The emerging role of somatic tumor sequencing in the treatment of urothelial cancer

作     者：Lexiaochuan Wen Cameron J.Britton Rohan Garje Benjamin W.Darbro Vignesh T.Packiam 

作者机构：Department of UrologyMayo ClinicRochesterMNUSA Division of HematologyOncologyBlood&Marrow TransplantationDepartment of Internal MedicineUniversity of IowaIowa CityIAUSA Stead Family Department of PediatricsUniversity of IowaIowa CityIAUSA Department of UrologyUniversity of IowaIowa CityIAUSA 

出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)

年 卷 期：2021年第8卷第4期

页      面：391-399页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Tumor sequencing Whole exome sequencing Next-generation sequencing Somatic mutations Bladder cancer Urothelial carcinoma 

摘      要：The development of rapid genome sequencing has greatly enhanced our understanding of the molecular biology underlying many *** exome sequencing has highlighted the individualistic nature of malignancies on a patient-to-patient basis and begun to revolutionize therapeutic *** recent years,whole genome sequencing of urothelial malignancies has identified a host of somatic mutations which contribute to growth,progression,and metastasis of urothelial carcinoma of the bladder and upper tract urothelial *** genetic sequencing continues,additional targets will be identified,allowing development of novel therapeutic agents targeting cancer on a molecular level,with the goal of delivering highly individualized care based on the underlying mutational profile of the patient’s *** this review,we aim to discuss known genetic alterations of urothelial malignancy and the implications these mutations carry in terms of prognostication and development of targeted therapeutic *** will focus on RNA-expression profiling and genomic DNA profiling,with a focus on comprehensive whole exome and whole genome sequencing relative to selected urothelial carcinoma-associated genes and circulating tumor DNA analysis.