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Low ADAMTS-13/VWF ratio and altered gut–liver axis predict complications of advanced chronic liver disease:a pilot study

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Gastroenterology Report 2022年第1期10卷 671-673页

作者： Francesca Romana Ponziani Monica Sacco Maira Tardugno Francesco Santopaolo Adriana Marsico stefano Manna stefano lancellotti Antonio Gasbarrini Raimondo De Cristofaro Maurizio Pompili Internal Medicine and Gastroenterology–Hepatology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly Translational Medicine and Surgery Department Catholic UniversityRomeItaly Hemorrhagic and Thrombotic Diseases Service Fondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly

Introduction Liver cirrhosis is characterized by a delicate balance between thrombosis and *** extinction due to microvascular thrombosis is involved in disease progression and anticoagulant therapy with low-molecular-weight heparin has been shown to reduce the frequency of hepatic decompensation[1].Dysbiosis and bacterial translocation,which are hallmarks of liver cirrhosis,can influence the coagulation system through inflammation or by the activation of Toll-like receptors on endothelial cells and platelets[2].However,little is known about the connections between the coagulation system,the occurrence of liver cirrhosis complications,and the gut microbiome.

关键词： complications inflammation bleeding

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Haemostatic system in inflammatory bowel diseases:New players in gut inflammation

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世界胃肠病学杂志：英文版 2011年第5期17卷 594-608页

作者： Franco Scaldaferri stefano lancellotti Marco Pizzoferrato Raimondo De Cristofaro Department of Inter nal Medicine and Medical Specialties Gastroenterology Divi sionCatholic University of Rome00168 RomeItaly Department of Internal Medicine and Medical Specialties Haemostasis Research CenterCatholic University of Rome00168 RomeItaly

Inflammation and coagulation constantly influence each other and are constantly in *** evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important in chronic inflammatory settings,such as inflammatory bowel disease(IBD).Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events,and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels,where most severe inflammatory abnormalities *** aims of this review are to update and classify the type of coagulation system abnormalities in IBD,and analyze the strict and delicate balance between coagulation and inflammation at the mucosal *** studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.

关键词：急性炎症凝血系统肠道疾病鸡传染性法氏囊病止血溃疡性结肠炎慢性炎症

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