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The role of MC1R gene in buffalo coat color

2012全国发育生物学大会

作者： Jian Sun,Yu Shi,Jie-Jing Li,Bing-Yu Mao state key laboratory of genetic resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences, Kunming,China,650223

The kidney is an essential organ that functions in filtering wastes,absorbing nutrients and *** pronephros of Xenopus,which contains a single nephron,offers a simplified in vivo system to study the events of tubulogenesis, including the establishment of cell polarity and lumen *** Eph receptors are the largest sub-family of receptor tyrosine kinases(RTKs) and are widely involved in animal growth and development,including segmentation,axon guidance,cell migration,***,their roles in kidney development remain largely *** found that EphA7 is specifically distributed at the subapical region in Xenopus embryonic pronephric tubule epithelial cells and knockdown of XEphA7 disturbed the epithelial cell polarity and blocked pronephric tubulogenesis,suggesting that polarized Eph signaling might be essential in the control of cell polarity and lumen formation in Xenopus pronephric tubulogenesis. Conclusions:Our data indicate that Xenopus EphA7 is necessary for the development of pronephros by maintaining the polarity of the tubule epithelial cells.

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Science China(Life Sciences) 2010年第2期53卷 267-272页

作者： MIAO YongWang1,2,WU GuiSheng3,WANG Lei2,LI DaLin4,TANG ShouKun5,LIANG JianPing2,MAO HuaMing2,LUO HuaiRong3 & ZHANG YaPing1,6 1 laboratory for Conservation and Utilization of Bio-resource,Yunnan University,Kunming 650091,China 2 Faculty of Animal Science and Technology,Yunnan Agricultural University,Kunming 650201,China 3 Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China 4 Yunnan Institute of Buffalo Science and Technology,Kunming 650021,China 5 Animal Husbandry and Veterinary Station of Luxi city,Luxi 678400,China 6 state key laboratory of genetic resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China laboratory for Conservation and Utilization of Bio-resource Yunnan University Faculty of Animal Science and Technology Yunnan Agricultural University Kunming Institute of Botany Chinese Academy of Sciences

Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many *** investigate if the MC1R gene is associated with coat color in water buffalo,the coding region of MC1R gene of 216 buffalo samples was sequenced,which included 49 black river buffalo (Murrah and Nili-Ravi),136 swamp buffalo (Dehong,Diandongnan,Dechang,Guizhou,and Xilin) with white and gray body,and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp *** the three variation sites found,SNP684 was synonymous,while SNP310 and SNP384 were nonsynonymous,leading to p.S104G and p.I128M changes,*** Individuals carrying homozygote EBR/EBR were *** genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of *** in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of *** results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.

关键词： Buffalo coat color MC1R

Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province,China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 807-815页

作者： Jun-jie YE Li MA Li-juan YANG Jin-huan WANG Yue-li WANG Hai GUO Ning GONG Wen-hui NIE Shu-hua ZHAO Yunnan key laboratory of Fertility Regulation and Minority Eugenics Yunnan Population and Family Planning Research Institute state key laboratory of genetic resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Department of Urology Kunming General Hospital of Chengdu Military Command Haiyuan College Kunming Medical University

Objective:There are many reports on associations between spermatogenesis and partial azoospermia factor c(AZFc) deletions as well as duplications;however,results are conflicting,possibly due to differences in methodology and ethnic *** purpose of this study is to investigate the association of AZFc polymorphisms and male infertility in the Yi ethnic population,residents within Yunnan Province,ChinaMethods:A total of 224 infertile patients and 153 fertile subjects were selected in the Yi ethnic *** study was performed by sequence-tagged site plus/minus(STS+/) analysis followed by gene dosage and gene copy definition analysis.Y haplotypes of 215 cases and 115 controls were defined by 12 binary markers using single nucleotide polymorphism on Y chromosome(Y-SNP) multiplex assays based on single base primer extension ***:The distribution of Y haplotypes was not significantly different between the case and control *** frequencies of both gr/gr(7.6% vs.8.5%) and b2/b3(6.3% vs.8.5%) deletions do not show significant ***,single nucleotide variant(SNV) analysis shows no significant difference of gene copy definition between the cases and ***,the frequency of partial duplications in the infertile group(4.0%) is significantly higher than that in the control group(0.7%).Further,we found a case with sY1206 deletion which had two CDY1 copies but removed half of DAZ ***:Our results show that male infertility is associated with partial AZFc duplications,but neither gr/gr nor b2/b3 deletions,suggesting that partial AZFc duplications rather than deletions are risk factors for male infertility in Chinese-Yi population.

关键词： Azoospermia factor c(AZFc) AZFc polymorphism b2/b3 gr/gr Infertility

Habitat use and seasonal Daily path length in polygynous black-crested gibbons:Is male's defense so important?

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Habitat use and seasonal Daily path length in polygynous bla...

第七届全国野生动物生态与资源保护学术研讨会

作者： Huang Bei~1,Jiang Xue-long~(1*) (1 state key laboratory of genetic resources and Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan,China Kunming Institute of Zoology,ChineseAcademy of Sciences,32 Jiaochang Donglu,Kunming,Yunnan 650223,China.*)

Gibbons are territorial small apes and most species are regularly found in monogynous groups, while western black-crested gibbon(Nomascus concolor),cao vit or eastern black-crested gibbon ((Nomascus nasutus),and Haina...

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史氏鲟和达氏鳇养殖亲鱼群体遗传多样性分析

水产学报 2010年第12期34卷 1795-1799页

作者：牛翠娟胡红霞罗静李陈中国科学院昆明动物研究所遗传资源与进化国家重点实验室北京师范大学生命科学学院教育部生物多样性与生态工程重点实验室北京市水产科学研究所

利用线粒体控制区序列片段(史氏鲟,425bp,达氏鳇,434bp)分析检测了两个养殖场留做后备亲鱼的史氏鲟和达氏鳇的遗传多样性。在所检测的养殖史氏鲟后备亲鱼4个年龄群体共34个体中,发现5个单倍型,共有11个多态位点,占碱基总数的2.6%,无简... 详细信息

利用线粒体控制区序列片段(史氏鲟,425bp,达氏鳇,434bp)分析检测了两个养殖场留做后备亲鱼的史氏鲟和达氏鳇的遗传多样性。在所检测的养殖史氏鲟后备亲鱼4个年龄群体共34个体中,发现5个单倍型,共有11个多态位点,占碱基总数的2.6%,无简约信息位点。不同单倍型之间有1～10个变异位点,占碱基总数的0.2%～2.4%。各单倍型之间的遗传距离为0.002～0.024。单倍型多样性Hd=0.768,平均核苷酸差异数k=4.367,核苷酸多样性Pi=0.011。而分别来自2个养殖场的2个达氏鳇养殖群体都是1个群体仅1个单倍型,2个单倍型之间仅有2个碱基差异,遗传距离为0.005,遗传变异极度缺乏。结果提示在利用史氏鲟和达氏鳇后备亲鱼进行繁殖育苗时要充分注意近交的影响。

关键词：史氏鲟达氏鳇后备亲鱼线粒体控制区遗传多样性

Asymmetric interaction will facilitate the evolution of cooperation

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Science China(Life Sciences) 2010年第8期53卷 1041-1046页

作者： WANG RuiWu1, HE JunZhou1,2, WANG YaQiang1,2, SHI Lei1,3 & LI YaoTang1,2 1 state key laboratory of genetic resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China 2 School of Mathematics and Statistics, Yunnan University, Kunming 650091, China 3 Statistics and Mathematics College, Yunnan University of Finance and Economics, Kunming 650221, China state key laboratory of genetic resources and Evolution Kunming Institute of Zoology Chinese Academy of Science School of Mathematics and Statistics Yunnan University

Explaining the evolution of cooperation remains one of the greatest problems for both biology and social science. The classical theories of cooperation suggest that cooperation equilibrium or evolutionary stable strategy between partners can be maintained through genetic similarity or reciprocity relatedness. These classical theories are based on an assumption that partners interact symmetrically with equal payoffs in a game of cooperation interaction. However, the payoff between partners is usually not equal and therefore they often interact asymmetrically in real cooperative systems. With the Hawk–Dove model, we find that the probability of cooperation between cooperative partners will depend closely on the payoff ratio. The higher the payoff ratio between recipients and cooperative actors, the greater will be the probability of cooperation interaction between involved partners. The greatest probability of conflict between cooperative partners will occur when the payoff between partners is equal. The results show that this asymmetric relationship is one of the key dynamics of the evolution of cooperation, and that pure cooperation strategy (i.e., Nash equilibrium) does not exist in asymmetrical cooperation systems, which well explains the direct conflict observed in almost all of the well documented cooperation systems. The model developed here shows that the cost-to-benefit ratio of cooperation is also negatively correlated with the probability of cooperation interaction. A smaller cost-to-benefit ratio of cooperation might be created by the limited dispersal ability or exit cost of the partners involved, and it will make the punishment of the non-cooperative individuals by the recipient more credible, and therefore make it more possible to maintain stable cooperation interaction.

关键词： Hawk–Dove game evolutionarily stable strategy asymmetric cooperation mixed strategy Nash equilibrium

Depth-dependent expression of obliquely incident wave induced radiation stress

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Progress in Natural Science:Materials International 2007年第9期17卷 1067-1073页

作者： Zheng Jinhai(state key laboratory of Hydrogy-Water resources and Hydrautic Engineering,MOE key laboratory of Coastal Disaster and Defence,Hohai University,Nanjing 210098,China) MOE key Lab. of Coastal Disaster and Defence Hohai University Nanjing 210098 China

The vertically dependent expressions of obliquely incident waves induced radiation stress are derived by use of the second order Stokes wave theory within three regions of the water column,that is,above the mean water level,below the wave trough level,and between these two *** indicate that the wave-induced radiation stress below the wave trough level is from the water wave particle velocity only,whereas both the water wave particle velocity and the wave pressure contribute to the tensor above the wave trough level;the vertical variations of the wave-induced radiation stress are influenced substantially by the velocity component in the direction of wave propagation;the distributions of the wave-induced radiation stress tensor over depth are non-uniform and the proportion of the tensor below the wave trough level becomes considerable in the shallow water;from water surface to seabed,the reversed variations occur for the predominant tensor components.

关键词： second order Stokes wave radiation stress depth-dependent expression

New insight into the role of miRNAs in leukemia

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Science China(Life Sciences) 2009年第3期52卷 224-231页

作者： ZHANG Hua & CHEN YueQin key laboratory of genetic Engineering of the Ministry of Education,state key laboratory of Biocontrol,Sun Yan-Sen University,Guangzhou 510275,China key laboratory of genetic Engineering of the Ministry of Education State Key Laboratory of Biocontrol Sun Yan-Sen University Guangzhou China

Recent studies have shown that microRNAs(miRNAs) play an important role in cell differentiation,growth,and death,including the functional study of miRNAs in *** date,miRNA expression profiles in many types of cancers have been identified and miRNA expression signatures associated with types and cytogenetics of leukemia have also been *** evidence has shown that miRNAs could function as either tumor suppressors or oncogenes in cancers such as leukemia,while other miRNAs might be benefitcial for diagnosis and prognosis,predicted to be newly developed *** this review,we summarize the recent progress about miRNAs in leukemia and present a miRNA-mediated network involved in differentiation,proliferation and apoptosis predicted to be the roles of miRNAs in the pathogenesis of leukemia.

关键词： miRNA leukemia regulation network clinical implication

Cloning and characterization of an up-regulated GA 20-oxidase gene in hybrid maize

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Progress in Natural Science:Materials International 2009年第2期19卷 161-166页

作者： Jinkun Du,Yingyin Yao,Zhongfu Ni,Qixin Sun Department of Plant genetics & Breeding and state key laboratory for Agrobiotechnology,key laboratory of Crop Genomics and genetic Improvement,Ministry of Agriculture/Beijing key laboratory of Crop genetic Improvement,China Agricultural University,Beijing 100094,China Department of Plant genetics & Breeding and state key laboratory for Agrobiotechnology Key Laboratory of Crop Genomics and Genetic Improvement Ministry of Agriculture/Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100094 China

Previous studies revealed that GA content and metabolism are positively correlated with a faster shoot growth rate of hybrid,and recently,genes participating in both GA biosynthesis and GA response pathways were also found to be differentially expressed between wheat hybrid and its parental inbreds. In this study,an up-regulated GA 20-oxidase gene in a maize hybrid,designated ZmGA20,was cloned. ZmGA20 contains an open reading frame (ORF) encoding 391 amino acid residues. BLASTX searches in GenBank revealed that the ZmGA20 is homologous to the sequences of GA20ox proteins from different species,and analysis also indicated that ZmGA20 had typical features of GA 20-oxidase proteins,including a "LPWKET" sequence. Semi-quantitative RT-PCR analysis showed that ZmGA20 was expressed in different tissues and/or organs. The expression level of ZmGA20 in the hybrid was higher than that in two parents (in roots,leaves,stems and embryo,and ears). The abundance of ZmGA20 transcript was equal to that of the highly expressed parents,which provided molecular evidence for the observed GA content heterosis in maize hybrids.

关键词： GA 20-oxidase Gene expression Maize Heterosis