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Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada

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World Journal of Gastroenterology 2018年第11期24卷 1216-1227页

作者： Mawuena Binka Zahid A Butt stanley wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua British Columbia Centre for Disease Control Vancouver BC V5Z4R4Canada School of Population and Public Health University of British ColumbiaVancouver BC V6T1Z3Canada Division of Population and Public Health Ministry of HealthVictoria BC V8W9P1Canada Department of Pathology and Laboratory Medicine University of British ColumbiaVancouver BC V6T1Z2Canada

AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since *** data were integrated with prescription drug,medical visit,hospitalization and mortality *** cases were classified as acute or chronic according to provincial *** compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative ***46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic *** alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative *** multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug *** odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic *** with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV *** odds increased with increasing socioeconomic *** Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,preven

关键词： Hepatitis B virus Ethnicity Drug use Acute hepatitis B BC Hepatitis Testers Cohort North America

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《晨光捕魚》

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海峡影艺 2013年第3期 57-页

作者： stanley wong

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Doubling over ten years of central obesity in Hong Kong Chinese working men

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Chinese Medical Journal 2007年第13期120卷 1151-1154页

作者： KO Gary Tin-choi CHAN Juliana CHAN Amy wong Patrick HUI stanley CHOW Ferrie TONG Spencer CHAN Cecilia Department of Medicine Alice HML Nethersole HospitalHong Kong SAR China The Chinese University of Hong Kong Hong Kong SARChina Hong Kong Hospital Authority Hong Kong SARChina The University of Hong Kong Hong Kong SARChina

Obesity is now an epidemic in most parts of the world. In this cross sectional study, we report the most recent data on obesity in Hong Kong Chinese working population and compare the changes over 10 years. Methods Between July 2000 and March 2002, 5882 adult subjects from the working class in Hong Kong were recruited （2716 men （46.2%） and 3166 women （53.8%））. They were randomly selected using computer generated codes according to the distribution of occupational groups. Results of this study were compared with the data collected from a prevalence survey for cardiovascular risk factors in a Hong Kong Chinese working population conducted in 1990 （1513 subjects, 910 men （60.1%） and 603 women （39.9%））. Results Standardized percentages of overweight, obesity, and central obesity, in Hong Kong Chinese working population were 59.7%, 35.0%, 26.7% in men and 32.0%, 21.7%, 26.7% in women. Compared to the data collected in 1990, the percentage of obesity increased by 5% in men and reduced by 6% in women. The percentage of central obesity doubled in men （from 12.2% to 26.7%） but remained stable in women.Conclusions There is a doubling of the percentage of central obesity in Hong Kong Chinese working men over previous decade. Education and proper lifestyle modification program to tackle this social health issue are urgently indicated.

关键词： obesity prevalence Hong Kong Chinese working population health promotion

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Effect of age on aortic atherosclerosis

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Journal of Geriatric Cardiology 2013年第2期10卷 135-140页

作者： Michael A. Chen Miwa Kawakubo Patrick M. Colletti Dongxiang Xu Laurie LaBree Dustin Robert Detrano stanley P Azen Nathan D. wong Xue-Qiao Zhao Department of Medicine Division of Cardiology Harborview Medical Center/University of Washington 325 9th Avenue Box 359748 Seattle WA 98104 USA Department of Preventive Medicine Division of Biostatistics Keck School of Medicine of the University of Southern California 2001 N Soto Street SSB 201A M/C 9234 Los Angeles CA 90089-9237 USA Department of Radiology Keck School of Medicine of the University of Southern California1 1500 San Pablo Street Second Floor Imaging Los Angeles CA 90033 USA Department of Radiology University of Washington School of Medicine Box 357115 1959 Pacific Street RR-215 Seattle WA 98195-7117 USA Department of Radiological Sciences University of California Irvine School of Medicine 101 the City Drive South Route 140 Orange CA 92868 USA Department of Medicine UC Irvine School of Medicine 333 City Blvd. West Suite 400 Orange CA 92868-3298 USA

Objective To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). Methods A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoracic aorta imaging by MRI. Maximum wall thickness was measured and the mean wall thickness ***/outer wall ratio was used as a normalized wall index (NWI) adjusted for artery size difference among participants. Percent wall volume (PWV) was calculated as NWI ×*** In this asymptomatic cohort (mean age: 76 years), the mean (SD) aortic wall area andwall thicknesswere 222 ±45 mm2 and 2.7 ±0.4 mm, respectively. Maximum wall thickness was 3.4 ±0.6 mm, and PWV was 32% ±4%. Women appeared to have smaller wall area,but after correcting for their smaller artery size, had significantly higher PWV than men (P = 0.03). Older age was associatedwith larger wall area (P = 0.04 for trend) with similar PWVs. However, there were no statistically significant associations between standard risk factors,Framingham global risk, or metabolic syndrome status, therapy for cholesterol or hypertension, coronary or aortic calcium score, and the aortic wall burden. Aortic calcificationwas associated with coronary calcification. Conclusions Asymptomatic elderly in this cohort had a greater descending thoracic aortic wall volume that correlated with age, andwomen had a significantly increased PWV compared to men. In these survivors, the atherosclerotic aortic wall burden was not significantly associated with traditional risk factors or with coronary or aortic calcium scores or coronary calcium progression. Results suggest that age, or as yet unidentified risk factor(s), may be responsible for the increase in atherosclerosis.

关键词： Aging Aortic atherosclerosis Atherosclerotic risk factors Magnetic resonance imaging

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Subclinical atherosclerosis in northern and southern China： the Chinese paradox

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Journal of Geriatric Cardiology 2011年第2期8卷 72-77页

作者： Jie Huang Yang-Feng Wu Xiao-Qing Liu Ding Ding Lian-Cheng Zhao Bin Lu Xian Li Nathan D wong Laurie D Dustin stanley P Azen Robert C Detrano Clinical Research Institute and Key Lab of Health Technology Assessment of Ministry of Health School of Public Health Fudan University Shanghai 200032 China Peking University School of Public Health and the George Institute for Global Health Beijing 100083 China Guangdong Provincial People＇s Hospital Guangzhou 510030 Guangdong Province China Hua Shan Hospital Fudan University Shanghai 200040 China Cardiovascular Institute and Fuwai Hospital Beijing 100004 China Division of Cardiology University of California Irvine CA 92697 USA Department of Preventive Medicine Keck School of Medicine University of Southern California Los Angeles CA 90089-0080 USA Department of Radiology School of Medicine University of California Irvine CA 92697 USA

背景冠的心疾病(CHD ) 的发生是更高的在北比在南部的中国，然而，在传统的 CHD 的差别冒险的，解释这。没有学习在可以帮助在发生解释差别的无临床症状的动脉粥样硬化检验了差别。这研究为在北、南部的中国之间的石灰化用冠的计算断层... 详细信息

背景冠的心疾病(CHD ) 的发生是更高的在北比在南部的中国，然而，在传统的 CHD 的差别冒险的，解释这。没有学习在可以帮助在发生解释差别的无临床症状的动脉粥样硬化检验了差别。这研究为在北、南部的中国之间的石灰化用冠的计算断层摄影术(CT ) 在无临床症状的动脉粥样硬化检验了这些差别。我们在一个大多中心选择了参加者的一件随机的样品的方法为冠的钙在一个北城市(诺思) 里扫描的进行中的流行病的学习(北京， n = 49 ) 并且在二个南部的城市(南方) 里(上海， n = 50，并且广州， n = 50 ) 。从三个领域中心的参加者(意味着年龄 67 年) 经历了用动脉粥样硬化扫描的多种族的学习为冠的钙测量扫描的冠的风险因素评估和心脏的 CT 协议。结果调整了在诺思中国(北京) 的转变木头的冠的动脉钙 20 是 3.1 +/-0.4 并且在华南(上海和广州) 是 2.2 +/- 0.3 (P = 0.04 ) 。为北京的北城市的吝啬的钙分数比广州的南部的城市的高三倍(P = 0.01 ) 并且比为上海的南部的城市高 2.5 倍(P = 0.03 ) 。结论无临床症状的动脉粥样硬化的程度在广州和上海的二个南部的城市里比那在北京的北城市里是显著地更高的，甚至在为标准心脏的风险因素调整以后。这发现建议标准风险因素充分不在临床的 CHD 发生解释北方南方差别。

关键词：动脉粥样硬化中国北部临床计算机断层扫描北方城市中国南方冠状动脉悖论

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Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations

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World Journal of Hepatology 2022年第4期14卷 754-765页

作者： Ross Apostolov Emily Gianatti Darren wong Numan Kutaiba Paul Gow Mathis Grossmann Marie Sinclair Department of Gastroenterology and Liver Transplant Unit Austin HealthHeidelberg 3084VICAustralia Department of Medicine University of MelbourneParkville 3010VICAustralia Department of Endocrinology Fiona Stanley HospitalMurdoch 6150WAAustralia Department of Radiology Austin HealthHeidelberg 3084VICAustralia Department of Endocrinology Austin HealthHeidelberg 3084VICAustralia

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in people with diabetes with no available *** To explore the effect of testosterone treatment on *** therapy improves insulin resistance and reduces total body fat,but its impact on the liver remains poorly *** This secondary analysis of a 40 wk,randomised,double-blinded,placebocontrolled trial of intramuscular testosterone undecanoate in men with type 2 diabetes and lowered serum testosterone concentrations evaluated the change in hepatic steatosis as measured by liver fat fraction on magnetic resonance imaging(MRI).RESULTS Of 88 patients enrolled in the index study,39 had liver MRIs of whom 20 received testosterone therapy and 19 received *** patients had>5%hepatic steatosis at baseline and 38 of 39 patients met diagnostic criteria for *** liver fat at baseline was 15.0%(IQR 11.5%-21.1%)in the testosterone and 18.4%(15.0%-28.9%)in the placebo *** ALT was 34units/L(26-38)in the testosterone and 32units/L(25-52)in the placebo *** week 40,patients receiving testosterone had a median reduction in absolute liver fat of 3.5%(IQR 2.9%-6.4%)compared with an increase of 1.2%in the placebo arm(between-group difference 4.7%P<0.001).After controlling for baseline liver fat,testosterone therapy was associated with a relative reduction in liver fat of 38.3%(95%confidence interval 25.4%-49.0%,P<0.001).CONCLUSION Testosterone therapy was associated with a reduction in hepatic steatosis in men with diabetes and low serum *** randomised studies of testosterone therapy in men with NAFLD focusing on liver-related endpoints are therefore justified.

关键词： Hepatic steatosis Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Testosterone therapy Testosterone undecanoate Type 2 diabetes

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Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer’s disease

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Translational Neurodegeneration 2013年第1期2卷 174-182页

作者： Shuk Wai Ho Yuk Tung Chanel Tsui Ting Ting wong stanley Kwok-Kuen Cheung William B Goggins Lau Ming Yi Kwok Kin Cheng Larry Baum Department of Surgery The University of Hong KongPokfulamHong KongChina School of Biomedical Sciences(Pharmacology) The University of NottinghamNottinghamUK Department of Microbiology The University of Hong KongPokfulamHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina School of Pharmacy The Chinese University of Hong KongShatinHong KongChina

Alzheimer’s disease(AD),the most common dementia,is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein,and their deposition as amyloid plaques and neurofibrillary tangles(NFTs).Tau aggregation also occurs in other common neurodegenerative *** dementia(FTD)can be caused by tau mutations that increase the susceptibility of tau to hyperphosphorylation and aggregation,which may cause neuronal dysfunction and deposition of NFTs.17-allylamino-17-demethoxygeldanamycin(17-AAG)is a potent inhibitor of heat shock protein 90(Hsp90),a cytosolic chaperone implicated in the proper folding and functions of a repertoire of client proteins.17-AAG binds to Hsp90 and enhances degradation of Hsp90 client *** sought to determine whether 17-AAG can reduce Aβ and tau pathology in the brains of AD and FTD model mice expressing Aβ or P301L mutant tau,*** were randomized to receive 25,5,or 0 mg/kg 17-AAG thrice weekly from age eight to 11 *** was performed by rotarod test on motor function,on the area occupied by plaques in hippocampus or NFTs in medulla tissue sections,and on mortality.A high dose of 17-AAG tended to decrease NFTs in male mice(p=0.08).Further studies are required to confirm the effect of 17-AAG in diseases of tau aggregation.

关键词： Dementia Mouse Tangles Plaques

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Flattening the biological age curve by improving metabolic health:to taurine or not to taurine,that’s the question

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Journal of Geriatric Cardiology 2023年第11期20卷 813-823页

作者： Kwok M.Ho Anna Lee William Wu Matthew T.V.Chan Lowell Ling Jeffrey Lipman Jason Roberts Edward Litton Gavin M.Joynt Martin wong Department of Intensive Care Medicine Fiona Stanley HospitalPerthAustralia Medical School The University of Western AustraliaPerthAustralia School of Veterinary&Life Sciences Murdoch UniversityPerthAustralia Department of Anaesthesia&Intensive Care Prince of Wales HospitalChinese University of Hong KongHong KongChina Jamieson Trauma Institute Royal Brisbane and Women’s HospitalBrisbaneQueenslandAustralia Division of Anaesthesiology Critical Care Emergency and Pain Medicine Nîmes University HospitalUniversity of MontpellierNîmesFrance University of Queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneAustralia Herston Infectious Diseases Institute(HeIDI) Metro North HealthBrisbaneAustralia Departments of Pharmacy and Intensive Care Medicine Royal Brisbane and Women’s HospitalBrisbaneAustralia JC School of Public Health and Primary Care Centre for Health Education and Health PromotionChinese University of Hong KongHong KongChina School of Public Health Peking UniversityBeijingChina School of Public Health Fudan UniversityShanghaiChina

The aging population is an important issue around the world especially in developed *** med-ical advances have substantially extended life span,the same cannot be said for the duration of health *** are seeing in-creasing numbers of elderly people who are frail and/or have multiple chronic conditions;all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare *** is mechanistically related to common medical conditions such as diabetes mellitus,ischemic heart disease,cognitive decline,and frailty.A recently accepted concept termed‘Accelerated Biological Aging’can be diagnosed when a person’s biological age—as measured by biomarkers of DNA methylation—is older than their corresponding chronological ***,a conditionally essential amino acid,has received much attention in the past few years.A substantial number of animal studies have provided a strong scientific foundation sug-gesting that this amino acid can improve cellular and metabolic health,including blood glucose control,so much that it has been labelled one of the‘longevity amino acids’.In this review article,we propose the rationale that an adequately powered random-ized-controlled-trial(RCT)is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health,and biological *** trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors,and also the community at large,to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.

关键词： rational meaningful Taurine

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Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5085-5095页

作者： Ye Peng Lin Zhang Chris K.P.Mok Jessica Y.L.Ching Shilin Zhao Matthew K.L.wong Jie Zhu Chunke Chen Shilan Wang Shuai Yan Biyan Qin Yingzhi Liu Xi Zhang Chun Pun Cheung Pui Kuan Cheong Ka Long Ip Adrian C.H.Fung Kenneth K.Y.wong David S.C.Hui Francis K.L.Chan Siew C.Ng Hein M.Tun Microbiota I-Center(MaglC) Hong KongChina Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina Centre for Gut Microbiota Research The Chinese University of Hong KongHong KongChina

The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be *** this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition.

关键词： vaccine immunity vaccines

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冠状动脉口部病变介入治疗中Szabo技术应用的安全性和可行性

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中华老年心脑血管病杂志 2011年第10期13卷 867-869页

作者：杨胜利刘惠亮 Aaron wong Jack Tan 刘英张蛟 LIM Soo Teik Paul Chiam stanley Chia 武警总医院心内科北京100039 新加坡国家心脏中心心内科

目的分析冠状动脉口部病变PCI中造影和血管内超声(intra vascular ultrasonography,IVUS)结果 ,评价Szabo技术的成功率、安全性和可行性。方法回顾性分析Szabo技术治疗冠状动脉口部病变患者39例PCI结果。结果经桡动脉途径31例(79.5%),... 详细信息

目的分析冠状动脉口部病变PCI中造影和血管内超声(intra vascular ultrasonography,IVUS)结果 ,评价Szabo技术的成功率、安全性和可行性。方法回顾性分析Szabo技术治疗冠状动脉口部病变患者39例PCI结果。结果经桡动脉途径31例(79.5%),经股动脉途径8例(20.5%)。罪犯血管为左前降支26例(66.7%),右冠状动脉5例(12.8%),左回旋支及钝缘支3例(7.7%),后降支5例(12.8%)。支架置入后,对30例(76.9%)罪犯血管和9例(23.1%)边支血管进行了IVUS检查。手术成功36例(92.3%)。所有患者造影成功率为100%。IVUS检测罪犯血管准确支架置入到口部患者29例(96.7%)和支架近端轻度凸出患者1例(3.3%)。结论 Szabo技术用于冠状动脉口部病变PCI中是安全可行的,而且具有极高的造影成功率。经过IVUS检查证实大部分支架在冠状动脉口部病变处能准确置入。

关键词：冠状动脉疾病支架超声检查介入性冠状血管造影术

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