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Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment

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World Journal of Clinical Cases 2025年第10期13卷 14-27页

作者： Antonio Pontoriero Paola Critelli Marco Zeppieri Alberto Bosurgi stefania Guercio Maria Caffo Filippo Flavio Angileri Silvana Parisi Salvatore Lavalle Stefano Pergolizzi Radiation Oncology Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of BiomedicalDental Science and Morphological and Functional ImagesMessinaItalyMessina 98125Italy Lavalle Department of Medicine and SurgeryUniversity of Enna"Kore"Enna 94100Italy

BACKGROUND Precision medicine is an emerging field that includes tumor-targeted delivery and tumor *** review explores the synergistic potential of combining nano-drug delivery systems with low radiation doses to achieve optimized therapeutic outcomes,particularly in the context of cancer ***-based drug carriers offer precise and targeted delivery,enhancing the therapeutic index of anticancer *** use of lower radiation doses has become a focus in radiation oncology to minimize off-target effects on healthy tissues in palliation treatment with high-target volume *** To conduct a bibliometric review of nanomedicine and glioblastoma(GBM),all relevant studies from the last two decades were *** The search strategy comprised the keywords“nanomedicine”and“glioblastoma”in the title and/or *** English-language documents from 1 January 2000 to 31 December 2023 were considered for the analysis.R code(version 4.2.0)with R Studio(version 2022.12.0-353)and the Bibliometrix package(version 4.0.1)were used for the analysis.A total of 680 documents were *** We analyzed the bibliometric features of nanomedicine in *** the limitations of the research,our analysis aims to highlight the increasing interest of researchers in the precision medicine field in GBM treatment and lead us to suggest further studies focusing on the association between nanomedicine and *** Due to the poor prognosis associated with GBM,new therapeutic approaches are *** is an increasing interest in precision medicine,which includes nanomedicine and radiotherapy,for GBM *** integration enhances the efficacy of targeted treatments and provides a promising avenue for reducing adverse effects,signifying a notable advancement in precision oncology.

关键词： Nanomedicine Nanoparticles Drug-delivery Radiotherapy Combination therapy

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Mechanisms of altered bone remodeling in children with type 1 diabetes

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World Journal of Diabetes 2021年第7期12卷 997-1009页

作者： Giacomina Brunetti Gabriele D'Amato stefania De Santis Maria Grano Maria Felicia Faienza Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity"A.Moro"of BariBari 70125Italy Department of Women’s and Children’s Health ASL BariNeonatal Intensive Care UnitDi Venere HospitalBari 70124Italy Department of Pharmacy-Drug Science University of Bari Aldo MoroBari 70126Italy Department of Emergency and Organ Transplantation Univ BariBari 70124Italy Department of Biomedical Sciences and Human Oncology Pediatric UnitUniversity"A.Moro"Bari 70124Italy

Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in *** mechanisms underlying diabetic bone fragility are not yet completely *** and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and *** factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone *** myokines may have a key role in regulating metabolic control and improving bone mass in T1DM *** aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM.

关键词： Type 1 diabetes Children Bone remodeling Osteoclasts Osteoblasts

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Evidence-based appraisal of the upfront treatment for unresectable metastatic colorectal cancer patients

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World Journal of Gastroenterology 2013年第46期19卷 8474-8488页

作者： Giuseppe Aprile stefania Eufemia Lutrino Laura Ferrari Mariaelena Casagrande Marta Bonotto Elena Ongaro Fabio Puglisi Department of Oncology University and General Hospital Department of Medical and Biological Sciences University of Udine

Colorectal cancer(CRC)is a significant health problem,with around 1 million new cases and 500000 deaths every year *** the last two decades,the use of novel therapies and more complex treatment strategies have contributed to progressively increase the median survival of patients with unresectable advanced CRC up to approximately 30 *** availability of additional therapeutic options,however,has created new challenges and generated more complicated treatment ***,several clinically important points are still in debate in first-line,such as the optimal treatment intensity,the most appropriate maintenance strategy,the preferred biologic to be used upfront in patients with KRAS wild-type CRC,and the need for more detailed information on tumor *** this moving landscape,this review analyses why the firstline treatment decision is crucial and how the choicemay impact on further treatment *** addition,it focuses on results of major phaseⅢrandomized trials.

关键词： Colorectal cancer Chemotherapy Ang-iogenic inhibitors Epidermal growth factor receptor inhibitors Maintenance First-line

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Increased phosphorus availability to corn resulting from the simultaneous applications of phosphate rock, calcareous rock, and biochar to an acid sandy soil

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Pedosphere 2020年第6期30卷 719-733页

作者： Rogério Borguete Alves RAFAEL Maria Luisa FERNÁNDEZ-MARCOS stefania COCCO Maria Letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257Mozambique Department of Agriculture Food and Environmental SciencesUniversitàPolitecnica delle MarcheAncona 60131Italy Department of Soil Science and Agricultural Chemistry Universidad de Santiago de CompostelaLugo 27002Spain Department of Materials Environmental Sciences and Urban PlanningUniversitàPolitecnica delle MarcheAncona 60131Italy Consiglio per la Ricerca e la Sperimentazione in Agricoltura Centro di Ricerca per lo Studio delle Relazioni tra Pianta e Suolo(C.R.E.A.-R.P.S.)Gorizia 34170Italy Instituto de Biodiversidade Agraria e Desenvolvemento Rural Universidad de Santiago de CompostelaLugo 27002Spain

Phosphorus(P)deficiency is one of the main constraints on crop production in Arenosols(acid sandy soil).The high cost of P fertilizers may represent an insurmountable obstacle in many poor countries,leaving the exploitation of their own calcareous and phosphate rocks as the only low-cost and long-term *** is suggested to have positive effects on soil properties;however,there is no published research on the synergistic effects of biochar and rocky materials in modifying soil *** aim of this study was to investigate the chemical and biochemical responses of an acid Arenosol treated with phosphate rock(PR),calcareous rock(CR),and biochar(BC),and the implications for corn yield.A soil from Marracuene District,Mozambique was used,where corn was grown for 90 d with the soil treated with:no addition(control),water-soluble zinc phosphite fertilizer(WSP),PR,WSP+CR,WSP+BC,WSP+CR+BC,PR+BC,and PR+CR+*** was produced by pyrolysis of babycorn peels for 4 h at 450?C and applied at 11 g *** soil pHH2 Oincreased from about 4.54 in the control to 7.38 in the PR+CR+BC *** oxidizable organic carbon,cation exchange capacity,and available P were higher in the treatments containing BC than in the *** treatments containing CR and/or BC led to the highest activities of alkaline phosphomonoesterase,phosphodiesterase,andα-glucosidase,which increased P availability and gave the greatest biomass and *** suggest that biochar provides additional soluble P and supplies adsorption sites for phosphate,preventing its evolution to unavailable ***,PR applied together with BC contributed to an 840%yield increase compared to the *** treatments containing WSP and BC facilitated phosphite oxidation to phosphate and increased crop yield.

关键词： Arenosols available P enzyme activity phosphite oxidation soil fertility

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In Vivo Toxicity Assessment of Gold Nanoparticles in Drosophila melanogaster

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Nano Research 2011年第4期4卷 405-413页

作者： Pier Paolo Pompa Giuseppe Vecchio Antonio Galeone Virgilio Brunetti stefania Sabella Gabriele Maiorano Andrea Falqui GiovanniBertoni Roberto Cingolani Italian Institute of Technology Center for Bio-Molecular Nanotechnology Via Barsanti 1-73010 Arnesano （Lecce） Italy Italian Institute of Technology Central Research Laboratories Via Morego 30-16136 Genova Italy

The growing use of nanomaterials in commercial goods and novel technologies is generating increasing questions about possible risks for human health and environment, due to the lack of an in-depth assessment of their potential toxicity. In this context, we investigated the effects of citrate-capped gold nanoparticles （AuNPs） on the model system Drosophila melanogaster upon ingestion. We observed a significant in vivo toxicity of AuNPs, which elicited clear adverse effects in treated organisms, such as a strong reduction of their life span and fertility, presence of DNA fragmentation, as well as a significant overexpression of the stress proteins. Transmission electron microscopy demonstrated the localization of the nanoparticles in tissues of Drosophila. The experimental evidence of high in vivo toxicity of a nanoscale material, which is widely considered to be safe and biocompatible in its bulk form, opens up important questions in many fields, including nanomedicine, material science, health, drug delivery and risk assessment.

关键词： Nanoparticles nanotoxicology gold in vivo studies

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Endoscopic ultrasonography:Transition towards the futureof gastro-intestinal diseases

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World Journal of Gastroenterology 2016年第5期22卷 1779-1786页

作者： stefania De Lisi Marc Giovannini Department of Gastroenterology A.O.Fatebenefratelli e Oftalmico20121 MilanItaly Department of Gastroenterology Paoli-Calmettes Institute13009 MarseilleFrance

Endoscopic ultrasonography(EUS) is a technique with an established role in the diagnosis and staging of gastro-intestinal tumors. In recent years, the spread of new devices dedicated to tissue sampling has improved the diagnostic accuracy of EUS fine-needle aspiration. The development of EUS-guided drainage of the biliopancreatic region and abdominal fluid collections has allowed EUS to evolve into an interventional tool that can replace more invasive procedures. Emerging techniques applying EUS in pancreatic cancer treatment and in celiac neurolysis have been described. Recently, confocal laser endomicroscopy has been applied to EUS as a promising technique for the in vivo histological diagnosis of gastro-intestinal, bilio-pancreatic and lymph node lesions. In this state-of-the-art review, we report the most recent data from the literature regarding EUS devices, interventional EUS, EUS-guided confocal laser endomicroscopy and EUS pancreatic cancer treatment, and we also provide an overview of their principles, clinical applications and limitations.

关键词： Endoscopic ultrasonography Endoscopicultrasonography fine-needle aspiration Confocal laserendomicroscopy Biliary drainage Pancreatic cancertreatment

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Chronically denervated distal nerve stump inhibits peripheral nerve regeneration

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Neural Regeneration Research 2017年第5期12卷 739-740页

作者： Giulia Ronchi stefania Raimondo Department of Clinical and Biological Sciences University of TorinoOrbassano(To)Italy Neuroscience Institute Cavalieri Ottolenghi(NICO) Orbassano(To)Italy

Schwann cells（SCs）and peripheral nerve regeneration：SCs are the principal glial cells of the peripheral nervous system（PNS）.In a healthy nerve,myelinating SCs wrap around larger caliber motor and sensory axons to form the myelin sheath,whereas non-myelinating SCs envelop and support multiple small diameter sensory axons to form Remak ***,they form a basal lamina which surround each SC-axon unit（Hall,2005）.When a peripheral nerve injury occurs,

关键词： SC cell NRG down length

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COVID-19 vaccine related hypermetabolic lymph nodes on PET/CT:Implications of inflammatory findings in cancer imaging

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Oncology Research 2023年第2期31卷 117-124页

作者： FERDINANDO CALABRIA ANTONIO BAGNATO GIULIANA GUADAGNINO MARIA TOTEDA ANTONIO LANZILLOTTA stefania CARDEI ROSANNA TAVOLARO MARIO LEPORACE Department of Nuclear Medicine and Theragnostics Mariano Santo HospitalCosenza87100Italy Department of Infectious and Tropical Diseases St.Annunziata HospitalCosenza87100Italy

We observed several patients presenting 2-[^(18)F]FDG uptake in the reactive axillary lymph node at PET/CT imaging,ipsilateral to the site of the COVID-19 vaccine *** finding was documented at[^(18)F]Choline PET/*** aim of our study was to describe this source of false positive *** patients examined by PET/CT were included in the *** concerning patient anamnesis,laterality,and time interval from recent COVID-19 vaccination were *** was measured in all lymph nodes expressing tracer uptake after *** 712 PET/CT scans with 2-[^(18)F]FDG,104 were submitted to vaccination;89/104 patients(85%)presented axillary and/or deltoid tracer uptake,related to recent COVID-19 vaccine administration(median from injection:11 days).The mean SUVmax of these findings was 2.1(range 1.6–3.3).Among 89 patients with false positive axillary uptake,36 subjects had received chemotherapy due to lymph node metastases from somatic cancer or lymphomas,prior to the scan:6/36 patients with lymph node metastases showed no response to therapy or progression *** mean SUVmax value of lymph nodal localizations of somatic cancers/lymphomas after chemotherapy was *** 1/31 prostate cancer patients examined by[^(18)F]Choline PET/CT showed post-vaccine axillary lymph node *** findings were not recorded at PET/CT scans with[^(18)F]-6-FDOPA,[^(68)Ga]Ga-DOTATOC,and[^(18)F]-*** COVID-19 mass vaccination,a significant percentage of patients examined by 2-[^(18)F]FDG PET/CT presents axillary,reactive lymph node ***,low-dose CT,and ultrasonography facilitated correct ***-quantitative assessment supported the visual analysis of PET/CT data;SUVmax values of metastatic lymph nodes were considerably higher than post-vaccine lymph nodes.[^(18)F]Choline uptake in reactive lymph node after vaccination was *** the COVID-19 pandemic,nuclear physicians need to take these potential false positive cases

关键词： [^(18)F]Choline 2-[^(18)F]FDG PET/CT COVID-19 Vaccine Italy Chemotherapy Inflammation SUVmax

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An Evaluation of Burnout among Foundation Doctors in Malta—A Cross-Sectional Observational Study

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Health 2021年第7期13卷 705-716页

作者： Marco Grech stefania Grech Department of Family Medicine Faculty of Medicine and Surgery University of Malta Msida Malta

Background: Postgraduate medical trainees are at an increased risk of burnout. Burnout has been defined as “a psychological condition of emotional exhaustion, depersonalization and reduced personal accomplishment occurring in people persistently exposed to emotional and interpersonal stressors at work”. It can arise either from within the individual, from the medical profession itself or from healthcare organisations. Burnout is associated with mental health issues in trainees, impaired work performance and suboptimal patient outcomes. Objective: To evaluate the level of burnout among trainees of the Malta Foundation Programme. Methods: A cross-sectional observational study of three cohorts of the Malta Foundation Programme was conducted using the Copenhagen Burnout Inventory (CBI) to evaluate incidence of personal-, work-related and client related burnout. The cohorts were at 3 months, 1 year and 2 years of training respectively. The CBI was administered via Google Forms after ethical clearance. Descriptive statistics and non-parametric comparative statistics were used to analyse the results through SPSS v25.0. Results: A global response rate of 26.5% was achieved. CBI and its subscales showed good internal validity. High scores for burnout in all three scales were identified except for client-related burnout in First Year doctors. Burnout peaked midway through the 2-year period. High numbers reported “feeling “tired” and “physically exhausted”. Males reported more burnout than females. Conclusion: The high level of burnout so early in the career of Maltese postgraduate medical trainees is of concern. More studies are needed on the causality of this burnout and what factors are associated with burnout in this population.

关键词： Burnout Malta Foundation Programme Copenhagen Burnout Inventory Graduate Medical Education

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Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 20-24页

作者： stefania Gioia Adriano De Santis Giulia d’Amati Silvia Nardelli Alessandra Spagnoli Arianna Di Rocco Lorenzo Ridola Oliviero Riggio Department of Translational and Precision Medicine Sapienza University of RomeRomeItaly Department of Radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly Department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal *** PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be *** these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be *** this setting ultrasonography may be valuable in differential *** aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing ***:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT ***,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse

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