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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ting-Bao ZHAO~(1,2,#),Shi-De LIN~(2,#),Xiao-Jun ZHANG~(1,2,#),Shu-Guang YANG~(1,#),Fan-Wen KONG~(1,#),Zheng YONG~3, Fang-Jin CHEN~1,Zhao-Qing LIU~1,Hai-Ping QUE~1,Guo-Hua WANG~1,Jian-Quan ZHENG~3,Dong-Hua TIAN~(1,4),San-Jun HU~5,Shu-Qian JING~(1,4),Shao-Jun LIU~(1,2,4,*) 1 Department of Neurobiology and state key laboratory of Proteomics,Institute of Basic Medical Sciences,27 Taiping Road,beijing 100850,china 2 Department of Spinal Cord Repair,Jinan General Hospital,25 Shifan Road,Jinan 250031,china 3 beijing Institute of Pharmacology and Toxicology,27 Taiping Road,beijing 100850,china 4 School of Social Development and Public Policy,beijing normal university,19 Xinjiekou Wai St.beijing 100875, china 5 Institute of neuroscience,The Fourth Military Medical university,Xian 710032,china

＜正＞Completely transected rat lower thoracic spinal cord was bridged either immediately or lingeringly by microsurgically linking T7 intercostal nerves to L3 dorsal root stumps to establish a bridged *** surgical sites were treated locally with a neurotrophin/growth factor *** the surgery,partial hind limb locomotion and visceral function were gradually *** nerve fibers were then traced to pass through linking sites,grow into L3 dorsal root stumps,enter the spinal cord and eventually contact with neurons in the gray matter of the spinal cord between L2 and *** bridged nerves could trigger evoked potentials in sciatic nerve, bladder,and colon,and induce hind limb *** the bridged nerves transected,the evoked potentials and hind limb locomotion disappeared,urinary retention and feces incontinence occurred *** observations demonstrate that physical and functional linkages between the segments of injured spinal cords have been established by bridging *** is first evidence that the peripheral nerves grow into the central nerve *** importantly,this innovative strategy is potentially applicable for clinic.

关键词： spinal cord injury novel strategy functional recovery neurotrophin/growth factor cocktail

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Modification of retinal horizontal cell morphology during photoreceptor degeneration in the RCS rats

Modification of retinal horizontal cell morphology during ph...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Qiang ZENG~1,Hai-Tao ZHANG~2,Zhi-Ping LIU~1,Yi WANG~2,Zheng-Qin YIN~(2*),Shi-Gang HE~(1,*) 1 state key laboratory of Brain and cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,beijing 100101,china 2 Southwest Eye Hospital,Chongqing 400038,china

＜正＞Objective The Royal College of Surgeons（RCS） rats undergo a sustained degeneration of photoreceptors from the retinal pigment epithelial cell *** one kind of intemeurons,horizontal cells connect to cone and rod photoreceptors directly in the outer plexiform layer,which may be influenced by the loss of *** order to examine the remodeling of the surviving secondary neurons,here we investigated the lamination and morphology of horizontal cells （HCs） during photoreceptor degeneration in the RCS *** RCS rats were sampled at different degeneration stages and compared with age-matched control *** immunostaining of the cryosections and DiI labeling of the wholemount retinas were carried out to examine soma,dendritic and axonal *** were acquired by confocol microscopy and analyzed with *** The staining of photoreceptors shows that at P35,the beginning of the photoreceptor degeneration,the loss of photoreceptors is not significant and the morphology of the HCs is not changed. At P45 the loss of photoreceptors is obvious in the RCS *** the lamination and morphology of the HCs are not significantly *** 2 months,with 20%or less photoreceptors left,the area of dendrites and axon terminals are both reduced significantly and dendritic arbors become much *** the lamination of the HCs is still normal at this stage. At 3 months,nearly all the photoreceptors are *** dendritic arbor area is reduced and some of the dendrites tangle with each other;the axon terminals show a very simple morphology with only some main *** axon terminals show ectropic branches and the lamination is *** The morphology of HCs changes with the loss of the photoreceptors in the RCS *** the dendrites and axon terminals become simpler and smaller,but the modification is slower than the loss of *** lamination of the HC neurites is normal in the outer plexiform layer even at

关键词： RCS rat horizontal cell DiI labeling

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Corss-modal learning of animals using "BatEars"

Corss-modal learning of animals using "BatEars"

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xin-Xiu XU~(1,2),Shi-Gang HE~(1,2),Ju-Fang HE~(1,2,3,*) 1 state key laboratory of Brain and cognitive Sciences 2 CAS-Hong Kong Joint laboratory for Visuo-auditory Integration,Institute of Biophysics,Chinese Academy of Sciences, beijing 100101,china 3 Department of Rehabilitation Sciences,The Hong Kong Polytechnic university,Hung Hom,Kowloon,Hong Kong

＜正＞Objective Cross-modal learning is crucial for daily activities and survival for both animals and *** recent results of fMRI study showed that the visual cortex was activated as well as the hippocampal system with the "BatEars" sound after a 2-week training *** further investigate the neural mechanisms underlying the cross-modal learning at the neuronal levels,animal model replicating the human studies is ***（1） Cats will be trained to use the electronic "BatEars" to navigate themselves in three types of mazes.（2） Neuronal activities of the auditory and visual cortices,and the entorhinal and/or perirhinal cortices in the hippocampal system will be simultaneously recorded while the animal is trained to use the "BatEars".Results The animal with deprived vision could learn to use the signals from the "BatEars" to navigate within circled maze.

关键词： Cross-modal learning neural plasticity hearing and vision

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Schizophrenia-related behavioral phenotypes in transgenic rats expressing elevated forebrain dopamine D5 receptors

Schizophrenia-related behavioral phenotypes in transgenic ra...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Hui-Kun WANG~1,Ting-He HU~2,Xue-Chu ZHEN~(1,*) 1 state key laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,china 2 Shanghai Institute of Brain Functional Genomics,East china normal university,Shanghai 200062,china

＜正＞Dysfunction of dopamine system in central nervous system is one of the key mechanisms in the pathological processing of *** the dominant roles of D2 receptor hyperfunction associated with positive symptoms of schizophrenia,the abnormal activities of D1-like receptor in the pathogenesis of negative symptoms and cognitive deficits in the disease have attracted great attention recently.D1-like receptors are comprised of D1 and D5 subtypes. Since no pharmacological tool is available to distinguish these two subtypes,the relative contribution between D1 and D5 receptors in schizophrenia remains largely *** taking the advantage of alpha-CaMKII-D5 transgenic rats,in which expression of D5 receptor in forebrain is selectively elevated,we explored the potential roles of D5 receptor in the schizophrenia-related *** transgenic rats exhibited similar basal activity of locomotion with their wild type （WT） *** acute injection of phencyclidine（PCP）,an NMD A receptor antagonist which can induce psychotic symptoms,male D5 transgenic rats showed comparably increase in total and central area locomotion with WT rats,while female D5 transgenic rats showed a longer latency to achieve enhanced central area locomotion than WT ***, male D5 transgenic rats exhibited normal sensory-motor gating properties in either basal condition or in response to PCP ***,compared to WT control,female D5 transgenic rats were more resistant to PCP-induced suppression of sensory-motor gating at the dosage of 3 mg/*** T-maze delayed alternation task,male D5 transgenic rats showed higher working memory capacity at the retention interval of 80s under basal ***,working memory of male D5 transgenic rats were more susceptible to be disrupted by psychostimulant *** summary,our present data demonstrated that alteration of D5 receptor activity may take a part in the pathogenesis of impaired working memory in schizop

关键词： schizophrenia dopamine D5 receptor transgenic rat behavior

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RCS大鼠视网膜变性过程中二级神经元形态学变化的研究

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生物物理学报 2010年第5期26卷 389-396页

作者：张海涛曾强阴正勤王一何士刚第三军医大学西南医院西南眼科医院重庆400038 中国科学院生物物理研究所脑与认知科学国家重点实验室北京100101

用免疫组织化学方法研究RCS大鼠(Royal College of Surgeon's rat,RCS rat)视网膜变性过程中早、中、晚期二级神经元形态的变化。结果发现,P1MRCS大鼠各二级神经元未见明显的形态改变。P2M RCS大鼠视网膜外核层萎缩约85%,视杆双极细胞... 详细信息

用免疫组织化学方法研究RCS大鼠(Royal College of Surgeon's rat,RCS rat)视网膜变性过程中早、中、晚期二级神经元形态的变化。结果发现,P1MRCS大鼠各二级神经元未见明显的形态改变。P2M RCS大鼠视网膜外核层萎缩约85%,视杆双极细胞顶端树突萎缩;水平细胞的树突与轴突在外网状层的分层未见改变。P3M RCS大鼠视网膜外核层萎缩近95%,RCS大鼠视杆双极细胞顶端萌生新的神经突起;水平细胞的树突分支明显丢失,轴突在外网状层的分层发生改变,出现新生神经突起;无长突细胞的树突在内网状层的分层至变性晚期也未见改变。该研究表明RCS大鼠视网膜二级神经元形态的改变是继发性改变,是感光细胞变性后对传入缺失的一种反应,即重构反应。在进行视网膜功能救治时需要考虑重构反应带来的影响。

关键词：视网膜色素变性二级神经元形态学 RCS大鼠重构

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中国数字化记忆门诊临床应用指南

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中华医学杂志 2023年第1期103卷 1-9页

作者：中国老年学和老年医学学会脑认知与健康分会中国老年医学学会认知障碍分会中国医师协会神经内科医师分会中华医学会神经病学分会痴呆与认知障碍学组中华中医药学会内科分会张占军贾建平贾建军陈晓春高颖李馨陈蕾安不详北京师范大学认知神经科学与学习国家重点实验室北京100875 首都医科大学宣武医院神经疾病高创中心神经内科北京100053 解放军总医院老年医学研究所北京100039 福建医科大学附属协和医院神经内科福州350001 北京中医药大学中医脑病研究院北京100029 北京师范大学认知神经科学与学习国家重点实验室中日友好医院神经内科

数字化记忆门诊是将电子化评估工具和数字化辅助设备应用到认知障碍管理中,联系各级医院的认知障碍诊疗方式,是加强认知障碍早期预防和早期治疗的重要手段之一。本指南系统检索和评价了数字化记忆门诊的适用人群、各应用场景下的评估工... 详细信息

数字化记忆门诊是将电子化评估工具和数字化辅助设备应用到认知障碍管理中,联系各级医院的认知障碍诊疗方式,是加强认知障碍早期预防和早期治疗的重要手段之一。本指南系统检索和评价了数字化记忆门诊的适用人群、各应用场景下的评估工具等问题涉及的有效性证据,并针对各级医院的情况推荐了相应的设备配置、人员配置和工作流程等建设方案。通过对近几年的实证研究与临床实践的深入分析,本指南规范了数字化记忆门诊建设中各个场景下评估工具的选择,细化了数字化评估设备的使用方式,明确地提出了各级医院应承担的职责。本指南的发布可以完善各级医院的数字化记忆门诊建设,规范认知障碍及其高风险人群的集中接诊、转诊、干预、随访等于一体的全流程专病管理,有效提升认知障碍诊疗效率。

关键词：认知障碍早期诊断记忆门诊

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脑功能磁共振成像研究及应用展望

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首都师范大学学报（自然科学版） 2004年第S1期25卷 38-42页

作者：周小祥李福利首都师范大学物理系北京100037

功能性核磁共振成像 (fMRI)技术可以显示大脑各个区域内静脉毛细血管中血液氧合状态所起的磁共振信号的微小变化 .fMRI作为无损和动态的探测技术 ,已日益成为观察大脑活动 ,进而揭示脑和思维关系的一种重要方法 .本文对功能磁共振成像... 详细信息

功能性核磁共振成像 (fMRI)技术可以显示大脑各个区域内静脉毛细血管中血液氧合状态所起的磁共振信号的微小变化 .fMRI作为无损和动态的探测技术 ,已日益成为观察大脑活动 ,进而揭示脑和思维关系的一种重要方法 .本文对功能磁共振成像的生物物理机制作了简要的描述 .然后分别介绍了脑高级功能磁共振成像研究过程中的实验设计、数据处理等环节 .最后给予了脑高级功能磁共振成像研究的最新进展和应用展望 .

关键词：大脑功能磁共振成像血氧水平依赖认知活动功能联结

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阿尔茨海默病针刺四关穴动脉自旋脑灌注初步研究

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阿尔茨海默病及相关病杂志 2018年第1期1卷 1-5页

作者：马天樊响倪虹李晖李坤成 china-ADNI 首都医科大学宣武医院放射科磁共振成像脑信息学北京市重点实验室

目的:应用三维动脉自旋标记技术探索阿尔茨海默病针刺四关穴脑血流灌注变化,初步评价针刺四关穴的治疗效果。材料与方法:搜集10例经首都医科大学宣武医院神经内科记忆障碍门诊诊断的AD患者(AD组)和10例年龄、性别和受教育程度与之相匹... 详细信息

目的:应用三维动脉自旋标记技术探索阿尔茨海默病针刺四关穴脑血流灌注变化,初步评价针刺四关穴的治疗效果。材料与方法:搜集10例经首都医科大学宣武医院神经内科记忆障碍门诊诊断的AD患者(AD组)和10例年龄、性别和受教育程度与之相匹配的正常老年人作为对照(NC组),其中AD组患者行针刺四关穴治疗6个月。采用三维动脉自旋标记(three-dimensional arterial spin labeling,3D-ASL)技术测量被试者脑多部位灌注信号强度,运用神经心理学量表辅助评估AD组及NC组的认知状态。AD组和NC组在入组时和6个月后完成MRI扫描和神经心理学量表测评,分析两组被试的异同。结果:(1)AD组和NC组被试年龄、性别、受教育年限匹配,组间差异无统计学意义(P>0.05); AD组简明精神状态检查量表(mini-mental state examination, MMSE)和蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分值显著低于NC组。(2)AD组和NC组被试基线数据左右侧脑灌注信号强度差异无统计学意义;AD组在双侧海马、双侧后扣带回、双侧额颞叶皮层、右侧枕叶皮层部位ASL信号强度降低,以右侧后扣带回为著。(3)AD组基线与6个月后复查ASL图像比较,左颞叶皮层、右侧尾状核信号强度减低,差异有统计学意义;NC组基线与6个月复查比较信号强度无显著性差异;AD和NC组二次检查脑灌注ASL的信号差异无统计学意义。结论:(1)应用3D-ASL技术可以显示AD脑灌注异常区,有可能作为AD早期诊断的指标之一。(2)针刺四关穴或可减缓AD脑灌注减低进程。

关键词：阿尔茨海默病三维动脉自旋标记针刺

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