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Risk of second primary cancers after testicular cancer in East and West Germany： a focus on contralateral testicular cancers

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Asian Journal of Andrology 2014年第2期16卷 285-289,I0010,I0011页

作者： Carsten Rusner Brigitte Streller Christa stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn britton Traberts Andreas Stang Institute of Clinical Epidemiology Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Common Cancer Registry of Berlin Berlin Saarland Cancer Registry Saarbrucken Institute of Medical Epidemiology Biostatistics and Informatics Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Germany Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD Department of Epidemiology Scfloof of Public Heaftfl Boston University Boston MA USA.

Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.

关键词： cancer registry incidence neoplasms second primary testicular neoplasms

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Grass-Root Coaches Knowledge, Understanding, Attitude And Confidence to Deliver Injury Prevention Training in Youth Soccer: a Comparison of Coaches in Three EU Countries

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Journal of Science in Sport and Exercise 2020年第4期2卷 367-374页

作者： Mark De ste Croix F.Ayala S.Hernandez Sanchez M.Lehnert J.Hughes School of Sport and Exercise University of GloucestershireCheltenham GL502RHUK Department of Sport Sciences Sport Research CentreMiguel Hernandez University of ElcheElche 03202Spain Department of Pathology and Surgery Physiotherapy Area Miguel Hernandez University of ElcheElche 03202Spain Department of Sport and Physical Culture Palacky UniversityOlomouc 77200Czech Republic

Purpose It is well recognised that injury prevention training can reduce injury incidence,however current coach education pathways do not provide grass-root coaches with the knowledge and confidence to deliver such training to youth *** aim of this study was to explore differences in knowledge,understanding,attitude and confidence to deliver such injury prevention training in three European *** A total of 269 grass-root soccer coaches from 3 European countries(Czech Republic,UK,Spain)were recruited for this study.A validated questionnaire exploring knowledge,understanding,attitude towards and confidence to deliver youth injury prevention training was completed prior to a 2 h workshop on injury prevention *** between countries was examined using Bayesian factors to quantify the evidence for and against the hypothesis of independence(H0)by assuming a Poisson sampling scheme(as there was no a priori restriction on any cell count,nor on the grand total)(BF10 Poisson).Results Current knowledge,attitude and confidence to deliver injury prevention training to youth players was poor across all three European *** few coaches were currently using injury prevention training in their coaching sessions(23%).There were some country specific differences for attitude towards injury prevention training and confidence to deliver injury training,with Spanish coaches reporting a more positive attitude and confidence to deliver such *** fewer coaches in the UK were using injury prevention training compared to coaches in Spain and the Czech *** As coaches identified a need for coach education and few were delivering injury prevention training,there is a clear need to embed and implement this programme into the grassroots coaching framework of sports governing bodies to improve adoption,implementation and maintenance.

关键词： Youth Injury prevention training Coach education Movement competency

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The HUman Micro Nucleus *** Date Base Comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes. Ⅰ.Effect of laboratory protocol,scoring criteria,and host factors on the frequency of micronuclei

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癌变．畸变．突变 2001年第4期13卷 217-219页

作者： ste fano Bonasi Michael Fenech 等 DepartmentofEnvironmentalEpidemiology IstitutoNazionaleperlaRicercasulCancroGenoaItaly CSIROHealthS

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Exploring the Transcriptome Landscape of Pomegranate Fruit Peel for Natural Product Biosynthetic Gene and SSR Marker Discovery

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Journal of Integrative Plant Biology 2011年第10期53卷 800-813页

作者： Nadia Nicole Ono Monica Therese britton Joseph Nathaniel Fass Charles Meyer Nicolet Dawei Lin Li Tian Department of Plant Sciences University of California Davis CA 95616 USA Genome Center University of California Davis CA 95616 USA

Pomegranate fruit peel is rich in bioactive plant natural products, such as hydrolyzable tannins and anthocyanins. Despite their documented roles in human nutrition and fruit quality, genes involved in natural product biosynthesis have not been cloned from pomegranate and very little sequence information is available on pomegranate in the public domain. Shotgun transcriptome sequencing of pomegranate fruit peel cDNA was performed using RNA-Seq on the Illumina Genome Analyzer platform. Over 100 million raw sequence reads were obtained and assembled into 9,839 transcriptome assemblies （TAs）（〉200 bp）. Candidate genes for hydrolyzable tannin, anthocyanin, flavonoid, terpenoid and fatty acid biosynthesis and/or regulation were identified. Three lipid transfer proteins were obtained that may contribute to the previously reported IgE reactivity of pomegranate fruit extracts. In addition, 115 SSR markers were identified from the pomegranate fruit peel transcriptome and primers were designed for 77 SSR markers. The pomegranate fruit peel transcriptome set provides a valuable platform for natural product biosynthetic gene and SSR marker discovery in pomegranate. This work also demonstrates that next-generation transcriptome sequencing is an economical and effective approach for investigating natural product biosynthesis, identifying genes controlling important agronomic traits, and discovering molecular markers in non-model specialty crop species.

关键词： hydrolyzable tannin naturat product pomegranate SSR marker transcriptome.

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Iron-Catalysed C(sp^(2))-H Borylation with Expanded Functional Group Tolerance

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Chinese Journal of Chemistry 2022年第24期40卷 2875-2881页

作者： Luke britton Jamie H.Docherty Gary S.Nichol Andrew P.Dominey stephen P.Thomas EaStCHEM School of Chemistry University of EdinburghEdinburghEH93FJ United Kingdom GSK Medicines Research Centre StevenageSG12NY United Kingdom

Arene C(sp^(2))-H bond borylation offers direct and efficient access to aryl boronic *** in situ catalyst activation and photoirradiation,the iron-catalysed C(sp^(2))-H borylation reaction of carboarenes,pyrroles,and indoles has been developed using only bench-stable pre-catalysts and *** functional group tolerance was observed including those not reported using previous methods(ArNH_(2),ArOH,ArSiR_(3),ArP(O)(O)_(2),ArC(O)NR_(2)).Mechanistic studies revealed iron-catalysed reductive deoxygenation,C—F protodefluorination,and a demethylation of aryl methyl ethers by C—O sigma bond hydroboration.

关键词： Iron Earth-abundant C-H borylation Boron Photochemistry

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Occupational injuries and burn out among orthopedic oncology surgeons

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World Journal of Orthopedics 2022年第12期13卷 1056-1063页

作者： Abdulrahman M Alaseem Robert E Turcotte Nathalie ste-Marie Mohammad M Alzahrani Saad M Alqahtani Krista A Goulding Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Orthopedic Surgery McGill University Health CentreMontreal H4A3J1Canada Department of Orthopedic Surgery College of MedicineImam Abdulrahman Bin Faisal universityDammam 34212Saudi Arabia Department of Orthopaedic Surgery Mayo ClinicPhoenixArizona 85054USA

BACKGROUND Orthopedic oncology surgeons commonly engage in prolonged and complex surgical *** types of surgeries increase the risk of physical and psychological stressors,which may in turn make these physicians prone to workrelated occupational *** The aim of this study was to explore in orthopedic oncologists,the prevalence of work-related physical injuries and psychological *** A modified version of the physical discomfort survey was developed to assess occupational injuries among orthopedic oncology surgeon members of the Musculoskeletal Tumor Society,the Canadian Orthopedic Oncology Society and European Musculoskeletal Oncology *** survey was sent by email,and it explored musculoskeletal complaints,psychological disturbances,treatment required for these complaints and the requirement of time off *** A total of 67 surgeon responses were collected.A high number of orthopedic oncologists(84%)reported an occupational *** back pain(39%)was the most prevalent musculoskeletal condition,followed by lumbar disk herniation(16%),shoulder tendinitis(15%)and lateral epicondylitis(13%).Of the cohort,46%required surgery and 31%required time off work due to their ***-three respondents reported a psychological ***(27%),anxiety(20%)and insomnia(20%)were the most commonly *** required off work due to injury was associated with old age and years in *** Orthopedic oncology surgeons report a high prevalence of work-related *** back related injury and burnout were the most reported *** operative room ergonomics and prevention of stress related to the work environment should be areas to explore in upcoming research.

关键词： Orthopedic oncology Surgeons Occupational Musculoskeletal Injuries

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A classical equation that accounts for observations of non-Arrhenius and cryogenic grain boundary migration

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npj Computational Materials 2022年第1期8卷 1492-1500页

作者： Eric R.Homer Oliver K.Johnson Darcey britton James E.Patterson Eric T.Sevy Gregory B.Thompson Department of Mechanical Engineering Brigham Young UniversityProvoUT84602USA Department of Chemistry and Biochemistry Brigham Young UniversityProvoUT84602USA Department of Metallurgical and Materials Engineering University of AlabamaTuscaloosaAL35401USA

Observations of microstructural coarsening at cryogenic temperatures,as well as numerous simulations of grain boundary motion that show faster migration at low temperature than at high temperature,have been troubling because they do not follow the expected Arrhenius *** work demonstrates that classical equations,that are not simplified,account for all these oddities and demonstrate that non-Arrhenius behavior can emerge from thermally activated *** to this classical model,this occurs when the intrinsic barrier energies of the processes become small,allowing activation at cryogenic *** thermal energy then allows the low energy process to proceed in reverse,so increasing temperature only serves to frustrate the forward *** classical form is shown to reconcile and describe a variety of diverse grain boundary migration observations.

关键词： cryogenic grain boundary

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Epidemiology of injuries in male and female youth football players:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第6期11卷 681-695,F0003页

作者： Francisco Javier Robles-Palazón Alejandro López-Valenciano Mark De ste Croix Jon L.Oliver Alberto García-Gómez Pilar Sainz de Baranda Francisco Ayala Department of Physical Activity and Sport Faculty of Sport SciencesCampus of Excellence Mare NostrumUniversity of MurciaMurcia 30720Spain Centre for Sport Studies King Juan Carlos UniversityMadrid 28933Spain School of Sport and Exercise University of GloucestershireGloucester GL29HWUK Youth Physical Development Centre School of Sport and Health SciencesCardiff Metropolitan UniversityCardiff CF236XDUK Sport Performance Research Institute New Zealand(SPRINZ) Auckland University of TechnologyAuckland 0632New Zealand Operative Research Centre Miguel Hernández University of ElcheElche 03202Spain

Background:To conduct a systematic review and meta-analysis of epidemiological data of injuries in male and female youth football ***:Searches were performed in MEDLINE/PubMed,Web of Science,Cochrane Library,and SPORTDiscus *** were considered if they reported injury incidence rate in male and female youth(≤19 years old)football *** reviewers(FJRP and ALV)extracted data and assessed trial quality using the Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)statement and the Newcastle Ottawa *** Grading of Recommendations Assessment,Development,and Evaluation approach determined the quality of *** were combined using a Poisson random effects regression ***:Forty-three studies were *** overall incidence rate was 5.70 injuries/1000 h in males and 6.77 injuries/1000 h in *** injury incidence(14.43 injuries/1000 h in males and 14.97 injuries/1000 h in females)was significantly higher than training injury incidence(2.77 injuries/1000 h in males and 2.62 injuries/1000 h in females).The lower extremity had the highest incidence rate in both *** most common type of injury was muscle/tendon for males and joint/ligament for *** injuries were the most common in both *** incidence rate of injuries increased with advances in chronological age in *** male players presented higher match injury incidence than sub-elite *** females,there was a paucity of data for comparison across age groups and levels of ***:The high injury incidence rates and sex differences identified for the most common location and type of injury reinforce the need for implementing different targeted injury-risk mitigation strategies in male and female youth football players.

关键词： Incidence Muscle injuries Severity Soccer Young athletes

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^（99m）Tc－HMPAOSPECT对偏头痛患者丘脑血流变化的研究

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中华核医学杂志 1995年第4期15卷 236-238页

作者：张志坚 ste.,TJ 福建医学院附属第一医院神经病学研究室

目的：了解偏头痛患者丘脑血流的变化。方法：用９９ｍＴｃ－六甲基两二胺肟和Ｎｏｖｏ－８１０高分辨率ＳＰＥＣＴ仪，以感兴趣区（ＲＯＩ）相对放射性计数百分率（ＲＯＩ％）为指标，对６０例次偏头痛患者的丘脑血流变化作了定量分析... 详细信息

目的：了解偏头痛患者丘脑血流的变化。方法：用９９ｍＴｃ－六甲基两二胺肟和Ｎｏｖｏ－８１０高分辨率ＳＰＥＣＴ仪，以感兴趣区（ＲＯＩ）相对放射性计数百分率（ＲＯＩ％）为指标，对６０例次偏头痛患者的丘脑血流变化作了定量分析。结果：与无预兆偏头痛组的平均ＲＯＩ％值（２４９．Ｉｆ１４．９）相比，预兆偏头痛组ＲＯＩ％升高（２５９．１±１７．１），差异有显著意义（Ｐ＜０．０５）；偏瘫、偏身感觉异常预兆偏头痛组升高更明显（２６３．８±１７．２），差异有极显著性（Ｐ＜０．０１）；而单纯视觉预兆组稍升高（２５５．１±１６．４），差异无显著意义（Ｐ＞０．０５）。结论：偏瘫、偏身感觉异常预兆组丘脑血流升高，原因可能为：①缺血后高灌注。②除丘脑外，其它脑区血流减少。③各种神经、化学性刺激的结果。

关键词：偏头痛丘脑血流放射性核素 CT 锝99m

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The emerging role of somatic tumor sequencing in the treatment of urothelial cancer

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Asian Journal of Urology 2021年第4期8卷 391-399页

作者： Lexiaochuan Wen Cameron J.britton Rohan Garje Benjamin W.Darbro Vignesh T.Packiam Department of Urology Mayo ClinicRochesterMNUSA Division of Hematology OncologyBlood&Marrow TransplantationDepartment of Internal MedicineUniversity of IowaIowa CityIAUSA stead Family Department of Pediatrics University of IowaIowa CityIAUSA Department of Urology University of IowaIowa CityIAUSA

The development of rapid genome sequencing has greatly enhanced our understanding of the molecular biology underlying many *** exome sequencing has highlighted the individualistic nature of malignancies on a patient-to-patient basis and begun to revolutionize therapeutic *** recent years,whole genome sequencing of urothelial malignancies has identified a host of somatic mutations which contribute to growth,progression,and metastasis of urothelial carcinoma of the bladder and upper tract urothelial *** genetic sequencing continues,additional targets will be identified,allowing development of novel therapeutic agents targeting cancer on a molecular level,with the goal of delivering highly individualized care based on the underlying mutational profile of the patient’s *** this review,we aim to discuss known genetic alterations of urothelial malignancy and the implications these mutations carry in terms of prognostication and development of targeted therapeutic *** will focus on RNA-expression profiling and genomic DNA profiling,with a focus on comprehensive whole exome and whole genome sequencing relative to selected urothelial carcinoma-associated genes and circulating tumor DNA analysis.

关键词： Tumor sequencing Whole exome sequencing Next-generation sequencing Somatic mutations Bladder cancer Urothelial carcinoma

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