Low ADAMTS-13/VWF ratio and altered gut–liver axis predict complications of advanced chronic liver disease:a pilot study

作     者：Francesca Romana Ponziani Monica Sacco Maira Tardugno Francesco Santopaolo Adriana Marsico Stefano Manna Stefano Lancellotti Antonio Gasbarrini Raimondo De Cristofaro Maurizio Pompili 

作者机构：Internal Medicine and Gastroenterology–Hepatology UnitFondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly Translational Medicine and Surgery DepartmentCatholic UniversityRomeItaly Hemorrhagic and Thrombotic Diseases ServiceFondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2022年第10卷第1期

页      面：671-673页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by“Ministero della Salute–Ricerca Corrente 2022” 

主　　题：complications inflammation bleeding 

摘      要：Introduction Liver cirrhosis is characterized by a delicate balance between thrombosis and *** extinction due to microvascular thrombosis is involved in disease progression and anticoagulant therapy with low-molecular-weight heparin has been shown to reduce the frequency of hepatic decompensation[1].Dysbiosis and bacterial translocation,which are hallmarks of liver cirrhosis,can influence the coagulation system through inflammation or by the activation of Toll-like receptors on endothelial cells and platelets[2].However,little is known about the connections between the coagulation system,the occurrence of liver cirrhosis complications,and the gut microbiome.