Based on recent mining rates and the exhaustion of global phosphorus(P)reserves,there is a need to mobilize P already stored in soils,and its recovery from secondary resources such as Ca-and Fe-phosphates is *** Ca-phosphate hydroxyapatite forms a good fertilizer source,while vivianite is formed in waterlogged soils and *** sludge treatment,the formation of vivianite has been identified,being mainly ***-term P release from both hydroxyapatite and vivianite was studied using different inorganic(CaCl2 and CaSO4)and organic(citric and humic acid)reagents during batch *** CaCl2 and CaSO4 represent the soil solution,while citric and humic acids as organic constituents affect P availability in the rhizosphere and during the process of ***,the flow-through reactor(FTR)technique with an infinite sink was used to study the long-term P release *** cumulative P release was higher by organic acids than by inorganic *** cumulative P release rates were higher in the FTR with CaCl2 as compared to the batch *** infinite sink application caused a continuously high concentration gradient between the solid and liquid phases,leading to higher desorption rates as compared to the batch *** predominant amount of the total P released over time was available for a short *** inorganic anion exchange occurred at easily available binding sites,organic acids affected the more heavily available binding sites,which could be embedded within the mineral *** results showed that organic compounds,especially citric acid,play a superior role as compared to the inorganic constituents of the soil solution during the recovery of already stored P from the tertiary phosphates vivianite and hydroxyapatite.

关键词： anion exchange batch technique citric acid flow-through reactor humic acid ligand exchange phosphate phosphorus recovery

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Social transformations of cultural heritage: from benefaction to sponsoring: Evidence from mountain regions in Greece

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Journal of Mountain Science 2020年第6期17卷 1475-1490页

作者： stella GIANNAKOPOULOU Dimitris KALIAMP AKOS Department of Rural and Surveying Engineering Aristotle University of Thessaloniki(AUTH)University Campus54124ThessalonikiGreece School of Mining and Metallurgical Engineering National Technical University of Athens(NTUA)9 Heroon Polytechnioustr.15780ZografouAthensGreece

The concept of benefaction,as shaped in the pre-industrial society,has been altered and replaced by the modern term of *** verbal transformation emerges from a deep cultural *** on the dipole of benefactionsponsoring,we examine the cultural transition from the traditional communities of long duration to the modern societies of consumption,taking the Greek mountainous regions as an *** investigate the cultural shift that generates the metastasis from the communities of benefaction to the modern brandplaces that consume their own cultural heritage,mainly,at the altar of the tourism *** society has adopted the concept of sponsoring,for the grace of which,culture has to prove evidence of economic value,in order to *** the extremely competitive frame of the free-market economy,mountain regions appear *** selling and buying of their culture are tempting and attractive under a constantly shrinking welfare-state and narrowing development *** depends on local and national society to rediscover and regenerate those social mechanisms able to create culture or let the modern consumption-oriented forces ***,authentic principles of benefaction may form an alternative perspective for social reorganization.

关键词： Benefaction Sponsoring Cultural heritage Mountain regions Place branding Place identity

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Protection of architectural heritage: attitudes of local residents and visitors in Sirako, Greece

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Journal of Mountain Science 2016年第3期13卷 424-439页

作者： stella GIANNAKOPOULOU Dimitris KALIAMPAKOS School of Architectural Engineering National Technical University of AthensMetsovion Interdisciplinary Research Center School of Mining and Metallurgical Engineering National Technical University of Athens Metsovion Interdisciplinary Research Center

Architectural heritage comprises one o the most important elements of mountain settlements in Greece. It holds high cultural value, represents the tangible continuation of the past and forms the unique character and identity of each mountain region. Yet, controversy regarding funding for its preservation often arises. In this paper, we used two Contingent Valuation surveys to estimate the socia benefit deriving from protecting the traditiona architecture in the mountainous village of Sirako and through it, to examine perceptions and attitudes o local residents and visitors. Research findings revealed a strong social will in favor of the good's protection followed by high percentages of positive willingness to pay(WTP). However, WTP is significantly higher among residents. Cultura heritage value, of the good, appears to prevail, along with the environmental one. However, both residents and visitors pointed out that local heritage, if wellpreserved, will boost tourism development. Residents appeared to better recognize the true level o architectural decay, expressed higher apprehension for its protection and were willing to pay higher amount of money. Tourists, on the other side expressed high satisfaction for their visit, appreciated the beauty and serenity emerging from local built and natural environment and spent several days visiting the surrounding area. The longer they stayed and gotfamiliar with the village, the more willing they were to contribute to local heritage's protection. Percentages reflecting indifference for protecting architecture were extremely low. Yet, they were higher among tourists. Traditional architecture is considered as public good; an opinion resulting in an important percentage of visitors stating that national government should provide the necessary funding. In addition, the architecture appears to hold a high level of topicality. Those descending from Sirako or emotionally connected to it, of both social groups,turned out to be more co

关键词： Architectural heritage Contingent valuation Mountains Cultural goods

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Effects of nanopillars and surface coating on dynamic traction force

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Microsystems & Nanoengineering 2023年第1期9卷 177-190页

作者： Yijun Cheng stella W.Pang Department of Electrical Engineering City University of Hong KongKowloonHong KongChina Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong KongChina

The extracellular matrix serves as structural support for cells and provides biophysical and biochemical cues for cell ***,material,and surface energy can regulate cell migration ***,the responses of MC3T3-E1 cells,including migration speed,morphology,and spreading on various platform surfaces,were ***(PDMS)micropost sensing platforms with nanopillars,silicon oxide,and titanium oxide on top of the microposts were fabricated,and the dynamic cell traction force during migration was *** relationships between various platform surfaces,migration behaviors,and cell traction forces were *** with the flat PDMS surface,cells on silicon oxide and titanium oxide surfaces showed reduced mobility and less *** the other hand,cells on the nanopillar surface showed more elongation and a higher migration speed than cells on silicon oxide and titanium oxide ***3T3-E1 cells on microposts with nanopillars exerted a larger traction force than those on flat PDMS microposts and had more filopodia and long *** the relationships between platform surface condition,migration behavior,and cell traction force can potentially lead to better control of cell migration in biomaterials capable of promoting tissue repair and regeneration.

关键词： coating traction surface

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Pavement sustainability index for highway infrastructures： A case study of Maryland

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Frontiers of Structural and Civil Engineering 2018年第2期12卷 192-200页

作者： stella O. OBAZEE-IGBINEDION Oludare OWOLABI Montgomery County Department of Transportation 100 Edison Park Drive Gaithersburg MD 20878 USA Department of Civil Engineering Morgan State University 1700 East Cold Spring Lane Baltimore MD 21251 USA

Pavement deterioration creates conditions that undermine their performances, which gives rise to the need for maintenance and rehabilitation. This paper develops a mathematical multi-linear regression analysis （MLRA） model to determine a pavement sustainability index （PSTI） as dependent variable for flexible pavements in Maryland. Four categories of pavement performance evaluation indicators are subdivided into seven pavement condition indices and analyzed as independent variables for each section of pavement. Data are collected from five different roadways using field evaluations and existing database. Results indicate that coefficient of determination （R^2） is correlated and significant, R^2 = 0.959. Of the seven independent variables, present serviceability index （PSI） is the most significant with a coefficient value of 0.032, present serviceability rating （PSR） coefficient value=0.028, and international roughness index （IRI） coefficient value = -0.001. Increasing each unit value of coefficients for PSI and PSR would increase the value of PSTI; thereby providing a more sustainable pavement infrastructure; which explains the significance of the model and why IR/ will most likely impact environmental, economic and social values.

关键词： pavement indices sustainability pavement performance flexible pavements

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Improving brain outcomes in the growth restricted newborn: treating after birth

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Neural Regeneration Research 2021年第5期16卷 978-979页

作者： Julie A.Wixey stella Tracey Bjorkman UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia

Intrauterine growth restriction(IUGR)occurs when a baby is unable to grow normally due to receiving inadequate nutrients while developing in the *** is a leading cause of perinatal death and longterm *** fetal brain is particularly vulnerable to IUGR conditions and adverse outcomes range from learning,attention and behavioral difficulties,to cerebral *** to medical advancements,more IUGR babies now survive,resulting in an even greater burden of disability.

关键词： restricted IUGR advancement

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Assessing the Economic Value of Vernacular Architecture of Mountain Regions Using Contingent Valuation

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Journal of Mountain Science 2011年第5期8卷 629-640页

作者： stella GIANNAKOPOULOU Dimitris DAMIGOS Dimitris KALIAMPAKOS School of Architectural Engineering National Technical University of Athens School of Mining and Metallurgical Engineering National Technical University of Athens

Human pressure on mountain resources poses certain threats to their natural and man-made environment. Although there are many parameters involved, one of the driving forces behind this situation is the emphasis given so far only to the market value of mountain goods and services, ignoring the true social and environmental costs of using mountain resources. Towards this direction, the use of non-market valuation techniques could prove to be beneficial. Bearing in mind the above remarks, the paper presents an application of the Contingent Valuation Method, which aims at estimating the monetary value of a mountain settlement’s vernacular architecture, namely Metsovo. For this purpose, the survey focuses on Metsovo visitors’ willingness to pay a single annual voluntary contribution to an institution that would be founded in order to undertake all necessary actions required to preserve the town’s traditional character. The results are very promising and indicate that vernacular architecture holds a significant economic value that could justify the implementation of appropriate policies towards the protection of vernacular settlements in mountain areas.

关键词： Non-market valuation Vernacular architecture Contingent valuation

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Acacia mangium Willd: benefits and threats associated with its increasing use around the world

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Forest Ecosystems 2019年第1期6卷 13-25页

作者： Lydie-stella Koutika David M.Richardson CRDPI Centre de Recherche sur la Durabilité et la Productivité des Plantations Industrielles Centre for Invasion Biology Department of Botany & Zoology Stellenbosch University

Background: Acacia mangium, a fast-growing tree native to parts of Indonesia, Papua New Guinea and Australia,has been cultivated outside its native environment and introduced into humid tropical lowland regions of Asia,South America and Africa over the last few decades. It is a multipurpose tree used in agroforestry, forestry and for restoration of degraded lands. It is also highly invasive in many regions where it has been introduced outside its native range. This paper reviews evidence of its obvious benefits and its negative impacts on ***: A literature review on Australian acacias and especially on A. mangium was undertaken to highlight both benefits and threats associated with their increasing worldwide use outside their native ***: Through N_2 fixed from the atmosphere, A. mangium improves soil fertility, especially by increasing N status and soil C accretion when introduced to N-limited areas; it thus has the potential to restore nutrient cycling in degraded systems. No studies have, however, been done to assess the effectiveness of A. mangium in restoring biodiversity of degraded lands. Most Australian acacias have traits that facilitate invasiveness, and 23 species have been recorded as invasive to date. A. mangium has been reported as invasive in Asia, Indonesia, Pacific Islands,Indian Ocean Islands, southern Africa and Brazil. Research on other invasive Australian acacias in several parts of the world has elucidated the types of impacts that are likely in different types of ecosystems and key options for mitigating ***: A. mangium has the potential to restore nutrient cycling in degraded systems, but is highly invasive wherever it is planted. Many parts of the world have a large invasion debt for this species. Experience with other invasive acacias around the world suggests a suite of interventions that could be used to reduce invasions and mitigate impacts. Careful risk assessments should be undertaken prior to

关键词： Biodiversity Biological invasions C sequestration Soil N status Tree invasions

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